Thesis (MMus (Music))--University of Stellenbosch, 2004. / ENGLISH ABSTRACT: The purpose of this study is to explore parallels between ‘The New Approach to violin playing’, which was developed by the Hungarian violinist Kató Havas, and the Alexander Technique, a method known for promoting kinaesthetic awareness and mind-body coordination. The specific objectives of the study are to identify the parallels between the two methods, and to obtain a deeper understanding of the New Approach, by using the Alexander Technique as a construct through which to examine the method. The study aims to illuminate some of the reasons for the reported efficacy of the New Approach, and to point the way towards achieving unity of mind and body in an expressive violin technique. Although the Alexander Technique is widely used and applied by musicians in order to improve their performance, problems are sometimes encountered in applying the Technique to the finer aspects of instrumental technique. A method of violin tuition that incorporates principles and procedures similar to those found in the Alexander Technique could bridge this gap and prove to be a very powerful tool in coordinating mind and movement in violin playing. It is the purpose of this study to show that ‘The New Approach to violin playing’ is such a method, and as such deserves to be more widely known. The research was conducted within a qualitative paradigm, using a multimethodological approach. An extensive comparative literature study of the two methods was combined with practical experience gained through regular Alexander lessons, and participation in New Approach lessons with Kató Havas and her personal representative, Gloria Bakhshayesh. The New Approach, like the Alexander Technique, is essentially a search for awareness, especially in the relationship between the player and the instrument. The particular value of the New Approach lies in the fact that Havas combines her expert knowledge of violin technique with an intuitive understanding of the conditions necessary for the optimal psychophysical functioning of the violinist. Through organising these principles into a systematised method, Havas makes the acquisition of an expressive technique more accessible to all. / AFRIKAANSE OPSOMMING: Die doel van hierdie studie is om ooreenkomste te ondersoek tussen ‘The New Approach to violin playing’ van die Hongaarse violiste, Kató Havas, en die Alexander-tegniek, ’n metode bekend daarvoor om kinestetiese bewustheid en geestelik-liggaamlike koordinasie te verhoog. Die spesifieke doel van die studie is om ooreenkomste tussen bogenoemde werkwyses te identifiseer, en om ’n beter begrip van die ‘New Approach’ te vekry, deur die Alexander-tegniek as ’n raamwerk te gebruik waardeur die metode bestudeer word. Die studie poog om sekere motiverings vir die effektiwiteit van die ‘New Approach’ uit te lig, en om die weg te wys na die verwesenliking van geestelik-fisieke eenheid in ’n ekspressiewe viooltegniek. Alhoewel die Alexander-tegniek dikwels deur uitvoerende musici gebruik word om hul spelvermoë te verbeter, word probleme soms ondervind in die toepassing van die tegniek op die fyner aspekte van instrumentale spel. ’n Metode van vioolonderrig wat beginsels en prosesse soortgelyk aan díé van die Alexander-tegniek insluit, sou hierdie probleem kon oorkom en as kragtige middel kon dien vir die koördinasie van denke en ligaamlike beweging in vioolspel. Hierdie studie poog om te illustreer dat die ‘New Approach’ hierdie kwaliteite het, en as sulks meer blootstelling aan vioolonderwysers verdien. In hierdie ondersoek is gebruik gemaak van ’n multi-metodologiese benadering binne ’n kwalitatiewe navorsingsparadigma. ’n Vergelykende literatuurstudie van die Alexander-tegniek en ‘The New Approach to violin playing’ is gekombineer met praktiese ervaring wat vekry is deur middel van gereelde Alexander lesse, asook deelname aan ‘New Approach’ lesse met Kató Havas en haar persoonlike verteenwoordiger, Gloria Bakhshayesh. Die ‘New Approach’ – net soos die Alexander-tegniek – is in wese ’n soeke na bewustheid, veral in die interaksie tussen die violis en die instrument. Die besondere waarde van die ‘New Approach’ is dat Havas haar gesaghebbende kennis van viooltegniek gekombineer het met ’n intuïtiewe begrip vir die optimale psigofisiese funksionering van die violis. Deur hierdie beginsels in ’n sistematiese metode te orden, skep Havas die moontlikheid om ’n ekspressiewe viooltegniek aan almal beskikbaar te stel.

