Introduction: Medicines are an important component of any health system. Even though the importance of medicines in the health system is indisputable, one of the major concerns remains the risk of adverse drug reactions when used by consumers. Adverse drug reactions place a burden on the healthcare system, usually as a result of complications requiring hospital admission or extended hospital admissions. In Africa, about 28.6% of adverse drug reactions reported in Africa were due to antiretroviral therapy. Recently, the adoption of the “test and treat” policy by the World Health Organisation increased the number of people receiving antiretroviral therapy. Therefore, this systematic review was conducted to explore the magnitude of antiretroviral therapy-related adverse drug reactions hospitalisations, and mortalities in the region, following the increase in people initiating therapy, and the implications to the service delivery component of the healthcare system. Methods: In March 2021, PubMed, EBSCOHost, and SCOPUS, databases were systematically searched for appropriate articles. The selection of articles was based on predefined inclusion and exclusion criteria. Data from included articles were extracted as per a set of defined criteria into a data extraction form. A meta-analysis was done using Stata package software 15.0 using Stata “metaprop” command. Results: The pooled prevalence of adverse drug reactions hospitalisations in all studies was 26.5% (95% confidence interval:18.4,35.4) and that of mortality was 6.1% (95% confidence interval:2.1,11.7). The most prevalent adverse reactions reported include hepatotoxicity, kidney injury, lactic acidosis, skin, neurologic, and hematologic reactions. The antiviral implicated, are non-nucleoside reverse transcriptase inhibitors, nucleoside/tide reverse transcriptase inhibitors, and protease inhibitors. The pediatric population was underrepresented as only two studies included pediatric patients. The economic impact of adverse reactions was impossible to estimate, as only one study reported on financial implications. Conclusion: Antiretroviral therapy-related adverse reactions hospitalisations and mortalities have a high prevalence in Africa. There are concerns about age-related morbidities and lifestyle diseases as risk factors related to adverse reactions. To adequately combat adverse reactions associated with antiretrovirals, African country health systems need multidisciplinary actions to strengthen strategies for prediction, identification, reporting, and prevention of adverse reaction occurrence.

Scholars contend that media accountability to the public and professional stakeholders has been improving in recent years because of the increased use of digital platforms. Since most studies related to online news media accountability have focused on developed countries, this research study examines the state of accountability in online news media in Nepal, where access to online media is very limited and audiences are barely aware of media's journalistic responsibilities. By employing case study research method with three data sources, this research study assesses the state of online media accountability in Nepal, key challenges for ensuring accountability in journalism created using digital platforms, and the role of audiences in making online news media accountable. The study finds that Internet accessibility, media literacy, and availability of resources are the primary challenges to making media accountable in Nepal. The study concludes by offering recommendations for future research and practical applications.

I detta examensarbete görs en diskursiv och historisk undersökning av kritikgenomgången i arkitektutbildningen. Kritikgenomgången utgör en central komponent i det samtida paradigmet för arkitektutbildning – studion. Examensarbetet går igenom och diskuterar aktuell forskning om kritikgenomgången, vilket ger en nedslående bild av kritikgenomgångens pedagogiska potential. Vidare undersöks kritikgenomgångens historiska rötter med fokus på den svenska kontexten, vilket ger vid handen att kritikgenomgången i sin nuvarande form fick sin roll i svensk arkitektutbildning under 1990-talet, alltså samtidigt med studioparadigmets genomslag. Dessutom redovisas resultaten av en intervjustudie med lärare vid KTH Arkitekturskolan, vilka visar att diskursen om kritikgenomgången innehåller flera motsägelser och problem. Resultaten av undersökningarna diskuteras sedan utifrån en förståelse av omdömet som centralt begrepp och förmåga för att förstå den implicita definition av arkitekten som manifesteras i kritikgenomgången och i disciplinens kanon. / This thesis presents a discursive and historical investigation of the origins and causes of the design review in architectural education. The design review, jury or ”crit” i s an integral and central part of the contemporary paradigm for architectural education – the design studio. The thesis discusses previous research on the design review, which paints a gloomy picture of the learning possibilities of the review. The historical roots of the review are studied with the Swedish context as a focus, showing that the review in its contemporary form was adopted concurrently with the design studio paradigm during the 1990’s. Furthermore, interviews were carried out with instructors at the School of Architecture at the Royal Institute of Technology in Stockholm. Results from the interviews point to several contradictions and issues in the discourse about the review. Seeing the concept and faculty of judgment as central to understand the implicit definition of the architect, as manifested in the review and in the canon of the discipline, these findings are the discussed and contextualised.

Background: Low back pain is very common and has a tremendous economic impact. With the prevalence and incidence of low back pain on the rise, individuals are turning to alternative treatments. Yoga is the most widely used complementary and alternative medicine treatment for low back pain and it is not fully certain how effective this method is for resolving the symptoms. Objectives: The purpose of this manuscript is to systematically review the current literature for randomized controlled trials that assess the outcomes of yoga intervention in individuals with low back pain. Methods: An electronic database search was performed to analyze studies. To be included in the review, the studies were required to be a randomized controlled trial, published in English, present in a peer reviewed journal, identify yoga as the primary treatment focus for low back pain in at least one group, and included participants with at least a 12 week history of low back pain. Results: A search of the databases revealed 177 articles, of which, 8 met the inclusion criteria. Conclusions: Yoga intervention appears to be effective in alleviating symptoms brought on by low back pain. Yoga was either demonstrated to significantly improve quality of life and reduce disability, stress, depression, and medication usage associated with low back pain in 6 of the 8 analyzed trials. More research is necessary to account for the lack of between-group differences in two trials.

