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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
171

Statistisk analys av tung trafik : Studie av trafiklastens verkliga omfång baserat på BWIM-mätningar / Statistical analysis of heavy traffic : Study of the actual scope of traffic loads - based on BWIM-measurements

Rios, Paul, Areida, Mohammad January 2018 (has links)
This degree project aims to provide the Swedish Traffic Administration with information about the pressure distribution generated by vehicles with gross weights above 3.5 tons. The aim is to provide sufficient information regarding the pressure distribution to facilitate a possible change of today's deterministic design model to a probability based method. To realize the aim, BWIM-measurements carried out by the Swedish Traffic Administration in 2015, 2016 and 2017 have been studied. Measured data showed large variations depending on vehicle type, indicating that the data originates from different statistical populations. For the surveyed years, the data of interest are vehicles loaded to at least 80% of their permitted gross weight and a lognormal distribution has been found to be best representative of the pressure from traffic loads. The studied data also showed that the magnitude of the pressure increases with reduced vehicle length and that shorter vehicles whom are more frequently overloaded, subjects the structure with a pressure magnitude as great as twice the design value of today's 20 kPa. While plotting the pressure distribution, a positive skewness was observed. This indicates that the majority of observed vehicles load within the legal boundaries of their permissible gross weight. The vehicles that generate extreme pressures therefore represent a small fraction of all vehicles. Based on the studied vehicles the characteristic value of the 98\% fractile was calculated to 18,5 kPa. For the theoretical case where overloading was non-existent, this value decreases with 5% / Detta examensarbete syftar till att förse Trafikverket med information om tryckfördelningen genererat av fordon med bruttovikter överstigande 3,5 ton. Syftet är att bidra med tillräcklig information för att underlätta en eventuell förändring av dagens deterministiska dimensioneringsmetod till en sannolikhetsbaserad metod.För realiseringen av frågeställningen har BWIM-mätningar utförda av Trafikverket för åren 2015,2016 och 2017 studerats. Mätdatan har visat sig variera kraftigt beroende på fordonstyp och slutsatsen har därmed dragits att mätdatan härstammar från olika statistiska populationer. För undersökta mätår har fordon lastade till minst 80% av sin tillåtna bruttovikt undersökts och en lognormal fördelning har visat sig mest representativ för trafiklasten. Vidare påvisade mätdatan att storleken på trycket ökar med minskad fordonslängd och överlast av kortare fordon kan utsätta vägkroppen för tryck upp till dubbla storleken av dagens dimensioneringsvärde på 20 kPa. Vid plottning av tryckfördelningen märks en tydlig positiv skevhet vilket påvisar att merparten av fordonen lastar inom ramen för sin tillåtna bruttovikt och att extrema tryck endast utgör en liten procentandel av alla fordon. Baserat på de undersökta fordonen har den karakteristiska lasten för de undersökta åren beräknats till 18,5 kPa och att detta värde sänks med 5% om överlast inte varit ett faktum.
172

Beta thalassemia: pathogenesis, progression, and treatment

Kitiashvili, Michael 10 March 2023 (has links)
β-thalassemia is an autosomal recessive blood disease caused by mutations in β-globin genes that either reduce or altogether abolish β-globin chain synthesis. Normally, two β-globin chains would combine with two α-globin chains and a heme group to form hemoglobin. Because α-globin chain synthesis is unaffected in β-thalassemia patients, the unpaired α-globin chains accumulate and precipitate. The reduced formation of hemoglobin and accumulation of unpaired α-globin chains are the two fundamental molecular pathologies. In the most serious cases of the disease, the resulting complications develop before two years of age. Most often, these include severe anemia, pallor, jaundice, abdominal enlargement, and distinct craniofacial features. If left untreated, the disease is fatal before the age of three in the most serious cases. Each year, more than 40,000 births, mostly in Southeast Asia, Middle East, or Africa, are affected with β-thalassemia. With increased migration, however, β-thalassemia is becoming more common in Europe and North America. Currently, the most widespread treatment for the disease is transfusions and iron chelation therapy, and the only cure is hematopoietic stem cell transplantation. In recent years, however, multiple treatments and potential cures such as fetal hemoglobin inducers and gene therapy have shown promise. By analyzing the cost-efficiency, viability, and therapeutic benefits of current and future treatments, it can be seen that a combination of fetal hemoglobin inducers, transfusions, and iron chelation therapy will have the greatest impact for the vast majority of β-thalassemia patients.
173

