The United States is ranked first for health care expenditure and 11th for quality of care. Surgical care is complex, multifactorial, and medical expenses continue to increase. The necessity for surgery normally disconnects the patient from their primary care provider, frequently resulting in uncoordinated care between medical providers regarding surgical care. A fragmented healthcare system results in unnecessary diagnostic labs and tests, insufficient surgical care resources, and patients experiencing a lapse in their medical care. If adopted, the Perioperative Surgical Home (PSH) model has the opportunity to improve patient outcomes by increasing patient satisfaction rates while decreasing surgical complications and hospital stay duration. The PSH model is patient-centered, and directed by anesthesia providers coordinating surgical care by adequately optimizing patients for surgery. The five model components are: patient involvement, comprehensiveness, coordination of care, accessibility, and commitment to quality and safety. Purpose: The purpose of this project was to perform a needs assessment at a Central Phoenix Hospital to identify if there was a need to implement the PSH model to decrease surgical complications and 30-day surgical hospital readmission rates. Methods: This was a non-experimental needs assessment. Retrospective data collection was used to explore and identify if the PSH model was needed at this Phoenix hospital. A needs assessment tool was created guided by the Rothwell and Kazana's needs assessment model utilizing their five key phases. The General Systems Theory was used to assess the complexity of an open surgical system to identify gaps in performance and results. Results: Data collected from fiscal year 2015 demonstrated a total of 7,829 surgical cases were performed at this hospital. The number of patients with a surgical complication was 826 (10.6%). A reported 147 (1.9%) patients had a surgical hospital readmission at this facility. Data from fiscal year 2016 demonstrated 7,778 (10.3%) total surgical cases. The number of surgical complications reported was 800 (1.5%). A reported 116 patients had a hospital surgical readmission at this facility. Conclusion: The reported high health care expenditure and low quality of care received in the U.S. supports the need to improve our health care delivery system with models such as the PSH. There was not an obvious problem in performance of surgical complications and 30-day surgical hospital readmission rates. There were identified system gaps in data collection of surgical reporting that correlate with clinical practice. These findings were the starting point for a needs analysis to follow by focusing on development and implementation of the PSH model if adopted.

A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Master of Science in Nursing Johannesburg, 2018. / Undergoing surgery without having general anaesthesia has become an option for many surgical patients. Awake patients are able to communicate with the surgical team which allows the surgical team to gain understanding of the patient’s experience. This is an important aspect of perioperative care and is in line with the theory of Human Becoming according to Parse, (2011). Literature suggests that patients who have received information preoperatively about their planned perioperative journey experience less anxiety and fear relating to their surgery. The purpose of this study was to explore the perioperative experiences and needs of patients undergoing awake surgery. A qualitative exploratory descriptive three step design of data collection was implemented for this study. In step one an integrative review identified patient experiences of the perioperative journey. The literature was critically analysed for relevance and inclusion. This information formed the basis for inclusion in step two. Step two explored the perioperative experience of participants who had undergone awake surgery by interviewing a group of participants using interviews and probe questions extracted from the literature. The information gleaned from the interviews was grouped for content similarity and was used to create an information pamphlet which informed participants about their perioperative journey. In step three the information pamphlet was handed to participants preoperatively and the same participants rated the usefulness of the information pamphlet postoperatively by answering a dichotomous question. Participants had the opportunity to add comments. The population for this study was all patients who were scheduled for ophthalmic, orthopaedic, urological or plastic, surgery using awake surgery in four large private hospitals in Gauteng and Mpumalanga. Patients younger than 18 years of age as well as those receiving sedation or general anaesthesia were excluded from the population. This study showed that participants had positive experiences of being awake during surgery. A number of participants found the experience of being awake during surgery interesting and enjoyed being able to ask questions and participate in dialogue. Participants rated the information pamphlet as useful. Two areas of concern was elicited, namely communication and nursing care within the operating theatre environment. The objectives for this study were met. Key words: perioperative journey, awake surgery, regional and local anaesthesia, nursing / LG2018

Recent high-risk coronary artery disease (CAD), defined as Canadian Cardiovascular Society (CCS) class III or IV angina or acute coronary syndromes (ACS) unstable angina, is independently associated with increased mortality and morbidity following non-cardiac surgery. It remains unclear how the components of high-risk CAD, use of stents and timing of surgery after a high-risk CAD event is associated with risk. This project will address these issues and how they affect current perioperative medicine. / Thesis / Master of Science (MSc)