Robert Mertons anomiteori har historiskt fått skarp kritik på grund av sitt svaga empiriska stöd och sina teoretiska antaganden. Vissa har dock menat att det svaga empiriska stödet beror på felaktiga operationaliseringar av Mertons teori. Den här studien syftar således till att studera operationaliseringar i tidigare forskning av Robert Mertons ursprungliga anomiteori som den presenterades år 1938 i Social Structure and Anomie. Först genomförs en noggrann genomgång och analys av artikeln Social Structure and Anomie och den teori som där presenteras. Genom en systematisk litteraturöversikt har sedan 13 artiklar som operationaliserat Mertons teori valts ut och sedan analyserats utifrån de centrala delarna av Robert Mertons paradigm. Resultaten visar att kulturellt definierade intressen nästan enbart har operationaliserats som akademiska och/eller ekonomiska mål och att de accepterade medlen operationaliserats i enlighet med de kulturellt definierade intressena. Vidare konstateras att varken anpassningsformer eller kulturperspektivet har någon framträdande plats i operationaliseringarna. / Historically, Robert Merton’s theory of anomie has suffered from harsh criticism on the basis of its weak empirical support and theoretical assumptions. Although, some have made the claim that the failing support is because of inadequate operationalization of Merton’s theory. The purpose of this study is therefore to analyze the operationalization in previous research of Robert Merton’s original theory of anomie, as it was presented in 1938 in Social Structure and Anomie. Firstly, a thorough examination and analysis is conducted on the article Social Structure and Anomie and the theory therein. Secondly, through a systematic review 13 articles that operationalize Merton’s theory were selected and then analyzed based on the core parts of Robert Merton’s paradigm. Results indicate that the culturally defined goals almost exclusively are operationalized as academic and/or economic goals and that the institutionalized means are operationalized in accord with the culturally defined goals. Furthermore, it is found that neither adaptations nor the cultural perspective have any significant place within operationalization.

Ladies Professional Golf Association Teaching Professionals are scattered throughout the country, many of whom are self-employed. There was not a review session for Class A written test preparation prior to this study. The focus of this research, thus, was to assist first time test takers in their preparation of the LPGA Class A written evaluation through an online medium. The study was conducted between July and November, 2005, and was offered to LPGA T & CP Class B first-time test takers. Components of the online review session included self-evaluations, discussion postings involving test-related content, and practice quizzes. The study compared the pass rate percentage of the participants in the online review session with the pass rate percentage of those who did not participate in the online review session. A test of proportions determined there was not a significant increase in the pass percentage rate of the online review session participants when compared to the test takers who did not receive intervention. However, pass rates and average test scores were higher for online review session participants. Suggested uses of this study include the future development of online review sessions for LPGA Class B and Apprentice written evaluations, with the goal of improving academic performances. Future research should include replication of the present study, but with a larger sample size. Future research should also involve Class B and Apprentice test takers and not be limited to first time test takers.

The United States Army currently uses after action reviews (AARs) to give personnel feedback on their performance. However, due to the growing use of geographically distributed teams, the traditional AAR, with participants and a moderator in the same room, is becoming difficult; therefore, distributed AARs are becoming a necessity. However, distributed AARs have not been thoroughly researched. To determine what type of distributed AARs would best facilitate team training in distributed Army operations, feedback media platforms must be compared. This research compared three types of AARs, which are no AAR, teleconference AAR, and teleconference AAR with visual feedback, to determine if there are learning differences among these conditions. Participants completed three search missions and received feedback between missions from one of these conditions. Multiple ANOVAs were conducted to compare these conditions and trials. Results showed that overall the teleconference AAR with visual feedback improved performance the most. A baseline, or no AAR, resulted in the second highest improvement, and the teleconference condition resulted in the worst overall performance. This study has implications for distributed military training and feedback, as well as other domains that use distributed training and feedback.