Snabbt, Snabbare, Snabbast : En kvalitativ studie om informationsstress och snabb digital kultur

Gawell, Linnea, Jämtbäck, Elias January 2023 (has links)
Den digitala underhållningsbranschen utvecklas ständigt där nya innovationer lanseras och konsumtionsmönster förändras. Snabbspolad kultur är ett fenomen som syftar till den trend där våra digitala underhållningsmedier ökar i hastighet. Detta innebär att ljudböcker spelas i höger hastighet, poddar rensas på andningspauser och tempot på låtar vrids upp (Ahlström & Laurell 2023). Denna trend samspelar även med en ökad kamp om konsumentens sjunkande uppmärksamhet samt ett ökat informationsflöde på marknaden. Syftet med studien är att öka förståelsen kring hur företag som producerar audiella produkter påverkas av trenden gällande snabb kultur samt hur de, genom marknadsföring, kan påverka en informations-stressad konsument av digital audiell underhållning. Konsumenternas perspektiv bearbetas även genom att se hur de förhåller sig till audiella produkter samt marknadsföringen av dem, i en kontext av snabb digital kultur och informationsstress. De audiella underhållningsmedierna är avgränsade till att beakta musik, poddar, ljudböcker och radio. Ett ljuddesignföretag har även intervjuats för att få ett ytterligare perspektiv på ämnet. De teorier och modeller som används i studien är bland annat: samskapande av värde (co-creation of value), 7p-modellen, interaktiva & transaktionella kommunikationsmodellerna samt den inverterade U-kurvan vid informationsöverbelastning. Studien är en tvärsnittsstudie som grundas på kvalitativa, semistrukturerade intervjuer som förts med både konsumenter och branschrepresentanter. Studiens resultat visade på att marknadsföringens kärnbudskap bör presenteras direkt i en annons för störst påverkan samt att marknadsföringen bör vara informativ vid låg uppmärksamhet hos konsument. Detta motsäger tidigare teorier som anser att känslobaserad marknadsföring är mer effektiv vid låg uppmärksamhet. Denna slutsats visar på studiens teoretiska bidrag. Andra slutsatser från studien visar på att digitala audiella underhållningsprodukter fått en mer funktionell roll hos konsumenter. Konsumenter har även blivit passiviserade i fråga om deras val av audiella medier där de låter algoritmer och streamingplattformar i större utsträckning styra deras val. En annan framträdande aspekt gällande studiens resultat var att audiella produkter tenderar att vara mer känsloladdade. Detta kan ses som en direkt reflektion av den snabba kulturens påverkan. Studiens praktiska bidrag ligger i studiens värde för företag som arbetar med audiella produkter. / This study examines the trend of fast-forward digital culture within digital audio entertainment products. By high-paced digital culture this study refers to the fact that we listen to podcasts in speed up versions and that high speed versions of songs become hits on platforms like TikTok. The aim is to increase the understanding of how companies that provide these products can reach and influence an information-stressed consumer with marketing activities, as well as how this trend affects the audio products itself. How audio entertainment companies relate and act upon this trend will also be included. Qualitative, semistructured interviews with both consumers and industry representatives have been carried out to be able to investigate this topic. The term digital audio entertainment products is limited to: audiobooks, podcasts, music and radio. A sound design bureau has also been interviewed in order to gain an additional perspective. The study includes, among other, the following theories and models: Co-creation of value, the 7 p’s model, the interactive and transactional model of communication and information overload as the inverted U-curve. One conclusion from the study shows that in order to reach an information-stressed customer, ads should be informative where the core messages should be exposed during the first seconds. This indicates the study's theoretical contribution since previous studies consider emotional based marketing to be more effective for information stressed customers. The study also has a practical contribution in the form of valuable knowledge for companies in the audio entertainment industry. Conclusions from the study also exposes the fact that audio products tend to be loaded with emotions to a higher distinction, in order to cut through the noise as well as to keep the listener engaged. Audio products also seem to have evolved a more functional role where customers choose products according to current activity or desired mood.
174

