The plasma sheath is essential for understanding the plasma-material interaction (PMI) since it regulates the plasma particle and energy fluxes to the wall. The key concept in sheath theory is the Bohm criterion that gives the lower bound of the plasma exit flow speed, also known as the Bohm speed. Traditionally, the Bohm speed is evaluated in the asymptotic limit of an infinitely thin sheath and ignores the transport physics in the plasma-sheath transition problem. Whereas in practical applications, the sheath has a finite thickness and the transport in the neighborhood of the sheath entrance is complicated. The focus of this thesis is on performing Bohm speed analysis for different applications that are away from the asymptotic limits, with an emphasis on the critical role of transport physics on the Bohm speed formulation. The classical sheath problem with a wide range of Coulomb collisionality is revisited. Here, we derive an expression for the Bohm speed from a set of anisotropic plasma transport equations. The thermal force, temperature isotropization and heat flux enter into the eval- uation of the Bohm speed. Away from the asymptotic limit, it is shown that there exists a plasma-sheath transition region, rather than a single point at the sheath entrance. In the transition region, the quasineutrality is weakly perturbed and the Bohm speed is predicted for the entire transition region. By comparison with kinetic simulation results, the Bohm speed model in our work is shown to be accurate in the sheath transition region over a broad range of collisionality. The Bohm speed analysis developed above can be applied to plasma-sheath transition prob- lems with more complex transport physics, such as a high recycling divertor in a fusion reactor. In the high recycling regime, the plasma particles hitting on the divertor surface will be recycled through reflection or desorption and return to the plasma in the form of neutrals. The plasma will interact with the recycled neutrals through atomic collisions such as ionization, excitation, or ion charge-exchange collision, complicating the plasma transport in the transition layer. A new Bohm speed model is proposed to account for the effect of the anisotropic transport and atomic collisions in the transition layer. A first principle ki- netic code VPIC with the atomic collision package is used to investigate a 1D self-consistent slab plasma with a high recycling boundary for tungsten and carbon divertors. The results demonstrate the accuracy of the Bohm speed model in predicting the ion exit flow speed in the transition region, as well as the reduction of the Bohm speed due to the ion-neutral friction. / Doctor of Philosophy / Controlled thermal nuclear fusion is a promising candidate for future energy supply. In a fusion reactor, a vast amount of energy is created and confined in the main plasma, while the boundary plasma can carry a certain amount of energy from the main plasma and deposit it on the surface of the plasma-facing component (PFC) of the reactor. The edge plasma and the material surface are strongly coupled through the plasma-material interaction (PMI). It is widely understood that PMI is a critical issue in realizing controlled thermonuclear fusion. The PMI problem involves complex physics phenomena that cover a wide range of spatial and temporal scales, posing a significant challenge to its modeling. This work mainly focuses on physics at the intermediate scale, where sheath/presheath physics dominates. The plasma sheath is a thin, positively charged layer that forms in front of the material surface to equalize the electron and ion fluxes. In classical sheath theory, an idealized point, the sheath entrance, connects the quasineutral plasma and non-neutral sheath. The ions can be accelerated by the presheath electric field and reach the Bohm speed (equal to the sound speed in classical sheath theory) at the sheath entrance. That is the Bohm criterion, a necessary condition for a stable sheath to form. The plasma sheath in a fusion reactor is exposed to a complex environment where the atoms and molecules are abundant and can interact with the plasma inelastically. As a result, many assumptions made in the classical sheath theory may not be valid for practical applications, such as a divertor sheath. The classical sheath theory is derived in the asymptotic limit of an infinitely thin sheath. In a real plasma, a sheath transition layer, rather than a singular sheath entrance, exists, and it connects the plasma and sheath smoothly. In the transition region, the quasineutrality is weakly perturbed, and the plasma transport is significant. Previous evaluation of the Bohm speed invokes drastic simplification of the transport physics, resulting in a Bohm speed equal to the sound speed. Here, we propose a new Bohm speed model that considers the dominating transport phenomena-anisotropic transport and collisional transport. The Bohm speed analysis is performed in two cases:(i) a classical sheath problem with absorbing boundaries and (ii) a high recycling divertor where the plasma-neutral interaction is significant. In the first case, we extend the classical sheath analysis to a regime that is away from the asymptotic limit. The counterpart of important concepts in the two-scale analysis, such as the sheath entrance and Bohm speed, is established and well explained. The transport dependent Bohm speed model is derived from a set of anisotropic transport equations, where the heat flux, thermal force, and Coulomb collisional isotropization are considered. The model can predict the ion exit flow speed in the transition region over a broad range of Coulomb collisionality, as shown by comparison with the kinetic simulation results. The second case is more practical, where the Bohm speed analysis is performed at the edge of a fusion reactor. The plasma transport in the transition region is complicated by the plasma-neutral interactions. As a result, the Bohm speed model includes atomic collisions, such as ionization, excitation, and ion charge-exchange collision. Among all the collision processes, the ion charge-exchange collision has the most significant influence on the Bohm speed. It acts as a significant momentum sink for the ions and makes the Bohm speed subsonic in the transition region.

