No description available.

No description available.

Non-ductile Reinforced Concrete Frames (RCF) with and without Unreinforced Masonry (URM) infills can be found in many places around the world including the Western United States, Eastern Europe, Asia and Latin America. These structures can have an unsatisfactory seismic performance which may even lead to collapse due to brittle failure modes. Furthermore, the effect of the infills on the seismic response of the structural system is not always accounted for in analysis and design. At present, there is no consensus on whether masonry infills are beneficial (by increasing the resistance of the system) or detrimental (by leading to brittle failure modes) for RCF construction. This study focuses on the development of a simplified modeling approach for non-ductile RCF with URMI that combines the simplicity of strut-and-tie models with the accuracy of Nonlinear Finite Element Analysis (NLFEA). Despite the fact that NLFEA procedures are the most advanced way to address the structural analysis of RCF with URM infills, their conceptual complexity and computational cost may hinder their widespread adoption as an analysis and design tool. At the same time, simplified methods, such as those based on the equivalent strut concept, may be overly crude and neglect essential aspects of the nonlinear response. To address the need for an adequately accurate, but computationally and conceptually efficient analysis method, this study establishes a novel method for planar RCF with URM infills subjected to lateral loads. The method, which is based on the Nonlinear Truss Analogy (NLTA) is shown to have an accuracy comparable to that of NLFEA. Specifically, the method is shown to adequately capture the strength and stiffness degradation and the damage patterns while entailing a reduced computational cost (compared to that of NLFEA). The proposed method is expected to bridge the gap between overly crude equivalent strut models and computationally expensive NLFEA. / Ph. D.

Compliant suspensions are often used in micromechanical devices and precision mechanisms as substitutes for kinematic joints. While their small-displacement behavior is easily captured in simple formulae, large-displacement behavior requires nonlinear finite element analysis. In this work, we present a method that helps capture the geometrically nonlinear behavior of compliant suspensions using parameterized non-dimensional maps. The maps are created by performing one nonlinear finite element analysis for any one loading condition for one instance of a suspension of a given topology and fixed proportions. These maps help retrieve behavioral information for any other instance of the same suspension with changed size, cross-section dimensions, material, and loading. Such quantities as multi-axial stiffness, maximum stress, natural frequency, etc. ,can be quickly and accurately estimated from the maps. These quantities are non-dimensionalized using suitable factors that include loading, size, cross-section, and material properties. The maps are useful in not only understanding the limits of performance of the topology of a given suspension with fixed proportions but also in design. We have created the maps for 20 different suspensions. Case studies are included to illustrate the effectiveness of the method in microsystem design as well as in precision mechanisms. In particular, the method and 2D plots of non-dimensional kinetoelastic maps provide a comprehensive view of sensitivity, cross-axis sensitivity, linearity, maximum stress, and bandwidth for microsensors and microactuators.

A nonlinear finite element analysis was performed for an existing road bridge in order to see if that could show a higher load bearing capacity, as an alternative to repairing or replacing. The regular linear analysis had shown that the bridge could not take any traffic load due to the effects from large and uneven support settlements. It is a five-span reinforced concrete bridge with a continuous slab on supports made out of rows of columns. The width-to-span ratio was around 1 and the supports were angled up to about 30°, giving rise to a complex three-dimensional behaviour, which was seen and studied in the nonlinear results. Since the bending moment was the limiting factor, the nonlinear analysis focused on that. The direct result was that the load bearing capacity was 730 kN for the traffic vehicle boogie load, B, in the ultimate limit state. This was however only for the load case tested, and several more disadvantageous vehicle positions may exist. Other aspects also became limiting, as the maximum allowed vertical deflection in the serviceability limit state was reached at 457 kN. The most restraining though, was the shear capacity from the linear analysis; 78 kN, since it was not possible to simulate that type of failure with the shell elements used in the nonlinear finite element analysis. The main aim of the thesis was nonetheless reached, since the nonlinear analysis was able to show a significant increase in load bearing capacity.  A comparison was made with the settlements for the nonlinear case, to see how much influence they had on the load bearing capacity for traffic load. This was performed for both the bridge and a simple two-span beam. Both showed that there was no effect on the load bearing capacity in the ultimate limit. One thing to note was that the full settlements were applied, and with no relaxation due to creep.  Another aim of the thesis was to make comments on the practical usability of the nonlinear finite element method in load bearing capacity assessments. A linear analysis was performed before the nonlinear in order to be able to determine the load case to be used in the latter. This worked well, as the strengths of the two methods could then be utilized. Convergence problems were however encountered for the nonlinear when using the regular static solver. Due to this, the dynamic explicit calculation scheme was used instead, treating the case as quasi-static. This managed to produce enough usable results. It was concluded that the nonlinear finite element method is useable for assessment calculations, but that its strengths and weaknesses must be known in order to make it an efficient method.

