This term project addresses the construction of kD tree acceleration structures and parallelization of this construction using GPU. At the beginning, there is an introduction of the reader into CUDA platform for parallel programming. There is a decription of generic principles as well as specific features that will be used in this thesis. Following that the reader is put into the issue of acceleration structures for Ray tracing. These structures are described and the kD tree acceleration structure and its variants are portrayed in detail. After that the analysis of chosen kD tree variant is broken down and the problems and issuse of its parallel implementation are adressed. As a part of implementation discription, there is a short descripton of CPU variant and detailed specifications of the CUDA kernels. The testing section brings the results of implementation in form of CPU vs GPU comparison, as well as evaluation of how much the metric set in design was fulfilled. In the end there is a summary of achieved goals and results followed by possible future improvements for the implementation.

Cerebral hemorrhages are a type of stroke causing bleeding in the brain from a ruptured brain vessel or an aneurysm. In the emergency department (ED), advanced practice nurses (APNs') play a pivotal role in identifying cerebral hemorrhages. Many APNs' lack the skills necessary to assess, diagnose, and manage this type of stroke. A delay in diagnosis of cerebral hemorrhages carries a high risk of morbidity and mortality and can lead to lifelong disability or death. The framework of this project is the Patricia Benner theory of novice-to-expert, which is a 5-step approach designed to strengthen nursing skills with the goal of developing nurses into experts in the neuroscience field. This project addressed whether a validated educational program for APNs' in the ED will increase knowledge to improve the assessment, diagnosis, and management of the cerebral hemorrhage stroke patient. A panel of experts were provided a comprehensive educational plan with multiple case scenarios. A 5-point Likert questionnaire was administered and a statistical analysis was performed. Results indicated the panel strongly agreed that the educational initiative increased APNs' knowledge and fostered a culture of change for APNs' in the ED. Potential implications of this educational module will be considered in satellite organizations impacting APNs' growth and improving patient care throughout the health system. The project determined that the significance of social change included increased APNs' knowledge and advanced professional growth, lowers mortality rates, and promotes an evidence-based quality improvement project.

Les virus sont au centre de problème de santé publique. En raison de l'apparition de nouveaux virus et pour certains de leur résistance aux traitements existants il est toujours d’actualité de développement de nouveaux agents antiviraux. En général, la stratégie de lutte contre les infections virales est basée sur la vaccination ou sur l'activité des petites molécules, interférant avec un ou plusieurs processus biologiques participant au cycle de vie du virus. Dans ce contexte, nous avons conçu et synthétisé des petites bibliothèques de molécules visant des propriétés anti-filovirus. Dans ce projet de recherche, nous avons mis l'accent sur le développement de composés ciblant la protéine Niemann-Pick C1, les protéases cathepsine et le processus de réplication. Lors du développement des inhibiteurs de Neimann-Pick C1 plus de 70 composés ont été synthétisés, portant le squelette pipérazine. Afin d'obtenir des inhibiteurs de cystéine cathepsines pouvant être impliqués dans la réplication du virus Ebola, nous avons synthétisé une petite bibliothèque de composés porteurs de groupement 1,3,5-triazine et possédant des activité de l’ordre du nanomolaire sur les cathepsines B, K, L et S. Enfin, pour inhiber la réplication du virus en ciblant SAH hydrolase, nous avons proposé une série de C-nucléosides carbocyclic ayant motif de 4-aza-7,9-dideazaadenosine. / The viruses cause the problem of public health. Due to the appearance of new viruses and their resistance to existing treatments there is still relevant to develop new antivirals. Generally, the strategy to combat viral infections is based on vaccination or on the activity of small molecules, interfering with one or more biological processes participating in virus life cycle. In this context, we took an effort to design and synthesize the library of small molecules possessing anti-filovirus properties. In this research project, we were focused on the developing of compounds targeting Niemann-Pick C1 protein, cathepsin proteases and replication process. In our effort into the development of the inhibitors of Neimann-Pick C1 we prepared the series of about 70 compounds, having in common the piperazine moiety. Diverse 1,4-N,N - substituents of piperazine, differencing in a size and shape were studied. In order to obtain efficient cysteine cathepsins inhibitors, we synthesized the small library of compounds bearing 1,3,5-triazine moiety. Finally, to inhibit the virus replication by targeting SAH hydrolase, we proposed the series of carbocyclic C-nucleosides having motif of 4-aza-7,9-dideazaadenosine.

Recently, non-cellular viral agents became the focus of a large number of scientific groups. A prominent and widespread group of these viruses are flaviviruses, which include, for example, Zika virus, Dengue fever virus, tick-borne encephalitis virus and West Nile virus. There is a considerable diversity among these viruses, however, highly conserved proteins can be found throughout this viral genus. The largest and most conserved protein encoded by flaviviruses is the nonstructural NS5 protein. Its N-terminal domain bears the methyltransferase (MTase) activity. Thanks to the methylation of its genome, it allows the virus to initiate translation and at the same time mask it from the host's immune system. By blocking the active site of this enzyme with a small molecule, viral infection could be stopped not only in one flavivirus, but, due to the high conservation of MTases, in all other flaviviruses. This diploma thesis deals with the aforementioned MTase domain of the NS5 protein, specifically of the West Nile virus (WNV). After designing an insert encoding the WNV MTase domain, amplifying it and ligating it into the vector, the MTase domain was prepared by a recombinant expression, followed by purification. Subsequently, complexes of the protein with small molecules (MTase ligands) were formed, in...