Environmental educators work to create an environmentally literate citizenry that is willing and able to tackle complex environmental problems such as climate change, potable water availability, and biodiversity loss. Environmental education (EE) research is a robust field that links practice and research, but lacks a comprehensive model connecting practices and outcomes. The goal of this grounded theory systematic review (GT-SR) was to create a model that identifies the context, strategies, outcomes, and core category associated with EE for secondary students in the United States (U.S.). Systematic review methods were used to locate and screen relevant, peer-reviewed research indexed in academic databases. The first search term, "environmental education," identified studies about EE. To narrow results to those focused on secondary education (grades 6–12), twelve search terms related to middle school and high school were used. After limiting the search to studies published between 2011 and 2018 and in English, 1,009 unique citation records were identified. A screening process for relevancy and quality excluded 982 records leaving 27 studies in the initial final sample. Theoretical sampling identified an additional 12 studies through a second database search and ancestry searching. Data from the 39 studies were analyzed through initial, focused, and theoretical coding using the constant comparative method. During initial coding, descriptive and In Vivo codes were used to organize the data into meaningful chunks. Focused and theoretical coding were used to further abstraction and identify categories. "Authenticity" emerged as the core category suggesting that, in order to be effective, EE for secondary students in the U.S. must be viewed as authentic in the eyes of the participants. The coding process informed the development of the Implementation of Authentic Environmental Education Programs (IAEEP) model. Although not designed to be applicable to all contexts, the model will aid EE practitioners in developing and implementing EE programs for secondary students in the U.S. and guide researchers as they evaluate EE programs. The development of the model also supports the use of a GT-SR as an appropriate and useful method for identifying, screening, and analyzing existing research to create a theoretical model. / Doctor of Philosophy / Environmental educators work to create an environmentally literate citizenry that is willing and able to tackle complex environmental problems such as climate change, lack of potable water, and loss of biodiversity. Environmental education research is a robust field that links practice and research, but lacks a comprehensive model that connects practices with agreed-upon outcomes. This systematic review used a grounded theory approach to create a grounded theory model that identifies the strategies, context, conditions, core category, and outcomes associated with environmental education for secondary students in the United States. Systematic review methods and theoretical sampling were used to locate and screen relevant, peer-reviewed environmental education research. Data from the primary studies were analyzed using initial, focused, and theoretical coding using the constant comparison method. Integration of data from the systematic review and theoretical sampling informed the development of the Implementation of Authentic Environmental Education Programs (IAEEP) model. This model will aid practitioners in developing and implementing environmental education programs for secondary students and guide researchers as they further evaluate environmental education programs.

In the development of a BMJ Rapid recommendation – an international practice guideline initiative led by the MAGIC Evidence Ecosystem Foundation, and aiming to produce trustworthy, accessible and timely guidance – of plasma exchange and dosage of corticosteroids for patients with ANCA-associated vasculitis (AAV) (Chapter 2) two methodological issues arose. The first issue is related to the rating of the certainty of evidence supporting the recommendations. Reviewers experienced challenges in making an explicit statement about what it was in which they were rating their certainty (i.e., the target of the rating of certainty of evidence). Through iterative discussions and presentations at GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) Working Group meetings, the research team developed new GRADE guidance (Chapter 3 and 4) to help systematic reviewers be aware of the importance of determining the target of their rating of certainty of evidence and provided practical principles to help systematic reviewers specify this target. The second issue arose from the process of moving from evidence to decisions. To help the BMJ Rapid recommendation panel interpret the magnitude of benefit and harm associated with plasma exchange, which required understanding patient values and preferences, the research team created a panel survey for eliciting the panelists’ view regarding patient values and preferences. The research team then applied the panel survey approach in some other guidelines. Based on the experience of developing panel surveys, and through iterative discussions and consensus, the research team developed a framework for using surveys to guide guideline panels in making inferences regarding patient values and preferences (Chapter 5). Using interpretive description, the team conducted a qualitative evaluation regarding the influence of the panel surveys on the panels’ understanding of patient values and preferences, interpretation of magnitude of benefits and harms, and on panels’ decision on guideline recommendations (Chapter 6). The panel surveys proved to help guideline panels explicitly consider and incorporate patient values and preferences in making recommendations. / Thesis / Candidate in Philosophy

Yes / The desalination of saltwater is a viable option to produce freshwater. All the desalination processes are energy-intensive and can be carried out on a large scale. Therefore, producing freshwater using renewable energy sources is the most desirable option considering the current energy crisis and the effect that fossil-fuel-based energy has on our carbon footprint. In this respect, the tray-type still, one of several solar power desalination still varieties, is popular owing to its straightforward design, economic materials of construction, and minimal maintenance requirements, especially in isolated island regions with restricted energy and natural water supplies. The traditional tray-type solar power has a few drawbacks, such as the inability to recover latent heat from condensation, reduced thermal convection, a large heat capacity, and comparatively minimal driving power through evaporation. Therefore, the improvement of heat and mass transfer capabilities in tray-type stills has been the subject of many studies. However, there is a lack of a comprehensive review in the open literature that covers the design and operational details of multistage solar stills. The purpose of this paper is to present a thorough overview of the past research on multistage solar stills, in terms of configurations, capabilities, and cutting-edge options. In comparison to a unit without a salt-blocking formation, the review indicates that a multistage distillation unit may run continuously at high radiation and generate pure water that is around 1.7 times higher than a unit without a salt-blocking formation. The most effective deign is found to be “V”-shaped solar still trays that attach to four-stage stills, since they are less expensive and more economical than the “floor” (Λ-shape) design, which requires two collectors. Additionally, it can be stated that the unit thermal efficiency, solar percentage, and collected solar energy (over the course of a year) increase by 23%, 18%, and 24%, respectively, when the solar collectors are increased by 26% (at the constant inflow velocity of the water).