Cette thèse est consacrée à une enquête sur la structure et la dynamique, avec des modèles théoriques et essais de laboratoire, sur deux types communs de défauts arrivant dans la molécule d’ADN, après des dégâts de radiation ou le produit chimique: mésappariements des base(MB) et casseurs de brin.Tels défauts pourraient arriver naturellement, d’imperfections dans le processus cellulaire, induit par l’environnement et ou induit artificiellement, comme pour la radiothérapie de cancer. Nous avons utilisé la spectroscopie de force moléculaire exécutée par des pinces optiques accompagnées par des simulations all-atom en Dynamique Moléculaire (MD), pour caractériser des MB dans des hairpin d’ADN. Ensuite nous avons construit des modèles structurels pour les casseurs de brin d’ADN, dans les deux indexent les éléments constitutifs de la chromatine: le ADN linker et le nucléosome. Grâce à l'application de diffèrent techniques (Essential Dynamics, Steered MD, …) on a caractérisé les stades précoces de l’évolution de cette lésion d’ADN dans les deux éléments. / This thesis is dedicated to a combined theoretical and experimental investigation of the structure and dynamics of two common types of defects occurring in the DNA molecule, after chemical or radiation damage: basemismatches and strand breaks. We used single-molecule force spectroscopy performed by optical tweezers accompanied by Molecular Dynamics (MD) all-atom simulations, to characterize mismatches in short DNA hairpins. We demonstrate that it is possible to use SMFS. Subsequently, we designed structural models for the DNA strand-break defects, in the two key constitutive elements of the chromatin: the DNA linker and the nucleosome. Using different techniques (Essential Dynamics, steered MD, covariant mechanical stress, …) we characterized the early stages of the evolution of this DNA lesion in the two elements.

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Ten years ago, J. Villadsen constructed the first examples of simple C*-algebras with stable rank other than one or infinity. Villadsen's examples all had a unique tracial state. It is natural to ask whether examples can be found of simple C*-algebras with higher stable rank and more than one tracial state; by building on Villadsen's construction, we describe such examples that admit arbitrary tracial state spaces.

Ambient explores the role of the viewer within an artistic situation. By combining function with sculptural form I am presenting a situation designed for interpretation, whether it is visual, tactile, or purely conceptual. Ambient is an opportunity for the viewer, or reader, to access all aspects of the work I create.

Ten years ago, J. Villadsen constructed the first examples of simple C*-algebras with stable rank other than one or infinity. Villadsen's examples all had a unique tracial state. It is natural to ask whether examples can be found of simple C*-algebras with higher stable rank and more than one tracial state; by building on Villadsen's construction, we describe such examples that admit arbitrary tracial state spaces.

In this thesis, we propose a simple trench oxide layer polysilicon thin-film Transistor (TO TFT) process and the self-heating effects can be significantly reduced because of its structural advantages. According to the ISE-TCAD simulation results, our proposed TO TFT structure has novel features as follows: 1. The buried oxide and the isolation oxide are carried out simultaneously in order to achieve a goal of simple process. 2. The trench design is used to improve both the sensing current windows (~ 84%) and the retention time (~ 57%). 3. The thermal stability is drastically improved by its naturally formed source/drain tie. The above mentioned features help our proposed device structure to demonstrate the desired characteristics that are better than that of a conventional TFT. Additionally, the thermal instability is drastically improved which is good for long-term device operation.

