Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / No decorrer das últimas décadas a pesquisa relacionada à contaminação de organismos marinhos por compostos organoclorados (OCs) se intensificou aliada à utilização de algumas espécies como sentinelas da qualidade ambiental quanto aos poluentes orgânicos. Dentre essas espécies, podem-se destacar os cetáceos, animais que entre outras características possuem grande longevidade, alta porcentagem lipídica em seus tecidos e são predadores de topo de cadeia trófica, tendendo assim a acumular altos níveis de OCs em seus tecidos. O presente estudo teve por objetivo determinar as concentrações de OCs de origem industrial e agrícola (PCBs, HCB e DDTs) em tecido hepático de oito diferentes espécies de cetáceos delfinídeos pertencentes a três distintas áreas oceânicas do Estado do Rio de Janeiro, são elas a região costeira, a plataforma continental e a região oceânica. A determinação foi realizada em cromatógrafo a gás (GC - Agilent 6890) conectado a um espectrômetro de massa (MS - Agilent 5973). Os valores de DDTs (1263617272 ng.g -1 lip.) e PCBs (7648877288 ng.g -1 lip.) aqui encontrados estão entre os mais altos já reportados para o táxon. Em todas as áreas observou-se uma predominância do ΣPCB, seguida do ΣDDT e HCB, em níveis que refletem o caráter fortemente industrial da região analisada. Entre os PCBs, a maior contribuição advém dos hexabifenis, seguida dos hepta e pentabifenis, sendo os congêneres 153, 138 e 180 os principais em todas as áreas. A razão p,pDDE/ΣDp,pDDT foi alta em todas as regiões (0,9), refletindo um input antigo do poluente na área. Foram realizadas correlações entre as concentrações de OCs e os parâmetros biológicos das espécies, como idade, sexo e comprimento total. A transferência placentária de OCs foi analisada em dois pares de fêmea-feto de Sotalia guianensis, mostrando uma maior transferência dos compostos com menor log Kow. Como esperado, foi encontrada uma diferença significativa no perfil de contaminação entre as espécies das diferentes regiões, relacionada à proximidade da fonte, características espécie-específicas e ao arranjo trófico das espécies. / Over the past decades the research on marine organisms contamination by organochlorine compounds (OCs) has been intensified, allied to the utilization of some species as sentinels of the environmental quality related to organic pollutants. Among these species, cetaceans stand out as animals that, between other characteristics, have great longevity, high lipid percentage on their tissues and are top predators in food chains, therefore having the tendency to accumulate high OCs levels in their tissues. The present study aimed to determine OCs concentrations from industrial and agricultural sources (PCBs, HCB and DDTs) in hepatic tissue of eight different species of delphinid cetaceans belonging to three different oceanic areas of Rio de Janeiro State, namely, coastal region, continental shelf and oceanic region. The determination was performed in an Agilent 6890 gas chromatograph (GC) connected to an Agilent 5973 mass spectrometer (MS). DDTs (1263617272 ng.g -1 lip.) and PCBs (7648877288 ng.g -1 lip.) values reported here are amongst the highest values ever reported for the taxon. In all areas ΣPCB predominance was observed, followed by ΣDDT and HCB in levels that reflect the highly industrial character of the analyzed region. Amongst PCBs, the largest contribution comes from hexa biphenyls, followed by hepta and penta biphenyls, being the 153, 138 and 180 the main congeners in all areas. The p,pDDE/ΣDp,pDDT ratio was high in all regions (0,9), reflecting an ancient input of the pollutant in the area. Correlations between OCs concentrations and biologic parameters such as age, sex and total body lenght were performed. OCs placental transfer was analyzed in two Sotalia guianensis mother-fetus pairs, showing a higher transfer of compounds with lower log Kow. As expected, a significant difference was found on the contamination profile between species from the different regions, related to source proximity, species-specific characteristics and the species trophic arrangement.