A nonlinear finite element analysis was performed for an existing road bridge in order to see if that could show a higher load bearing capacity, as an alternative to repairing or replacing. The regular linear analysis had shown that the bridge could not take any traffic load due to the effects from large and uneven support settlements. It is a five-span reinforced concrete bridge with a continuous slab on supports made out of rows of columns. The width-to-span ratio was around 1 and the supports were angled up to about 30°, giving rise to a complex three-dimensional behaviour, which was seen and studied in the nonlinear results. Since the bending moment was the limiting factor, the nonlinear analysis focused on that. The direct result was that the load bearing capacity was 730 kN for the traffic vehicle boogie load, B, in the ultimate limit state. This was however only for the load case tested, and several more disadvantageous vehicle positions may exist. Other aspects also became limiting, as the maximum allowed vertical deflection in the serviceability limit state was reached at 457 kN. The most restraining though, was the shear capacity from the linear analysis; 78 kN, since it was not possible to simulate that type of failure with the shell elements used in the nonlinear finite element analysis. The main aim of the thesis was nonetheless reached, since the nonlinear analysis was able to show a significant increase in load bearing capacity. A comparison was made with the settlements for the nonlinear case, to see how much influence they had on the load bearing capacity for traffic load. This was performed for both the bridge and a simple two-span beam. Both showed that there was no effect on the load bearing capacity in the ultimate limit. One thing to note was that the full settlements were applied, and with no relaxation due to creep. Another aim of the thesis was to make comments on the practical usability of the nonlinear finite element method in load bearing capacity assessments. A linear analysis was performed before the nonlinear in order to be able to determine the load case to be used in the latter. This worked well, as the strengths of the two methods could then be utilized. Convergence problems were however encountered for the nonlinear when using the regular static solver. Due to this, the dynamic explicit calculation scheme was used instead, treating the case as quasi-static. This managed to produce enough usable results. It was concluded that the nonlinear finite element method is useable for assessment calculations, but that its strengths and weaknesses must be known in order to make it an efficient method.

No description available.

<p>Breast cancer is the most commonly diagnosed cancer type worldwide. Given high survivorship, increased focus has been placed on long-term treatment outcomes and patient quality of life. While breast-conserving surgery (BCS) is the preferred treatment strategy for early-stage breast cancer, anticipated healing and breast deformation (cosmetic) outcomes weigh heavily on surgeon and patient selection between BCS and more aggressive mastectomy procedures. Unfortunately, surgical outcomes following BCS are difficult to predict, owing to the complexity of the tissue repair process and significant patient-to-patient variability. To overcome this challenge, we developed a predictive computational mechanobiological model that simulates breast healing and deformation following BCS. The coupled biochemical-biomechanical model incorporates multi-scale cell and tissue mechanics, including collagen deposition and remodeling, collagen-dependent cell migration and contractility, and tissue plastic deformation. Available human clinical data evaluating cavity contraction and histopathological data from an experimental porcine lumpectomy study were used for model calibration. The computational model was successfully fit to data by optimizing biochemical and mechanobiological parameters through the Gaussian Process. The calibrated model was then applied to define key mechanobiological parameters and relationships influencing healing and breast deformation outcomes. Variability in patient characteristics including cavity-to-breast volume percentage and breast composition were further evaluated to determine effects on cavity contraction and breast cosmetic outcomes, with simulation outcomes aligning well with previously reported human studies. The proposed model has the potential to assist surgeons and their patients in developing and discussing individualized treatment plans that lead to more satisfying post-surgical outcomes and improved quality of life.</p>