Product design affects many aspects of people¡¦s life. This research use qualitative and quantitative methods, and focus on how simple design cause different consumer responses. First of all, we process a content analysis aiming for household and digital product, and then we conduct the definition and characteristics of simple design. Second, we use experimental design to figure out the pattern of consumer responses to product design both psychological and physical. For psychological responses, we observe the consumer expectation and satisfaction in product appearance, assortment size and functional information; we also exam the different decision making tendency (Maximizer & Satisficer) in consumer approach behavior. According to our research, we conclude that the required elements of simple design are (1) Single Color, (2) Unique Personality, (3) Simple Shapes, (4) Practical Function, (5) Easy to Use, (6) Match, (7) Materials, (8) Aesthetics and (9) Culture & Emotion. For product external appearance, there is high expectation for simple design, and also satisfaction still has a big room to improve. To be more specific, in the aspects of attention drawing, unique symbol and ergonomic is the biggest gap between expectation and satisfaction. In the part of assortment size, simple design causes a higher expectation when the size is large. However, satisfaction did not drop as previous studies suggested, it remains indifferent which could be the suggestion for future product development. In function information, it plays a important role in digital product which means mainly simple designed appearance can only achieve limited benefits. In behavioral response, satisfaction and approach behavior have positive relation, and the responses of store are apparently stronger than the responses of single product. In different decision making tendency, product personality, attention drawing and assortment size are significant, but there is no clear result for function information.

Heat transfer and fluid flow are studied numerically for a repeating microchannel array with water as the circulating fluid. Generalized transport equations are discretized and solved in three dimensions for velocities, pressure, and temperature. The SIMPLE algorithm is used to link pressure and velocity fields, and a thermally repeated boundary condition is applied along the repeating direction to model the repeating nature of the geometry. The computational domain includes solid silicon and fluid regions. The fluid region consists of a microchannel with a hydraulic diameter of 85.58μm. Independent parameters that were varied in this study are channel aspect ratio and Reynolds number. The aspect ratios range from 0.10 to 1.0 and Reynolds number ranges from 50 to 400. A constant heat flux of 90 W/cm2 is applied to the northern face of the computational domain, which simulates thermal energy generation from an integrated circuit. A simplified model is validated against analytical fully developed flow results and a grid independence study is performed for the complete model. The numerical results for apparent friction coefficient and convective thermal resistance at the channel inlet and exit for the 0.317 aspect ratio are compared with the experimental data. The numerical results closely match the experimental data. This close matching lends credibility to this method for predicting flows and temperatures of water and the silicon substrate in microchannels. Apparent friction coefficients linearly increase with Reynolds number, which is explained by increased entry length for higher Reynolds number flows. The mean temperature of water in the microchannels also linearly increases with channel length after a short thermal entry region. Inlet and outlet thermal resistance values monotonically decrease with increasing Reynolds number and increase with increasing aspect ratio. Thermal and friction coefficient results for large aspect ratios (1 and 0.75) do not differ significantly, but results for small aspect ratios (0.1 and 0.25) notably differ from results of other aspect ratios.

A group G is called locally finite if every finitely generated subgroup of G is finite. In this thesis we study the centralizers of subgroups in simple locally finite groups. Hartley proved that in a linear simple locally finite group, the fixed point of every semisimple automorphism contains infinitely many elements of distinct prime orders. In the first part of this thesis, centralizers of finite abelian subgroups of linear simple locally finite groups are studied and the following result is proved: If G is a linear simple locally finite group and A is a finite d-abelian subgroup consisting of semisimple elements of G, then C_G(A) has an infinite abelian subgroup isomorphic to the direct product of cyclic groups of order p_i for infinitely many distinct primes pi. Hartley asked the following question: Let G be a non-linear simple locally finite group and F be any subgroup of G. Is CG(F) necessarily infinite? In the second part of this thesis, the following problem is studied: Determine the nonlinear simple locally finite groups G and their finite subgroups F such that C_G(F) contains an infinite abelian subgroup which is isomorphic to the direct product of cyclic groups of order pi for infinitely many distinct primes p_i. We prove the following: Let G be a non-linear simple locally finite group with a split Kegel cover K and F be any finite subgroup consisting of K-semisimple elements of G. Then the centralizer C_G(F) contains an infinite abelian subgroup isomorphic to the direct product of cyclic groups of order p_i for infinitely many distinct primes p_i.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2009. / Härtill 4 uppsatser.