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The overall aim of this thesis was to describe patients’ experience and reconstruction regarding the onset of, and events surrounding being struck by a Subarachnoid Haemorrhage (SAH), and to describe patients’ and relatives’ views of patients’ memory ability, emotional status and activities of living, in a long-term perspective. Methods: Both inductive and deductive approaches were used. Nine open interviews were carried out in home settings, in average 1 year and 7 seven months after the patients’ onset, and discourse analysis was used to interpret the data. Eleven relatives and 11 patients, 11 years after the onset, and 15 relatives and 15 patients, 6 years after the onset, participated in two studies. Interviews using a questionnaire with structured questions and memory tests were used to collect data. Fischer’s exact test and Z-scores were used for the statistical analysis. Results: Patients with experience of a SAH were able to judge their own memory for what happened when they became ill. The reconstruction of the illness event may be interpreted as an identity creating process. The process of meaning-making is both a matter of understanding SAH as a pathological event and a social and communicative matter, where the SAH is construed into a meaningful life history, in order to make life complete (I). Memory problems, changes in emotional status and problems with activities of living were common (II-IV). There was correspondence between relatives’ and patients’ statements regarding the patients’ memory in general and long-term memory. Patients judged their own memory ability better than relatives, compared with results on memory tests. Relatives stated that some patients had meta-memory problems (II). The episodic memory seemed to be well  reserved, both concerning the onset and in the long-term perspective (I, II). There were more problems with social life than with P- and I-ADL (III), and social company habits had changed due to concentration difficulties, mental fatigue, and  patients’ sensitivity to noisy environments and uncertainty (IV). Relatives rated the patients’ ability concerning activities of living and emotional status, and in a similar manner to patients’ statements (III-IV). Conclusions: The reconstruction of the illness event can be used as a tool in nursing for understanding the patient’s identity-construction. Relatives and patients stated the patients’ memory, emotional status and activities of living in a similar manner, and therefore both patients’ and relatives’ statements can be used as a tool in nursing care, in order to support the patient. However, the results showed: meta-memory problems (relatives’ statements) and that the patients’ judged their own memory ability better than relatives in comparison with results on memory tests. Nevertheless, there was a high degree of concordance between relatives’ and patients’ evaluations concerning patients´ memory ability, emotional status, emotional problems, social company habits and activities of living. Therefore both relatives’ and patients’ statements can be considered to be reliable. However, sometimes the patients and the relatives judge the patients’ memory differently. Consequently, memory tests and formalized dialogues between the patient, the relative and a professional might be required, in order to improve the mutual family relationship in a positive way. Professionals however, must first assume that patients can judge their own memory, emotional status and ability in daily life.

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This thesis deals with ray tracing methods and their acceleration. It gives partial study and review of algorithms from classical ray shooting algorithm to recursive approach up to distributed ray tracing algorithm. Significant part of this thesis is devoted to BSP tree structure and its subclass of k-D tree, it shows simple algorithm for its construction and traversal. The rest of thesis is dealing with k-D tree construction techniques, which are based on the right choice of the splitting plane inside the every cell of k-D tree. The techniques upon the thesis is based on are space median, object median and relatively new cost model technique named SAH, otherwise as surface area heuristic. All three techniques are put into testing and performance comparison. In the conclusion the results of tests are reviewed, from where SAH is coming out as a winner.

This study deals with modern mission history in north eastern Africa. When the rigid Islamistic Mahdi regime in the Sudan was defeated by an Anglo-Egyptian army in 1898, H G Guinness and K Kumm came to Aswan and initiated the Sudan Pionier Mission (SPM) in 1900. The SPM had its spiritual roots in the Holiness Movement and became an interdenominational German-based faith mission. Although the SPM was started in Aswan to advance from there to the south to evangelize animistic people groups in the Eastern Sudan, the SPM actually consolidated its work in and around Aswan for internal and external reasons. Thus, the focus of the SPM shifted from an animistic to an Islamic audience with a special emphasis on the Nile-Nubians occupying the Nile valley between Aswan and Dongola. This study contributes generally to the historiography of the SPM between 1990 until 1966 and analyzes especially the development of the SPM into a mission among the Nile-Nubians during this period. The ethnic groups of the Nile-Nubians will be introduced and their historical, political, social, economic, linguistic and religious situation will be presented. This thesis further describes the topographical development of the SPM and its missiological approach. A special emphasis is given to the life story of the Kunuuzi Nubian convert Samu’iil Ali Hiseen (SAH-1863-1900) and his multifaceted contribution to the work of the SPM. SAH was the first Nubian evangelist in modern times and the major stakeholder of the Nubian vision. Neither the history of the SPM as “Nubian Mission” nor the life and work of SAH have been researched and presented before. / Christian Spirituality, Church History and Missiology / D. Th. (Missiology)