The objective of this work is to study crack path deflection under proportional and non-proportional mixed-mode fatigue and predict crack branching direction based on linear elastic fracture mechanics (LEFM) driving forces. Under proportional in-phase mixed Mode I / Mode II loading conditions, crack growth direction has previously been observed in some materials to shift from tensile-dominated Mode I to shear-dominated Mode II or mixed-mode crack growth at higher proportions of initial Mode II loading, but non-proportional loads are not well-characterized. An LEFM approach is desired in order to implement the model in crack growth software such as the boundary element-based fracture analysis package FRANC3D. A novel specimen configuration has been designed and analyzed for generation of wide ranges of mixed-mode loading conditions in a single test. This specimen and a more conventional thin-walled tubular specimen have been used to test polycrystalline nickel-base superalloy Inconel 718 under proportional in-phase and 3 kinds of non-proportional fatigue loading. Stress intensity factors for the various configurations have been analyzed with FRANC3D. Modal transition from Mode I (tensile) to Mode II (shear) crack branching has been observed in several load cases. Qualitative microscopy of fracture surfaces was used to characterize the difference between crack branch modes. An LEFM approach based on an effective stress intensity factor range, which incorporates the maximum value and range of each appropriate stress intensity (Mode I or Mode II), has been used to successfully predict the crack deflection angles, and in some cases to quantify modal transition, within each load case considered. Variability between load cases and specimen configurations points to the limitations of LEFM in providing a general predictor of crack path behavior across all types of non-proportional mixed mode loading.

Univ., Diss.--Uppsala, 1999. / Zsfassung in engl. Sprache.

Thesis (Ph. D.)--University of Canterbury, 2008. / Typescript (photocopy). Includes bibliographical references (p. 445-468). Also available via the World Wide Web.

Thesis (M.S. in Electrical Engineering)--Naval Postgraduate School, December 1990. / Thesis Advisor(s): Titus, Harold A. Second Reader: Powell, James R. "December 1990." Description based on title screen as viewed on April 1, 2010. DTIC Descriptor(s): Guided Missiles, Simulation, Forward Areas, Optimization, Transfer Functions, Guided Missile Warheads, Dynamics, Two Dimensional, Theses, Targets, Time, Three Dimensional, Solutions (General), Homing Devices, Maneuvers, Evasion, Simplification, Proportional Navigation, Automatic Pilots, Guided Missile Components, Miss Distance. DTIC Identifier(s): Proportional Navigation, Guided Missile Targets, Evasion, Flight Maneuvers, Intercept Trajectories, Guided Missile Trajectories, Antiaircraft Missiles, Aircraft Defense Systems, Miss Distance, Optimization, Adjoint Models, Survivability, Barrel Roll Maneuver, Split S Maneuver, Scenarios, Computer Programs, Theses. Author(s) subject terms: Proportional Navigation, Miss Distance, Adjoint. Includes bibliographical references (p. 111). Also available in print.

Thesis (Ph.D.)--University of Alabama at Birmingham, 2010. / Title from PDF title page (viewed on June 28, 2010). Includes bibliographical references.

Thesis (M.A.)--University of South Florida, 2006. / Title from PDF of title page. Document formatted into pages; contains 71 pages. Includes bibliographical references.