<p>Breast cancer affects 12.5\% of women over their life time and tissue expansion (TE) is the most common technique for breast reconstruction after mastectomy. However, the rate of complications with TE can be as high as 15\%. Even though the first documented case of TE happened in 1957, there has yet to be a standardized procedure established due to the variations among patients and the TE protocols are currently designed based on surgeon's experience. There are several studies of computational and theoretical framework modeling skin growth in TE but these tools are not used in the clinical setting. This dissertation focuses on bridging the gap between the already existing skin growth modeling efforts and it's potential application in the clinical setting.</p> <p><br></p> <p>We started with calibrating a skin growth model based on porcine skin expansions data. We built a predictive finite element model of tissue expansion. Two types of model were tested, isotropic and anisotropic models. Calibration was done in a probabilistic framework, allowing us to capture the inherent biological uncertainty of living tissue. We hypothesized that the skin growth rate was proportional to stretch. Indeed, the Bayesian calibration process confirmed that this conceptual model best explained the data. </p> <p><br></p> <p>Although the initial model described the macroscale response, it did not consider any activity on the cellular level. To account for the underlying cellular mechanisms at the microscopic scale, we have established a new system of differential equations that describe the dynamics of key mechanosensing pathways that we observed to be activated in the porcine model. We calibrated the parameters of the new model based on porcine skin data. The refined model is still able to reproduce the observed macroscale changes in tissue growth, but now based on mechanistic knowledge of the cell mechanobiology.  </p> <p><br></p> <p>Lastly, we demonstrated how our skin growth model can be used in a clinical setting. We created TE simulations matching the protocol used in human patients and compared the results with clinical data with good agreement. Then we established a personalized model built from 3D scans of a patient unique geometry. We verified our model by comparing the skin growth area with the area of the skin harvested in the procedure, again with good agreement.</p> <p><br></p> <p>Our work shows that skin growth modeling can be a powerful tool to aid surgeons design TE procedures before they are actually performed. The simulations can help with optimizing the protocol to guarantee the correct amount of skin is growth in the shortest time possible without subjecting the skin to deformations that can compromise the procedure.</p>

There exists several different methods that can be used to implement a level of safety when performing non-linear finite element analysis of a structure. These methods are called safety formats and they estimate safety by different means and formulas which are partly discussed further in this thesis. The aim of this master thesis is to evaluate a model uncertainty factor for one safety format method called the estimation of coefficient of variation method (ECOV) since it is suggested to be included in the next version of Eurocode. The ECOV method will also be compared with the most common and widely used safety format which is the partial factor method (PF). The first part of this thesis presents the different safety formats more thoroughly followed by a theoretical part. The theory part aims to provide a deeper knowledge for the finite element method and non-linear finite element analysis together with some beam theory that explains shear mechanism in different beam types. The study was conducted on six beams in total, three deep beams and three slender beams. The deep beams were previously tested in the 1970s and the slender beams were previously tested in the 1990s, both test series were performed in a laboratory. All beams failed due to shear in the experimental tests. A detailed description of the beams are presented in the thesis. The simulations of the beams were all performed in the FEM- programme ATENA 2D to obtain high resemblance to the experimental test. In the results from the simulations it could be observed that the ECOV method generally got a higher capacity than the PF method. For the slender beams both methods received rather high design capacities with a mean of about 82% of the experimental capacity. For the deep beams both method reached low design capacities with a mean of around 46% of the experimental capacity. The results regarding the model uncertainty factor showed that the mean value for slender beams should be around 1.06 and for deep beams it should be around 1.25.