A reação de hidrodescloração catalítica (HDC) de bifenilas policloradas (PCB) foi estudada em diversos sistemas reacionais: solventes orgânicos, dióxido de carbono supercrítico, presença e natureza de aditivos (bases e co-solventes) a temperaturas na faixa de 25 °C a 100 °C e pressões de 1 bar até 250 bar. Os reagentes utilizados foram um composto modelo (2,4- diclorobifenil), misturas comerciais de PCB (Aroclor, Ascarel) e outros compostos halogenados (clorobenzenos e bromoclorobenzeno). Os catalisadores avaliados, paládio suportado em carvão ativo (Pd/C), paládio suportado em sílica mesoporosa (Pd/SiO2), nanopartículas ferromagnéticas de paládio (FFSiNH2Pd), e nanopartículas ocas de paládio (PdNP) e de platina (PtNP), mostraram-se versáteis nas mais diversas condições, quer sejam condições supercríticas, presença ou não de água, presença e natureza da base e diferentes doadores de hidrogênio. Em dióxido de carbono, dois regimes reacionais foram avaliados: dióxido de carbono subcrítico, onde o gás atua como agente expansor da fase líquida ao se dissolver nela permitindo que a reação ocorra em uma fase líquida rica em gás hidrogênio; e dióxido de carbono supercrítico, sistema onde a temperatura influencia fortemente a reação e a pressão tende a ter efeito negativo sobre a velocidade de reação, devido a efeitos de diluição e de competição das moléculas do gás com as moléculas dos reagentes. A condição reacional ótima foi determinada para o regime supercrítico e dados cinéticos foram obtidos para os regimes sub- e supercrítico. / The catalytic hydrodechlorination reaction (HDC) of polychlorinated biphenyls (PCB) was studied in several reactional systems: organic solvents, supercritical carbon dioxide, presence and nature of additives (bases and co-solvents), in temperatures of 25 °C to 100 °C and pressures of 1 bar to 250 bar. The reagents used were: a model compound, 2,4-dichlorobiphenyl, commercial mixtures of PCB (Aroclor, Ascarel) and other halogenated compounds (chlorobenzenes and bromochlorobenzene). The catalysts evaluated, palladium supported in activated carbon (Pd/C), palladium supported in mesoporous silica (Pd/SiO2), palladium ferromagnetic nanoparticles (FFSiNH2Pd), and hollow palladium ((PdNP) and platinum (PtNP) nanoparticles, showed to be versatile in several conditions, either supercritical conditions, presence or not of water, nature of the base, and different hydrogen donors. In carbon dioxide, two reaction regimes were evaluated: subcritical carbon dioxide, where the gas acts as an expansion agent of the liquid phase when it dissolves in it, allowing that the reaction happens in a liquid phase rich in hydrogen; and supercritical carbon dioxide, a system where the temperature has a strong influence over the reaction and the pressure has a negative effect on the rate of the reaction, due to dilution and the competition of gas molecules with the reagents molecules for the catalyst. The optimal reaction condition was determined for the supercritical regime and kinetic data were obtained for both the sub and supercritical regimes.

Purpose of this master´s thesis is a construction proposal of German Equatorial Mount capable to load capacity to 20kg inclusive both shaft-actuators. The solution contains design options of actuators of mount, design proposal of partial systems and parts and calcualtions. More is contain drafts of overal assembly, motor pinion and shaft.

