Background: According to recent studies in children, IgE sensitization not only against perennial allergens, but also against food allergens, is related to asthma risk and increased airway inflammation. During the last decade, a new technique for IgE determination based on allergen components has become available, but its use in epidemiological studies has been limited. Aims: To investigate the relationship between the pattern of IgE sensitization to allergen components and the prevalence of asthma, airway inflammation and hyperresponsiveness in a population-based setting. To examine the relationship of IgE sensitization to allergen extract, and airway inflammation, airway hyperresponsiveness and blood eosinophilia in asthmatics. To examine the natural history of IgE sensitization to food allergens in adults. To compare extract-based and component-based IgE measurements in relation with new-onset respiratory disease and airway inflammation and hyperresponsiveness. Methods: The present thesis is based on cross-sectional and longitudinal analyses of the adult, the population-based study ECRHS (European Community Health Survey) and a cross-sectional, observational study of young subjects with asthma. IgE sensitization was examined by means of both extract-based and component-based tests. Airway inflammation was assessed by exhaled NO and airway hyperresponsiveness with methacholine test. Results: IgE sensitization to food allergens independently related to increased airway inflammation in both a population-based study and a study of asthmatics. Furthermore, a relation was found with increased blood eosinophils in asthmatics. The decrease in prevalence of IgE sensitization against food allergens during a 9-year follow-up was larger than the decrease of aeroallergens. Subjects with IgE sensitization to both cat extract and components showed more frequent airway inflammation, greater bronchial responsiveness and higher likelihood of developing asthma and rhinitis than subjects with IgE sensitization only to cat extract. Conclusions: The presence of IgE antibodies against food allergens was independently associated with airway and systemic inflammation. Both aeroallergens and food allergens should be examined in order to understand the signaling of local and systemic inflammation in asthma. Prevalence of IgE sensitization to food decreased in adults to a larger extent than IgE sensitization against aeroallergens. Measurement of IgE sensitization to cat allergen components appears to have a higher clinical value than extract-based measurement

This thesis considers exhibitions in natural history museums as a process of negotiation between three parties: the museum as an institution, the museum staff, and the visitors. These represent different interests that shape exhibitions relating to nature. The thesis asks the following main question: In what way do discourses play a role in the staff’s work within natural history museums? The empirical sources are based on interviews conducted with staffmembers from eight different natural history museums: six in Austria and two in Norway. The interviews are analysed based on the principles of discourse psychology and critical discourse analysis. The theoretical framework is based on postmodernism as a reaction and countermovement to modernism. Kant’s theory of knowledge, the concept of representation and discourse theory are considered in relation to one another and form an ontological departure for the epistemology. The methodology combines critical discourse analysis and discourse psychology as applied to conversational text. The discourse analysis reveals different discourses concerning the museum as institution, professional museum staff, and the visitors. The thesis concludes that the museum as institution is characterised by a knowledge culture/tradition that was particularly substantiated during the Enlightenment. In turn, the knowledge tradition is characterised by discourse that places expectations regarding the procedures of the employee, but also through the visitors’ expectations as to what a museumis and what the exhibitions provide them with. The employees meet the museum understood as discourse through mainly three different strategies for how exhibitions should function. I call these strategies ‘action promotion’, ‘communication focus’ and ‘political context’. In this way, the identities and actions of the employees depend considerably on their personal relationship to the museum as a concept and discourse, as well as to the visitors’ presumptions, expectations and experiences concerning museums. / Diese Master-Arbeit betrachtet die Ausstellung eines naturgeschichtlichen Museums als Ergebnis eines Verhandlungsprozesses zwischen drei Parteien mit unterschiedlichen Interessen: dem Museumspersonal, dem Museum als Institution sowie dem Publikum. Die Hauptfragestellung der Arbeit lautet: In welcher Weise spielen Diskurse in der Arbeit derwissenschaftlichen Angestellten naturgeschichtlicher Museen eine Rolle? Der theoretische Rahmen der Arbeit basiert auf dem Postmodernismus als einer Reaktion auf und Gegenbewegung zum Modernismus. Kants Erkenntnistheorie, das Konzept der Repräsentation sowie die Diskurstheorie bilden zusammen die ontologische Grundlage der Epistemologie. Die Methodologie kombiniert gesprächsbezogene kritische Diskursanalyse und Diskurspsychologie. Das empirische Material besteht aus Interviews mit wissenschaftlichen Angestellten acht naturgeschichtlicher Museen, davon sechs in Österreich und zwei in Norwegen. Die Diskursanalyse deckt unterschiedliche Diskurse hinsichtlich des Museums als Institution, der wissenschaftlichen Angestellten sowie des Publikums auf. Die Arbeit schlussfolgert, dass das Museum als Institution von einer Wissenskultur gekennzeichnet ist, die insbesondere in der Zeit der Aufklärung begründet ist. Diese Kultur ist insofern diskursgeprägt, als dass sie bestimmte Erwartungen an die Arbeit des Museumspersonals beinhaltet, aber auch durch die Erwartungen des Publikums an ein Museum und seine Ausstellungen. Die Angestellten nähern sich dem Museum als Diskurs, in dem sie hauptsächlich drei verschiedene Strategien im Hinblick auf die Funktion von Ausstellungen verfolgen: Inspiration zu eigenständigem Handeln (”Handlungspromotion”),auf das Publikum zugeschnittene Kommunikation (”Kommunikationsfokus”) sowie Einbeziehung politischen Kontexts. Insofern hängen Identität und Handeln der Angestellten stark von ihrer persönlichen Beziehung zum Museum als Konzept und Diskurs ab, ebenso wie von ihren Annahmen bezüglich der Erwartungen des Publikums und dessen Erfahrungen mit Museen.

