Die Standortnotwendigkeit ist Problem und Chance für Unternehmen (Standortsuche) und Standorte (Standortmarketing) gleichermaßen. Unternehmen sind dabei dem Einfluss durch die Gewichtung von Shareholder- und/oder Stakeholderinteressen unterworfen und der Wirkung harter wie weicher Standortfaktoren ausgesetzt. Die klassische Standortlehre allein stellt dabei nur einen unzureichenden Handlungsablauf dar. Ihr gegenüber ist die Annahme eines Standortfaktorenmix mit objektiven wie subjektiven Kriterien sinnvoller. Die Standortanalyse klassischer Ansätze kann durch verhaltens- und strukturorientierte Vorgehensweisen sinnvoll erweitert werden, um dem Situationsgemenge aus ökonomischem Ziel, unternehmerischer Situation und subjetiver Standortentscheidung besser gerecht zu werden. Die Annahme vollständiger Produktionsverlagerung weicht der Verlagerung einzelner Wertschöpfungsstufen innerhalb einer Wertschöpfungskette. Ein vernünftiger Analyse- und Entscheidungprozess muss daher ganzheitlicher erfolgen und führt dann zu besser abgesicherten Antworten auf die Fragen nach dem "was" wird "weshalb" notwendigerweise "wohin" verlagert.

Táto práca sa zaoberá prispôsobením (tailoring) mikroštruktúry vybraných pokročilých keramických materiálov (oxid hlinitý, kubický a tetragonálny oxid zirkoničitý) metódou izostatického lisovania za tepla (post-HIPing) s cieľom pripraviť vzorky s teoretickou hustotou and minimálnou veľkosťou zŕn. Vzhľadom na to, že izostatické lisovanie je vo väčšine prípadov používané ako dokončovacia metóda, pred-slinovanie (príprava vzoriek v štádiu uzavretej pórovitosti) bolo tiež dopodrobna študované. Extenzívny teoretický a experimentálny výskum pred-sintrovania pokročilých keramických materiálov ukázal niekoľko výsledkov. Bolo zistené, že uzatváranie pórov je materiálová charakteristika riadená medzi-povrchovými energiami (uzatváranie pórov nastáva pri 92-96 % t.d. pre skúmané materiály), je nezávislé na technológii prípravy keramického polotovaru a je nezávislé na histórii sintrovacieho procesu. Pre analýzu mikroštruktúry skenovacím elektrónovým mikroskopom a výrazné zvýšenie efektivity mikroštruktúrnej analýzy, bola vyvinutá nízkoteplotná metóda termálneho leptania. Táto metóda umožňuje zviditeľnenie leštenej mikroštruktúry pri leptacej teplote 900 °C a výdrži 1 hodina čiastočne sintrovaných a plne hutných vzoriek bez teplotnej kontaminácie (zvýšenie hustoty a veľkosti zŕn). Pred-sintrované vzorky boli post-HIPované nadizajnovaným kombináciami teploty (1200-1400 °C), aplikovaného tlaku (50 a 200 MPa) a času výdrže (0,5 až 9 hodín) s cieľom štúdia vplyvu týchto post-HIPovacích parametrov na mikroštruktúru vzoriek. Najdôležitejší výsledok experimentov je, že aplikovaný tlak vykazuje iba minimálny vplyv na rast zŕn v priebehu post-HIPovania, pričom výrazne posilňuje zhutňovanie. Sintrovacia teplota a čas výdrže tiež vykazovali zhutňovací potenciál, avšak s negatívnym efektom na veľkosť zŕn počas post-HIPovania rešpektujúc kinetickú rovnicu rastu zŕn – exponenciálny rast pre teplotu a parabolický rast pre čas. Tieto výsledky boli použité pre optimalizáciu post-HIPovacích cyklov pre študované materiály. Výsledné vzorky boli zhutnené nad 99,7 % t.d. a s minimálnym (pod 10 %) nárastom veľkosti zŕn v porovnaní s pred-sintrovanou veľkosťou zŕn. Aplikáciou získaných znalostí bola pripravená transparentná korundová keramika dopovaná erbiom s fotoluminiscenčnými vlastnosťami. Pripravená vzorka s tvrdosťou HV 10 26,9 GPa a so skutočnou inline priepustnosťou RIT 56 % vykazuje najlepšie hodnoty tvrdosti a priepustnosti v doposiaľ publikovaných korundových keramických materiáloch dopovaných prvkami vzácnych zemín.

Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-06-12T15:19:44Z No. of bitstreams: 2 Dissertação - Vinicius de Medeiros Alves - 2014.pdf: 3082084 bytes, checksum: da4838d5fe24841429f43de84204d98a (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-06-12T15:21:40Z (GMT) No. of bitstreams: 2 Dissertação - Vinicius de Medeiros Alves - 2014.pdf: 3082084 bytes, checksum: da4838d5fe24841429f43de84204d98a (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-06-12T15:21:40Z (GMT). No. of bitstreams: 2 Dissertação - Vinicius de Medeiros Alves - 2014.pdf: 3082084 bytes, checksum: da4838d5fe24841429f43de84204d98a (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-05-12 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / Introduction: Skin sensitization is a major environmental and human health hazard. Although many chemicals have been evaluated in humans, there have been no efforts to model these data to date. Skin sensitization is commonly evaluated using structural alerts. However, there has been a growing concern that alerts disproportionally flag too many chemicals as toxic, which questions their reliability as toxicity markers. The main goal of this thesis was to develop and apply new cheminformatics methods to predict skin sensitization of chemical compounds that lack experimental data. Methodology: It has been compiled, curated, analyzed, and compared the available human data and the murine (performed in mice) animal model data, named LLNA (local lymph node assay). Using these data, it was developed reliable computational models and applied them for virtual screening of chemical libraries to identify putative skin sensitizers. It was developed a freely accessible web-based application for the identification of potential skin sensitizers. In addition, it was demonstrated that contrary to the common perception of QSAR models as “black boxes” they can be used to identify statistically significant chemical substructures (QSAR-based alerts) that influence toxicity. Results and discussion: The overall concordance between murine LLNA and human skin sensitization responses for a set of 135 unique chemicals was low (R = 28-43%), although several chemical classes had high concordance. We have succeeded to develop predictive QSAR models of all available human data with the external correct classification rate of 71%. A consensus model integrating concordant QSAR predictions and LLNA results afforded a higher correct classification rate of 82% but at the expense of the reduced external dataset coverage (52 %). We used the developed QSAR models for virtual screening of CosIng database and identified 1,061 putative skin sensitizers; for seventeen of these compounds, we found published evidence of their skin sensitization effects. The developed Pred-Skin web app (http://www.labmol.com.br/predskin/) is based on binary QSAR models of human (109 compounds) and LLNA (515 compounds) data with good external correct classification rate (70-81% and 72-84%, respectively). It is also included a multiclass potency model based on LLNA data (accuracy ranging between 73-76%). Conclusions: Models reported herein provide more accurate alternative to LLNA testing for human skin sensitization assessment across diverse chemical data. In addition, they can also be used to guide the structural optimization of toxic compounds to reduce their skin sensitization potential. The Pred-Skin web app is a fast, reliable, and user-friendly tool for early assessment of chemically-induced skin sensitization. A new approach that synergistically integrates structural alerts and rigorously validated QSAR models for a more transparent and accurate safety assessment of new chemicals was also proposed. / Introdução: A sensibilização cutânea é um importante parâmetro de avaliação de toxicidade humana e ambiental. Embora muitos compostos tenham sido avaliados em seres humanos, não foi reportado até o momento modelos de QSAR (do inglês, quantitative structure-activity relationships) gerados com esses dados. Comumente, a sensibilização cutânea é avaliada computacionalmente usando-se alertas estruturais. No entanto, tem havido uma preocupação crescente de que alertas sinalizam a maioria dos compostos como tóxicos, o que questiona sua confiabilidade como marcadores de toxicidade. O objetivo geral do presente trabalho foi desenvolver e aplicar novos métodos de quimioinformática para predizer a sensibilização cutânea de compostos químicos que carecem de dados experimentais. Metodologia: Foram compilados, preparados, analisados e comparados os dados de sensibilização cutânea de pele