Computers since their inception have been used to solve engineering problems. Toward support of next-generation, customizable, generalized software, a mathematical equation editor has been designed, developed, and tested using object oriented (OO) programming techniques. The motivating purpose of this equation editor is to allow a user to graphically define mathematical equations to be solved in a computational partial differential equation-based problem solving environment. The OO scripting language Python was used in conjunction with the OO GUI toolkit Qt to create the editor. Analysis of the underlying abstraction of a general equation yielded the key concept of an information-holding bounding box. Such boxes hierarchically contain every character and symbol in an equation. Specific rules were formulated to spatially arrange a set of boxes into a properly formatted equation. Robust insertion logic of alphanumeric characters, mathematical symbols, and common function names was implemented for intuitive point-and-click equation building.

Les canaux sodiques sont des protéines membranaires d'une importance primordiale. Ils sont impliqués dans le déclenchement des potentiels d'action et sont nécessaires à l'excitabilité des cellules. Ils participent à la contraction des muscles striés squelettiques, cardiaques et lisses. Des dysfonctionnements de ces canaux, dûs à des mutations, peuvent engendrer de graves pathologies et atteintes cardiaques telles que le syndrome du QT long, le syndrome de Brugada, ou la cardiomyopathie dilatée. L'étude de ces mutations constitue un enjeu essentiel dans la compréhension des mécanismes de ces canaux et du développement des pathologies associées. Plus les connaissances avancent et plus il devient alors possible d'envisager des études précises sur le développement des traitements appropriés. Cette étude se concentre sur l'analyse de deux nouvelles mutations du gène SCN5A codant pour le canal Nav1.5, et a permis de mettre en évidence les caractéristiques biophysiques dysfonctionnelles de ces mutants et de confirmer le diagnostic médical. / Sodium channels are important transmembrane proteins. They are involved in the upstroke of action potential and they are necessary for the cardiac cell excitability. Their dysfunctions caused by mutations can lead to serious pathologies and cardiac impairments such as long QT syndrome, Brugada syndrome, dilated cardiomyopathy and even sudden death. The study of these mutations is a key step toward the comprehension of the pathophysiological mechanisms involved. The knowledge progress allows to lead accurate studies on drug development. This study focused on the analysis of two novel SCN5A mutations and allowed to highlight the dysfunctional biophysic characteristics of these mutants and to confirm the medical diagnosis.

Introduction: Temporary QT-interval prolongation following intracranial hemorrhage and hydrocephalus has been repeatedly reported in adults. Case: We report a case of excessive QT prolongation with sudden bradycardia resulting in 2:1 atrioventricular conduction in a preterm infant most likely associated with a congenital hydrocephalus. Pathomechanisms are discussed. Conclusion: Congenital hydrocephalus predisposes to excessive QT prolongation in preterm infants.

The automotive industry today is getting more and more competitive with accelerating demand to attract car consumer with new technologies. Three-dimensional user interfaces (3D UIs) support user tasks in many non-traditional interactive systems such as augmented reality and virtual environments. Although 3D UI researchers and developers have been successfully identified basic user tasks, evaluating the usability of 3D interaction techniques, as well as finding an improvement of the usability of many applications, the researches and developments are still in the direction of finding better approaches and to be more innovative to fulfill the demands in the context of automotive user interface. The concept of a framework presented in this master thesis is to integrate technology of the Qt framework that is widely used for traditional 2D interfaces on different platforms and operating systems with the availability of open sources in order to realize the goal of having the ability to import the external 3D asset completely, specifically in FBX format by Autodesk that is widely used in the automotive industry. In addition, QML as part of the Qt framework that include JavaScript as an easy Object-Oriented scheme to manipulate object properties such as position and color of the graphical object is also integrated. The main aim of the framework is to have a full access to the imported FBX asset that is created by digital content creation applications such as Autodesk 3Ds Max or Autodesk Maya and visualize them within the Qt framework. With the newest technology of the Qt framework, it seems to be a promising solution to develop an interactive user interface. Hence, the framework approach of this master thesis is based on the Qt framework and Qt3D 2.0, in order to satisfy the requirements and introduces a solution to satisfy the demands in multimedia and 3D user experiences in the automotive industry. In the last fifteen years, Qt has proven as a robust development environment that produces powerful and stable software applications. Together with the abilities of Qt3D 2.0 that offers several abstract ways to control the rendering setup that helps the framework to realize the aim of this master thesis. This master thesis contains a detailed specification and concept for the development of a framework for 3D dynamic user interface application in vehicles. As the result of this master thesis, some typical use cases for automotive industry are realized as prototype applications in order to prove that the framework has the ability to load the 3D asset, specifically in FBX format, into the Qt framework and rendered together with the components of the Qt framework as an interactive and dynamic 3D user interface.

This work concerns with problems of the QT sequences detection in ECG signal. The first part introduces electrophysiology of heart and his electrical manifestation. For main detection were used two algorithms, which were afterwards modified and programmed in Matlab. The work includes developed custom applications for measurement and evaluation of the length of QT interval. The final lengths of the QT interval, which we got from this two methods, were compared with reference length.