Les nouveaux composants à semi-conducteur de type grand gap ont été développés pour des applications de conversion de puissance en raison de leurs hautes fréquences de commutation (de centaine kHz à quelques MHz) et pertes faibles. Afin de bien profiter ses avantages, la technologie des circuits imprimés (PCB) est intéressante pour une intégration à haute densité de puissance grâce à sa flexibilité et son faible coût. Cependant, à cause de la mauvaise conductivité thermique du matériau FR-4 utilisé pour le substrat PCB et la haute densité de puissance réalisée, il est primordial de trouver des solutions thermiques pour améliorer les performances thermiques de la structure de PCB. Dans cette thèse, trois solutions thermiques pour les structures de PCB ont été proposées, y compris des solutions avec des vias thermiques, de cuivre épais sur le substrat de PCB ainsi que des dispositifs de refroidissement thermoélectrique (TEC). Nos études sont basées sur la modélisation électrothermique et la méthode d’éléments finis en 3D. Tout d’abord, l’optimisation des paramètres des vias (diamètre, épaisseur de placage, surface formée par des vias, la distance entre des vias etc.) a été réalisée pour optimiser l’effet de refroidissement. Ensuite, on constate que les performances thermiques des structures de PCB peuvent être améliorées en utilisant cuivre épais sur le substrat de PCB. Cuivre épais augmente le flux thermique latéral dans la couche de cuivre. Les influences de l’épaisseur de cuivre (35 à 500 µm) ont été étudiées. Cette solution est facile à réaliser et peut être combinée à d’autres solutions de refroidissement. Enfin, le dispositif thermoélectrique comme les modules Peltier est une technologie de refroidissement local. Les influences des paramètres de Peltier (Propriétés du matériau thermoélectrique, nombre d’éléments Peltier, distance entre la source de chaleur et les dispositifs Peltier, etc.) ont été identifiées. Il est démontré que des modules Peltier ont l’application potentielle pour le développement d’intégration de PCB attendu que son active contrôle des températures. / The emerging wide bandgap (WBG) semiconductor devices have been developed for power conversion applications instead of silicon devices due to higher switching frequencies (from few 100 kHz to several MHz) and lower on-state losses resulting in a better efficiency. In order to take full advantage of the WBG components, PCB technology is attractive for high power density integration thanks to its flexibility and low cost. However, due to poor thermal conductivity of the commonly used material Flame Retardant-4 (FR4), efficient thermal solutions are becoming a challenging issue in integrated power boards based on PCB substrates. So it is of the first importance to seek technological means in order to improve the thermal performances. In this thesis, three main thermal management solutions for PCB structures have been investigated including thermal vias, thick copper thickness on the PCB substrate as well as thermoelectric cooling (TEC) devices. Our studies are based on the electro-thermal modeling and 3D finite element (FE) methods. Firstly, optimization of the thermal via parameters (via diameter, via plating thickness, via-cluster surface, via pattern, pitch distance between vias etc.) has been realized to improve their cooing performances. We presented and evaluated thermal performances of the PCB structures by analyzing the thermal resistance of the PCB substrate with different thermal vias. Secondly, it is found that thermal performances of the PCB structures can be enhanced by using thick copper thickness on top of the PCB substrate, which increases the lateral heat flux along the copper layer. Influences of the copper thickness (35 µm to 500 µm) has been discussed. This solution is easy to realize and can be combined with other cooling solutions. Thirdly, thermoelectric cooler like Peltier device is a solid-state cooling technology that can meet the local cooling requirements. Influences of Peltier parameters (Thermoelectric material properties, number of Peltier elements, distance between the heating source and the Peltier devices etc.) have been identified. All these analyses demonstrate the potential application of Peltier devices placed beside the heating source for PCB structures, which is a benefit for developing the embedding technology in such structures.

In this thesis, a wireless module in form of a portable peripheral printed circuit board that can connect to a master device, periodically sending values from a sensor, has been developed to the company Biotage. A literature study has been made on antennas and PCB-design for high frequency applications and a prototype has been designed through CAD software. This thesis handles the design process behind the module which consists of choosing suitable components, measurements/matching of an antenna and design of a suitable rechargeable power supply module. The prototype resulted in a portable, fully wireless device with a long expected battery life with the help of Bluetooth Low Energy technology and low power usage components.

