Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-06-05T17:52:22Z No. of bitstreams: 1 LianaCostaPereiraDissertacao2014.pdf: 1788731 bytes, checksum: aaf1eef40e98ed7a21c08304f7dce33b (MD5) / Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-06-05T17:54:37Z (GMT) No. of bitstreams: 1 LianaCostaPereiraDissertacao2014.pdf: 1788731 bytes, checksum: aaf1eef40e98ed7a21c08304f7dce33b (MD5) / Made available in DSpace on 2017-06-05T17:54:37Z (GMT). No. of bitstreams: 1 LianaCostaPereiraDissertacao2014.pdf: 1788731 bytes, checksum: aaf1eef40e98ed7a21c08304f7dce33b (MD5) Previous issue date: 2014-05-29 / Viral infections affect every living organism. Health care programs and vaccines have been developed to control and prevent those infections, but there is still the occurrence of severe diseases and with great social-economic importance, whose only alternative is the treatment with antivirals drugs. Those compounds possess different mechanisms of action and are specific for each virus. Nevertheless, with many viruses resistant strains rise, a growing interest in novel antivirals development or in the improvement of existing drugs have been observed. In the last few years, antimicrobial peptides have shown antiviral activities making them candidates for antiviral drugs. The present study aimed to evaluate the possible antiviral activities of synthetic peptides clavanin MO, LL-37, Cn-AMP1 and variants of the Pa-MAP1 against HSV-1 and the Aichivirus replication. The peptides cytotoxic effects against Vero cells were evaluated by MTT method, whereas the clavanin MO, the Pa-MAP 1.8 and Pa-MAP 18br showed more cytotoxicity, with concentrations higher than 15,4 ??M and 12 ??M, respectively. Considering the antivirals assays, it was observed that the peptide Pa-MAP 1 causes 90 % of HSV-1 replication, with a SI higher than 4.8 and a virucidal mechanism of action, but null against the Aichivirus. Futhermore LL- 37 presented 90 % of Aichivirus inhibition, with a SI of 3.4. Others peptides tested showed percentages below 41 %. Future studies are need in order to elucidate which HSV-1 structure does Pa-MAP1 interacts and futher extend to in vivo tests. In summary, this study it is the first one to describe antiviral tests for the treatment of the Aichivirus infection. / As infec????es virais acometem todos os organismos vivos. Para o controle e preven????o dessas infec????es, programas de sa??de p??blica e vacinas t??m sido desenvolvidos, mas ainda h?? a ocorr??ncia de doen??as graves e de grande impacto socioecon??mico cuja ??nica alternativa ?? o tratamento com antivirais. Estes possuem diferentes mecanismos de a????o e s??o espec??ficos para cada tipo viral. Entretanto, o surgimento de variantes resistentes de muitos tipos virais tem levado h?? um crescimento no interesse de desenvolver novos antivirais ou at?? mesmo melhorar os existentes. Nos ??ltimos anos, estudos sobre pept??deos antimicrobianos relatam a atividade antiviral desses compostos, tornando-os candidatos a medicamentos antivirais. O presente estudo teve como objetivo avaliar a poss??vel atividade antiviral dos pept??deos sint??ticos clavanina MO, LL-37, Cn-AMP1 e variantes da Pa-MAP contra o Herpes v??rus humano 1 e Aichiv??rus. O efeito citot??xico dos pept??deos em c??lulas Vero foi avaliado pelo m??todo do MTT, sendo que a clavanina MO, a Pa- MAP 1.8 e Pa-MAP 18br demonstraram maior citotoxicidade em concentra????es maiores que 15,4 ??M, e 12 ??M, respectivamente. Considerando os ensaios antivirais, observou-se que o pept??deo Pa-MAP1 apresentou 90 % de inibi????o da replica????o do HHV-1, com um IS maior que 4,8, sendo que seu mecanismo de a????o foi definido como virucida, por??m contra o Aichiv??rus o PI foi nulo. Al??m disso, LL-37 apresentou 90 % de inibi????o do Aichiv??rus com um IS de 3,4. Os outros pept??deos testados apresentaram percentuais abaixo de 41 % contra ambos os v??rus. Futuros estudos moleculares s??o necess??rios para se determinar com qual estrutura do HHV-1 a Pa-MAP1 interage e para estender os testes para modelos in vivo. Este estudo ?? o primeiro a relatar testes antivirais para o tratamento do Aichiv??rus.