Solar wind-magnetosphere-ionosphere (SW-M-I) coupling is investigated with three different computational models that characterize space plasma dynamics on distinct spatial/temporal scales. These models are used to explore three important aspects of SW-M-I coupling. A particle-in-cell (PIC) model has been developed to explore the kinetic scale dynamics associated with the magnetotail dipolarization front (DF), which is generated as a result of magnetotail reconnection. The PIC study demonstrates that the electron-ion hybrid (EIH) instability could relax the velocity shear within the DF via emitting lower hybrid waves. The velocity inhomogeneity driven instability is highlighted as an important mechanism for energy conversion and wave emission during the solar wind-magnetosphere coupling, which has been long neglected before. The Lyon-Fedder-Mobbary (LFM) global magnetohydrodynamic (MHD) model is used to explore the fluid scale electrodynamic response of the magnetosphere-ionosphere to the interplanetary electric field (IEF). It is found that the cross polar cap potential (CPCP) varies linearly with very large IEF if the solar wind density is high enough. With controlled experiments of global MHD modeling driven by observed parameters, the linearity was interpreted as a result of the magnetosheath force balance theory. This study highlights the role of solar wind density in the electrodynamic SW-M-I coupling under extreme driving conditions. The LFM-TIEGCM-RCM (LTR) model, which is the Coupled-Magnetosphere-Ionosphere-Thermosphere (CMIT) model with Ring Current extension, is used to explore the integrated SW-M-I system. The LTR simulation study focuses on the subauroral polarization streams (SAPS), which involve both MHD and non-MHD processes and three-way coupling in the SW-M-I system. The global structure and dynamic evolution of SAPS are illustrated with state-of-the-art first-principle models for the first time. This study has successfully utilized multiscale models to characterize the forefront issues in the space plasma dynamics, which is required by the facts that plasmas have both particle and fluid featured properties and those properties are vastly different across geospace regions. It is highlighted that SW-M-I coupling could be significantly influenced by both microscopic and macroscopic processes. In order for a comprehensive understanding of the SW-M-I coupling, multiscale models and integrated framework of their combinations are critical. / Doctor of Philosophy / Three numerical models are used to explore the processes occurring in the Earth’s space environment from an altitude of ∼ 100 km to 10s Earth radii (R_E). This environment is mainly filled with plasma, the gaseous state of charged particles that collectively behave like a fluid and are also subject to complex electromagnetic interactions. The intrinsic features of plasma determine that the physics on the scale of charged particles and that on the scale of fluids are both very important. On the other hand, considering the vast differences in the plasma properties throughout space, different regions need to be represented by different physically-based models. This dissertation study addresses the processes on three distinct spatial/temporal scales with different models. A particle model that treats plasma as a group of charged particles is used to explore wave generation in the magnetotail (10s R_E in the nightside). It is found that inhomogeneous plasma flow in the sharp boundary layer at the magnetotail (called “dipolarization front”) can excite plasma waves to dissipate the energy originating from the solar wind (high speed plasma ejected from the sun). A magnetohydrodynamic (MHD) model that treats the plasma as a magnetized fluid is used to explore the efficiency of electric field mapping from the solar wind (10s R_E) to the ionosphere (∼ 100 km altitude). The electric field in the ionosphere usually linearly increases with solar wind electric field until it is too strong. An observational event showed that their relationship remains linear for very large driving field. MHD modeling experiments demonstrate that the linearity at large driving field is due to the high solar wind density, which is explained with force balance theory. An integrated model framework is used to explore the system level response of geospace by investigating the enhanced plasma flow in the subauroral ionosphere (called the subauroral polarization streams, SAPS). The generation of SAPS involves driving and feedback processes in different regions (magnetosphere, ring current, ionosphere) that can not be simulated with any individual model. The global structures and dynamic evolution of SAPS have never been explored before with first-principle characterization of the effects from the solar wind to geospace. This integrated modeling represents a state-of-the-art model framework to explore processes in coupled geospace. These studies illustrate that different models are necessary to explore fundamental physics on small and large scales and the coupling processes between different space regions. It is also suggested that incorporating the different models into an integrated framework is necessary to get a comprehensive understanding of the dynamics in geospace.