In this work endocrine disrupting potential of Delor 103, a commercial mixture of PCB congeners, was studied along with its effect on production of laccase by the ligninolytic fungus Trametes versicolor. Using a gene-reporter yeast assay for evaluation of hormonal activity Delor 103 showed an androgenic activity with an EC50 value of 2.29. 10-2 mg/l. Chlorbenzoic acids, Delor 103 potential metabolites resulting from microbial degradation, displayed on the other hand an estrogenic activity, indicating possible changes in hormonal activity of Delor 103 during its microbial degradation. The addition of Delor 103 to mineral medium T. versicolor cultures resulted in an up to 257times higher laccase activities detected in fungal cultures. Delor 103 induced enzymes showed different pI values from those of control cultures. In a complex malt-extract glucose medium (MEG) the stimulation effect of Delor 103 was kept down. Further, the production of laccase and synthesis of different pI forms depended strongly on the growth phase of fungal cultures. Exponencially growing cultures of T. versicolor were able to produce up to 7 different pI forms of laccase in responce to Delor 103 whereas stationary cultures produced only 4 enzyme forms with higher pI values. Stimulation of laccase activities in T. versicolor,...

Allt fler människor är beroende av medicinering för sin överlevnad. Dessa hittas främst i de äldre åldersgrupperna. Många av dessa tar medicin dagligen och bördan av medicinering är påtaglig. På grund av deras problematik skapas en oerhörd stress i samband med medicinering eftersom dessa människor har särskilt svårt att minnas när den ska intas, vilken dos, men också vilken medicin. En del behöver ta medicin så ofta som 8 ggr på en dag.Dessa människor behandlas av läkare. Läkare bedömer medicineringens verkningsgrad baserat på patientens förmåga och vilja att återge korrekt information medicineringens följsamhet. Allt för ofta återger patienten fel information.Vi har fått i uppgift att vidareutveckla en prototyp för en ”smart” pillerdosa vars mål är att förbättra patientens upplevelse av medicinering samt ge läkaren ett pålitligt och säkert sätt att följa sina patienters följsamhet till medicinering.Vi har vidareutvecklat en tidigare framtagen prototyp genom att utveckla en ny prototyp som implementerar alla önskvärda funktioner på ett måttanpassat kretskort.Fördelarna med en speciellt framtagen kretskortsprototyp gentemot en modulbaserad prototyp undersöks med avseende på storleksförminskning, energieffektivisering samt kostnadseffektivisering.Ett lämpligt tillvägagångsätt för att utveckla en kretskortsprototyp, resultatet av undersökning samt rekommendationer för vidareutveckling avhandlas och presenteras i rapporten.En kretskortsprototyp enligt angivna specifikationer utvecklades på utsatt tid. Undersökningarna visade att storleksförminskning, energieffektivisering samt kostnadseffektivisering kunde uppnås. / More and more people are dependent on medication for their survival. These are mainly found in older age groups. Many of these are medicated daily and the burden of medication is noticeable. Because of their problems, enormous stress is associated with medication because it is particularly difficult to remember when it is to be taken, which dose, but also which medicine. Some need to take medicine as often as eight times in one day.These people are treated by doctors. Doctors assess the effectiveness of medication based on the patient's ability and willingness to recall accurate information regarding their compliance with medication. All too often, the patient recalls wrongful information.We have been given the task of further developing a prototype for a "smart" pillbox whose goal is to improve the patient's experience in medication and give the doctor a reliable and safe way to follow the patients' compliance with medication.We have further developed a previous prototype by creating a new prototype that implements all the desired features on a customized circuit board.The advantages of a specially developed circuit board prototype against a modular prototype are investigated regarding size reduction, energy efficiency and cost efficiency.A suitable approach for developing a circuit board prototype, the results of the investigation and recommendations for further development are discussed and presented in the report.A circuit board prototype according to the stated specifications was successfully developed in the specified timeframe. The investigation showed that greater sizereduction, energy-efficiency and cost-efficiency were possible to achieve.

