The use of grading scales is common in clinical practice and research settings. A number of grading scales are available to the practitioner, however, despite their frequent use, they are only poorly understood and may be criticised for a number of things such as the variability of the assessments or the inequality of scale steps within or between scales. Hence, the global aim of this thesis was to study the McMonnies/Chapman-Davies (MC-D), Institute for Eye Research (IER), Efron, and validated bulbar redness (VBR) grading scales in order to (1) get a better understanding and (2) attempt a cross-calibration of the scales. After verifying the accuracy and precision of the objective and subjective techniques to be used (chapter 3), a series of experiments was conducted. The specific aims of this thesis were as follows: • Chapter 4: To use physical attributes of redness to determine the accuracy of the four bulbar redness grading scales. • Chapter 5: To use psychophysical scaling to estimate the perceived redness of the four bulbar redness grading scales. • Chapter 6: To investigate the effect of using reference anchors when scaling the grading scale images, and to convert grades between scales. • Chapter 7: To grade bulbar redness using cross-calibrated versions of the MC-D, IER, Efron, and VBR grading scales. Methods: • Chapter 4: Two image processing metrics, fractal dimension (D) and % pixel coverage (% PC), as well as photometric chromaticity (u’) were selected as physical measures to describe and compare redness in the four bulbar redness grading scales. Pearson correlation coefficients were calculated between each set of image metrics and the reference image grades to determine the accuracy of the scales. • Chapter 5: Ten naïve observers were asked to arrange printed copies of modified versions of the reference images (showing vascular detail only) across a distance of 1.5m for which only start and end point were indicated by 0 and 100, respectively (non-anchored scaling). After completion of scaling, the position of each image was hypothesised to reflect its perceived bulbar redness. The averaged perceived redness (across observers) for each image was used for comparison to the physical attributes of redness as determined in chapter 4. • Chapter 6: The experimental setup from chapter 5 was modified by providing the reference images of the VBR scale as additional, unlabelled anchors for psychophysical scaling (anchored scaling). Averaged perceived redness from anchored scaling was compared to non-anchored scaling, and perceived redness from anchored scaling was used to cross-calibrate grades between scales. • Chapter 7: The modified reference images of each grading scale were positioned within the 0 to 100 range according to their averaged perceived redness from anchored scaling, one scale at a time. The same 10 observers who had participated in the scaling experiments were asked to represent perceived bulbar redness of 16 sample images by placing them, one at a time, relative to the reference images of each scale. Perceived redness was taken as the measured position of the placed image from 0 and was averaged across observers. Results: • Chapter 4: Correlations were high between reference image grades and all sets of objective metrics (all Pearson’s r’s≥0.88, p≤0.05); each physical attribute pointed to a different scale as being most accurate. Independent of the physical attribute used, there were wide discrepancies between scale grades, with sometimes little overlap of equivalent levels when comparing the scales. • Chapter 5: The perceived redness of the reference images within each scale was ordered as expected, but not all consecutive within-scale levels were rated as having different redness. Perceived redness of the reference images varied between scales, with different ranges of severity being covered by the images. The perceived redness was strongly associated with the physical attributes of the reference images. • Chapter 6: There were differences in perceived redness range and when comparing reference levels between scales. Anchored scaling resulted in an apparent shift to lower perceived redness for all but one reference image compared to non-anchored scaling, with the rank order of the 20 images for both procedures remaining fairly constant (Spearman’s ρ=0.99). • Chapter 7: Overall, perceived redness depended on the sample image and the reference scale used (RM ANOVA; p=0.0008); 6 of the 16 images had a perceived redness that was significantly different between at least two of the scales. Between-scale correlation coefficients of concordance (CCC) ranged from 0.93 (IER vs. Efron) to 0.98 (VBR vs. Efron). Between-scale coefficients of repeatability (COR) ranged from 5 units (IER vs. VBR) to 8 units (IER vs. Efron) for the 0 to 100 range. Conclusions: • Chapter 4: Despite the generally strong linear associations between the physical characteristics of reference images in each scale, the scales themselves are not inherently accurate and are too different to allow for cross-calibration based on physical redness attributes. • Chapter 5: Subjective estimates of redness are based on a combination of chromaticity and vessel-based components. Psychophysical scaling of perceived redness lends itself to being used to cross calibrate the four clinical scales. • Chapter 6: The re-scaling of the reference images with anchored scaling suggests that redness was assessed based on within-scale characteristics and not using absolute redness scores, a mechanism that may be referred to as clinical scale constancy. The perceived redness data allow practitioners to modify the grades of the scale they commonly use so that comparisons of grading estimates between calibrated scales may be made. • Chapter 7: The use of the newly calibrated reference grades showed close agreement between grading estimates of all scales. The between-scale variability was similar to the variability typically observed when a single scale is repeatedly used. Perceived redness appears to be dependent upon the dynamic range of the reference images of the scale. In conclusion, this research showed that there are physical and perceptual differences between the reference images of all scales. A cross-calibration of the scales based on the perceived redness of the reference images provides practitioners with an opportunity to compare grades across scales, which is of particular value in research settings or if the same patient is seen by multiple practitioners who are familiar with using different scales.