This thesis demonstrates the practicability of using Resonant Ultrasound Spectroscopy (RUS) in combination with Finite Element Analysis (FEA) to determine the size and location of a defect in a material of known geometry and physical constants. Defects were analyzed by comparing the actual change in frequency spectrum measured by RUS to the change in frequency spectrum calculated using FEA. FEA provides a means of determining acceptance/rejection criteria for Non-Destructive Testing (NDT). If FEA models of the object are analyzed with defects in probable locations; the resulting resonant frequency spectra will match the frequency spectra of actual objects with similar defects. By analyzing many FEA-generated frequency spectra, it is possible to identify patterns in behavior of the resonant frequencies of particular modes based on the nature of the defect (location, size, depth, etc.). Therefore, based on the analysis of sufficient FEA models, it should be possible to determine nature of defects in a particular object from the measured resonant frequency. Experiments were conducted on various materials and geometries comparing resonant frequency spectra measured using RUS to frequency spectra calculated using FEA. Measured frequency spectra matched calculated frequency spectra for steel specimens both before and after introduction of a thin cut. Location and depth of the cut were successfully identified based on comparison of measured to calculated resonant frequencies. However, analysis of steel specimens with thin cracks, and of ceramic specimens with thin cracks, showed significant divergence between measured and calculated frequency spectra. Therefore, it was not possible to predict crack depth or location for these specimens. This thesis demonstrates that RUS in combination with FEA can be used as an NDT method for detection and analysis of cracks in various materials, and for various geometries, but with some limitations. Experimental results verify that cracks can be detected, and their depth and location determined with reasonable accuracy. However, experimental results also indicate that there are limits to the applicability of such a method, the primary one being a lower limit to the size of crack – especially thickness of the crack - for which this method can be applied.

No description available.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-02-22T23:19:51Z No. of bitstreams: 1 DaiseMariaCunhaDeSousaCarvalho_DISSERT.pdf: 1677103 bytes, checksum: 02762c1d44bfc8363c0e7f941c0a3284 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-02-26T00:20:08Z (GMT) No. of bitstreams: 1 DaiseMariaCunhaDeSousaCarvalho_DISSERT.pdf: 1677103 bytes, checksum: 02762c1d44bfc8363c0e7f941c0a3284 (MD5) / Made available in DSpace on 2016-02-26T00:20:08Z (GMT). No. of bitstreams: 1 DaiseMariaCunhaDeSousaCarvalho_DISSERT.pdf: 1677103 bytes, checksum: 02762c1d44bfc8363c0e7f941c0a3284 (MD5) Previous issue date: 2015-03-31 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / A dengue ? uma doen?a infecciosa aguda, geralmente transmitida por mosquitos Aedes aegypti. O agente etiol?gico pertence ? fam?lia Flaviviridae, g?nero Flavivirus e compreende quatro sorotipos antigenicamente relacionados, por?m distintos: DENV-1, 2, 3 e 4. No Brasil, a doen?a representa um problema de sa?de p?blica nacional. O objetivo do presente estudo foi descrever os aspectos epidemiol?gicos da dengue no Estado do Rio Grande do Norte, no per?odo de 2013 a 2014. Um total de 483 amostras de sangue ou soro, no per?odo de Janeiro de 2013 a Dezembro de 2014, foi estudado pela metodologia de RT-PCR para a detec??o e tipagem viral. A infec??o foi confirmada em 36,44% (176/483) dos casos estudados. Este estudo detectou a circula??o de tr?s sorotipos do v?rus da dengue no Rio Grande do Norte, DENV-1, 2 e 4. O sorotipo predominante em 2013-2014 foi o DENV-4, representando 83,51% (81/97) e 68,35% (54/79) dos casos positivos, respectivamente. Em rela??o ? distribui??o espacial, a maioria dos casos ocorreu em Natal e Caic?, com 9,28% (9/97) e 18,99% (15/79), respectivamente. Os meses com maior circula??o viral no RN foram Mar?o, em 2013 e Maio, em 2014. O sexo feminino foi o mais acometido, representando 69,07% (67/97) em 2013 e 54,43% (43/79) em 2014. A faixa et?ria mais acometida foi a de 21-30 anos (2013) e a de 11-20 anos (2014), com 25,77% (25/97) e 20,25% (16/79) dos casos positivos, respectivamente. A an?lise filogen?tica indicou que o gen?tipo V (DENV-1) e o gen?tipo II (DENV-4) circularam no Estado. Nossos resultados fornecem informa??es sobre a din?mica dos DENV no Rio Grande do Norte, importantes para o desenvolvimento de estrat?gias de controle da doen?a. / Dengue is an acute infectious disease, usually transmitted by Aedes aegypti mosquitoes. The etiologic agents belong to the family Flaviviridae, genus Flavivirus, and occur as four antigenically related but distinct serotypes designated DENV-1, 2, 3, and 4. In Brazil, the disease represents a national public health problem. The purpose of the present study was to describe epidemiological aspects of dengue in the State of Rio Grande do Norte, from 2013 to 2014. A total of 483 blood or serum samples, collected from January 2013 to December 2014, were studied by RT-PCR for viral detection and typing. The infection was confirmed in 36.44% (176/483) of the cases studied. This study detected the circulation of three serotypes of dengue virus in Rio Grande do Norte, DENV-1, 2, and 4. The predominant serotype in 2013-2014 was the DENV-4, representing 83.51% (81/97) and 68.35% (54/79) of the positive cases, respectively. Regarding the spatial distribution, most of the cases occurred in Natal and Caic?, with 9.28% (9/97) and 18.99% (15/79), respectively. The months with the biggest viral circulation in RN were March 2013 and May 2014. The female gender was the most affected, representing 69.07% (67/97) in 2013 and 54.43% (43/79) in 2014. The most affected age groups were 21-30 years (2013) and 11-20 years (2014) with 25.77% (25/97) and 20.25% (16/79) positive cases, respectively. Phylogenetic analysis indicated that genotype V (DENV-1) and genotype II (DENV-4) circulated in the State. Our results provide information about the dynamics of DENV in the Rio Grande do Norte, important for the development of disease control strategies.

