Made available in DSpace on 2014-10-09T12:52:25Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T14:01:43Z (GMT). No. of bitstreams: 0 / Dissertação (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

Orientador: Maria Jaqueline Mamprim / Banca: Júlio Sequeira Lopes / Banca: Franklin de Almeida Sterman / Resumo: O linfoma canino é uma das neoplasias mais frequentes na medicina veterinária e podendo acometer vários órgãos, tanto linfonodos superficiais como profundos, bem como o baço, fígado, tonsilas, medula óssea, podendo ainda apresentar massas tumorais nos pulmões e coração. O exame ultrassonográfico tem grande importância na detecção das alterações que essa doença produz. O presente estudo teve por objetivo avaliar as alterações ultrassonográficas dos órgãos abdominais em animais com diagnóstico citológico de linfoma pela citologia, bem como agrupar os padrões de imagem a elas relacionados. Foram reavaliadas as imagens ultrasssonográficas abdominais de 70 cães com diagnóstico de linfoma, assim como os seus exames laboratoriais e suas características. Dos animais analisados, houve predomínio de cães sem raça definida, sem predileção por sexo, com ampla variação de peso e de faixa etária de 4 a 11 anos, e presença de elevação da fosfatase alcalina. Das alterações ultrassonográficas podemos salientar o maior envolvimento dos linfonodos ilíacos mediais, 54,2% hepatomegalia e 51,4% de esplenomegalia. Dos animais que foram submetidos à citologia dos linfonodos superficiais, 64 cães apresentavam alterações ultrassonográficas compatíveis com linfoma hepático, enquanto que 55 cães apresentavam alterações ultrassonográficas compatíveis com linfoma esplênico. Destes 82,8% apresentaram alterações ultrassonográficas difusas no fígado e 54,5% tinham a aparência ultrassonográfica normal no baço. Diante dos resultados apresentados, podemos concluir que o linfoma canino é uma doença complexa e que necessita de vários exames complementares para o correto diagnóstico e prognóstico da doença. Assim, o exame ultrassonográfico, em conjunto com a avaliação citologia ou histologia dos órgãos acometidos... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Canine lymphoma is one of the most frequent cancer in veterinary medicine and it can affect many organs, such as superficial and deep lymph nodes, and organs like the liver, spleen, tonsils, bone marrow, it may also make tumor masses in the lungs and heart. The ultrasound examination is a valuable procedure to diagnose the lesions produced by this disease. This study aimed to evaluate the ultrasonographic alterations of the abdominal organs in animals with cytologic diagnosis of lymphoma by and to assembly image patterns related to them. We reviewed the abdominal ultrasonographic images of 70 dogs diagnosed with lymphoma, as well as their laboratory and their clinic history. There was a predominance of mixed breed dogs with no gender preference, wide variation between the weight, age ranged 4 to 11 years, and with a predominant elevation of alkaline phosphatase. It was observed a frequently involvement of the medial iliac lymph nodes, hepatomegaly (54.2%) and splenomegaly (51,4%). Of the animals that were submitted to the cytology of superficial lymph nodes, 64 dogs had ultrasound changes consistent with hepatic lymphoma, whereas 55 dogs had ultrasound changes consistent with splenic lymphoma. Of these 82.8% had ultrasound changes in diffuse liver and 54.5% had a normal ultrasound appearance in the spleen. Considering the results presented we can conclude that the canine lymphoma is a complex disease and requires several laboratory tests for the diagnosis and prognosis of the disease. So the ultrasound examination in association with cytology or histological assessment of the lesions, can provide information of the involved organs and assist in the staging and prognosis of the treatment of sick animals. / Mestre

A avaliação da presença de destruição óssea provocada por neoplasias malignas de boca e orofaringe é um fator de fundamental importância no estabelecimento da terapêutica adequada para o caso, como também, para a determinação do prognóstico do paciente. O presente estudo teve por objetivo determinar os aspectos clínicos (localização, forma de apresentação e estadiamento) que podem estar associadas com o potencial de infiltração do osso subjacente a lesão, como também determinar a sensibilidade e especificidade do exame físico. A população de estudo consistio de vinte e cinco pacientes (17 homens e 8 mulheres, média de idade de 57,88 anos) portadores de neoplasias malignas de boca e orofaringe atendidos no Ambulatório de Semiologia da Faculdade de Odontologia da Universidade de São Paulo – campus São Paulo, no período de agosto de 2003 a agosto de 2004, os quais foram submetidos ao exame clínico e a tomografia computadorizada (TC). A TC foi considerada o padrão ouro para a avaliação da