High-power microwave, HPM, systems can be used as non-lethal weapons with the ability to destroy or disturb electronics, by damaging internal circuits and inducing high currents. Today microwave sources are being developed with peak powers exceeding 1 GW, one of these devices is the vircator, a narrowband source which is unique to the HPM community. In order to understand and develop microwave sources like the vircator it is necessary to have computer models, as simulations gives an invaluable understanding of the mechanisms involved during operation, saving time and development costs.                                                                  This thesis presents the results from a theoretical analysis and a simulation study using a well known electromagnetic particle-in-cell code, Computer Simulation Technology Particle Studio. The results are then compared to measured data from a HPM system, the Bofors HPM Blackout. The results show that CST PS can be used to design and study the coaxial vircator with good results.

De part ses nombreuses applications scientifiques et sociétales comme la radiographie protonique ou encore la protonthérapie, l’accélération d’ions par laser suscite un grand intérêt. Cette thèse s’inscrit dans ce cadre et présente une étude de l’interaction d’une impulsion laser d’intensité relativiste avec un plasma de densité modérée. Dans ce régime, le plasma est transparent à l’onde laser et les électrons oscillent à des vitesses relativistes dans le champ de l’onde incidente. Ces conditions sont favorables à un transfert efficace de l’énergie laser vers le plasma, et donc sont intéressantes pour l’accélération d’ions par laser. Ce régime permet également la création de solitons électromagnétiques et acoustiques dont les mécanismes de formation et les propriétés nécessitent une meilleur compréhension. Nous réalisons une étude détaillée de simulations Particle-In-Cell (réalisées avec le code OCEAN) de l’interaction d’une impulsion laser intense avec un plasma sous dense. Nous montrons que la diffusion Raman stimulée (SRS) dans le régime relativiste est le principal processus responsable de l’absorption de l’énergie laser par le plasma et qu’il est, en outre, très efficace puisqu’il permet de transférer près de 70 % de l’énergie de l’impulsion laser aux électrons. Cette instabilité apparaît dans des plasmas dont la densité est nettement supérieure à la densité quart-critique du fait de la diminution de la fréquence plasma électronique et se développe sur des temps très courts. Il permet ainsi un chauffage homogène des électrons tout le long de la propagation de l’impulsion laser à travers le plasma. Ces électrons participent à la détente du plasma, et créent sur ses bords raids un champ électrostatique permettant l’accélération des ions. Ces derniers gagnent 30 % de l’énergie laser initiale. Nous avons aussi développé un modèle simple qui permet de prédire et donc d’optimiser le taux de rétro-diffusion du plasma du fait du développement de l’instabilité SRS. Nous nous intéressons également à la séquence des processus permettant la formation des cavités électromagnétiques. Cette analyse souligne le rôle joué par l’instabilité modulationnelle ou de Benjamin-Feir sur le front de l’impulsion laser qui est divisée en un train de plusieurs solitons électromagnétiques. À l’aide d’une étude détaillée, nous montrons que ces solitons excitent des ondes plasmas dans leur sillage en se propageant dans le plasma, perdent de l’énergie et finissent par être piégés. Ils forment également des dépressions (cavités) des densités électroniques et ioniques du plasma. Ces cavités sont des pièges pour les champs électromagnétiques rayonnés par le plasma (par exemple du fait de l’instabilité SRS) et survivent grâce à un équilibre entre la pression de radiation des champs piégés et les pressions cinétiques électroniques à leurs bords. Ces cavités absorbent une part importante de l’énergie laser mais elles n’en conservent qu’une partie sous forme d’énergie électromagnétique piégée. Le reste de l’énergie permet l’expansion de la cavité, la génération de solitons acoustiques supersoniques et l’accélération de particules. / The laser-accelerated ions draw an increasing interest due to their potential applications and to their unique properties. This manuscript presents a study of the interaction between a relativistic intense laser pulse and a low density plasma. In this regime, the plasma is transparent to the laser pulse and electrons oscillate with relativistic velocities in the field of the incident wave. These conditions make the transfer of the laser pulse energy to the plasma efficient, and therefore are interesting for the ion acceleration. This regime generates also electromagnetic and acoustic solitons whose formation mechanisms and properties need to be better understood. We carry out a detailed analysis of Particle-In-Cell simulations (performed with the code OCEAN) of