Introduktion: Den perioperativa omvårdnaden där operationssjuksköterskan ingår innefattar faserna före, under och efter operation och kan ses som ett arbetssätt. Perioperativ omvårdnad har utarbetats under 1990-talet. Arbetssättet har inte efterlevts i någon stor grad trots positiva effekter för patienter och personal. Operationssjuksköterskans arbete är fortfarande övervägande traditionellt, med fokus på tiden då patienten är sövd och opereras. Vårdenhetschefers och sektionsledares uppfattningar om den perioperativa omvårdnaden har betydelse för hur arbetet bedrivs på operationsavdelningar. Syfte: Att beskriva vårdenhetschefers och sektionsledares uppfattningar om operationssjuksköterskans perioperativa omvårdnadsarbete samt om införandet av perioperativ omvårdnad. Metod:Datainsamling skedde genom öppna intervjuer med fyra vårdenhetschefer och fyra sektionsledare inom operationssjukvården på två länssjukhus och två universitetssjukhus i Sverige. Insamlad data har analyserats kvalitativt med manifest innehållsanalys. Huvudresultat: Perioperativ omvårdnad som arbetssätt hade enligt vårdenhetschefer och sektionsledare inom operationssjukvård ett värde genom att förnya operationssjuksköterskans arbetssätt vilket anses förbättra patientens omvårdnad. För att införa perioperativ omvårdnad krävdes att olika behov tillgodoses, som tydliggörande av patientnyttan, stöd som skapar rätt förutsättningar, samt att det behövs motivation hos operationssjuksköterskor. Slutsats: Perioperativt omvårdnadsarbete är, trots dess värde, inte möjligt att genomföra utan långtgående förändringar i synsätt och organisation. / Introduction: Perioperative care in which the operating room nurse takes part includes the phases before, during and after operation and can be seen as a way of working in parallel with the care process. This approach has however not been applied to any great extent in pratice despite several studies having shown the positive effects for both patients and staff. The common view of the operating room nurse’s role is still a traditional one with the focus on the time when the patient is anaesthetized and during the actual surgery. Unit managers and section leaders perceptions of perioperative care are important since it affects how the approach is applied in practice. Aim: To describe the unit managers and section leaders perceptions of the operating nurse’s perioperative care work together with how the process is applied in practice. Method: Data were collected by semi-structured interviews with four unit managers and four section leaders within the operating room unit of two provincial hospitals and two university hospitals in Sweden. Data have been analysed with a qualitative content analysis. Main results: Perioperative care as an approach has, according to the unit managers and section leaders in the operating room unit, a value as it revitalises the operating room nurse’s method of working which in turn is thought to improve patient care. It is maintained that in order to introduce perioperative care certain requirements need to be fulfilled, such as clarification of the benefit to patients, support in order to create the right conditions, as well as the need for motivated operating room nurses. Conclusion: Perioperative nursing care is, despite its value, not possible to implement without farreaching changes to how operating room nursing is approached as well as organisational changes.

Vid den perioperativa dialogen möter den perioperativa sjuksköterskan patienten vid tre tillfällen i samband med operation. Detta har visat sig komma både patienter och sjuksköterskor till godo. För att införa perioperativ dialog krävs förändringar i organisationen. Syftet med arbetet var att undersöka vilka förutsättningar som krävs för att införa och arbeta med perioperativ dialog på operationsavdelning. Arbetet är en pilotstudie med kvalitativ ansats, där chefssjuksköterskor intervjuats. I resultatet framkom kategorierna förutsättningar och hinder med sub- och sub-subkategorier. Chefssjuksköterskorna i undersökningen hade svårt att se hur perioperativ dialog skulle kunna införas i deras operationsverksamhet. De pekade på personalbrist, och genom det svårigheter för operationssjuksköterskan att få tid att följa patienten. Vidare framkom det att det måste finnas ett behov hos patienter och personal av att använda perioperativ dialog. De såg också möjligheter att införa det i elektiv verksamhet och att det finns behov av en drivande person som kan starta upp införandet genom projekt. / Perioperative dialogue is a way of working where the perioperative nurse meets the patient at three occasions, which has proved to be beneficial for both patients and nurses. To implement the perioperative dialogue, organization changes are needed. The aim of the study was to investigate what is required to implement and work with perioperative dialogue. A pilot study has been performed, with a qualitative approach, where head-nurses were interviewed. The result presented two main categories, opportunities and hindrances with sub- and sub-subcategories. The interviewed head-nurses had difficulties to see how to implement perioperative dialogue in their organization. Shortage of staff, and therefore difficulties for the theater nurse to have the time to follow the patient was emphasized. Perioperative dialogue demands a need from patients and staff. In daily work the participating head nurses did see the possibility for easier implementation in elective surgery and also the need for a special person to head the project.