presença de destruição óssea. Foi observada a presença de infiltração neoplásica para o tecido ósseo adjacente em 68% dos casos (17 pacientes). O exame físico dos pacientes revelou uma sensibilidade de 80% e especificidade de 87,50% na análise de comprometimento do osso, além de uma acurácia de 84%. As lesões que se apresentavam clinicamente como uma úlcera do tipo infiltrativa e lesões do tipo nodulares, não ulceradas, foram as que apresentaram maior potencial de infiltrar-se para o osso, 68,75% e 100% respectivamente. A localização do tumor em determinados sítios, também influenciou diretamente na presença de invasão óssea,principalmente lesões localizadas em região de gengiva, trígono retromolar, palato duro e orofaringe. O estadiamento das lesões revelou relação existente entre o tamanho do tumor e a presença de metástases à distância com a presença de infiltração da neoplasia para o tecido ósseo. Concluindo, observou-se que a identificação de determinados parâmetros clínicos como localização, forma de apresentação clinica, tamanho da lesão e a presença de metástases à distância, associado a um criterioso exame físico regional podem servir como valiosas ferramentas para a análise de envolvimento ósseo por neoplasias malignas de boca e orofaringe. / The assessment of bone destruction by oral and oropharynx malignant neoplasms is a critical factor in the therapeutic planning and to determine the patient prognostic. The aim of this study was to determine the clinical aspects (localization, clinical manifestation and stage) that can be associated with the potential of bone infiltration, and also determine the physical exam sensibility and specificity. The study population consisted of twenty five patients (17 men and 8 women, mean age 57.88 years-old), with malignant neoplasms of the mouth and oropharynx, of the Stomatology Clinic of the College of Dentistry at the Sao Paulo University - campus Sao Paulo, in the period of august 2003 to august 2004, who were submitted to a clinical and computed tomography (CT) examinations. CT was considered the gold standard to evaluate the presence of bone involvement. The presence of bone destruction by the tumor was observed in 68% of the cases (17 patients). The physical examination of the patients revealed 82% of sensibility, 87.50% of specificity, and 84% of accuracy in the assessment of bone invasion by these diseases. The lesions that were clinical considered to be infiltrative ulcer and nodular lesions, non-ulcerated, presented the highest potential to cause bone destruction, 68.75% and 100% respectively. The tumor localization in specific sites also influenced the presence of bone invasion, meanly with the lesions localized in the gingival, retromolar trigone, hard palate and oropharynx. The stage of the lesions revealed a relation between the size and the presence of distant metastasis, with the presence of invasion by the neoplasm. In conclusion, it was determined that the identification of some clinical parameters such localization, clinical presentation, lesion size and the presence of distant metastasis, associated with a perceptive regional physical exam must be use as a value tool is the assessment of bone destruction by oral and oropharynx malignant neoplasms.

A lacuna existente na compreensão das repercussões do câncer de mama feminino para casais que vivenciaram esse processo motivou a realização deste estudo, que objetivou compreender os sentidos para o câncer de mama feminino entre casais que permaneceram unidos na vivência dessa enfermidade, por meio do referencial teórico do construcionismo social. Os dados foram coletados numa amostra de sete casais entrevistados separadamente, em entrevistas semi-estruturadas com a utilização do diário de campo. A partir disso, foram identificadas três grandes temáticas referentes aos sentidos do câncer e da conjugalidade. Os sentidos do câncer foram agrupados no item vivência da doença, que contém os temas: confirmação da doença e fase do tratamento, esta subdividida nos seguintes sub-temas: a) ficando mais em casa; b) conversando omitindo a doença; c) transportando as esposas; d) cuidado fornecido por outras mulheres; e) realização do serviço doméstico: terceirizado; f) sexualidade: afastamento. E os sentidos da conjugalidade foram agrupados na temática ser marido e ser esposa. Essas temáticas emergiram dos discursos dos entrevistados ancorados na história do câncer e na moral do modelo de conjugalidade tradicional. O câncer foi associado a uma doença com sentidos de provação e morte, que despertou nos participantes sentimentos de revolta e ansiedade e a relação com Deus. Além disso, o compromisso assumido no casamento e a não revelação dos sentimentos mais íntimos experimentados por eles em relação ao câncer de mama, possibilitou a manutenção do laço conjugal em meio à experiência dolorosa da doença. Diante disso, sugere-se a relevância da