interaction of an intense laser pulse with a low density plasma.We show that the stimulated Raman scattering (SRS) is the main mechanism responsible for the absorption of laser energy in plasma. This process is very efficient : it leads to the transfer of 70 % of the laser pulse energy to electrons. This instability occurs in plasmas with a density larger than the quarter critical one due to the decrease of the electron plasma frequency and develops in a very short time scale. It leads to an homogeneous electron heating all along the distance of propagation of the laser pulse through the plasma. The ions are efficiently accelerated at the plasma edges and can get nearly 30%of the initial laser energy. This study is accompanied by a simple analytical model which is able to predict and so optimize the laser backscattering fraction due to the development of the SRS instability. We also present a sequence of stages which lead to the formation of electromagnetic cavities. This analysis highlights the role of the modulationnal or Benjamin-Feir instability in the front of the laser pulse, which is split in a train of electromagnetic solitons. Our detailed study shows that these solitons excite plasmas waves in their wake, lose energy and are finally trapped in the plasma. They lead to the formation of density depressions (cavities) which may trap the electromagnetic fields produced in the plasma (by the SRS instability, for example). These structures may survive for a long time thanks to an equilibrium of the trapped field radiation pressure and the electronic kinetic pressure at their borders. These cavities absorb an significant part of the laser energy but only a part of it is trapped inside. The remaining part is invested in the cavity expansion, generation of acoustic solitons and acceleration of charged particles.

Un plasma est défini comme un gaz partiellement ou totalement ionisé. Bien que très présent dans l'univers visible, les plasmas naturels sont rares sur Terre. Cependant, ils représentent un intérêt majeur pour les industries et les instituts de recherche (traitement de surface, propulsion spatiale). Toutefois, la compréhension du comportement d'un plasma est complexe et fait appel à de nombreux domaines de la physique. De plus, ces plasmas peuvent être magnétisé i.e. lorsqu'un champ magnétique extérieur ou induit influence significativement la trajectoire des particules : r/L<1 où r est le rayon de Larmor et L la longueur caractéristique du système. Ce travail de thèse s'intéresse à la modélisation du comportement du plasma présent dans deux dispositifs : l'accélérateur de l'Injecteur de Neutres (IdN) rapides d'ITER et le magnétron en régime DC ou HiPIMS. La réalisation de la fusion nucléaire sur Terre fait actuellement l'objet de nombreuses recherche dans le monde. Du fait de l'énergie nécessaire au franchissement de la barrière de répulsion coulombienne, le plasma doit être confiné. Dans le cas d'ITER, le confinement est réalisé par de puissant champ magnétique. Cependant, pour atteindre les conditions nécessaires aux réactions de fusion, notamment en température, un injecteur de particules neutres à haute énergie (1MeV) est nécessaire. L'accélération de ces particules est une phase critique dans la création du faisceau de neutres et elle représente un défi technologique qui fait l'objet d'une étude dans ce travail de thèse. Le magnétron est un procédé industriel permettant la réalisation de couches minces par pulvérisation cathodique. Les ions créés par un plasma de décharge arrachent les atomes de la cathode qui se déposent sur l'anode. Le champ magnétique créé par des aimants permanents piège les électrons à proximité de la cathode augmentant l'efficacité du dispositif. Le comportement du plasma magnétron est ainsi étudié en régime continu ou pulsé ainsi que l'apparition de structures auto-organisées en rotation autour de l'axe du magnétron dans certaines conditions. Afin d'étudier ces dispositifs, plusieurs programmes de simulation numérique ont été développés. La méthode Paticle-In-Cell a été choisie car elle permet de prendre en compte la charge d'espace des particules de manière auto-cohérente. Diverses techniques (technique de collision nulle, Monte Carlo Collision, a posteriori Monte Carlo) et améliorations (maillage non uniforme, projections de charges au troisième ordre) ont été développées et implémentées. De plus, une méthode originale, Pseudo 3D, permettant un traitement à trois dimension du magnétron a été utilisées avec succès. Enfin, ces programmes ont été parallélisés afin de réduire le temps de calcul. / A plasma is defined as a partially or completely ionized gas. Even though, they are very present in the visible universe, natural plasmas are rare on Earth. However, they are a major interest for industries and research institutes (surface treatment, spatial propulsion). Nevertheless, the understanding of plasma behavior is complicated because of