The 4-Stroke inverter topology is investigated and implemented in thisthesis as a method to damp the oscillation at the MOSFET drain-sourcevoltage when reverse recovery occurs. The aim is lower ElectromagneticInterference source level from the power inverter. The designprocess is coming from analyzing the appropriate inductor, making asimulation in LTSPICE and making a high-performance six-layer PCBfor the high current application. Finally, the prototype is tested in differentcontrol timing, radiated emission test and conducted emissiontest. / 4-taktsomvandlarens topologi undersöks och implementeras i dennaavhandling som en metod för att dämpa oscillation när reverse recoverysker i slutstegets MOSFET. Syftet är att dämpa elektromagnetiskstörning från kraftomvandlaren. Designprocessen är att analyseralämplig induktans, göra en simulering i LTSPICE och designa ett högpresterande6-lager PCB för kraftiga strömmar. Slutligen testas prototypenmed olika kontrolltider, elektromagnetisk emission och elektromagnetiskkonduktion.

In use today are ‘normal’ DC-DC switching regulators with considerable switching noise and ringing, which is bad for noise-sensitive applications. This project involves a solution based on ‘Silent Switchers’ to prove its effectiveness in reducing noise. This idea is then coupled into identifying the susceptibility of a PLL synthesizer to ensure we understand the sensitivity of this type of component and if this can be used with a silent switcher. A particular PLL synthesizer evaluation board is currently powered by linear regulators, which is used as a basis for comparing results. A new board involving silent switchers is designed and manufactured. Phase noise measurements are done to evaluate if silent switchers are a suitable alternative for power supply. / Idag används ’vanliga’ DC-DC switching regulatorer med betydande kopplingsbrus och ringningar, vilket är dåligt för bruskänsliga applikationer. Detta projekt innefattar en lösning baserad på Silent Switchersför att bevisa dess effektivitet när det gäller att minska bruset från dessa regulatorer. Denna lösning används sedan till att identifiera känsligheten hos en PLL-synthesizer för att se till att vi förstår känsligheten hos denna typ av component och om den kan användas med en Silent Switcher". Som referens för studien används ett särskilt PLL-synthesizer- utvärderingskort, drivet av linjära regulatorer. Ett nytt kort med Silent Switchers"istället för linjära regulatorer har konstruerats och tillverkats. Fasbrusmätningar görs på båda korten för att utvärdera om Silent Switchers"är ett lämpligt alternativ för denna applikation.

Universities and other higher education institutions have been struggling with high levels of student dropouts and poor graduation rates for a long time. As a result, there has been an interest in modifying traditional teaching techniques and implementing new ones to improve student learning outcomes. Interactive Lecture Demonstrations (ILD) is one such teaching technique which has shown positive results in terms of improving student learning outcomes. An audio recorder and player application with the addition of a DC/DC converter was developed. Six different PCB versions of the audio application were created, containing different combinations of deliberate design deficiencies. The deliberate design deficiencies came in the form of different configurations of decoupling capacitors and ground planes. The DC/DC converter served as a noise source to expose weaknesses in the design. In order to make certain that design deficiencies were exposed effectively, the conversion frequency of the DC/DC converter was switchable between a "high" and a "low" setting. The "low" conversion frequency setting was chosen to comfortably fall in the frequency range of human hearing. Measurements of voltage (time domain and spectral), current spectrum, audio spectrum and radiated emissions were collected. Audio recordings illustrating the impact of decoupling capacitors and interference from the DC/DC converter were performed. The measurement results and audio recordings were used to produce an ILD in video format. The ILD was structured around a modified version of the PODS (Predict-Observe-Discuss-Synthesize) model, which is a four-step process used in ILDs. The ILD contained four separate demonstrations that covered the impact of decoupling capacitors, ground