By positioning within an alternative development and agency/actor-oriented perspectives, and by employing diverse qualitative research methods, this study examines the dynamics of community self-help development and scaling up. The study investigates the processes and factors that contribute to successful community self-help development that leads to community capacity and empowerment. The diverse processes, through which poor people, through their individual and collective agency, strategize their actions, resist and negotiate with other stakeholders is emphasised. Community’s own mobilization for self-management, based on the networks of self-help groups; trusted leadership drawn from community members with excellent mobilization skill to spark community’s own mobilization for empowerment; poor people’s collective agency; trust that builds community and promotes collective actions; genuine participation within the community, which is realized because of planned and spontaneous interaction among intimate, small groups of people; and outside supports from government and NGOs, based on the bottom up proposals of communities are the main processes and elements of successful community self-help development. On the other hand, the study has shown that the scaling up of such successful community self-help development in Ethiopia is constrained by unfavourable institutional arrangements within the government structures, lack of capacity and power among local governments and inescapable nominal and instrumental participation, rather than genuine participation to build local people’s capability. Methodological limitations and lack of awareness about the goal of scaling up within the existing replication efforts are other challenges of scaling up. The researcher argues that the existing institutions and participatory practices may present opportunities for a gradual actualization of people’s agency, because the poor are capable of formulating new ways of strategizing and combining available resources in a new manner to solve problems. Thus, by using the available, small opportunity and systematically combining with other grassroots development approaches, by emphasizing on small, intimate groups of people (community/village), alternative spaces of scaling up can be identified and used.

Advances in the development of simple and cheap sensors give new possibilities with large sensor network deployments in monitoring and surveillance applications. Commonly, the sensor positions are not known, specifically, when sensors are randomly spread in a big area. Low cost sensors are constructed with as few components as possible to keep price and energy consumption down. This implies that self-positioning and communication capabilities are low. So the question: “How do you localize such sensors with good precision with a feasible approach?” is central. When no information is available a stable and robust localization algorithm is needed. In this thesis an acoustic sensor network is considered. With a movable acoustic source a well-defined and audible signal is transmitted at different spots. The sensors measure the time of arrival which corresponds to distance. A two-step sensor localization approach is applied that utilizes the estimated distances. A novel approach in the first step is presented to incorporate more measurements and gain more position information. Localization and ranging performance is evaluated with simulations and data collected at field trials. The results show that the novel approach attains higher accuracy and robustness.

In this thesis two versions of a single filter frequency masking narrow-band high-speed recursive digital filter structure, proposed in [1], have been implemented and evaluated considering the maximal clock frequency, the maximal sample frequency and the power consumption. The structures were compared to a conventional filter structure, that was also implemented. The aim was to see if the proposed structure had some benefits when implemented and synthesized, not only in theory. For the synthesis standard cells from AMS csx 0.35 mm CMOS technology were used.

Over the past decade, low power, energy efficient VLSI design has been the focal point of active research and development. The rapid technology scaling, the growing integration capacity, and the mounting active and leakage power dissipation are contributing to the growing complexity of modern VLSI design. Careful power planning on all design levels is required. This dissertation tackles the low-power, low-energy challenges in deep sub-micron technologies on the architecture and circuit levels. Voltage scaling is one of the most efficient ways for reducing power and energy. For ultra-low voltage operation, a new circuit technique which allows bulk CMOS circuits to work in the sub-0. 5V supply territory is presented. The threshold voltage of the slow PMOS transistor is controlled dynamically to get a lower threshold voltage during the active mode. Due to the reduced threshold voltage, switching speed becomes faster while active leakage current is increased. A technique to dynamically manage active leakage current is presented. Energy reduction resulting from using the proposed structure is demonstrated through simulations of different circuits with different levels of complexity. As technology scales, the mounting leakage current and degraded noise immunity impact performance especially that of high performance dynamic circuits. Dual threshold technology shows a good potential for leakage reduction while meeting performance goals. A model for optimally selecting threshold voltages and transistor sizes in wide fan-in dynamic circuits is presented. On the circuit level, a novel circuit level technique which handles the trade-off between noise immunity and energy dissipation for wide fan-in dynamic circuits is presented. Energy efficiency of the proposed wide fan-in dynamic circuit is further enhanced through efficient low voltage operation. Another direct consequence of technology scaling is the growing impact of interconnect parasitics and process variations on performance. Traditionally, worst case process, parasitics, and environmental conditions are considered. Designing for worst case guarantees a fail-safe operation but requires a large delay and voltage margins. This large margin can be recovered if the design can adapt to the actual silicon conditions. Dynamic voltage scaling is considered a key enabler in reducing such margin. An on-chip process identifier to recover the margin required due to process variations is described. The proposed architecture adjusts supply voltage using a hybrid between the one-time voltage setting and the continuous monitoring modes of operation. The interconnect impact on delay is minimized through a novel adaptive voltage scaling architecture. The proposed system recovers the large delay and voltage margins required by conventional systems by closely tracking the actual critical path at anytime. By tracking the actual critical path, the proposed system is robust and more energy efficient compared to both the conventional open-loop and closed-loop systems.