É extremamente comum que o solo de uma determinada região não tenha os parâmetros geotécnicos favoráveis a implementação de projetos de pavimentação e fundações. Com o passar do tempo, o homem ocupou praticamente todos os locais onde as características do solo são favoráveis à construção civil, principalmente nos grandes centros urbanos, restando os locais que desafiam os projetistas a fazerem obras de baixo custo e qualidade técnica. Com intuito de solucionar este problema, vários trabalhos estão sendo desenvolvidos através da técnica de melhoramento ou estabilização de solos com agentes cimentantes. Deste modo, o presente trabalho teve como objetivo validar uma nova abordagem para a obtenção de parâmetros de resistência ao cisalhamento de uma areia artificialmente cimentada. Para aplicação desta abordagem, utilizou-se resultados de compressão simples e diametral, sendo estes comparados com os resultados obtidos a partir de ensaios de compressão triaxial consolidados e drenados com as mesmas características dos ensaios de compressão não confinada. Com o intuito de enriquecer o conhecimento sobre o assunto, também foram aplicados outros modelos de previsão de resistência ao cisalhamento, tais como, o critério de ruptura de Griffith (1921) e o modelo experimental de Mitchell (1981). Para isto, o solo utilizado foi uma areia de granulometria fina com adição de Cimento Portland CPV-ARI, com três diferentes porcentagens de cimento em relação a massa de solo seco (3, 5,1 e 8,6) e, para tempos de cura de 03, 07, 28 e 90 dias. Baseados nos resultados obtidos através deste trabalho, concluiu-se que: quanto ao comportamento tensão-deformação, os ensaios apresentaram pico de resistência bem definido com comportamento de material rígido e queda acentuada da resistência após a ruptura; quanto a utilização da nova abordagem proposta, os parâmetros de resistência do modelo quando comparados com os resultados obtidos pelos ensaios triaxiais foram satisfatórios, deste modo validando esta metodologia. O emprego da teoria de Griffith e do modelo de Mitchell, não apresentaram resultados com a mesma qualidade obtida pela nova abordagem proposta. / It is extremely common that the soil of a particular region does not have the favorable geotechnical parameters for implementing paving and foundations projects. With the passage of time men has occupied virtually all locations where soil characteristics are favorable for constructions, especially in large urban centers, leaving the places that challenge engineers to design works of low cost and technical quality. In order to solve this problem, several studies are being developed through soil improvement and stabilization technique with cementing agents. Thus, the present study aimed to validate a new approach to obtain shear strength parameters of an artificially cemented sand. To apply this approach, results of unconfined compression tests were used, which were compared to the results obtained from consolidated and drained triaxial compression tests, with the same characteristics of the unconfined compressive tests. In order to enrich the knowledge on this subject, other models were applied to predict parameters of resistance, such as the Griffith (1921) failure criterion and the experimental model of Mitchell (1981). The soil used was a fine grained sand with addition of Portland cement CPV-ARI, with 3.00, 5.06 and 8.60 percentage of cement in relation to the mass of dry soil at curing times of 03, 07, 28 and 90 days. Based on the results obtained through this work, it was concluded that the use of the new approach proposed is valid because the strength parameters of the model when compared with the results obtained by the triaxial tests were satisfactory. The use of the Griffith theory and Mitchell model did not obtain results with the same quality obtained by the new approach proposed. Regarding the stress-strain behavior, the triaxial tests showed peak strength with well-defined behavior of rigid material and sharp drop in resistance after the rupture.