assistência interdisciplinar com o intuito de desconstruir a negatividade associada ao câncer, bem como a reflexão sobre a relevância do discurso religioso como ferramenta do cuidado assistencial a essa população. / The existent gap in the comprehension of repercussions of the feminine breast cancer for couples that lived this process motivated the accomplishment of this study, which aimed to understand the meanings for the feminine breast cancer among couples that stayed united in living of this illness, through the social construction theory. The data were collected in a sample of seven couples interviewed separately, in semi-structured interviews with the use of field notes. From this, were identified three thematic related to the meanings of cancer and related to couples\' life. The meanings of cancer were gathered in disease living item that has these themes: disease confirmation and phase of treatment. The phase of treatment was subdivided in the following sub-themes: a) staying more at home; b) talking omitting the disease; c) transporting the wives; d) care supplied by other women; e) accomplishment of the domestic service: servant; f) sexuality: stand back. And the meanings of couples\' life were gathered at the thematic to be husband and to be wife. These thematic emerged of the interviewees\' speeches anchored in the history of cancer and in the moral of traditional couples\' life model. The cancer was associated it a disease with meanings of probation and death, that emerged in the participants feelings of revolt and anxiety in relation with God. Besides, the commitment assumed in the marriage and the non revelation of the most intimate feelings experienced by them in relation to breast cancer, it made possible the maintenance of the matrimonial bow amid the painful experience of the disease. Before this, it is suggested the importance of interdisciplinary assistance with the intention to construct different meanings than negativity of cancer, as well as the reflection of the importance of the religious discourse as a tool in the care of this population.

Submitted by isabela.moljf@hotmail.com (isabela.moljf@hotmail.com) on 2017-05-18T15:50:08Z No. of bitstreams: 1 terezacristinaesteves.pdf: 997708 bytes, checksum: 9a6b71b08caa714fe1f7fe5dbc1d9535 (MD5) / Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-05-18T15:57:15Z (GMT) No. of bitstreams: 1 terezacristinaesteves.pdf: 997708 bytes, checksum: 9a6b71b08caa714fe1f7fe5dbc1d9535 (MD5) / Made available in DSpace on 2017-05-18T15:57:15Z (GMT). No. of bitstreams: 1 terezacristinaesteves.pdf: 997708 bytes, checksum: 9a6b71b08caa714fe1f7fe5dbc1d9535 (MD5) Previous issue date: 2008-02-29 / Objetivo: descrever as características demográficas, sociais e clínicas de pacientes pediátricos portadores de tumores sólidos na infância e adolescência e o status vital dos pacientes ao término do estudo e do tratamento, a partir de dados de prontuários médicos e registro hospitalar de câncer. Método: trata-se de um estudo observacional, descritivo e retrospectivo, em que foram analisados os pacientes de zero a 16 anos portadores de tumores sólidos assistidos no município de Juiz de Fora, Minas Gerais, no período de janeiro de 1997 a dezembro de 2006. Resultados: foram avaliados 231 pacientes portadores de tumores sólidos assistidos no município de Juiz de Fora. A ocorrência dos casos foi crescente no decorrer do período. O sexo masculino foi mais acometido com 56,7%. O câncer ocorreu em 39,9% na faixa etária de zero e quatro anos, a renda familiar per capita em 66,7% dos pacientes correspondeu a menos de meio salário mínimo. O SUS financiou o tratamento em 85,3% dos pacientes. Eram analfabetas 18,2% das mães e 50% dos pacientes conseguiram freqüentar a escola durante o tratamento. O sinal-sintoma mais freqüente da doença ao diagnóstico foi a dor em 34,8% seguido pela percepção do tumor em 27,8% dos pacientes. A base para o diagnóstico foi a histologia ou imunohistoquímica em 90,5%. O código morfológico foi maligno em 83, 2% e baixo grau em 15,6%. A neoplasia do SNC foi o tumor mais freqüente com 31,6% dos casos. O estadiamento foi avançado em 66,7% dos pacientes. Foi adotada conduta terapêutica após o diagnóstico de observação e controle clínico oncológico em 16,8% dos casos. A abordagem terapêutica mais utilizada foi a quimioterapia, realizada em 41,8% dos pacientes. Encontram-se vivos 28,6% dos pacientes com doença metastática, 90% dos pacientes com estádio I e II e 61,2% do total de pacientes ao término do estudo. / Objective: describe the demographic, social, and clinical characteristics of patients with solid tumors of childhood and adolescence, along with their vital status at the end of the study, based on data from medical files and hospital records. Method: retrospective, descriptive, observational study comprising patients within the 0-16 year age range, diagnosed with solid tumors, and followed in the municipality of Juiz de Fora, Minas Gerais, Brazil, from January 1997 to December 2006. Results: 231 patients with solid tumors were studied. There was an increasing occurrence during the period of study. Males were more often affected (56.7%). 