Wireless Networks have been the topic of fundamental research in recent years with the aim of achieving reliable and efficient communications. However, due to their complexity, there are still many aspects of such configurations that remain as open problems. The focus of this thesis is to investigate some throughput limits of wireless networks. The network under consideration consists of $n$ source-destination pairs (links) operating in a single-hop fashion. In Chapters 2 and 3, it is assumed that each link can be active and transmit with a constant power P or remain silent. Also, fading is assumed to be the dominant factor affecting the strength of the channels between transmitter and receiver terminals. The objective is to choose a set of active links such that the throughput is maximized, where the rate of active links are either unconstrained or constrained. For the unconstrained throughput maximization, by deriving an upper bound and a lower bound, it is shown that in the case of Rayleigh fading: (i) the maximum throughput scales like $\log n$, (ii) the maximum throughput is achievable in a distributed fashion. The upper bound is obtained using probabilistic methods, where the key point is to upper bound the throughput of any random set of active links by a chi-squared random variable. To obtain the lower bound, a threshold-based link activation strategy (TBLAS) is proposed and analyzed. The achieved throughput of TBLAS is by a factor of four larger than what was obtained in previous works with centralized methods and with multihop communications. When the active links are constrained to transmit with a constant rate $\lambda$, an upper bound is derived that shows the number of active links scales at most like $\frac{1}{\lambda} \log n$. It is proved that TBLAS \emph{asymptotically almost surely(a.a.s.)} yields a feasible solution for the constrained throughput maximization problem. This solution, which is suboptimal in general, performs close to the upper bound for small values of $\lambda$. To improve the suboptimal solution, a double-threshold-based link activation strategy (DTBLAS) is proposed and analyzed based on some results from random graph theory. It is demonstrated that DTBLAS performs very close to the optimum. Specifically, DTBLAS is a.a.s. optimum when $\lambda$ approaches $\infty$ or $0$. The optimality results are obtained in an interference-limited regime. However, it is shown that, by proper selection of the algorithm parameters, DTBLAS also allows the network to operate in a noise-limited regime in which the transmission rates can be adjusted by the transmission powers. The price for this flexibility is a decrease in the throughput scaling law by a factor of $\log \log n$. In Chapter 4, the problem of throughput maximization by means of power allocation is considered. It is demonstrated that under individual power constraints, in the optimum solution, the power of at least one link should take its maximum value. Then, for the special case of $n=2$ links, it is shown that the optimum power allocation strategy for throughput maximization is such that either both links use their maximum power or one of them uses its maximum power and the other keeps silent.