Acute Responses to Combined Accentuated Eccentric Loading and Rest Redistribution

Chae, Sungwon 01 August 2023 (has links) (PDF)
This dissertation was 2 parts of investigations of various acute responses to high-volume combined accentuated eccentric loading and rest redistribution (AEL + RR). Resistance-trained men (n = 12, 25.6 ± 4.4 years, 1.77 ± 0.06 m, 81.7 ± 11.4 kg) completed a back squat (BS) 1 repetition maximum (1RM) and weight releaser familiarization session. Three BS exercise conditions (sets × repetitions × eccentric/concentric loading) comprised AEL + RR 5: 3 × (5 × 2) × 110/60%, AEL + RR 2: 3 × (2 × 5) × 110/60%, and traditional sets (TS): 3 × (1 × 10) × 60/60% 1RM. The AEL + RR 5 resulted in significantly (p < 0.05) greater concentric peak velocity (PV) (1.18 ± 0.17 m∙s–1) and power (PP) (2,304 ± 499 W) compared to AEL + RR 2 (1.11 ± 0.19 m∙s–1 and 2,148 ± 512 W) and TS (1.10 ± 0.14 m∙s–1 and 2,079 ± 388 W). Furthermore, AEL + RR 5 resulted in significantly greater PV and PP across all 10 repetitions compared to TS. Although AEL + RR 5 resulted in significantly greater concentric mean force (MF) (1,706 ± 224 N) compared with AEL + RR 2 (1,697 ± 209 N) and TS (1,685 ± 211 N), no condition by set or repetition interactions were found. The AEL + RR 5 yielded greater total volume load (sets × repetitions × eccentric + concentric loading) (6630.1 ± 1210.4 kg) compared with AEL + RR 2 (5944.3 ± 1085.2 kg) and TS (5487.0 ± 1001.7 kg). The AEL + RR 5 led to significantly (p < 0.05) greater rating of perceived exertion (RPE) after set 2 and 3 and lower blood lactate (BL) after set 3, 5-, 15-, and 25-minute post-exercise than AEL + RR 2 and TS. There was a main effect of condition for BL between AEL + RR 5 (5.11 ± 2.90 mmol∙L–1), AEL + RR 2 (6.23 ± 3.22 mmol∙L–1), and TS (6.15 ± 3.17 mmol∙L–1). In summary, AEL + RR 5 results in unique acute mechanical, physiological, and perceptual responses in high-volume BS exercise.
175

The Effect of Age on Stem Cell Mediated Repair of the Heart in Pressure Overload

Sopko, Nikolai Anton January 2011 (has links)
No description available.
176

THE SYSTEMIC STEM CELL RESPONSE TO CARDIAC PRESSURE OVERLOAD

Finan-Marchi, Amanda Rose 20 June 2012 (has links)
No description available.
177

Gendered Differences in Job Satisfaction: How Men and Women Cope with Work and Family

Sarwar, Mazen A. 28 April 2014 (has links)
No description available.
178

An Examination of the Time Management Behaviors and Work-Life Balance of K-12 Music Educators

Bley, Scott A. 20 April 2015 (has links)
No description available.
179

THE ROLE OF CALCINEURIN IN SKELETAL MUSCLE HYPERTROPHY AND FIBER TYPE DIVERSITY

PARSONS, STEPHANIE A. 31 March 2004 (has links)
No description available.
180

Role overload and health behaviors: Demonstrating adaptation longitudinally

Henderson, Alexandra A. January 2015 (has links)
No description available.

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