Neste trabalho são propostos métodos para a estimação de parâmetros de motores de indução através do método dos Mínimos Quadrados com medição apenas de tensões, correntes e resistência do estator em um ensaio de partida em vazio. São detalhados os procedimentos para o tratamento dos sinais medidos, além das estimações do fluxo magnético e da velocidade mecânica do motor. Para a estimação dos parâmetros elétricos, são propostos métodos que diferem nos requisitos e no tratamento dos parâmetros como invariantes ou variantes no tempo. Em relação a esse último caso, é empregado um método de estimação de parâmetros por janelas de dados, aplicando um modelo com parâmetros invariantes no tempo localmente em diversas partes do ensaio. São feitas simulações para validar os métodos propostos, e dados de ensaio de três motores de diferentes potências são utilizados para analisar a escala de variação paramétrica durante a partida. É feita uma comparação entre os resultados obtidos com e sem consideração de variação nos parâmetros. / In this work, methods are proposed to estimate the parameters of induction motors through the Least Squares method with the measurement of only voltages, currents and resistance of the stator in a no-load startup test. Procedures are detailed to process the measured signals, as well as to estimate magnetic flux and rotor mechanical speed. In order to estimate the electrical parameters, methods are proposed which differ in their requisites and in the treatment of parameters as time invariant or time-varying. For the latter, a methodology for parameter estimation through data windows is used, applying a model with time invariant parameters locally to different parts of the test. Simulations are made to validate the proposed methodology, and data from tests of three motors with different powers are used to analyze the scale of parameter variation during startup. A comparison is made between the results obtained with and without the consideration of variation in the parameters.

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1980. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING. / Bibliography: leaves 215-218. / by Leon K. Ekchian. / M.S.

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1980. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING. / Bibliography: leaves 289-293. / by Wei-Yuan Hwang. / Ph.D.

A 13C-Análise de Fluxos Metabólicos (13C-MFA) tornou-se uma técnica de alta precisão para estimar fluxos metabólicos e obter informações importantes sobre o metabolismo. Este método consiste em procedimentos experimentais, técnicas de medição e em cálculos para análise de dados. Neste contexto, os grupos de pesquisa de engenharia metabólica necessitam de ferramentas computacionais precisas e adequadas aos seus objetos de estudo. No presente trabalho, foi construída uma ferramenta computacional na plataforma MATLAB que executa cálculos de 13C-MFA, com balanços de metabólitos e cumômeros. Além disso, um módulo para estimar os fluxos metabólicos e um módulo para quantificar as incertezas das estimativas também foram implementados. O programa foi validado com dados presentes na literatura e aplicado a estudos de caso. Na estimação de fluxos de Pseudomonas sp. LFM046, identificou-se que esse micro-organismo possivelmente utiliza a Via das Pentoses em conjunto com a Via Entner-Doudoroff para a biossíntese de Polihidroxialcanoato (PHA). No design ótimo de experimentos para uma rede genérica de Pseudomonas, identificou-se a glicose marcada no átomo cinco como um substrato que permitirá determinar o fluxo na Via das Pentoses com menor incerteza. / 13C-Metabolic Flux Analysis (13C-MFA) has become a high-precision technique to estimate metabolic fluxes and get insights into metabolism. This method consists of experimental procedures, measurement techniques and data analysis calculations. In this context, metabolic engineering research groups demand accurate and suitable computational tools to perform the calculations. A computational tool was implemented in MATLAB platform that performs 13C-MFA calculation, using metabolite and cumomer balances, as well as a module to estimate the fluxes and a module to quantify their uncertainty. The program was validated with some classical cases from literature. From the flux estimates of Pseudomonas sp. LFM046, it was identified that the microorganism possibly uses the Pentose Phosphate Pathway along with the Entner-Doudoroff Pathway for Polyhydroxyalkanoate (PHA) biosynthesis. From the optimal experimental design for a generic Pseudomonas network, it was possible to conclude that glucose labeled at atom five is the best option to determine the flux in the Pentose Phosphate Pathway with smaller uncertainty.