In Chapter 1 I study the iterative strategy elimination mechanisms for normal form games. The literature is mostly clustered around the order of elimination. The conventional elimination also requires more strict knowledge assumptions if the elimination is iterative. I define an elimination process which requires weaker rationality. I establish some preliminary results suggesting that my mechanism is order independent whenever iterative elimination of weakly dominated strategies (IEWDS) is so. I also specify conditions under which the \undercutting problem" occurs. Comparison of other elimination mechanisms in the literature (Iterated Weak Strategy Elimination, Iterated Strict Strategy Elimination, Generalized Strategy Eliminability Criterion, RBEU, Dekel-Fudenberg Procedure, Asheim- Dufwenberg Procedure) and mine is also studied to some extent. In Chapter 2 I study the axiomatic characterization of a well-known bankruptcy rule: Proportional Division (PROP). The rule allocates shares proportional to agents' claims and hence, is intuitive according to many authors. I give supporting evidence to this opinion by first defining a new type of consistency requirement, i.e. union-consistency and showing that PROP is the only rule that satisfies anonymity, continuity and union-consistency. Note that anonymity and continuity are very general requirements and satisfied by almost all the rules that have been studied in this literature. Thus, I prove that we can choose a unique rule among them by only requiring union-consistency. Then, I define a bankruptcy operator and give some intuition on it. A bankruptcy operator is a mapping from the set of bankruptcy operators to itself. I prove that any rule will converge to PROP under this operator as the claims increase. I show nice characteristics of the operator some of which are related to PROP. I also give a definition for continuity of an operator. In Chapter 3 investigate risk-averse investors' behaviour towards a risky firm. In order to find Pareto Optimal allocations regarding a joint venture, I employ a 2-stage game, first stage of which involves a social-planner committing to an ex-post bankruptcy rule. A bankruptcy rule is a set of suggestions for solving each possible bankruptcy problem. A bankruptcy problem occurs when there is not enough endowment to allocate to the agents each of whom has a claim on it. I devise the game-theoretic approach posed in K1br1s and K1br1s (2013) and extend it further. In fact, that paper considers a comparison among 4 renowned bankruptcy rules whereas mine do not restrict attention to any particular rule but rather aim to find a Pareto Optimal(PO) one. I start with 2 agent case in order to give some insight to the reader and then, generalise the results to an arbitrary number of investors. I find socially desirable (PO) allocations and show that the same can be achieved through financial markets by the help of some well-known results.

É conhecida ao longo da história da humanidade a grande quantidade de acidentes vinculados à ação de cargas cíclicas. Há mais de 100 anos, metodologias levam em conta o fenômeno de fadiga em projetos de novos componentes. As metodologias existentes para avaliar a vida em fadiga são empíricas e têm sido aplicadas com sucesso na determinação da vida do componente em fadiga quando o mesmo é submetido a carregamento uniaxial ou a carregamento multiaxial proporcional. Mas a evidencia experimental tem mostrado que quando a solicitação é multiaxial e não proporcional, as leis antes mencionadas deixam de ser adequadas. Dessa forma os critérios clássicos utilizados não preveem corretamente a vida do componente. Neste contexto o presente trabalho avalia algumas das metodologias de fadiga multiaxial não proporcionais disponíveis na bibliografia especializada. Os resultados obtidos com estes métodos são comparados entre sim e com os resultados obtidos utilizando a metodologia de fadiga multiaxial proporcional. Para comparar as metodologias citadas é apresentado um exemplo de solicitação simples, e também a análise do componente de uma máquina agrícola solicitada por um histórico de tensões típicas, obtida a partir do teste da máquina em campo. Finalmente são apresentadas as conclusões sobre as metodologias utilizadas e sobre a importância de levar em conta a não proporcionalidade de um estado de tensões multiaxial oscilantes. / It is known throughout human history the large amount of accidents linked to action of cyclic loading. For over 100 years, methodologies take into account the fatigue phenomenon of new components projects. Existing methodologies for assessing the fatigue life are empirical and have been successfully applied in the determination of fatigue life of the component when it is subjected to uniaxial loading or proportional multiaxial loading. But the experimental evidence has shown that when the request is multiaxial and not proportional, the laws mentioned above are no longer adequate. Thus the classical criteria used not correctly predict component life. In this context, this paper analyzes some of the methodologies of multiaxial fatigue non proportionate available in the relevant literature. The results obtained with these methods are compared with the results so obtained and using the proportional multiaxial fatigue methodology. To compare the methods mentioned is an example of simple request, and also the analysis component of an agricultural machine requested by a history of typical strains, obtained from the machine field testing on a test track. Finally conclusions on the methodologies used and the importance of taking into account the non-proportionality of a state of oscillating multiaxial stresses are presented.