The use of grading scales is common in clinical practice and research settings. A number of grading scales are available to the practitioner, however, despite their frequent use, they are only poorly understood and may be criticised for a number of things such as the variability of the assessments or the inequality of scale steps within or between scales. Hence, the global aim of this thesis was to study the McMonnies/Chapman-Davies (MC-D), Institute for Eye Research (IER), Efron, and validated bulbar redness (VBR) grading scales in order to (1) get a better understanding and (2) attempt a cross-calibration of the scales. After verifying the accuracy and precision of the objective and subjective techniques to be used (chapter 3), a series of experiments was conducted. The specific aims of this thesis were as follows: • Chapter 4: To use physical attributes of redness to determine the accuracy of the four bulbar redness grading scales. • Chapter 5: To use psychophysical scaling to estimate the perceived redness of the four bulbar redness grading scales. • Chapter 6: To investigate the effect of using reference anchors when scaling the grading scale images, and to convert grades between scales. • Chapter 7: To grade bulbar redness using cross-calibrated versions of the MC-D, IER, Efron, and VBR grading scales. Methods: • Chapter 4: Two image processing metrics, fractal dimension (D) and % pixel coverage (% PC), as well as photometric chromaticity (u’) were selected as physical measures to describe and compare redness in the four bulbar redness grading scales. Pearson correlation coefficients were calculated between each set of image metrics and the reference image grades to determine the accuracy of the scales. • Chapter 5: Ten naïve observers were asked to arrange printed copies of modified versions of the reference images (showing vascular detail only) across a distance of 1.5m for which only start and end point were indicated by 0 and 100, respectively (non-anchored scaling). After completion of scaling, the position of each image was hypothesised to reflect its perceived bulbar redness. The averaged perceived redness (across observers) for each image was used for comparison to the physical attributes of redness as determined in chapter 4. • Chapter 6: The experimental setup from chapter 5 was modified by providing the reference images of the VBR scale as additional, unlabelled anchors for psychophysical scaling (anchored scaling). Averaged perceived redness from anchored scaling was compared to non-anchored scaling, and perceived redness from anchored scaling was used to cross-calibrate grades between scales. • Chapter 7: The modified reference images of each grading scale were positioned within the 0 to 100 range according to their averaged perceived redness from anchored scaling, one scale at a time. The same 10 observers who had participated in the scaling experiments were asked to represent perceived bulbar redness of 16 sample images by placing them, one at a time, relative to the reference images of each scale. Perceived redness was taken as the measured position of the placed image from 0 and was averaged across observers. Results: • Chapter 4: Correlations were high between reference image grades and all sets of objective metrics (all Pearson’s r’s≥0.88, p≤0.05); each physical attribute pointed to a different scale as being most accurate. Independent of the physical attribute used, there were wide discrepancies between scale grades, with sometimes little overlap of equivalent levels when comparing the scales. • Chapter 5: The perceived redness of the reference images within each scale was ordered as expected, but not all consecutive within-scale levels were rated as having different redness. Perceived redness of the reference images varied between scales, with different ranges of severity being covered by the images. The perceived redness was strongly associated with the physical attributes of the reference images. • Chapter 6: There were differences in perceived redness range and when comparing reference levels between scales. Anchored scaling resulted in an apparent shift to lower perceived redness for all but one reference image compared to non-anchored scaling, with the rank order of the 20 images for both procedures remaining fairly constant (Spearman’s ρ=0.99). • Chapter 7: Overall, perceived redness depended on the sample image and the reference scale used (RM ANOVA; p=0.0008); 6 of the 16 images had a perceived redness that was significantly different between at least two of the scales. Between-scale correlation coefficients of concordance (CCC) ranged from 0.93 (IER vs. Efron) to 0.98 (VBR vs. Efron). Between-scale coefficients of repeatability (COR) ranged from 5 units (IER vs. VBR) to 8 units (IER vs. Efron) for the 0 to 100 range. Conclusions: • Chapter 4: Despite the generally strong linear associations between the physical characteristics of reference images in each scale, the scales themselves are not inherently accurate and are too different to allow for cross-calibration based on physical redness attributes. • Chapter 5: Subjective estimates of redness are based on a combination of chromaticity and vessel-based components. Psychophysical scaling of perceived redness lends itself to being used to cross calibrate the four clinical scales. • Chapter 6: The re-scaling of the reference images with anchored scaling suggests that redness was assessed based on within-scale characteristics and not using absolute redness scores, a mechanism that may be referred to as clinical scale constancy. The perceived redness data allow practitioners to modify the grades of the scale they commonly use so that comparisons of grading estimates between calibrated scales may be made. • Chapter 7: The use of the newly calibrated reference grades showed close agreement between grading estimates of all scales. The between-scale variability was similar to the variability typically observed when a single scale is repeatedly used. Perceived redness appears to be dependent upon the dynamic range of the reference images of the scale. In conclusion, this research showed that there are physical and perceptual differences between the reference images of all scales. A cross-calibration of the scales based on the perceived redness of the reference images provides practitioners with an opportunity to compare grades across scales, which is of particular value in research settings or if the same patient is seen by multiple practitioners who are familiar with using different scales.