As North American plants took root in Parisian botanical gardens and regularly appeared in scientific texts in the seventeenth and eighteenth centuries, they retained their connections to networks of ecological and cultural exchange in colonial North America. In this dissertation I study the history of French botany and natural history as it became an Atlantic enterprise during this time, analyzing the production of knowledge about North American flora and the place of this knowledge in larger processes of colonialism and imperial expansion in the French Atlantic World. I focus particular attention on recovering the role of aboriginal peoples in the production of knowledge about colonial environments on both sides of the Atlantic. Rather than integrating aboriginal collectors, chefs and healers into traditional histories of western science, I integrate familiar histories of science into larger histories of cultural contact in an Atlantic World with multiple centres of knowledge production and exchange. This dissertation develops two closely related arguments. First, I argue that French encounters with American environments and Native cultures were inseparable. Jesuit missionaries, for example, called both a plant and a native culture “wild rice,” conflating descriptions of local ecological and morphological features of the Great Lakes plant with accounts of indigenous cultural and moral attributes. Second, “Plants and Peoples” also analyzes the process by which the Paris-based Académie Royale des Sciences expanded its reach into North America and argues that French colonial naturalists drew on a vibrant conversation between diverse colonial and indigenous communities. Yet indigenous participation and the knowledges they provided were progressively effaced over the course of the seventeenth and eighteenth centuries. This research therefore presents both a new understanding of the history of early modern and enlightenment botany and a lens through which to revisit and enrich familiar histories of cultural exchange in colonial North America.

The natural history of localized prostate cancer is not fully understood. In most patients the tumor will never progress to a lethal disease, while a subset of patients will ultimately die of the disease. Efficient tools to separate indolent from lethal disease is currently lacking which means that many patients will be offered treatment without any benefit, but still be at risk of experiencing treatment related side effects. The aims of these studies were to get more insight into the natural history of untreated localized prostate cancer, to assess the prognostic value of established clinical parameters such as Gleason score, nuclear grade and tumor volume and, moreover, some new prognostic markers Ki-67, AMACR and MUC-1. We also aimed to study time trends in the detection of incidental tumors in Sweden. Patients with localized disease (n=223) and no initial treatment were followed for 21 years. Most patients had a favorable outcome. However, a subset of patients developed lethal disease even beyond 15 years of follow-up and these patients define the group that may benefit most from treatment with curative intent. Patients with poorly differentiated tumors experienced a 9 time higher risk of dying in prostate cancer. The studies on prognostic markers are based on a cohort of patients (n=253) with incidental prostate cancer detected by transurethral resection for presumed benign hyperplasia. All patients were left without initial treatment. Gleason grade, nuclear grade and tumor volume turned all out to be independent prognostic factors. MUC-1, AMACR and Ki-67 also carried prognostic information. However, after adjustment for Gleason grade, nuclear grade and tumor volume only MUC-1 and AMACR remained as statistically significant prognostic factors. When tested for sensitivity and specificity they all failed and, consequently, they seem to be of less value in daily practice for cancelling an individual patient regarding the choice of treatment. Time trends in incidental prostate tumors in Sweden were analyzed in a cohort of patients with prostate tumors detected by transurethral resection (TUR-P). Through linkage of the national registration number (NRN) with several registers, e.g. the Swedish Cancer Registry, the National Inpatient registry and the Cause of Death Registry we identified, during the period 1970 through 2003, in total 23288 patients with incidental prostate cancer, who constituted the study group. As comparison group we choose all patients diagnosed with prostate cancer between 1970-2003 excluding those with incidental cancer, in total 112204 patients. Our result confirms earlier findings that there has been a dramatic change over time in incidence of incidental prostate cancers in Sweden, which parallels the introduction of prostate specific antigen. We also found that the cumulative incidence of prostate cancer death is high in the incidental group, opposing earlier findings that incidental tumours are a non-lethal disease.