Huang Changquan. / "April 2002." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2002. / Includes bibliographical references (p. 62-71). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. Ann Arbor, MI : ProQuest Information and Learning Company, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Neste trabalho, investigamos um algoritmo para estimação dos parâmetros de geradores síncronos baseado em análise de sensibilidade de trajetórias. Os parâmetros são estimados através da resolução de um problema de otimização não-linear de mínimos quadrados. Medidas são comparadas com as soluções obtidas dos modelos dinâmicos do gerador e o algoritmo busca minimizar a diferença entre as medidas e a saída do modelo matemático. As medidas foram obtidas de forma artificial por intermédios de simulações computacionais, admitindo-se não somente as dinâmicas transitórias da máquina, mas também considerando as dinâmicas sub-transitórias. O algoritmo proposto é adequado para medidas acessíveis em campo e permite estimar os parâmetros a partir de medidas de perturbações do sistema sem a necessidade da desconexão da máquina do sistema. A principal contribuição deste trabalho é a proposição de uma nova modelagem empregada para estimar os parâmetros do gerador síncrono. Para isto, propõe-se um modelo simplificado, modificado do modelo de dois eixos do gerador, que utiliza a corrente de campo do gerador como uma das entradas. Este modelo é constituído por um conjunto de equações algébrico-diferenciais (EADs) que contém uma equação algébrica de balanço de corrente. Esta equação elimina a necessidade de medidas de variáveis de difícil acesso. O algoritmo proposto foi testado com dados obtidos de simulações dinâmicas realizadas a partir de um sistema teste com resultados satisfatórios. Os resultados obtidos são analisados frente a resultados obtidos também para o modelo de dois eixos utilizando a tensão de campo como uma entrada. Através destes resultados é possível observar a possibilidade de sua utilização em aplicações reais. / In this work, we investigate an algorithm for estimating parameters of synchronous generators based on trajectories sensitivity analysis. The parameters are estimated by solving a nonlinear optimization problem of least squares. Measurements are compared with the solutions obtained from the dynamic model of the generator and the algorithm seeks to minimize the difference between the measurements and the output of the mathematical model. Measurements were obtained artificially by means of simulations, assuming not only the transient dynamics of the machine, but also considering the subtransient dynamics. The proposed algorithm is suitable for accessible measurements in the field and allows the estimation of parameters from measurements of system disturbances, without the necessity of disconnecting the machine from the system. The main contribution of this work is to propose a new generator model to estimate the parameters of the synchronous generator. To this end, a simplified model is proposed. This model is a modification of the two-axis model of the generator, which uses the generator field current as an input of the model. This model consists of a set of differential-algebraic equations (DAEs) containing an algebraic equation of balance of current. This equation eliminates the need of measuring variables that are difficult to access. The proposed algorithm has been tested with data obtained from dynamic simulations conducted from a test system with satisfactory results. The results has been analysed against the results of the two-axis model using the generator field voltage as an input of the model. These results indicate the possibility of application in real machines.

In this thesis we modify an existing model for the spread of resistant bacteria in a hospital. The existing model does not account for some of the trends seen in the data found in literature. The new model takes some of these trends into account. For the new model, we examine issues relating to identifiability, sensitivity analysis, parameter estimation, uncertainty analysis, and equilibrium stability.

abstract: A critical problem for airborne, ship board, and land based radars operating in maritime or littoral environments is the detection, identification and tracking of targets against backscattering caused by the roughness of the sea surface. Statistical models, such as the compound K-distribution (CKD), were shown to accurately describe two separate structures of the sea clutter intensity fluctuations. The first structure is the texture that is associated with long sea waves and exhibits long temporal decorrelation period. The second structure is the speckle that accounts for reflections from multiple scatters and exhibits a short temporal decorrelation period from pulse to pulse. Existing methods for estimating the CKD model parameters do not include the thermal noise power, which is critical for real sea clutter processing. Estimation methods that include the noise power are either computationally intensive or require very large data records. This work proposes two new approaches for accurately estimating all three CKD model parameters, including noise power. The first method integrates, in an iterative fashion, the noise power estimation, using one-dimensional nonlinear curve fitting, with the estimation of the shape and scale parameters, using closed-form solutions in terms of the CKD intensity moments. The second method is similar to the first except it replaces integer-based intensity moments with fractional moments which have been shown to achieve more accurate estimates of the shape parameter. These new methods can be implemented in real time without requiring large data records. They can also achieve accurate estimation performance as demonstrated with simulated and real sea clutter observation datasets. The work also investigates the numerically computed Cram\'er-Rao lower bound (CRLB) of the variance of the shape parameter estimate using intensity observations in thermal noise with unknown power. Using the CRLB, the asymptotic estimation performance behavior of the new estimators is studied and compared to that of other estimators. / Dissertation/Thesis / Doctoral Dissertation Electrical Engineering 2019

In this thesis we develop new mathematical models, using dynamical systems, to represent localized gene delivery of bone morphogenetic protein 2 into bone marrow-derived mesenchymal stem cells and rat calvarial defects. We examine two approaches, using pDNA or cmRNA treatments, respectively, towards the production of calcium deposition and bone regeneration in in vitro and in vivo experiments. We first review the relevant scientific literature and survey existing mathematical representations for similar treatment approaches. We then motivate and develop our new models and determine model parameters from literature, heuristic approaches, and estimation using sparse data. We next conduct a qualitative analysis using dynamical systems theory. Due to the nature of the parameter estimation, it was important that we obtain local and global sensitivity analyses of model outputs to changes in model inputs. Finally we compared results from different treatment protocols. Our model suggests that cmRNA treatments may perform better than pDNA treatments towards bone fracture healing. This work is intended to be a foundation for predictive models of non-viral local gene delivery systems.

System Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disorder that affects many parts of the body including skin, joints, kidneys, brains and other organs. Lupus Nephritis (LN) is a disease caused by SLE. Given the complexity of LN, we establish an optimal treatment strategy based on a previously developed mathematical model.For our thesis work, the model variables are: Immune Complexes (I), Pro-inflammatory mediators (P), Damaged tissue (D), and Anti-inflammatory mediators (A). The analysis in this research project focuses on analyzing therapeutic strategies to control damage using both parameter estimation techniques (integration of data to quantify any uncertainties associated with parameters) and optimal control with the goal of minimizing time spent on therapy for treating damaged tissue by LN.