the numerous physical fields involved. Moreover, theses plasmas can be magnetized, i.e., a magnetic field, external or induced, affects significantly the particle trajectories: r/L<1 where r is the Larmor radius and L the typical length of the system. This thesis is focused on the plasma modeling in two device: the accelerator of the ITER's neutral beam injector (NBI) and the magnetron in DC or HiPIMS regime. The feasibility of nuclear fusion on Earth is subject of numerous research around the world. Because of the energy necessary to get over the Coulomb barrier, the plasma must be confined. For ITER, the confinement is achieved by intense magnetic fields. However, to reach the required conditions of nuclear fusion reactions, especially in temperature, a high energy (1MeV) neutral beam injector is needed. The particle acceleration is a critical part in the creation of the neutral beam and it represents a technical challenge which is studied in this thesis work. The magnetron is an industrial process for creating thin film by physical sputtering. The ions created by a plasma discharge tear the atoms out of the cathode which are then deposited on the anode. The magnetic field created by permanent magnets trap the electrons near the cathode improving the process efficiency. The plasma behavior inside the magnetron is studied in direct and pulsed current as well as the appearance of self-organized structures in rotation around the magnetron axis. To study these devices, several program of numerical simulation have been developed. The Particle-In-Cell methode has been chosen because it takes into account, self-consistently, the space charge of the particules. Several techniques (null collision technique, Monte Carlo Collision, a posteriori Monte Carlo) and improvement (Non uniform mesh, third order charge projection) have been developed and implemented. Moreover, an original method, Pseudo 3D, allowing a three dimensional study of the magnetron, has been used with success. Finally, these programs have been parallelized to reduce the computation time.

L’estimation de la charge d’un satellite et du risque de décharge nécessite dans certains cas la prise en compte dans les modèles numériques d’échelles spatiales très différentes. En particulier, les interconnecteurs présents à la surface des générateurs solaires d’un satellite sont susceptibles de modifier son équilibre électrostatique lors de missions spatiales rencontrant un environnement plasma dense. Une modélisation classique de cet effet nécessiterait le maillage d’éléments à des échelles submillimétriques,sur un satellite de plusieurs dizaines de mètres d’envergure, ce qui rendrait la simulation extrêmement onéreuse en temps de calcul. De plus, ces interconnecteurs sont parfois fortement chargés positivement par rapport à l’environnement, ce qui empêche l’application du modèle de Maxwell-Boltzmann classiquement utilisé pour les populations d’électrons. Dans une première partie, nous avons développé une méthode itérative de type Patch adaptée à la résolution du problème non-linéaire de Poisson-Boltzmann pour la simulation du plasma spatial. Cette méthode numérique multigrille permet la simulation de l’impact d’éléments de petite taille à la surface d’un satellite complet. Dans une seconde partie, nous avons développé un schéma correctif permettant d’utiliser le modèle de Maxwell-Boltzmann pour la population d’électrons, malgré la présence de surfaces satellites chargées positivement, en y ajoutant un terme de correction calculé à l’aide de la méthode Particle-in-Cell. Nous avons montré que ce schéma permet, tout en limitant le coût en calculs, de déterminer avec précision les courants collectés par les surfaces du satellites, qu’elles soient chargées négativement ou positivement. / The numerical simulation of spacecraft charging can require to resolve widely different geometrical scales. In particular, solar array interconnects on the surface of solar panels have a major impact ona satellite electrostatic equilibrium. A classical model of this effect would require a mesh refined tosub-millimetre scales, on a spacecraft spanning several dozen metres, which would make the simulation computationally expensive. Moreover, the solar array interconnects can have a large positive potentialrelative to the space plasma, preventing the use of the classical Maxwell-Boltzmann model for theelectrons in the plasma. In a first part, we have developed an iterative patch method to solve thenonlinear Poisson-Boltzmann equation used in plasma simulations. This multigrid numerical scheme allows to resolve the impact of small-scale components on the surface of a complete spacecraft. In asecond part, we have developed a corrective scheme for the Maxwell-Boltzmann model to account for the presence of charged surfaces in the simulation. We have shown that this simple model is able to precisely compute the currents collected by the spacecraft surfaces.