The aim of this research is to examine the much neglected body of writings on New Zealand and the Maori by German-speaking explorers and travellers during the colonising period of the 1840s to 1880s. To the nineteenth-century breed of visitor from Germany and Austria, 'Old' New Zealand often presented itself as an unexplored field of scientific curiosities, from botany and geology to ornithology and ethnology, at the same time as a paradise for immigrant workers. The investigation begins with an evaluation of the eighteenth-century account of Georg Forster, who accompanied Captain Cook on his second voyage to the South Pacific. Forster's account is entrenched in the early racial stereotypes and theories of the 'savage', and provides the first major primary source for all of German-speaking Europe up to the period under investigation. The second main source to be considered is the dominant 'paradise' image which evolved out of the propaganda of the New Zealand Company and continued right through the colonising era. The principal figures to be examined include Ernst Dieffenbach, the official Company naturalist, Friedrich August Krull, the first German Consul in New Zealand, Ferdinand von Hochstetter, the resident geologist on the Novara expedition, Julius von Haast, the founder and director of the Canterbury Museum, Andreas Reischek, the taxidermist and collector, as well as other notable visitors including Max Buchner, Franz Reuleaux, Otto Finsch, Alexander von Hübner and Robert von Lendenfeld. Thus, it is the goal of this investigation to analyse the perception of New Zealand and the Maori in selected works by German-speaking explorers and travellers who arrived in the colony between 1839 and 1889 through, first of all, confronting the prevailing stereotypes and images inherent in the philosophical attitudes of the eighteenth and nineteenth centuries towards the 'savage' and those present in the 'paradise' rhetoric of the British campaigners of colonisation, and secondly, examining the origins, patterns and evolution of their respective perceptions, impressions and opinions in order to reveal the true extent of their non-British 'Germanic' viewpoint.

The aim of this research is to examine the much neglected body of writings on New Zealand and the Maori by German-speaking explorers and travellers during the colonising period of the 1840s to 1880s. To the nineteenth-century breed of visitor from Germany and Austria, 'Old' New Zealand often presented itself as an unexplored field of scientific curiosities, from botany and geology to ornithology and ethnology, at the same time as a paradise for immigrant workers. The investigation begins with an evaluation of the eighteenth-century account of Georg Forster, who accompanied Captain Cook on his second voyage to the South Pacific. Forster's account is entrenched in the early racial stereotypes and theories of the 'savage', and provides the first major primary source for all of German-speaking Europe up to the period under investigation. The second main source to be considered is the dominant 'paradise' image which evolved out of the propaganda of the New Zealand Company and continued right through the colonising era. The principal figures to be examined include Ernst Dieffenbach, the official Company naturalist, Friedrich August Krull, the first German Consul in New Zealand, Ferdinand von Hochstetter, the resident geologist on the Novara expedition, Julius von Haast, the founder and director of the Canterbury Museum, Andreas Reischek, the taxidermist and collector, as well as other notable visitors including Max Buchner, Franz Reuleaux, Otto Finsch, Alexander von Hübner and Robert von Lendenfeld. Thus, it is the goal of this investigation to analyse the perception of New Zealand and the Maori in selected works by German-speaking explorers and travellers who arrived in the colony between 1839 and 1889 through, first of all, confronting the prevailing stereotypes and images inherent in the philosophical attitudes of the eighteenth and nineteenth centuries towards the 'savage' and those present in the 'paradise' rhetoric of the British campaigners of colonisation, and secondly, examining the origins, patterns and evolution of their respective perceptions, impressions and opinions in order to reveal the true extent of their non-British 'Germanic' viewpoint.