39.9% of the cases occurred in the 0-4 year age range. 66.7% of the patients belonged to families with a per capita income lower than half the national minimum wage. The national health scheme (Sistema Único de Saúde – SUS) sponsored the treatment of 85.3% of the patients. 18.2% of the mothers were illiterate, and 50% of the patients were able to keep school attendance during treatment. Pain was the presenting symptom in 34.8%, followed by tumor perception in 27.8%. Histopathology or immunohistochemistry made the diagnosis in 90.5%. The morphological code was malignant in 83.2% and of low degree in 15.6%. Neoplastic disorders affecting the central nervous system were the most frequent tumors (31.6%). Staging revealed advanced disease in 66.7%. Watchful waiting with clinical control was the management strategy in 16.8%. Chemotherapy was the most frequently used strategy, being instituted in 41.8%. At the end of the study, 28.6% of the patients with metastases, 90% of stages I and II patients, and 61.2% of all patients were alive.

BACKGROUND: Organ transplantation is one of the best modalities for treating fatal organ failure. Despite the success of this procedure, an increasing incidence of cancer in this population has drawn the attention of public health officials in recent years. OBJECTIVES: The overall objective of this study is to conduct a detailed examination of adverse health outcomes among Canadian organ transplant recipients, with an emphasis on cancer incidence and mortality. METHODS: This project employed a retrospective cohort follow-up study design, whereby Canadian Organ Replacement Registry records were linked to the Canadian Mortality Database and the Canadian Cancer Registry Database. The study population consisted of more than 16,000 solid organ transplant recipients registered between January 1, 1981 and December 31, 1998. This study was designed to assess the risks of developing cancer, overall and site-specific, in transplant recipients in comparison to the general Canadian population using Standardized Incidence Ratios (SIR), Standardized Mortality Ratios (SMR), and Proportionate Mortality Ratios (PMR). In addition, Cox and logistic models were used to assess the effects of various risk factors on cancer incidence and mortality in transplant sub-populations, while cumulative incidence was used to study the patient survival pattern. Lastly, Population Attributable Risk (PAR) was used to quantify the impact of organ transplantation on cancer incidence and mortality. RESULTS: Among major causes of death, the highest PMRs are due to genitourinary diseases, followed by endocrine, nutritional and metabolic diseases, and infectious diseases. SIRs indicate that cancer incidence and mortality were relatively lower than that observed for other major causes of death, and slightly higher than that observed in the general Canadian population. Lastly, logistic regression results indicate that age, year of surgery, and smoking status were significant risk factors in mortality due to all causes, while the Cox regression model shows that age, sex and year of surgery were significant risk factors for cancer incidence. Overall, the PAR in this cohort was very minimal, indicating that the risk in mortality and cancer incidence due to organ transplantation is negligible. CONCLUSION: Life threatening diseases such as those of the genitourinary system, as well as endocrine, nutritional and metabolic diseases and infectious diseases are leading causes of death. Future research should be directed at ways of reducing incidence and subsequent mortality due to these causes.

This work includes a series of studies that examines the health and economic impacts of screening mammography from international and Canadian perspectives. This work is a compendium of several researched chapters that include an introduction, four body chapters, and a discussion. The body chapters include a systematic review of the health economic literature on screening mammography, a review of quantitative models used to examine the consequences of breast cancer screening, and cost-effectiveness analyses of screening mammography programs in Canada for the general female population and for subgroups of the population at high-risk for breast cancer. There are three analytic chapters that will be submitted as manuscripts for peer-reviewed publication. The main results of this research show that current screening mammography practices in Canada may extend life at an acceptable cost to the health care system. Due to the outlined methodological limitations of this research the results should be interpreted with caution.