A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Master of Medicine in the branch of Anaesthesia Johannesburg, April 2013 / BACKGROUND: Once lauded as one of the most valuable interventions across all fields of contemporary medicine, perioperative beta blockade (PBB) is a practice that has come under intense scrutiny. Publication of the PeriOperative ISchemic Evaluation (POISE) study forced a modification of recommendations for PBB in consensus guidelines. Practice in South Africa has not been previously reported. OBJECTIVES: The primary objective of this study was to describe current intended practice, with respect to PBB, in patients undergoing major vascular surgery at South African specialist training facilities. Secondary objectives were describing participant satisfaction with current strategy, reporting suggested modifications to clinician responsibilities in the future, and identifying potential barriers to the intervention. METHOD: One anaesthesiologist and one vascular surgeon from each of the seven recognised training facilities for vascular surgery in South Africa were included in a partially selective observational survey. Data was generated by the use of a semi-structured questionnaire specifically developed to address the objectives of the study. RESULTS: The POISE study results and updated international consensus guidelines had not prompted a change in approach at most facilities. There was inconsistency in methods of risk stratification, treatment implementation, titration practices, and the timing of withdrawal of medication. Anaesthesiologist and vascular surgeon opinion on current intended practice correlated poorly. Opinions correlated least well at facilities where both clinicians claimed responsibility for PBB, implying that communication may be a problem. Similarities, where they did occur, were in keeping with recommendations that are widely supported in the literature. Less than half of the participants were satisfied with current practice. The involvement of the anaesthesiologists in the perioperative management of vascular surgery patients was less than reported in other countries. The participants supported a major role for anaesthesiologists in the future, and a move towards multidisciplinary involvement in policy development and patient management. The need for appropriate monitoring was identified as one of many important barriers. CONCLUSIONS: This study describes current intended practice at South African training facilities for vascular surgery. The variable practice across the country; the poor correlation of participant responses; widespread dissatisfaction with current strategy; suggested changes to clinician responsibilities; and the identification of multiple barriers to the implementation of strategy, highlight the need for review at all facilities. Further research is needed, since the optimal strategy for reducing risk in patients undergoing vascular surgery remains elusive.