This diploma thesis focuses on determination of the QT interval in ECG. The thoretical part desribes physiology of the heart, electronic activity of the heart and possible methods of ECG measurement. The theoretical part also describes methods of signal processing, the processed signal is then used for determination of the QT interval. The practical part focuses on two chosen methods of QT interval determination and on implementation of the methods in a computer program. The results part is evaluation of measured QT intervals and a comparision of the results with reference values.

This master thesis deals with creating of the cross-platform audio player with the possibility of its use in the speech-language pathology clinic. The theoretical part is focused on the comparison of two multi-platform libraries, of which was one chosen for creating of the player. Subsequently on functionality SQLite database, which was also used as part of the final application. The basis of the practical part is the creation of the cross-platform audio player which is extended about database of patients and also extended about speech signal analysis with the help of VST plugin.

CrossDump is a GPS application developed for modern industrial vehicles, specifically those in municipal solid waste collection. The application is developed for CrossControl AB, a company selling computers and electronics for heavy machinery and industrial trucks. CrossDump will be used to demonstrate the potential of CrossControl’s display computers. In contrast to GPS applications like Google Maps, CrossDump is tailor-made for CrossControl’s displays, mounted on the dashboard by the driver in a vehicle. The system helps garbage truck drivers navigate safely and efficiently between waste collection sites and supplies location-specific information relevant to the driver’s work tasks. CrossDump is built to minimize the driving distance, which contributes to a more sustainable environment. To show the full capacity of CrossControl’s hardware the application has been designed specifically with performance in mind. / CrossDump är en GPS-applikation utvecklad för moderna industrifordon, specifikt de inom kommunal avfallshantering. Applikationen är skapad åt CrossControl AB, ett företag som säljer datorer och elektronik till industriella fordon och maskiner. CrossDump kan demonstrera potentialen hos CrossControls displaydatorer. Till skillnad från GPS-applikationer som Google Maps, är CrossDump skräddarsydd för CrossControls displayer, som kan monteras framme vid föraren i ett fordon. Applikationen hjälper sopbilsförare att navigera tryggt och effektivt mellan sopplatser och visar platsbaserad information om vilka uppgifter föraren ska utföra. CrossDump är byggd för att minimera förarens körsträcka för att bidra till en mer hållbar miljö. För att utveckla ett system som visar hårdvarans förmåga har applikationen designats specifikt med prestanda i åtanke.

Indiana University-Purdue University Indianapolis (IUPUI) / The cardiac voltage-gated sodium channel α subunit Nav1.5 generates the cardiac sodium current, which is essential for the initiation and propagation of the cardiac action potentials. Mutations of SCN5A, the gene that encodes Nav1.5, have been well documented to cause long-QT syndrome (LQTs) by disrupting channel inactivation and increasing late sodium current. Previous studies have revealed the importance of the intracellular loop region between transmembrane domain III and IV of sodium channel α subunit in regulating the fast inactivation. A recent clinical case study reported an infant patient with LQTs carrying a phenylalanine (F) deletion at amino acid 1486 of the Nav1.5 channel. This study reported that the patient showed severe cardiac arrhythmia reflected as LQTs and subsequent ventricular tachycardia, which was refractory to antiarrhythmic drug lidocaine treatment. Therefore, it was hypothesized that the deletion of F1486 on Nav1.5 would substantially alter electrophysiological properties of the channel and reduce the potency of lidocaine on sodium channel. Using HEK293 cells and neonatal rat cardiomyocytes, the F1486del channel was functionally characterized by whole-cell patch clamp techniques. Studies revealed that the deletion of F1486 causes a combination of changes including a loss-of-function alteration reflected as a substantial reduction of peak current density and a number of gain-of-function alterations including reduced channel inactivation, substantial augmentation of late sodium current, and an increase in ramp current. In addition, lidocaine sensitivity was dramatically reduced. By contrast, the voltage for half maximal activation (V1/2) and the time constant for channel deactivation for the F1486del channel were identical to the wild type channels. Using neonatal rat cardiomyocytes, we were able to study the functional consequence of F1484del on action potential duration (APD). Cardiomyocytes expressing F1486del channel have substantial APD prolongation and prominent spontaneous early afterdepolarizations, which likely underlie the subsequent LQTs in the patient. Taken together, despite the reduction in peak current density, the substantial gain-of-function changes are sufficient to cause the APD prolongation, which is a prominent characteristic of LQTs. These findings provide knowledge for understanding the relationships between sodium channel structure, pharmacology and the physiological consequence of sodium channel mutations that underlie LQT3.

Long QT syndrome (LQTS) can present with syncope and seizure-like activity in the setting of torsades de pointes (TdP) with hemodynamic instability. Electrolyte abnormalities and medications can predispose to TdP in the setting of latent LQTS. An implantable cardioverter defibrillator (ICD) is needed if patients with TdP continue to be symptomatic despite medical treatment. We report a case of a patient who presented with seizures and was found to have prolonged corrected QT interval (QTc). During her admission, she was treated with ondansetron. She went into torsades de pointes and continued to have prolonged QTc. She underwent implantable cardioverter defibrillator (ICD) placement and remains asymptomatic to date.