The intensification of land-water management due to agriculture, forestry, and urbanization is a global phenomenon increasing the pressure on worlds water resources and threatening water security in North America. The Prairie Pothole Region of North America covers approximately 775,000 km2 and contains millions of wetlands that serve important hydrological and ecological functions. The unique hummocky topography and the variable effect of different processes contribute to high spatio-temporal variability in soil water, posing major challenges in hydrological studies. The objectives of this study were to a) examine the spatial pattern of soil water storage and its scale and location characteristics; and b) to identify its controls at multiple scales. Soil water content at 20 cm intervals down to 140 cm was measured along a transect extending over several knolldepression cycles in a hummocky landscape. High water storage in depressions and low water storage on the knolls created a spatial pattern that was inversely related to elevation. Spatial patterns were strongly similar within any given season (intra-season rank correlation coefficient as high as 0.99), moreso than between the same season over different years (inter-annual rank correlation coefficient as high as 0.97). Less similar spatial patterns were observed between different seasons (inter-season rank correlation coefficients as high as 0.90). While the intra-season and inter-annual spatial patterns were similar at scales >18 m, the inter-season spatial patterns were similar at much large scales (>72 m). This may be due to the variations in landform elements and micro-topography. The similarity at scales >72 m were present at any time and depth. However, small- and medium-scale spatial patterns changed with depth and with season due to a change in the hydrological processes. The relative dominance of a given set of processes operating both within a season and for the same season over different years yielded strong intra-season and inter-annual similarity at scales >18 m. Moreover, similarity was stronger with increasing depth, and was thought to be due to the dampening effect of overlying soil layers that are more dynamic. Similarity of spatial patterns over time helps to identify the location that best represents the field averaged soil water and improves sampling efficiency. Change in the similarity of scales of spatial pattern helps identify the change in sampling domain as controlled by hydrological processes. The scale information can be used to improve prediction for use in environmental management and modeling of different surface and subsurface hydrological processes. The similarity of spatial pattern between the surface and subsurface layers help make inferences on deep layer hydrological processes as well as groundwater dynamics from surface water measurements.

The scaling of specific cutting energy is studied when micro-cutting ductile metals. A unified framework for understanding the scaling in specific cutting energy is first presented by viewing the cutting force as a combination of constant, increasing, and decreasing force components, the independent variable being the uncut chip thickness. Then, an attempt is made to isolate the constant force component by performing high rake angle orthogonal cutting experiments on OFHC Copper. The data shows a trend towards a constant cutting force component as the rake angle is increased. In order to understand the source of this constant force component the chip-root is investigated. By quickly stopping the spindle at low cutting speeds, the chip is frozen and the chip-workpiece interface is examined in a scanning electron microscope. Evidence of ductile tearing ahead of the cutting tool is seen at low and high rake angles. At higher cutting speeds a quick-stop device is used to obtain chip-roots. These experiments also clearly indicate evidence of ductile fracture ahead of the cutting tool in both OFHC Copper and Al-2024 T3. To model the cutting process with ductile fracture leading to material separation the finite element method is used. The model is implemented in a commercial finite element software using the explicit formulation. Material separation is modeled via element failure. The model is then validated using the measured cutting and thrust forces and used to study the energy consumed in cutting. As the thickness of layer removed is reduced the energy consumed in material separation becomes important. Simulations also show that the stress state ahead of the tool is favorable for ductile fracture to occur. Ductile fracture in three locations in an interface zone at the chip root is seen while cutting with edge radius tool. A hypothesis is advanced wherein an element gets wrapped around the tool edge and is stretched in two directions leading to fracture. The numerical model is then used to study the difference in stress state and energy consumption between a sharp tool and a tool with a non-zero edge radius.

The International Technology Roadmap for Semiconductors (ITRS) predicts that microprocessor power consumption will continue to increase in the foreseeable future. It is also well known that microprocessor performance can be improved by lowering the junction temperature: recent analytical studies show that for a power limited chip, there is a non-linear scaling effect that offers a 4.3x performance enhancement at -100 °C, compared to 85 °C operation. Vapor Compression Refrigeration (VCR) is a sufficiently compact, low cost, and power efficient technology for reducing the junction temperature of microprocessors below ambient, while removing very high heat fluxes via phase change. The current study includes a scaling analysis of single- and multiple-stage VCR systems for electronics cooling and an experimental investigation of small-scale, two-stage cascaded VCR systems. In the scaling analysis, a method for estimating the size of single- and multiple-stage VCR systems is described, and the resulting trends are presented. The compressor and air-cooled condenser are shown to be by far the largest components of the system, dwarfing the evaporator, expansion device, and inter-stage heat exchanger. For systems utilizing off-the-shelf components and removing up to 200 W at evaporator temperatures as low as 173 K, compressor size dominates the system and scales with the compressor s motor. The air-cooled condenser is the second largest component, and its size is constrained by the air-side heat transfer coefficient. In the experimental work, a two-stage cascaded VCR system with a total volume of 60000 cm3 is demonstrated that can remove 40 W at -61 °C.