Background: Adolescent idiopathic scoliosis (AIS) affects 1 – 3% of all children aged 10 – 16 years; of these approximately 80% are girls. Scoliosis surgery is a major (one of the most extensive) elective paediatric orthopaedic procedure and is known to cause severe and excruciating pain that requires advanced postoperative pain management. Until now, scoliosis surgery has mainly been studied in terms of corrective surgical outcomes, and techniques for surgery and pain management. Adolescents’ narratives and experiences of recovery after scoliosis surgery, as well as psychological aspects in correlation to postoperative pain have seldom been studied. Aim: The overall aim of this thesis was to explore adolescents’ experiences of undergoing scoliosis surgery, experiences and self-reporting of pain, and psychological consequences. Methods: This thesis comprises four studies. The participants in Studies I and II belonged to the same cohort, all of whom underwent corrective surgery in the period from 2004 to 2007. In Study I there was a cohort of 87 adolescents and young adults with different types of scoliosis, some of whom had impaired verbal communication. The patients and their parents/caregivers were asked to complete a survey with questions regarding experienced pain, nausea and overall satisfaction with the hospital stay. Study II was a qualitative study in which six adolescents from the cohort in Study I were interviewed. The adolescents included in Study II had idiopathic scoliosis, and the interviews took place about two years after they had undergone surgery. Study III, which included 37 adolescents, was a prospective study of adolescents with idiopathic scoliosis (AIS) from four spine centres in Sweden. They completed two psychometric instruments and one structured interview both before surgery and about six months afterward. They also self-measured pain on the third postoperative day. In Study IV the adolescents included belonged to the same cohort as in Study III. In this prospective, mixed-method study, the participants self-reported pain before surgery, every four hours for the first five days after surgery, once a day for the first fourteen days at home after discharge from the hospital, and finally at the six-month follow-up. They were also asked to keep a diary during the first two weeks at home after discharge from the hospital. At the six-month follow-up they were interviewed about the overall experience of undergoing scoliosis surgery: how they experienced the time before surgery, during the hospital stay and the recovery period up through the date of the interview. iv Results: Study I showed that the patients experienced severe pain and nausea postoperatively during the hospital stay. The parents/caregivers felt helpless and sometimes lacked confidence in the nurses. Despite this, overall satisfaction with the hospital stay was rated as good. Study II showed that the adolescents experienced nervousness and fear before surgery, severe pain and postoperative nausea and vomiting (PONV) during the hospital stay, had problems with the scars and experienced social difficulties during recovery. Nightmares were reported for up to two years after surgery. In Study III, the ratings of stress symptoms were higher before surgery than after. There were significant correlations between stress symptoms before surgery and levels of postoperative pain. There were also significant correlations between levels of postoperative pain and stress symptoms at the six-month follow-up. In Study IV, postoperative pain ratings showed great individual variation, and in the analysis of drop-outs it was found that those who did not keep a diary at home self-reported higher levels of pain at the six-month follow-up as well as higher levels of stress symptoms and internalizing symptoms. The participants described experiences of severe pain at the hospital and also during recovery. Nausea, constipation and lack of energy emerged from the narratives - but so did the desire to get back to school, sports and friends. The adolescents described how they were hovering between suffering and control and also striving towards normality. Conclusion: The results indicate a need for interventions among adolescent patients to reduce stress symptoms before major surgery. Nurses need to identify adolescents with stress symptoms, use stress-reduction techniques, and support adolescent patients with coping strategies aimed at reducing preoperative stress and managing postoperative pain. Postoperative pain management needs to be improved, both as regards pain assessment and pharmacological and non-pharmacological pain management. Nurses need to improve their medical technical skills in order to optimize pain treatment. After discharge from the hospital adolescents have to struggle with difficulties at home such as pain, nausea, constipation, mobilization and a lack of energy. An intervention with follow-up telephone calls during the second week at home could reduce stress and help resolve difficulties. Since this study indicates stress symptoms at the six-month follow-up, there should also be a nurse interview to check on well-being and to see if any further intervention is needed at that time. If preoperative stress can be reduced, postoperative pain management optimized and the recovery period better supported, the overall experience of going through scoliosis surgery should improve.

FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico / Trata-se de uma revisÃo integrativa da literatura, que teve como objetivo buscar e avaliar as evidÃncias disponÃveis na literatura sobre o cuidado no perÃodo perioperatÃrio prestado à paciente submetida à mastectomia. Para a seleÃÃo dos estudos, foram consultadas as bases de dados PUBMED, LILACS e CINAHL. A amostra constituiu-se de sete estudos. NÃo foi identificado nenhum estudo nas bases de dados LILACS e CINAHL, sete estudos foram provenientes do PUBMED. Houve uma prevalÃncia de seis estudos (86%) com nÃvel de evidÃncia 2 e um estudo (14%) com nÃvel de evidÃncia 3. ApÃs a anÃlise dos aspectos abordados nestes artigos, reuniu-se em uma categoria temÃtica: o manejo da dor, contendo os sete estudos. O primeiro estudo concluiu que uma dose de 600 mg de gabapentina administrada uma hora antes da cirurgia produz analgesia pÃs-operatÃria significativa apÃs a mastectomia total. O segundo estudo demonstrou que o uso do EMLA em pacientes mastectomizadas reduziu a solicitaÃÃo de analgÃsicos no pÃs-operatÃrio e uma reduÃÃo da incidÃncia e a intensidade da dor crÃnica. No terceiro estudo nÃo foram encontradas diferenÃas no manejo da dor pÃs-operatÃria entre 3,75 mg / ml de ropivacaÃna e infiltraÃÃo da ferida com soluÃÃo salina antes da mastectomia. O quarto estudo concluiu que a administraÃÃo preventiva com cetoprofeno por via endovenosa (100 mg) produz maior alÃvio da dor pÃs-operatÃria em pacientes submetidas à mastectomia. O quinto estudo evidenciou que a administraÃÃo de 8 mg de dexametasona diminui efetivamente o uso de analgÃsicos em mulheres submetidas à anestesia geral para a mastectomia. O sexto estudo nÃo demonstrou associaÃÃo entre o Ãndice de Ãxido nÃtrico e o desenvolvimento de dor crÃnica pÃs-operatÃria. O sÃtimo estudo concluiu que a administraÃÃo perioperatÃria de venlafaxina reduz significativamente a incidÃncia de sÃndrome da dor pÃs-mastectomia. O estudo apresentou como limitaÃÃes o fato de que ao longo dos 10 anos pesquisados, o Ãnico cuidado perioperatÃrio da cirurgia de mastectomia encontrado na literatura foi relacionado ao manejo farmacolÃgico da dor, ademais os estudos analisados nÃo mostraram uma associaÃÃo entre si, visto que em cada um foi avaliado uma droga diferente, dificultando o consenso e a recomendaÃÃo relacionada ao uso de fÃrmacos para o controle/minimizaÃÃo da dor. A evidÃncia nÃo apresentou um consenso para o cuidado perioperatÃrio de mastectomia, pois encontrou-se uma diversidade de uso de fÃrmacos para o controle da dor e em grande parte dos estudos existiu divergÃncias e divisÃo de opiniÃes. Contudo, observou-se a preocupaÃÃo por parte dos profissionais em minimizar/prevenir a dor prÃ, intra e pÃs-operatÃria. Desse modo, a enfermagem deve estar atenta, tanto à atualizaÃÃo dos tratamentos farmacolÃgicos no manejo da dor quanto ao desenvolvimento de futuras pesquisas relacionadas ao cuidado de enfermagem no perÃodo perioperatÃrio de mastectomia. / It is an integrative literature review, which aimed to search and evaluate the available evidence in the literature on perioperative care provided to patients undergoing mastectomy. To select the studies were consulted the databases PUBMED, LILACS and CINAHL and the sample consisted of seven studies. No study has been identified in the databases LILACS and CINAHL, and all seven studies were from the PUBMED. There was a prevalence of 6 studies (86%) with level of evidence 2 and 1 study (14%) with level of evidence 3. After analyzing the issues addressed in these articles, gathered in atopical category: pain management, containing the seven studies. The first study found that a dose of 600 mg of gabapentin administered 1 h before surgery produces significant postoperative analgesia after total mastectomy. The second study showed that use of EMLA in mastectomy patientsreduced the request of analgesics postoperatively and a reductionin the incidence and intensity of chronic pain. In the study 03 found no differences in the management of postoperative pain between 3.75 mg / ml and ropivacaine wound infiltration with saline prior to mastectomy. The fourth study found that preventive administration of ketoprofen intravenously (100 mg) produces greater relief of postoperative pain in patients undergoing mastectomy. The fifth study showed that administration of dexamethasone 8 mgeffectively decreases the use of analgesics in women undergoinggeneral anesthesia for mastectomy. The sixth study showed no association between the index of nitric oxide and the development of chronic postoperative pain. The seventh study found that perioperative administration of venlafaxine significantly reduces the incidence of pain syndromeafter mastectomy. The study had limitations the fact that over the 10 years studied, the only perioperative care of the mastectomy surgery in the literature was related to the pharmacological management of pain and the studies analyzed did not show an association between them, since in each was assessed a different drug, hindering consensus and recommendation regarding the use of drugs to control / minimize the pain. The evidence did not show a consensus for the perioperative care of mastectomy, because we found a diversity of use of drugs for pain control and in most studies there were differences and division of opinion. However, we noted the concern on the part of professionals to minimize / prevent pain before, during and after surgery, and nursing must be attentive to both the update of pharmacological treatments in pain management, for the development of future research related to the care of perioperative nursing.

