Le régulateur transcriptionnel Cux1 est impliqué dans le processus de migration des cellules cancéreuses. Dans un modèle d’inflammation intestinale de type colite expérimentale, l’absence de Cux1 entraîne une perte de la restitution de l'épithélium intestinal. Ceci nous a amenés à poser l’hypothèse que Cux1 serait fonctionnellement impliqué dans le processus de migration cellulaire lors de la régénération épithéliale en contexte de maladies inflammatoires intestinales. En utilisant des conditions de culture limitant la prolifération, une diminution de la réponse migratoire des cellules épithéliales a été observée en absence de Cux1. Cette diminution de migration a été accompagnée d’une perte du remaniement du cytosquelette d'actine et d’une diminution du nombre de lamellipodes formés au front de migration. En vérifiant l’activité des voies classiques de migration RhoA et Rac1, une modulation des modifications post-traductionnelles sur chacune des protéines terminales de ces voies a été observée. Une augmentation du niveau de phosphorylation inhibitrice sur sérine 3 de la cofiline et une diminution de la phosphorylation activatrice sur la protéine ribosomale S6 ont été observées en absence de Cux1. Toutefois, ces protéines ne sont pas des cibles transcriptionnelles du régulateur Cux1. Une analyse par micropuce a permis d’identifier de nouveaux substrats de Cux1 pertinents au processus de restitution épithéliale. Ainsi, les gènes FgfR2, Shc4 et Vav2 ont été découverts pour être impliqués autant au niveau cellulaire que physiologique en contexte inflammatoire. De plus, Cux1 semble en mesure de cibler directement ces trois promoteurs. Un essai de récupération du phénotype en inhibant la voie RhoA a permis d'observer un rétablissement partiel de la réponse migratoire des cellules n’exprimant pas Cux1, suggérant que Vav2 et la voie Rac1 auraient une importance dans cette restitution épithéliale intestinale. Des modulations de gènes impliqués dans la restitution ont été observées par séquençage des ARNs chez des souris mutantes pour Cux1.

In der Magisterarbeit spricht man ueber die Restitution in vertraeglichen Beziehungen. Man bringt die Herkunft des Instituts von Restitution in altere Roma vor, man analysiert der Begriff der Restitution und seine juristischen Natur in Litauen und der Zivilrecht des Auslands. Der Autor beschreibt kurz die Art und Weise des Restitution. Am meistens schenkt man die Aufmerksamkeit eingehender Analyse der Grundlage von der Anwendung der Restitution in vertraeglichen Beziehungen. In der Praxis am haeufigsten ist vorkommende Grundlage die Ungueltigkeit des Geschaeftes, ueber sie am meistens spricht man in der Arbeit.

国立情報学研究所で電子化したコンテンツを使用している。

Darmstadt, Techn. University, Diss., 2008. / Erscheinungsjahr an der Haupttitelstelle: 2007.

Thesis (MSD(Social Work and Criminology))-University of Pretoria, 2007. / Includes bibliographical references.

Magister Philosophiae - MPhil / This dissertation explores the notions of community identity as they relate to land restitution. Specifically, the dissertation examines how community is (re)constructed in the Popela case study by examining how the claimants (former labour tenants) have framed their experience of dispossession and their understanding of their rights in land. Oftentimes, claimant groups will articulate their shared history as it relates to the land, and within this narrative they will seek to highlight the legitimacy of their claim. In this regard, rural communities tend to submit claims for restitution on the basis of the forced dispossession of the tribe. In contrast, labour tenants’ claims for restitution are based on the dispossession of grazing and cropping rights linked to their labour as individuals. The dissertation explores how the Popela claimants have (re)constructed their community identity. It shows that their discourse is characterized by conflicting notions of community and belonging, and traces the connections between these contradictions and the concessions the claimants had to make in adopting definitions and terms that have been imposed on them. It argues that while claimants appear to have accepted the Constitutional Court’s view of the basis of their claim, a ‘hidden transcript’ of commitment to community identity still persists, carefully hidden from public view in order to be awarded restitution.

v anglickém jazyce Legal and Historical Background of Shortcomings and Problems of State Property Privatization after 1989 The Doctoral Thesis provides a comprehensive analysis of the legal - historical background of the shortcomings and problems of the process of privatization of state property after 1989 in the Czechoslovak (Czech) Republic in relation to each of the fundamental privatization methods - i.e. small privatization, large privatization (inl. coupon privatization) and restitution. The Doctoral Thesis introduces the historical context of the adoption of relevant legal norms, then provides a detailed legal analysis of their shortcomings and focuses on problems induced by their application. With regards to the identified shortcomings and problems, the Doctoral Thesis analyzes the forms of their mitigation; i.e. addresses the not only the amendments of the respective privatization legal acts, but also the decisions of the general courts as well as the Constitutional court which contributed to their righteous interpretation. Despite the fact that from the time perspective, the first half of 90- s is the decisive period for the Doctoral Thesis, one can identify several overlaps until the present time given by the inconclusive character of several privatization processes. The remarkable...

Previous work has systematically and numerically demonstrated feasibility and performance benefits of the tension-element concept in golf club heads; however, higher fidelity models needed to be created and validated for this concept. There is a need for more accurate models for this concept to further investigate its performance benefits. Performance is measured in terms of impact efficiency of the ball and head and is referred to as coefficient of restitution (COR). COR is affected by the dynamic effective face stiffness and mass properties of the club. This thesis creates and validates high-fidelity, non-linear, dynamic finite element models for the tension-element golf club concept. These models predicted COR with less than one percent error when compared to dynamic experimentation results.

From the earliest civilizations, victorious armies would loot defeated cities or nations. the practice evolved into art theft as a symbol of power. Cultural superiority confirmed a country or empire’s regime. Throughout history, the Greeks and Romans cultivated, Napoleon Bonaparte refined, and Adolf Hitler perfected the practice of plunder. As the tides of Second World War began to shift in favor of the Allied Powers, special commissions, established to locate the Germans’ hoards of treasure, discovered Nazi art repositories filled with art objects looted from throughout Europe. the Soviet Union Trophy Commission and the Western Allies Monuments, Fine Arts, and Archives Commission competed to discover Nazi war loot. the two organizations not only approached the subject of plunder as a treasure hunt, but the ideology motivating both commissions made uncovering the depositories first, a priority. the Soviet trophy brigades’ mission was to dismantle all items of financial worth and ship them eastward to help rebuild a devastated Soviet economy. the Soviet Union wished for the re-compensation of cultural valuables destroyed by the Nazis’ purification practices regarding “inferior” Slavic art and architecture; however, the defeated German nation did not have the ability to reimburse the Soviet State. the trophy brigades implemented a process of restitution in kind to make physical reparations through the confiscation of Nazi war loot. the Western Allies disagreed with the Soviet Union’s policy. the Monuments, Fine Arts, and Archives Commission endeavored to return artwork looted by the Germans to the rightful owners or surviving descendants. Historically, the Western perspective of the Soviet Union’s actions was that the trophy brigades looted the conquered German Reich; however, during the period of Glasnost and after the fall of the Soviet Union, personal memoirs and interviews of Soviet trophy brigade members and museum officials have become available, and the Soviet viewpoint better understood. By analyzing both organization’s principles and actions, historians can assume a new disposition. the trophy brigades and the MFAA worked to salvage Nazi war loot, but the two commissions took divergent approaches as to what should be done with the spoils of war. It must be appreciated that decisions made sixty-seven years ago were made by nations attempting to do what they deemed morally correct but the lack of communication behind each ideology has made Western nations stand in judgment of the Soviet Union’s response.

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