Les accélérateurs par onde de sillage plasma produites par faisceaux de particules (PWFA) ou par faisceaux laser (LWFA) appartiennent à un nouveau type d’accélérateurs de particules particulièrement prometteur. Ils permettent d’exploiter des champs accélérateurs jusqu’à cent Gigaélectronvolt par mètre alors que les dispositifs conventionnels se limitent à cent Megaélectronvolt par mètre. Dans le schéma d’accélération par onde de sillage plasma, ou par onde de sillage laser, un faisceau de particules ou une impulsion laser se propage dans un plasma et créé une structure accélératrice dans son sillage : c’est une onde de densité électronique à laquelle sont associés des champs électromagnétiques dans le plasma. L’un des principaux résultats de cette thèse a été la démonstration de l’accélération par onde de sillage plasma d’un paquet distinct de positrons. Dans le schéma utilisé, un plasma de Lithium était créé dans un four, et une onde plasma était excitée par un premier paquet de positrons (le drive ou faisceau excitateur) et l’énergie était extraite par un second faisceau (le trailing ou faisceau témoin). Un champ accélérateur de 1,36 GeV/m a ainsi été obtenu durant l’expérience, pour une charge accélérée typique de 40 pC. Nous montrons également ici la possibilité d’utiliser différents régimes d’accélération qui semblent très prometteurs. Par ailleurs, l’accélération de particule par sillage laser permet quant à elle, en partant d’une impulsion laser femtoseconde de produire un faisceau d’électron quasi-monoénergétique d’énergie typique de l’ordre de 200 MeV. Nous présentons les résultats d’une campagne expérimentale d’association de ce schéma d’accélération par sillage laser avec un schéma d’accélération par sillage plasma. Au cours de cette expérience un faisceau d’électrons créé par laser est refocalisé lors d’une interaction dans un second plasma. Une étude des phénomènes associés à cette plateforme hybride LWFA-PWFA est également présentée. Enfin, le schéma hybride LWFA-PWFA est prometteur pour optimiser l’émission de rayonnement X par les électrons du faisceau de particule crée dans l’étage LWFA de la plateforme. Nous présentons dans un dernier temps la première réalisation expérimentale d’un tel schéma et ses résultats prometteurs. / Plasma wakefield accelerators (PWFA) or laser wakefield accelerators (LWFA) are new technologies of particle accelerators that are particularly promising, as they can provide accelerating fields of hundreds of Gigaelectronvolts per meter while conventional facilities are limited to hundreds of Megaelectronvolts per meter. In the Plasma Wakefield Acceleration scheme (PWFA) and the Laser Wakefield Acceleration scheme (LWFA), a bunch of particles or a laser pulse propagates in a gas, creating an accelerating structure in its wake: an electron density wake associated to electromagnetic fields in the plasma. The main achievement of this thesis is the very first demonstration and experimental study in 2016 of the Plasma Wakefield Acceleration of a distinct positron bunch. In the scheme considered in the experiment, a lithium plasma was created in an oven, and a plasma density wave was excited inside it by a first bunch of positrons (the drive bunch) while the energy deposited in the plasma was extracted by a second bunch (the trailing bunch). An accelerating field of 1.36 GeV/m was reached during the experiment, for a typical accelerated charge of 40 pC. In the present manuscript is also reported the feasibility of several regimes of acceleration, which opens promising prospects for plasma wakefield accelerator staging and future colliders. Furthermore, this thesis also reports the progresses made regarding a new scheme: the use of a LWFA-produced electron beam to drive plasma waves in a gas jet. In this second experimental study, an electron beam created by laser-plasma interaction is refocused by particle bunch-plasma interaction in a second gas jet. A study of the physical phenomena associated to this hybrid LWFA-PWFA platform is reported. Last, the hybrid LWFA-PWFA scheme is also promising in order to enhance the X-ray emission by the LWFA electron beam produced in the first stage of the platform. In the last chapter of this thesis is reported the first experimental realization of this last scheme, and its promising results are discussed.