humana e do modelo animal murino (realizado em camundongos), denominado LLNA (local lymph node assay). Modelos de QSAR foram desenvolvidos utilizando esses dados e aplicados para a triagem de quimiotecas virtuais para identificar potenciais sensibilizadores. Foi desenvolvido um aplicativo gratuito para a identificação de potenciais sensibilizadores cutâneos. Além disso, foi demonstrado que modelos de QSAR podem ser usados para identificar subestruturas químicas estatisticamente significativas (alertas estruturais baseados em QSAR) que influenciam a toxicidade. Resultados e discussão: A concordância global (R) entre respostas de sensibilização cutânea humana e murina para um conjunto de 135 substâncias químicas únicas foi baixa (R = 28-43%), embora várias classes químicas apresentassem alta concordância. Foi possível desenvolver modelos de QSAR preditivos com taxa de classificação correta externa de 71%. Um modelo de consenso que integrava predições concordantes de QSAR e dados de LLNA proporcionaram uma acurácia 82%. Utilizou-se os modelos de QSAR desenvolvidos para a triagem virtual da base de dados CosIng e foram identificados 1061 potenciais sensibilizadores cutâneos. Para dezessete desses compostos, encontrou-se evidências publicadas de seus efeitos de sensibilização cutânea em seres humanos. O aplicativo desenvolvido, Pred-Skin (http://www.labmol.com.br/predskin/), baseia-se em modelos de QSAR classificatórios de dados humanos (109 compostos) e murinos (515 compostos) com boa taxa de classificação correta externa (70-81% e 72-84%, respectivamente). Esse aplicativo também possui um modelo de multiclassificatório desenvolvido com dados de LLNA (precisão que varia entre 73-76%). Conclusões: Os modelos de QSAR desenvolvidos forneceram uma alternativa mais precisa do que o modelo animal para avaliação da sensibilização cutânea humana. Além disso, a interpretação dos modelos de QSAR permitem orientar a otimização estrutural de compostos tóxicos para reduzir o potencial de toxicidade. O aplicativo Pred-Skin é uma ferramenta rápida, confiável e de fácil utilização para a avaliação da sensibilização cutânea de compostos químicos. Foi também proposta uma nova abordagem que integra sinergicamente alertas estruturais e modelos de QSAR rigorosamente validados para uma avaliação de toxicidade mais transparente e precisa de novos produtos químicos.

Die Standortnotwendigkeit ist Problem und Chance für Unternehmen (Standortsuche) und Standorte (Standortmarketing) gleichermaßen. Unternehmen sind dabei dem Einfluss durch die Gewichtung von Shareholder- und/oder Stakeholderinteressen unterworfen und der Wirkung harter wie weicher Standortfaktoren ausgesetzt. Die klassische Standortlehre allein stellt dabei nur einen unzureichenden Handlungsablauf dar. Ihr gegenüber ist die Annahme eines Standortfaktorenmix mit objektiven wie subjektiven Kriterien sinnvoller. Die Standortanalyse klassischer Ansätze kann durch verhaltens- und strukturorientierte Vorgehensweisen sinnvoll erweitert werden, um dem Situationsgemenge aus ökonomischem Ziel, unternehmerischer Situation und subjetiver Standortentscheidung besser gerecht zu werden. Die Annahme vollständiger Produktionsverlagerung weicht der Verlagerung einzelner Wertschöpfungsstufen innerhalb einer Wertschöpfungskette. Ein vernünftiger Analyse- und Entscheidungprozess muss daher ganzheitlicher erfolgen und führt dann zu besser abgesicherten Antworten auf die Fragen nach dem "was" wird "weshalb" notwendigerweise "wohin" verlagert.:Einleitung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1 Das Unternehmen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1 Beziehungen zur Umwelt . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Einflussfaktoren . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.3 Shareholder oder der eigentu¨merbezogene Standpunkt. . . . . . . . . . . . . . . . . . 6 1.4 Stakeholder oder der gesellschaftspolitische Standpunkt . . . . . . . . . . . . . . . . . 7 1.5 Unternehmerische Verantwortung und Standortwahl. . . . . . . . . . . . . . . . . . . . 7 1.6 Standortstrategien . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2 Der Standort. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.1 Standortlehre . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.1.1 Klassischen Ansatze . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.1.2 Neue Konzepte . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 2.2 Standortfaktoren . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2.2.1 Begriff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 2.2.2 Harte Standortfaktoren . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 2.2.3 Weiche Standortfaktoren . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.2.4 Bedeutung der Standortfaktoren fu¨r die Standortwahl . . . . . . . . . . . . . . . . 15 2.3 Standortwettbewerb . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 2.3.1 Drei Ebenen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 2.3.2 Kanale des Standortwettbewerbes . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2.4 Standortmarketing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 2.4.1 Bedeutung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 2.4.2 Standortmarketing am Beispiel des Regionalen Wachstumskerns Spremberg . . . 23 3 Das Problem . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 3.1 Bedeutung der Standortwahl . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 3.2 Standortanalyse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 3.2.1 Klassische, normative Ansatze. . . . . . . . . . . . . . . . . . . . . . . . . . 28 3.2.2 Behavioristischer Ansatz bzw. Modell von Pred . . . . . . . . . . . . . . . . . . . . 33 3.2.3 Struktureller Ansatz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 3.3 Standortentscheidung und Verlagerung . . . . . . . . . . . . . . . . . . . . . . . . . . 37 3.3.1 Prozess der Standortentscheidung . . . . . . . . . . . . . . . . . . . . . . . . . . 37 3.3.2 Prozess der Verlagerung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 4 Zusammenfassung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Literaturverzeichnis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46

Aims: to explore if the consumption of pornography have influence on a relationship, if the consumption of pornography have a negative impact on a first intercourse and on a initial masturbation behavior, to find out if it is a difference between younger and older women in the frequency of pornography consumption, explore if religiosity have some impact on frequency of pornography consumption and one of the aims is to disrupt the myth about primary pornography consumption by men. Method: the representative data vere collected from 413 Slovak women, the data were based on a quota sampling by agency 2muse according to three categories (age, education and address), the sample age was from 18 to 77 years old and average age was 40 years old (SD±14,62). Results: average age of first pornography consumption is 20,01 years old (SD±7,56), the most interesting age of pornography consumption is 23,44 (SD±9,12). The frequency of pornography consummation is couple of times per year for 107 (25,9%) respondents and most often is watching less than 5 minutes per day. Religiosity has a protective factor of frequency of pornography consumption depending of strengths of religious beliefs and the frequency of implementation of religious requirements. Pornography is not an accelerating factor an initial masturbating...

Práca sa zaoberá problematikou kontroly a blokovania externých zariadení v operačnom systéme Apple macOS za účelom ochrany pred únikom citlivých dát. Implementované riešenie ukazuje zvolené prístupy pre blokovanie externých a cloudových diskov. Pre blokovanie USB diskov bol použitý DiskAbitration framework, čo je najvodnejšie riešenie tohto typu úlohy. Avšak cloudové disky sú v skutočnosti synchronizované zložky a úlohu nehrajú ovládače ani strom pripojených zariadení. Ku kontrole operácií v cloudových diskoch bol použitý Endpoint Security framework. Aktuálne podporovaní cloudový poskytovatelia sú iCloud a Dropbox a prístup k nim môže byť obmedzený úplne alebo iba na čítanie. Schopnosť synchronizácie vzdialenýh zmien bola zachovaná avšak v prípade Dropboxu si to žiada nepoužívať ich aplikáciu na správu súborov.

This work deals with proteins, especially with their structure and kinds of tertiary, or 3D, structure prediction. Tertiary structure prediction is very important for function prediction of this vitally important substance. Bioinformatics do this prediction much more effective and faster, because classical methods of structure prediction directly from molecule are very expensive and slow. On the other hand they are much more exact. Objective of this thesis is to describe tertiary structure prediction methods, describe used tools and possibility of automatic communication with them.  Next objective is describe implementation of server, that will serve to protein engineers for more effective finding of information about tertiary structure from more servers without requesting each of them separately. Results of testing will be described in this work too.