topology and the DC/DC converter on the audio quality and radiated emissions. The ILDs were presented in such a way that the measurement results and audio recordings were correlated with the underlying design theory. Students who had taken either one of two courses related to PCB and electronics design offered at the Royal Institute of Technology (KTH) in the spring of 2019 and 2020 were invited to view the ILD video. The effectiveness of the ILD presentation in terms of pedagogic value was measured via a survey which the students were asked to fill out after watching the video. The results were overall very positive. The feedback received indicate that the students found the demonstrations to be informative and educational. By being able to see and hear the effects of neglecting good PCB design practices in two key areas, the demonstrations were able to provide a more realistic and real-world view of the consequences of neglecting to adhere to good design practices in these two areas that may not be apparent in the theoretical literature. In addition, since PCB design is such a vast subject, the results motivates further developments and study of the ILD concept related to other PCB design concepts such as transmission lines, layer ordering, signal integrity (crosstalk, timing, noise, etc), and others. / Universitet och andra högre lärosäten har länge kämpat mot höga nivåer av studentavhopp och låg genomströmning. Som en följd av detta har det funnits ett intresse att göra förändringar i de traditionella undervisningsmetoderna samt att implementera nya sådana. Interaktiva föreläsningsdemonstrationer (Interactive Lecture Demonstrations, ILD) är en undervisningsmetod som har visat på positiva resultat gällande studenters förmåga att uppnå läromålen. En ljudinspelnings- och uppspelningstillämpning med en likspänningsomvandlare konstruerades. Sex olika kretskort med en kombination av olika avsiktliga konstruktionsbrister producerades. De avsiktliga konstruktionsbristerna innefattade olika kombinationer av avkopplings-kondensatorer och jordplan. Likspänningsomvandlaren agerade som en störningskälla vars syfte var att blottlägga svagheter i konstruktionen. För att säkerställa att konstruktionsbristerna skulle kunna blottläggas tydligt var omvandlingsfrekvensen på likspänningsomvandlaren ställbar mellan ”hög” och ”låg”. Omvandlingsfrekvensen på inställningen ”låg” valdes så att den med god marginal hamnade inom frekvensområdet för mänsklig hörsel. Matningar av spänning (tids- och frekvensdomän), strömspektrum, ljudspektrum och utstrålad radioenergi genomfördes. Ljudinspelningar som belyste inverkan av avkopplings-kondensatorerna och störningar från likspänningsomvandlaren samlades in. Mätningarna och ljudinspelningarna användes för att producera en ILD i videoformat. ILD:erna konstruerades kring en modifierad version av PODS-modellen (Predict- Observe- Discuss- Synthesize, ung. Förutspå-Observera-Diskutera-Inlärning), vilken är en fyrstegsprocess för ILD:er. ILD:en innehöll fyra separata demonstrationer som belös avkopplingskondensatorernas, jordtopologins och likspänningsomvandlarens inverkan på ljudkvaliteten och den utstrålade radioenergin. ILD:en presenterades på ett sådant sätt att mätresultaten och ljudinspelningarna korrelerades till den bakomliggande konstruktionsteorin. Studenter som hade läst endera av två kurser relaterade till kretskorts- och elektronik-konstruktion vid Kungliga Tekniska högskolan (KTH) under våren 2019 och 2020 mottog en inbjudan att titta på videon. Utvärdering av effektiviteten hos ILD-presentationen gällande dess pedagogiska värde gjordes via en enkät vilka studenterna ombads att fylla i efter att de tittat på videon. Resultatet var övervägande positivt. Återkopplingen tyder på att studenterna tyckte att demonstrationerna var informativa och lärorika. Genom att kunna se effekterna av att försumma god PCB-konstruktionssed inom två nyckelområden så lyckades demonstrationerna ge en mer realistisk syn på konsekvenserna av att inte följa god konstruktionssed på ett sätt som inte är uppenbart i den teoretiska litteraturen. Eftersom att PCB-konstruktion är ett så pass omfattande ämnesområde så motiverar resultaten vidare utveckling och studier av ILD-konceptet inom andra PCB-konstruktionskoncept, t.ex transmissionsledningar, lager-ordning, signalintegritet (¨överhörning, timing, brus, etc), samt andra.