The aim of this research is to examine the much neglected body of writings on New Zealand and the Maori by German-speaking explorers and travellers during the colonising period of the 1840s to 1880s. To the nineteenth-century breed of visitor from Germany and Austria, 'Old' New Zealand often presented itself as an unexplored field of scientific curiosities, from botany and geology to ornithology and ethnology, at the same time as a paradise for immigrant workers. The investigation begins with an evaluation of the eighteenth-century account of Georg Forster, who accompanied Captain Cook on his second voyage to the South Pacific. Forster's account is entrenched in the early racial stereotypes and theories of the 'savage', and provides the first major primary source for all of German-speaking Europe up to the period under investigation. The second main source to be considered is the dominant 'paradise' image which evolved out of the propaganda of the New Zealand Company and continued right through the colonising era. The principal figures to be examined include Ernst Dieffenbach, the official Company naturalist, Friedrich August Krull, the first German Consul in New Zealand, Ferdinand von Hochstetter, the resident geologist on the Novara expedition, Julius von Haast, the founder and director of the Canterbury Museum, Andreas Reischek, the taxidermist and collector, as well as other notable visitors including Max Buchner, Franz Reuleaux, Otto Finsch, Alexander von Hübner and Robert von Lendenfeld. Thus, it is the goal of this investigation to analyse the perception of New Zealand and the Maori in selected works by German-speaking explorers and travellers who arrived in the colony between 1839 and 1889 through, first of all, confronting the prevailing stereotypes and images inherent in the philosophical attitudes of the eighteenth and nineteenth centuries towards the 'savage' and those present in the 'paradise' rhetoric of the British campaigners of colonisation, and secondly, examining the origins, patterns and evolution of their respective perceptions, impressions and opinions in order to reveal the true extent of their non-British 'Germanic' viewpoint.

The aim of this research is to examine the much neglected body of writings on New Zealand and the Maori by German-speaking explorers and travellers during the colonising period of the 1840s to 1880s. To the nineteenth-century breed of visitor from Germany and Austria, 'Old' New Zealand often presented itself as an unexplored field of scientific curiosities, from botany and geology to ornithology and ethnology, at the same time as a paradise for immigrant workers. The investigation begins with an evaluation of the eighteenth-century account of Georg Forster, who accompanied Captain Cook on his second voyage to the South Pacific. Forster's account is entrenched in the early racial stereotypes and theories of the 'savage', and provides the first major primary source for all of German-speaking Europe up to the period under investigation. The second main source to be considered is the dominant 'paradise' image which evolved out of the propaganda of the New Zealand Company and continued right through the colonising era. The principal figures to be examined include Ernst Dieffenbach, the official Company naturalist, Friedrich August Krull, the first German Consul in New Zealand, Ferdinand von Hochstetter, the resident geologist on the Novara expedition, Julius von Haast, the founder and director of the Canterbury Museum, Andreas Reischek, the taxidermist and collector, as well as other notable visitors including Max Buchner, Franz Reuleaux, Otto Finsch, Alexander von Hübner and Robert von Lendenfeld. Thus, it is the goal of this investigation to analyse the perception of New Zealand and the Maori in selected works by German-speaking explorers and travellers who arrived in the colony between 1839 and 1889 through, first of all, confronting the prevailing stereotypes and images inherent in the philosophical attitudes of the eighteenth and nineteenth centuries towards the 'savage' and those present in the 'paradise' rhetoric of the British campaigners of colonisation, and secondly, examining the origins, patterns and evolution of their respective perceptions, impressions and opinions in order to reveal the true extent of their non-British 'Germanic' viewpoint.

Thesis (M.S.)--University of Montana, 2004. / Typescript. Additional information available on author's web site. Includes bibliographical references (leaves 138-142).

Thesis (M.C.A.-Res.)--University of Wollongong, 2007. / Typescript. Includes bibliographical references: leaf 49-54.