É extremamente comum que o solo de uma determinada região não tenha os parâmetros geotécnicos favoráveis a implementação de projetos de pavimentação e fundações. Com o passar do tempo, o homem ocupou praticamente todos os locais onde as características do solo são favoráveis à construção civil, principalmente nos grandes centros urbanos, restando os locais que desafiam os projetistas a fazerem obras de baixo custo e qualidade técnica. Com intuito de solucionar este problema, vários trabalhos estão sendo desenvolvidos através da técnica de melhoramento ou estabilização de solos com agentes cimentantes. Deste modo, o presente trabalho teve como objetivo validar uma nova abordagem para a obtenção de parâmetros de resistência ao cisalhamento de uma areia artificialmente cimentada. Para aplicação desta abordagem, utilizou-se resultados de compressão simples e diametral, sendo estes comparados com os resultados obtidos a partir de ensaios de compressão triaxial consolidados e drenados com as mesmas características dos ensaios de compressão não confinada. Com o intuito de enriquecer o conhecimento sobre o assunto, também foram aplicados outros modelos de previsão de resistência ao cisalhamento, tais como, o critério de ruptura de Griffith (1921) e o modelo experimental de Mitchell (1981). Para isto, o solo utilizado foi uma areia de granulometria fina com adição de Cimento Portland CPV-ARI, com três diferentes porcentagens de cimento em relação a massa de solo seco (3, 5,1 e 8,6) e, para tempos de cura de 03, 07, 28 e 90 dias. Baseados nos resultados obtidos através deste trabalho, concluiu-se que: quanto ao comportamento tensão-deformação, os ensaios apresentaram pico de resistência bem definido com comportamento de material rígido e queda acentuada da resistência após a ruptura; quanto a utilização da nova abordagem proposta, os parâmetros de resistência do modelo quando comparados com os resultados obtidos pelos ensaios triaxiais foram satisfatórios, deste modo validando esta metodologia. O emprego da teoria de Griffith e do modelo de Mitchell, não apresentaram resultados com a mesma qualidade obtida pela nova abordagem proposta. / It is extremely common that the soil of a particular region does not have the favorable geotechnical parameters for implementing paving and foundations projects. With the passage of time men has occupied virtually all locations where soil characteristics are favorable for constructions, especially in large urban centers, leaving the places that challenge engineers to design works of low cost and technical quality. In order to solve this problem, several studies are being developed through soil improvement and stabilization technique with cementing agents. Thus, the present study aimed to validate a new approach to obtain shear strength parameters of an artificially cemented sand. To apply this approach, results of unconfined compression tests were used, which were compared to the results obtained from consolidated and drained triaxial compression tests, with the same characteristics of the unconfined compressive tests. In order to enrich the knowledge on this subject, other models were applied to predict parameters of resistance, such as the Griffith (1921) failure criterion and the experimental model of Mitchell (1981). The soil used was a fine grained sand with addition of Portland cement CPV-ARI, with 3.00, 5.06 and 8.60 percentage of cement in relation to the mass of dry soil at curing times of 03, 07, 28 and 90 days. Based on the results obtained through this work, it was concluded that the use of the new approach proposed is valid because the strength parameters of the model when compared with the results obtained by the triaxial tests were satisfactory. The use of the Griffith theory and Mitchell model did not obtain results with the same quality obtained by the new approach proposed. Regarding the stress-strain behavior, the triaxial tests showed peak strength with well-defined behavior of rigid material and sharp drop in resistance after the rupture.