Une impulsion laser ultra-courte et ultra-intense se propageant dans un gaz de faible densité est capable d'accélérer une partie des électrons de ce gaz à des énergies relativistes, de l'ordre de quelques centaines de MeV, sur des distances de seulement quelques millimètres. Pendant leur accélération et dû à leur mouvement transverse, ces électrons émettent de plus un rayonnement X fortement collimaté et dirigé vers l'avant appelé rayonnement bétatron. Les caractéristiques de cette source la rendent intéressante pour son utilisation en imagerie à ultra-haute résolution.Dans ce manuscrit, nous explorons trois axes de travail autour de cette source à l'aide de simulations réalisées avec les codes Particle-In-Cell CALDER et CALDER-Circ. Nous commençons ainsi par étudier la création d'une source bétatron avec des impulsions laser de durée picoseconde et d'énergie kilojoule, donc plus longues et plus puissantes que celles habituellement utilisées par la communauté. Nous montrons que malgré les paramètres inhabituels de ces impulsions lasers il est toujours possibles de générer des sources X, et ce dans deux régimes différents.Ensuite, afin de comprendre une partie des différences généralement observées entre expériences et simulations, nous montrons dans une autre étude que l'utilisation dans les simulations de profils lasers réalistes au lieu de profils parfaitement Gaussiens dégrade fortement les performances de l'accélérateur laser-plasma et de la source bétatron. De plus, ceci conduit à un meilleur accord qualitatif et quantitatif avec l'expérience.Enfin nous explorons plusieurs techniques pour augmenter l'émission X basées sur une manipulation des profils de plasmas utilisés pour l'accélération. Nous trouvons que l'utilisation d'un gradient transverse ou d'une marche de densité conduisent tous deux à une augmentation de l'amplitude du mouvement transverse des électrons, et donc de l'énergie émise par la source bétatron. Alternativement, nous montrons que cet objectif peut-être atteint par la transition d'un régime de sillage laser vers un régime d'accélération par sillage plasma induit par une augmentation de la densité. L'accélération des électrons est optimisée dans le premier régime, tandis que l'émission X est fortement favorisée dans le second. / An ultra-short and ultra-intense laser pulse propagating in a low-density gas can accelerate in its wake a part of the electrons ionized from the gas to relativistic energies of a few hundreds of MeV over distances of a few millimeters only. During their acceleration, as a consequence of their transverse motion, these electrons emit strongly collimated X-rays in the forward direction, which are called betatron radiations. The characteristics of this source turn it into an interesting tool for high-resolution imagery.In this thesis, we explore three different axis to work on this source using simulations on the Particles-In-Cells codes CALDER and CALDER-Circ. We first study the creation of a betatron X-ray source with kilojoule and picosecond laser pulses, for which duration and energy are then much higher than usual in this domain. In spite of the unusual laser parameters, we show that X-ray sources can still be generated, furthermore in two different regimes.In a second study, the generally observed discrepancies between experiments and simulations are investigated. We show that the use of realistic laser profiles instead of Gaussian ones in the simulations strongly degrades the performances of the laser-plasma accelerator and of the betatron source. Additionally, this leads to a better qualitative and quantitative agreement with the experiment.Finally, with the aim of improving the X-ray emission, we explore several techniques based on the manipulation of the plasma density profile used for acceleration. We find that both the use of a transverse gradient and of a density step increases the amplitude of the electrons transverse motions, and then increases the radiated energy. Alternatively, we show that this goal can also be achieved through the transition from a laser wakefield regime to a plasma wakefield regime induced by an increase of the density. The laser wakefield optimizes the electron acceleration whereas the plasma wakefield favours the X-ray emission.