Estudos que comprovem a superioridade de um fármaco em relação a outros já existentes no mercado são de grande interesse na prática clínica. Através deles a Agência Nacional de Vigilância Sanitária (ANVISA) concede registro a novos produtos, que podem curar mais rápido ou aumentar a probabilidade de cura dos pacientes, em comparação ao tratamento padrão. É de suma importância que os testes de hipóteses controlem a probabilidade do erro tipo I, ou seja, controlem a probabilidade de que um tratamento não superior seja aprovado para uso; e também atinja o poder de teste regulamentado com o menor número de indivíduos possível. Os testes de hipóteses existentes para esta finalidade ou desconsideram o tempo até que o evento de interesse ocorra (reação alérgica, efeito positivo, etc) ou são baseados no modelo de riscos proporcionais. No entanto, na prática, a hipótese de riscos proporcionais pode nem sempre ser satisfeita, como é o caso de ensaios cujos riscos dos diferentes grupos em estudo se igualam com o passar do tempo. Nesta situação, o modelo de chances proporcionais é mais adequado para o ajuste dos dados. Neste trabalho desenvolvemos e investigamos dois testes de hipóteses para ensaios clínicos de superioridade, baseados na comparação de curvas de sobrevivência sob a suposição de que os dados seguem o modelo de chances de sobrevivências proporcionais, um sem a incorporação da fração de cura e outro com esta incorporação. Vários estudos de simulação são conduzidos para analisar a capacidade de controle da probabilidade do erro tipo I e do valor do poder dos testes quando os dados satisfazem ou não a suposição do teste para diversos tamanhos amostrais e dois métodos de estimação das quantidades de interesse. Concluímos que a probabilidade do erro tipo I é subestimada quando os dados não satisfazem a suposição do teste e é controlada quando satisfazem, como esperado. De forma geral, concluímos que é imprescindível satisfazer as suposições dos testes de superioridade. / Studies that prove the superiority of a drug in relation to others already existing in the market are of great interest in clinical practice. Based on them the Brazilian National Agency of Sanitary Surveillance (ANVISA) grants superiority drugs registers which can cure faster or increase the probability of cure of patients, compared to standard treatment. It is of the utmost importance that hypothesis tests control the probability of type I error, that is, they control the probability that a non-superior treatment is approved for use; and also achieve the test power regulated with as few individuals as possible. Tests of hypotheses existing for this purpose or disregard the time until the event of interest occurrence (allergic reaction, positive effect, etc.) or are based on the proportional hazards model. However, in practice, the hypothesis of proportional hazards may not always be satisfied, as is the case of trials whose risks of the different study groups become equal over time. In this situation, the proportional odds survival model is more adequate for the adjustment of the data. In this work we developed and investigated two hypothesis tests for clinical trials of superiority, based on the comparison of survival curves under the assumption that the data follow the proportional survival odds model, one without the incorporation of cure fraction and another considering cure fraction. Several simulation studies are conducted to analyze the ability to control the probability of type I error and the value of the power of the tests when the data satisfy or not the assumption of the test for different sample sizes and two estimation methods of the quantities of interest. We conclude that the probability of type I error is underestimated when the data do not satisfy the assumption of the test and it is controlled when they satisfy, as expected. In general, we conclude that it is indispensable to satisfy the assumptions of superiority tests.