É extremamente comum que o solo de uma determinada região não tenha os parâmetros geotécnicos favoráveis a implementação de projetos de pavimentação e fundações. Com o passar do tempo, o homem ocupou praticamente todos os locais onde as características do solo são favoráveis à construção civil, principalmente nos grandes centros urbanos, restando os locais que desafiam os projetistas a fazerem obras de baixo custo e qualidade técnica. Com intuito de solucionar este problema, vários trabalhos estão sendo desenvolvidos através da técnica de melhoramento ou estabilização de solos com agentes cimentantes. Deste modo, o presente trabalho teve como objetivo validar uma nova abordagem para a obtenção de parâmetros de resistência ao cisalhamento de uma areia artificialmente cimentada. Para aplicação desta abordagem, utilizou-se resultados de compressão simples e diametral, sendo estes comparados com os resultados obtidos a partir de ensaios de compressão triaxial consolidados e drenados com as mesmas características dos ensaios de compressão não confinada. Com o intuito de enriquecer o conhecimento sobre o assunto, também foram aplicados outros modelos de previsão de resistência ao cisalhamento, tais como, o critério de ruptura de Griffith (1921) e o modelo experimental de Mitchell (1981). Para isto, o solo utilizado foi uma areia de granulometria fina com adição de Cimento Portland CPV-ARI, com três diferentes porcentagens de cimento em relação a massa de solo seco (3, 5,1 e 8,6) e, para tempos de cura de 03, 07, 28 e 90 dias. Baseados nos resultados obtidos através deste trabalho, concluiu-se que: quanto ao comportamento tensão-deformação, os ensaios apresentaram pico de resistência bem definido com comportamento de material rígido e queda acentuada da resistência após a ruptura; quanto a utilização da nova abordagem proposta, os parâmetros de resistência do modelo quando comparados com os resultados obtidos pelos ensaios triaxiais foram satisfatórios, deste modo validando esta metodologia. O emprego da teoria de Griffith e do modelo de Mitchell, não apresentaram resultados com a mesma qualidade obtida pela nova abordagem proposta. / It is extremely common that the soil of a particular region does not have the favorable geotechnical parameters for implementing paving and foundations projects. With the passage of time men has occupied virtually all locations where soil characteristics are favorable for constructions, especially in large urban centers, leaving the places that challenge engineers to design works of low cost and technical quality. In order to solve this problem, several studies are being developed through soil improvement and stabilization technique with cementing agents. Thus, the present study aimed to validate a new approach to obtain shear strength parameters of an artificially cemented sand. To apply this approach, results of unconfined compression tests were used, which were compared to the results obtained from consolidated and drained triaxial compression tests, with the same characteristics of the unconfined compressive tests. In order to enrich the knowledge on this subject, other models were applied to predict parameters of resistance, such as the Griffith (1921) failure criterion and the experimental model of Mitchell (1981). The soil used was a fine grained sand with addition of Portland cement CPV-ARI, with 3.00, 5.06 and 8.60 percentage of cement in relation to the mass of dry soil at curing times of 03, 07, 28 and 90 days. Based on the results obtained through this work, it was concluded that the use of the new approach proposed is valid because the strength parameters of the model when compared with the results obtained by the triaxial tests were satisfactory. The use of the Griffith theory and Mitchell model did not obtain results with the same quality obtained by the new approach proposed. Regarding the stress-strain behavior, the triaxial tests showed peak strength with well-defined behavior of rigid material and sharp drop in resistance after the rupture.

Cette étude vise à comparer les représentations du mythe de l’androgyne dans la littérature française fin-de-siècle et à l’époque de la Jeune Pologne sur l’exemple des œuvres choisies de Rachilde, Huysmans, Komornicka et Przybyszewski. La genèse de ce mythe reflète le caractère complexe et hétérogène de l’être à sexe indéterminé, mettant en valeur la continuité de la vie des mythes dans les textes littéraires. Néanmoins, son entrée dans la littérature marquerait la dégradation du mythe par rapport au mythe primaire. Autrement dit, l’androgyne fin-de-siècle de chair et d’os marque la rupture avec l’androgyne initial, incarnation de l’union harmonieuse, ce qui impose une certaine hiérarchie aux versions postérieures du récit mythique. L’objectif est d’adopter une nouvelle approche envers la figure du Double à l’aube du XXe siècle, en ajoutant un apport polonais. L’accent est mis sur le contexte et les sens polyvalents transmis par l’androgyne. Dans l’optique de la méthode du comparatisme différentiel, l’objectif est d’instaurer un rapport non hiérarchisant entre les versions du mythe de l’androgyne en France et en Pologne. La perspective de l’analyse s’étend sur les rapprochements entre les deux mondes littéraires, la réception, les influences partagées et le différentiel. / This study aims to compare various depictions of the myth of androgyny in late-century French literature and during the Young Poland period on the example of selected works by Huysmans, Rachilde, Komornicka and Przybyszewski. The genesis of this myth reflects the complex and heterogeneous character of the figure of indeterminate sex, highlighting the continuity of the existence of myths in literary texts. Nevertheless, its entry into the literature would be perceived as a mark of degradation of the myth in comparison to the primordial one. In other words, the androgyny of flesh and bone demonstrates the break with the initial androgyny being the incarnation of the harmonious union, which imposes a certain hierarchy on the perception of later versions of the mythical narrative. The goal is to take a new approach to the figure of Double at the dawn of the twentieth century, by adding a Polish contribution. The focus is on the context and the versatile meanings conveyed. In the context of the differential comparatism method, the aim is to establish a non-hierarchical relationship between different versions of the myth of androgyne in the works of French and Polish authors. The perspective of the analysis extends to the connections between the two literary worlds, the reception, the shared influences and the differences.