Rare bleeding disorders are a group of inherited conditions caused by a deficiency of blood coagulation factors. Due to the low prevalence of these conditions in the general population, there is a scarcity of data to make informed, evidence-based clinical decisions. In this population who are highly susceptible to excessive bleeding, surgeries and invasive procedures pose an additional level of risk for bleeding-related and non-bleeding-related complications, especially in the perioperative period. The data scarcity in patients with rare bleeding disorders is further compounded by an infrequent rate of invasive procedures, sometimes attributed to the hemostatic challenges faced by such interventions among other factors. To address the problem of insufficient data for healthcare decision-making, as well as the assessment of perioperative outcomes in this population, this thesis explores the use of routinely collected data for the creation of a novel surgical database used for the assessment of perioperative hemostasis, complications, and initial surgical plan deviations in patients with rare bleeding disorders. Across five chapters, this thesis provides the methodology for the creation of the Indiana Hemostasis and Thrombosis Center (IHTC) Surgical Database, a descriptive analysis of the population and procedures, and assessment of perioperative outcomes. Approaches to ensure the validity of study results including confounder adjustment by variable selection methods, data quality improvement, missing data description, and imputation methods, were explored. Evidence from randomized controlled was also reviewed using Cochrane methodology to summarize the efficacy of clotting factor concentrates for the prevention of bleeds and bleeding-related complications in patients with hemophilia. Based on findings from the different approaches (observational study designs, randomized controlled trials, and systematic review methodology), recommendations were made regarding methodological and analytical considerations required to ensure valid and reliable perioperative outcome assessment in patients with rare bleeding disorders. The following provides a brief outline of each chapter. Chapter 1 is an introduction that outlines each of the studies in this thesis. Chapter 2 is a descriptive overview of the design, structure, and exploratory analysis of data captured in the IHTC-Surgical Database over a 21-year period. Chapter 3 is a retrospective cohort study that assessed the association between inhibitor status and perioperative hemostasis, complications, and initial surgical plan deviations in patients with hemophilia A and B. Chapter 4 is a systematic review that examined the efficacy of clotting factor concentrates for the prevention of bleeds and bleeding-related complications in patients with hemophilia. Chapter 5 outlines key findings, limitations, implications of the research in this thesis, and methodological considerations for the assessment of perioperative outcomes in patients with bleeding disorders. / Thesis / Doctor of Philosophy (PhD)

The patient-important outcomes of cardiac and non-cardiac surgery are well-recognized but poorly understood. The causes of major morbidity and mortality in patients undergoing non-cardiac are not known. This is not the case in cardiac surgery, which is provided to a homogenous patient population that has been well-described through clinical registries. Recent improvements to the care of cardiac surgical patients have led to dramatic decreases in major morbidity and mortality. However, neurocognitive and functional impairments after cardiac surgery remain the most feared by patients and least understood by clinicians. This thesis comprises 6 chapters that inform these knowledge gaps and establish the basis upon which future research will be based. Chapter 1 is an introduction providing the rationale for conducting each of the included studies. Chapter 2 reports the VISION Mortality study, which explores the relationship between major complications and death within 30-days of undergoing inpatient, noncardiac surgery. Chapter 3 reports a study validating the use of the Standardized Assessment of Global activities in the Elderly (SAGE) scale in patients undergoing cardiac surgery. Chapter 4 presents a pilot observational study that establishes the feasibility of conducting a large, prospective cohort study to determine the relationship between decreases in cerebral saturation during cardiac surgery and postoperative functional decline. Chapter 5 presents a pilot study conducted to inform the feasibility of a large, randomized cluster crossover trial examining whether an institutional policy of restricted benzodiazepine administration during cardiac surgery (compared to liberal administration) would reduce delirium after cardiac surgery. Chapter 6 discusses the conclusions, limitations, and implications of the research presented in this PhD thesis. / Thesis / Candidate in Philosophy