Master thesis Politics and religion in Subcarpathian Rus between years 1919-1929 focuses on the problems of political and religious matters in Subcarpathian Rus between the years 1919 and 1929. The introductury is dedicated to the brief historical overview until the unification with Czechoslovakia. Further it deals with the administrative division and with the analysis of the political situation. The thesis summarises different political parties - autonomous, czechoslovakian, jewish and hungarian. It deals with the municipal elections and with the parliamentary elections in 1924, 1925 and 1929. Religion is essentially contected to Subcarpathian Rus. Most of the Rusyn inteligence were clergymen, some of them were also politically active. Therefor the final part is dedicated to the religious matters and the relationship between Greek Catholic Church and Eastern Othodox Church.

No description available.

La pénétration des Scandinaves en Russie, qui s’insère dans un vaste mouvement d’échanges qui entre les VIIIe et XIIe siècles fait circuler hommes et biens, apparaît à bien des égards comme un stimulant économique et politique d’envergure dans l’émergence d’organisations politiques et sociales qui aboutirent au développement de centres proto-urbains et du premier État russe. L’objectif de cette étude est donc de s’attacher à travers le traitement des sources historiographiques scandinaves et leur croisement avec les corpus slavon, byzantin et arabo-persan, à l’appréhension des modalités de transport de ces Scandinaves qui empruntèrent la voie de l’Est. Ce traitement nous permettra alors en plus de mesurer la variété et la richesse des contacts et des types de voyages entrepris, de redessiner des itinéraires, et d’appréhender plus en détail de quelle manière l’historiographie envisageait la géographie russe ainsi que le voyage en ces régions. / The penetration of the Scandinavians in Russia, which takes place in this vast movement of exchanges between the eighth and twelfth centuries where men and goods where circulating around Europe, appears in many respects as a political and economic stimulus in the emergence of political and social organizations that led to the development of proto-urban centers and to the creation of the first Russian state. So the aim of this study is through the analyze of the Scandinavian historiography and its crossing with the Slavonic, Byzantine and Arabo-persian corpuses, to focus on the transport modalities of these Scandinavians who took the road to the East. This treatment will allow us to underline the wide variety of contacts and journeys undertaken, and in addition to reconstruct itineraries, and to understand in a better way how historiography dealt with Russian geography and with the journey across those regions as a pattern.