The topic of my diploma thesis is removing the technical barriers of the trade of goods via harmonization of the essential requirements on the products -- mainly the legal aspects and practical consequences of the conformity assessment and the CE conformity marking. The goal of my thesis is firstly to find out what the main objective of the CE marking is and whether it really fulfills its role. Secondly, I want to find out how the process of conformity assessment looks like in practice. Thirdly I want to find out how the market surveillance is organized and how effective it is. My thesis is divided into six chapters. The first chapter depicts the situation as it had been before the marking was introducted. The second describes the statutory regulation of the CE marking system. The fourth chapter is dedicated to the process of the conformity assessment. The fifth chapter is about the market surveillance. The final sixth chapter explores problems that are related to the CE marking system.

The conventional battery for genotoxicity testing is not well-suited to assessing the large number of chemicals needing evaluation. Traditional in vitro tests lack throughput capacity, provide little mechanistic information, and have poor specificity in predicting in vivo genotoxicity. The Health Canada GeneTox21 research program is developing a multi-endpoint platform for modernized in vitro genotoxicity assessment. The GeneTox21 assays include the TGx-DDI transcriptomic biomarker (i.e., 64-gene expression signature to identify DNA damage-inducing (DDI) substances), the MicroFlow® assay (i.e., a flow cytometry-based micronucleus (MN) test), and the MultiFlow® assay (i.e., a multiplexed flow cytometry-based reporter assay that yields mechanism-of-action (MoA) information). As part of GeneTox21 development, the objective of this study was to investigate the utility of the TGx-DDI transcriptomic biomarker, multiplexed with the MicroFlow® and MultiFlow® assays, as an integrated testing strategy for screening data-poor substances prioritized by Health Canada’s New Substances Assessment and Control Bureau. Human lymphoblastoid TK6 cells were exposed to 3 control and 10 data-poor substances, using a 6-point concentration range. Cells were exposed for 4 hours with or without exogenous metabolic activation. Gene expression profiling was conducted using the targeted TempO-SeqTM assay, and the TGx-DDI classifier was applied to the dataset. Classifications were compared with those based on the MicroFlow® and MultiFlow® assays. Benchmark Concentration (BMC) modeling was used for potency ranking. The results of the integrated hazard calls indicate that five data-poor compounds are genotoxic in vitro, causing DNA damage via a clastogenic MoA, and one is positive via a pan-genotoxic MoA. Two compounds are likely irrelevant positives in the MN test; two are considered possibly genotoxic causing DNA damage via an ambiguous MoA. From quantitative analyses of concentration-response data, we observed nearly identical potency rankings for each assay with two main potency groups being observed. This ranking was maintained when all endpoint BMCs were converted into a single score using the Toxicological Prioritization (ToxPi) approach. Overall, this study contributes to the establishment of a modernized approach for effective genotoxicity assessment and chemical prioritization for further regulatory scrutiny. We conclude that integration of the TGx-DDI biomarker with other GeneTox21 assays is an effective NAM-based strategy for genotoxicity assessment of data-poor compounds.