Previous studies had demonstrated the presence of the p70 (CAMAL) molecule in human myeloid leukemia cells and the promyelocytic leukemia cell line HL60, but not in equivalent preparations of normal cells (Malcolm et al., 1982, 1984; Shipman et al., 1983; Logan et al., 1984). Subsequent studies demonstrated that the p70 (CAMAL) protein was detectable and expressed in human myeloid leukemia cells and the leukemic cell lines HL60, KG1, K562 and U937. The association of p70 (CAMAL) expression with human myeloid leukemia cells prompted its consideration as a candidate leukemia-associated antigen. The demonstration, following CAMAL purification and peptide sequencing, that two tryptic peptides (tp27, tp31) displayed significant homology to sequences present in human serum albumin (HSA) and human alpha-1-fetoprotein (AFP), while one tryptic peptide (tp20) displayed unique peptide sequence, suggested that CAMAL might represent a protein that was structurally and functionally related to the albumins. Consequently, a comparative biochemical analysis of CAMAL and HSA was initiated. The results of the comparative studies demonstrated that although CAMAL and HSA shared conformational antigenic determinants, both proteins were also shown to be distinct molecules by a number of other criteria. The possibility that the CAMAL preparation, used for protein sequencing and comparative studies, was contaminated with HSA was thought likely, in view of the HSA/AFP-related peptide sequences from the CAMAL tryptic peptide sequence analysis. However, other results, particularly the antibody reactivity and ligand binding studies, showed that the CAMAL preparation was not contaminated with HSA. The unique CAMAL tryptic peptide (tp20) sequence supported further the contention that CAMAL was a distinct protein with regions homologous to HSA and AFP. Further analysis of the CAMAL molecule, through extensive protein sequencing, will be, in all likelihood, the only means by which to establish the degree of relatedness between CAMAL, HSA and AFP. / Science, Faculty of / Microbiology and Immunology, Department of / Graduate

When injected with live P815 tumour cells, DBA/2 mice developed cytotoxic cells reactive to the tumour. In addition, T helper cells from tumour-bearing mice enhanced the iri vitro generation of cytotoxic cells from normal DBA/2 spleen cells. The helper cells had the following properties (1) expression of the Thy-1.2 antigen; (2) resistance to y-radiation; (3) specific enhancement of the cytotoxic response to P815; (4) detectability in P815-bearing mice at the peak of cytotoxic cell activity; (5) activity in the early phase of cytotoxic cell activation. In parallel to the development of helper cell activity, suppressor cells were generated which suppressed the cytotoxic response to P815. These suppressor cells were removed by pre-treating mice with low doses of cyclophosphamide. High doses of cyclophosphamide reduced the cytotoxic response to both P815 and C57B1/6 alloantigens. Cyclophosphamide treatment reduced the frequency of cytotoxic precursor cells directed against P815, and an antigen-reactive helper cell involved in interleukin 2 production. Both interleukin 2 and thymocytes from P815-primed mice, restored the cytotoxic response against P815, to normal levels. Twenty six percent of animals primed with tumour cells cleared a challenge dose of P815 faster than unprimed control mice. Of these, 88% survived longer than the control animals. Eighteen percent of the recipients of cells from tumour-primed mice, cleared a challenge dose of P815 faster than mice injected with normal cells. Of these 53% survived significantly longer than control groups given either normal cells or no cells at all. Cells from mice primed to PPD showed significantly enhanced proliferative responses to soluble and P815-bound PPD, when compared with unprimed animals. However, cells from only a few PPD-primed mice showed enhanced cytotoxicity against P815 tumour cells, and PPD-primed cells either did not alter, or suppressed, the cytotoxic response of normal DBA/2 spleen cells, when stimulated with PPD-coated P815. / Science, Faculty of / Microbiology and Immunology, Department of / Graduate