Made available in DSpace on 2016-12-12T20:25:12Z (GMT). No. of bitstreams: 1 CLODOALDO SCHUTEL FURTADO NETO.pdf: 8051100 bytes, checksum: 8087fda1ce7bcc1fb1f0f63da1457107 (MD5) Previous issue date: 2015-07-28 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / A Universidade do Estado de Santa Catarina construiu um simulador de vôo de baseado robô paralelo axissimétrico com 6 DoF (graus de liberdade) que incorpora ambiente de realidade virtual de imersão. Este simulador de vôo apresenta cadeia cinemática 6-RUS que é a segunda arquitetura mais comum para esta aplicação. Robôs paralelos são mecanismos de cadeia fechada que apresentam bom desempenho em termos de precisão, rigidez e capacidade para manipular grandes cargas. Este trabalho tem como objetivo otimizar um robô paralelo 6- RUS para determinar os melhores localizações das juntas ativas ( posição e orientação ) para uma tarefa de simulação de vôo usando um algoritmo PSO (Particle Swarm Optimization) para escapar de mínimos locais e um algoritmo de Ponto Interior para acelerar a procurar pelo ótimo na região indicada por PSO ou seja o algoritmo de Ponto Interior trabalha para encontrar fundo do vale indicado pelo PSO. / The Santa Catarina State University built a flight simulator based on 6-DoF axisymmetric parallel robot which incorporates virtual reality immersion environment. This flight simulator presents 6-RUS kinematic chain which is the second most common architecture for this application. Hunt proposed this chain architecture early in 1983. Parallel robots are closed-loop mechanisms that present good performance in terms of accuracy, rigidity and ability to manipulate large loads. This work aims to optimize a 6- RUS parallel robot to determine the optimal active joints locations (position and orientation) for a flight simulation task using a PSO (Particle Swarm Optimization) algorithm to escape from local minima and an Interior Point algorithm to accelerate the search for the optimum in the region indicated by PSO i.e. Interior Point algorithm work to find bottom of the valley indicated by PSO.

Abstract The thesis deals with the relation of Ivan Olbracht and Subcarpathian Rus. Giving a brief summary of examined territory's history, the authoress attends to Olbracht's Subcarpathian stay and its influence on his work. Olbracht was challenged by the social and political conditions of fossil region to write a set of reportages released in newspaper and afterwards in a double book edition (Země bez jména, Hory a staletí). In the reportages he prepaired a factual and epical field for his prosaic pieces - Nikola Šuhaj loupežník and Golet v údolí (for completeness' sake it's essential to mention Marijka nevěrnice). Authoress devotes herself to a thematic analysis of reportages observing the way Olbracht depicted no longer existing culture and community. She applies this thematic outline on the outlaw novel and the triptych of short stories. It is hereby documented Olbracht's methodics consisting in a stratified narration based on two main layers: factual (empirical) and legendary (poetic).

A Povst vremennyh lt ou, nesta versão em português, Narrativa dos anos passados é uma crônica monástica, de autoria indefinida, compilada na segunda década do século XII, no Monastério das Cavernas, em Kiev. A obra relata os feitos dos príncipes guerreiros de origem escandinava que reinaram sobre populações eslavas e fino-úgricas a partir da segunda metade do século IX, ao mesmo tempo em que busca inserir a Rus numa narrativa universal de caráter cristão. Para tanto, o texto segue de perto modelos cronográficos bizantinos e emprega constantemente episódios bíblicos, tanto canônicos, como apócrifos, além de escritos patrísticos. Por sua extensão, conteúdo, linguagem e estilo, considera-se a Povst vremennyh lt uma das principais obras da literatura eslava oriental antiga. Ademais, é a principal fonte para o estudo da história do principado de Kiev, tendo grande relevância para medievalistas, linguistas e estudiosos da cultura eslava em geral. O presente trabalho tem por objetivo apresentar uma tradução completa da crônica, direta do eslavo oriental, acompanhada de aparato crítico selecionado, comentários e apêndices. O texto da tradução é antecedido por uma breve contextualização histórica, uma apresentação do documento e dos manuscritos que o atestam, e uma reflexão a respeito das dificuldades práticas e teóricas do traduzir. / The Povst vremennyh lt, known in English as the Russian Primary Chronicle or The Tale of Bygone Years, is a monastic chronicle, compiled by an unknown author, during the second decade of the 12th century in the Monastery of the Caves in Kiev. It tells the deeds of the Scandinavian warrior princes that reigned over Slavic and Finno- Ugric populations from the second half of the 9th century. At the same time, it tries to fit the land of Rus into a Christian universal narrative. For this purpose, the chronicler emulates Byzantine models, and makes constant use of Biblical episodes, not only from the canon, but also apocryphal and patristic writings. Due to its length, its content and style, the Povst vremennyh lt is considered one of the most important works in Old East Slavic Literature, and one of the main sources for the study of Kievan Rus history. It is also valuable in the fields of medieval studies and linguistics. The present work aims to present a complete version of the chronicle in portuguese, translated directly from the Old East Slavic, with a selection of textual variants, notes and appendices. As a guide to the PVL, the reader will find a brief historical overview, a short analysis of the extant manuscripts and some comments on practical and theoretical translation topics.