Du coeur artificiel au pansement en passant par les prothèses, lentilles correctrices, fauteuils roulants ou appareils de radiologie, la notion de dispositif médical recouvre un vaste ensemble de produits ayant en commun leur finalité médicale et leur action qui n’est pas obtenue par des moyens pharmacologiques ou immunologiques ni par métabolisme. Les dispositifs médicaux ont été règlementés dans les années 1990 par des directives fondées sur les principes de la nouvelle approche (définition d’exigences essentielles et renvoi à l’harmonisation technique, place importante laissée aux acteurs professionnels et rôle limité conféré aux autorités publiques, évaluation de la conformité des produits par des organismes notifiés et absence d’autorisation de mise sur le marché). Malgré les avantages liés à leur souplesse, ces directives n’ont qu’imparfaitement réussi à garantir la sécurité des dispositifs médicaux, ainsi que cela a été rappelé dans le contexte de l’affaire des prothèses PIP : évaluation clinique, information et traçabilité des produits insuffisantes, contrôle par et sur les organismes notifiés limité, faible coordination entre les autorités, etc. Pour renforcer la sécurité des dispositifs médicaux européens, plutôt qu’une transposition du cadre juridique des médicaments ou des dispositifs médicaux américains, un cadre juridique sur mesure, adapté à leur niveau variable de risque, est à envisager. C’est ce que proposent les règlements qui seront prochainement adoptés. / From artificial heart to bandage through implants, corrective lenses, wheelchairs or radiology devices, the concept of medical device covers a wide range of products having in common their medical purpose and their action which is not obtained by pharmacological, immunological or metabolic means. Medical devices were regulated in the 1990s by directives based on the principles of the new approach (definition of essential requirements and reference to technical harmonization, important role for professional actors and limited role for public authorities, evaluation of the conformity of products by notified bodies and absence of marketing authorization). Despite the advantages of their flexibility, these directives have only partially succeeded in guaranteeing the safety of medical devices, as underlined in the circumstances of PIP implants scandal: limited clinical evaluation, information and traceability of products, limited control by and on notified bodies, lack of coordination between authorities, etc. To strengthen the safety of European medical devices, rather than transposing the legal framework of medicinal products or American medical devices, a custom-made legal framework, adapted to their varying level of risk, is to be considered. This is what the upcoming regulations put forward.

The increasingly observable excess capacity in the fixed networks calls into question the established long-standing pricing standards for wholesale services based on forward-looking long-run incremental costs (FL-LRAIC). The FL-LRAIC standard has worked quite well in expanding markets, although even there price-squeeze problems have appeared. In contracting markets the price-squeeze issue, however, becomes paramount and lower prices both at the wholesale and retail levels would be efficient. This would favor a retail-minus approach (RM) under long-term contraction. Because both expansion and contraction could be relevant in the future, we propose an optional approach based on the wholesale price formula p = min(FL-LRAIC, RM). This will generally protect alternative competitors against price-squeeze while at the same time allowing the fixed-network incumbent full downward price flexibility. It also protects alternative competitors and end users against excessively high prices. Hence, implementing this option successfully at wholesale level would eliminate the need to regulate retail markets. The combination of RM and FL-LRAIC seems to be most realistic, because it is relatively simple and internationally partly tested already. We show that this option is superior to FL-LRAIC or RM alone and to other approaches, such as short-run marginal costs. We also consider a possible combination with capacity-based charging, which may have particular merits for converged services in next generation networks (NGNs). / Series: Working Papers / Research Institute for Regulatory Economics

This Master’s thesis deals with the new approach and global policies and their consequences on the process of conformity assessment. Furthermore, the modules those are used for this assessment and risk analysis, which is essential in this process. The practical part is focused on an analysis of risks to the submersible pump sets series U with electric motor TU-85.