Recent advances in plasma-based propulsion systems have led to the development of electromagnetic Radio-Frequency (RF) plasma generation and acceleration systems, called Helicon Plasma Thrusters (HPT). One of the pioneer companies developing this new type of space propulsion is T4i Technology for Propulsion and Innovation s.p.a., with its cutting-edge project called REGULUS, among which this study has been performed. A crucial part of HPT systems is the acceleration region, where, by the means of a magnetic nozzle, the thermal energy of the plasma is converted into axial acceleration and, in turn, into thrust. This study is focused on the numerically simulation of the plasma dynamics in the acceleration stage, using Xenon gas. A three-dimensional full Particle-In-Cell (PIC) simulation strategy is used to simulate the plume in the magnetic nozzle. The code developed for the plasma simulation is based on the open-source software Spacecraft Plasma Interaction Software (SPIS). The code has been conveniently modified and improved, neutrals and collision processes were added to evaluate their impact on the plasma properties. The features added improved the validity of the results, now one step closer to the physical reality. The code has been proven to be an extremely versatile and powerful tool for optimization and adaptation to different mission scenarios. / De senaste framstegen i plasmaframdrivning har lett till utvecklingen Helicon Plasma Thruster (HPT) som kombinerar elektromagnetisk högfrekvent (RF) plasmakälla och ett accelerationssystem. En av företagen som är pionjärer i att utveckla denna nya framdrivningsteknik är T4i Technology for Propulsion and Innovation s.p.a., med dess banbrytande projekt REGULUS, som detta arbete bygger på. En viktig del av HPT-systemet är accelerationsområde där plasmats termiska energin omvandlas till axiell accelleration i en magnetisk dysa. Denna rapport fokuserar på numeriska modelleringen av plasmadynamiken accelerationsområdet vid användning av Xenongasen. En tredimensionell Particle-In-Cell (PIC) simulering används för att studera plasmautflödet i magnetiska dysan. Koden bygger på den öppna mjukvaran Spacecraft Plasma interaction Software (SPIS). Koden har modifierats och förbättrats, en neutral komponent samt kollisionsprocesser har lagts till och deras påverkan på plasmabeteende har studerats. Dessa nya element förbättrade giltigheten av simulerings-resultaten. Nu ett steg närmre den fysiska verkligheten. Koden är ett mångsidigt och kraftfullt verktyg för optimering och anpassning till olika användningsscenarier.

Background The foamy virus (FV) replication cycle displays several unique features, which set them apart from orthoretroviruses. First, like other B/D type orthoretroviruses, FV capsids preassemble at the centrosome, but more similar to hepadnaviruses, FV budding is strictly dependent on cognate viral glycoprotein coexpression. Second, the unusually broad host range of FV is thought to be due to use of a very common entry receptor present on host cell plasma membranes, because all cell lines tested in vitro so far are permissive. Results In order to take advantage of modern fluorescent microscopy techniques to study FV replication, we have created FV Gag proteins bearing a variety of protein tags and evaluated these for their ability to support various steps of FV replication. Addition of even small N-terminal HA-tags to FV Gag severely impaired FV particle release. For example, release was completely abrogated by an N-terminal autofluorescent protein (AFP) fusion, despite apparently normal intracellular capsid assembly. In contrast, C-terminal Gag-tags had only minor effects on particle assembly, egress and particle morphogenesis. The infectivity of C-terminal capsid-tagged FV vector particles was reduced up to 100-fold in comparison to wild type; however, infectivity was rescued by coexpression of wild type Gag and assembly of mixed particles. Specific dose-dependent binding of fluorescent FV particles to target cells was demonstrated in an Env-dependent manner, but not binding to target cell-extracted- or synthetic- lipids. Screening of target cells of various origins resulted in the identification of two cell lines, a human erythroid precursor- and a zebrafish- cell line, resistant to FV Env-mediated FV- and HIV-vector transduction. Conclusions We have established functional, autofluorescent foamy viral particles as a valuable new tool to study FV - host cell interactions using modern fluorescent imaging techniques. Furthermore, we succeeded for the first time in identifying two cell lines resistant to Prototype Foamy Virus Env-mediated gene transfer. Interestingly, both cell lines still displayed FV Env-dependent attachment of fluorescent retroviral particles, implying a post-binding block potentially due to lack of putative FV entry cofactors. These cell lines might ultimately lead to the identification of the currently unknown ubiquitous cellular entry receptor(s) of FVs.