O Atendimento Pré Hospitalar (APH) é um importante recurso no atendimento à vítimas de trauma. No entanto, há muitas dificuldades para demonstrar o efeito benéfico das intervenções do APH na sobrevivência das vítimas, sobretudo as de suporte avançado à vida (SAV). A proposta deste estudo é caracterizar as vítimas de acidentes trânsito, com Revised Trauma Score (RTS) <11, atendidas pelo SAV municipal e encaminhadas a hospitais terciários em São Paulo, além de identificar as variáveis da fase pré-hospitalar associadas à sobrevivência e avaliar o valor predeterminante dessas variáveis sobre o resultado obtido pelas vítimas. As variáveis avaliadas foram: sexo, idade, mecanismos do acidente, procedimentos de suporte básico e SAV realizados, repercussão fisiológica do trauma na cena do acidente, (considerando o RTS , seus parâmetros e flutuações), o tempo consumido no APH, gravidade do trauma segundo o Injury Severity Score (ISS),a Maximum Abbreviated Injury Scale (MAIS) e número de lesões para cada segmento corporal. Os resultados obtidos por 175 vítimas entre 12 e 65 anos, foram submetidos a ”Análise de Sobrevivência de Kaplan Meier” e ao “Modelo de Riscos Proporcionais de Cox”. A variável dependente foi o tempo de sobrevivência após o acidente, considerando os intervalos até 6h,12h, 24h, 48h, até 7 dias e até o término da internação. Os homens (86,9%) e a faixa etária de 20 a 29 anos (36,0%) foram as mais freqüentes. Os atropelamentos (45,1%) e o envolvimento de motocicletas e seus ocupantes (30,9%) foram os destaques dentre os mecanismos de trauma. A média do RTS na cena e do ISS, foram respectivamente 8,8 e 19,4.Os segmentos corpóreos mais atingidos foram: cabeça (58,8%), membros inferiores (45,1%) e superfície externa (40%). A média de tempo consumido na fase de APH foi 41min (tempo de cena 20,2min). Ocorreram 36% de óbitos, (metade em até 6 horas). A análise estatística revelou 24 fatores associados à sobrevivência, dentre eles, os procedimentos respiratórios avançados e os circulatórios básicos, as variáveis relativas ao RTS e a gravidade (ISS, MAIS e o número de lesões). No modelo final de Cox, ter sido submetido a procedimentos respiratórios avançados, compressões torácicas, apresentar lesão abdominal e ISS>25, foi associado a maior risco para o óbito até 48h após o trauma. Até 7 dias, a compressão torácica não se manteve no modelo final e a PAS de zero a 75mmHg apresentou associação com a morte após o acidente. Até a alta hospitalar, a ausência de PAS na avaliação inicial permaneceu no modelo. A reposição de volume foi o único fator com valor protetor para o risco de óbito presente em todos os momentos / The prehospital care (PH) is an important resource to trauma victims’ care. Nevertheless, there is great difficulty in demonstrating the PH intervention’s positive effect in victim’s survival, especially when concerning the advanced life support (ALS). The aim of this study is to characterize motor vehicle crash victims with Revised Trauma Score (RTS) <11 cared by municipal ALS and moved to tertiary hospitals in São Paulo in addition to identifying the prehospital variables associated to survival, and to evaluate their values as victim survival outcome determinant. The variables evaluated were: sex, age, trauma mechanism, basic life support and ALS procedures, physiological measures in the accident scene (considering the RTS, its parameters and fluctuations), the time consumed in PH phase, trauma severity by Injury Severity Score (ISS), the Maximum Abbreviated Injury Scale (MAIS) and number of lesions in each body region. The main results obtained by 175 victims between 12 e 65 years of age were submitted to the Kaplan Meier Survival Analysis and to Cox Proportional hazards Regression Analysis. The dependent variable was the survival time after the motor vehicle accident considering the intervals up to 6,12,24 and 48hs , up to 7 days and until the time of hospital discharge. Men (86,9%) and the 20 to 29 aged group (36%) were the most frequent. The pedestrians struck by car (45,1%) and the motorcycles (and their riders) (30,9%)were the highlight in trauma mechanisms. The RTS and the ISS average were 8,8 and 19,4 respectively. The more damaged body regions were head (58,8%), lower limbs (45,1%) and external surface (40%).The prehospital time average was 41 min (scene time 20,2min).Death rate was 36% (half of which up to 6hs).The statistical analysis revealed 24 survival associated factors. The ALS and the circulatory basic procedures, the RTS variables and the trauma severity (ISS,MAIS and number of lesions) were within them. In the final Cox Model were associated to higher risk of death up to 48hs after trauma: the submission to ALS respiratory procedures, chest compressions, the presence of abdominal injuries and ISS>25 .Until the 7th day the chest compression was not sustained in a final model and the systolic blood pressure (SBP) from zero to 75mmHg revealed statistical association with death after trauma. Until hospital discharge the SBP absence in scene evaluation remained in the model. The prehospital intravenous fluid refilling was the only factor of protector value to death risk in all moments