Orientadores: Gustavo Antonio de Souza, Maria Salete Costa Gurgel / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-08T02:38:19Z (GMT). No. of bitstreams: 1 Oliveira_MarianaMaiaFreirede_M.pdf: 2870270 bytes, checksum: 3cc12d99aeebd1b7364b222041edf8b1 (MD5) Previous issue date: 2007 / Resumo: A fisioterapia no pós-operatório de câncer de mama visa a prevenir as complicações e promover a independência funcional. Porém, não há dados na literatura sobre a influência da fisioterapia realizada durante a radioterapia, bem como qual a melhor abordagem. Objetivo: Avaliar a eficácia da realização da fisioterapia durante a radioterapia na prevenção das seguintes complicações físicas loco-regionais: limitação da amplitude de movimento do ombro, aumento da circunferência e incapacidade funcional do membro superior e aderência cicatricial em mulheres em tratamento por câncer de mama. Sujeitos e Métodos: Ensaio clínico controlado randomizado, realizado no Serviço de Fisioterapia do Centro de Atenção Integral à Saúde da Mulher da Universidade Estadual de Campinas, com 66 mulheres em tratamento radioterápico após cirurgia para câncer de mama e fisioterapia pós-operatória. As mulheres foram alocadas no Grupo 1 (32 mulheres) que realizou fisioterapia durante a radioterapia e no Grupo 2 (34 mulheres), controle, sendo avaliadas no início e no final da radioterapia e 6 meses após seu término. A amplitude de movimento do ombro foi avaliada através da goniometria, a circunferência do braço, pela cirtometria e a aderência cicatricial, pela palpação e fricção cicatricial. A capacidade funcional foi graduada através de escore de dificuldade para movimentar o ombro. Para cálculos estatísticos foram utilizados MANOVA com estatísitca de Wilks ou Friedman e os testes de associação qui-quadrado ou exato de Fisher, assumindo nível de significância a = 5%. Resultados: A idade média foi de 52,3 ± 10,6 anos no Grupo 1 e de 48,7 ± 10,8 anos no Grupo 2. Os valores médios de amplitude de movimento do ombro para abdução e flexão observados nas três avaliações revelaram melhores resultados para Grupo1 em relação ao Grupo 2 (p= 0,0244 e 0,0044, respectivamente). Os valores médios da circunferência do braço obtidos nas avaliações não se alteraram em ambos os grupos. Há evidências de que a fisioterapia realizada durante a radioterapia possa favorecer a melhora da capacidade funcional. Na avaliação final, a freqüência de aderência cicatricial no Grupo1 foi duas vezes menor que a observada no Grupo 2 (24% e 48%, p= 0,0477). Conclusão: A fisioterapia realizada durante a radioterapia para tratamento de câncer de mama previne a limitação na amplitude de movimento do ombro e minimiza a incidência de aderência cicatricial. Os resultados sugerem também favorecer a melhora da capacidade funcional. No período estudado, não foi encontrada associação entre a realização da fisioterapia e alteração na circunferência do braço / Abstract: Physiotherapy following surgery for breast cancer is recommended for the prevention of complications and to stimulate functional independence. However, there are no data in the literature on the influence of physiotherapy carried out during radiotherapy (RT), nor on its optimal management. Objective: To evaluate the influence of physiotherapy carried out during radiotherapy on the following physical, locoregional complications: limitations in amplitude of movement and functional capacity, increased arm circumference, and the presence of scar tissue. Subjects and Methods: A randomized, controlled clinical trial was carried out in the Physiotherapy Department of the Center for Women¿s Integrated Healthcare, Universidade Estadual de Campinas, in 66 women undergoing radiotherapy following surgery for breast cancer, and postoperative physiotherapy. Women were randomized to Group 1 (G1) in which physiotherapy was provided, and Group 2 (G2), the control group. Evaluations were carried out at the beginning and at the conclusion of RT, and 6 months after its conclusion. Amplitude of shoulder movement was evaluated by goniometry; arm circumference was measured, and the presence of scar tissue was evaluated by digital palpation of the region. Functional capacity was graded according to a score evaluating difficulty of the patient in moving the shoulder. Statistical analysis was carried out using multivariate analysis of variance (MANOVA) with the Wilks or Friedman tests, and the chi-square or Fisher¿s exact tests of association. Significance level was established as a = 5%. Results: Thirty-two women were randomized to G1 and 34 to G2. Mean age was 52.3 ± 10.6 years in G1 and 48.7 ± 10.8 years in G2. The mean values of amplitude of shoulder movement with respect to abduction and flexion found at the three evaluation times indicated better results for G1 compared to G2 (p=0.0244 and 0.0044, respectively). During the period of this study, no association was found between physiotherapy and changes in arm circumference. There are evidences that the physiotherapy carried out during radiotherapy could encourage an improvement in functional capacity. At the final evaluation, the presence of scar tissue in G1 was half that found in patients in G2 (24% and 48%, p=0.0477). Conclusion: Physiotherapy carried out during radiotherapy for breast cancer prevents limitations in the amplitude of shoulder movement, minimizes the presence of scar tissue and appears to result in an improvement in functional capacity. During the period studied, no association was found between carrying out physiotherapy and changes in arm circumference / Mestrado / Ciencias Biomedicas / Mestre em Tocoginecologia