Zhao, Jin. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2008. / Includes bibliographical references (leaves 79-83). / Abstracts in English and Chinese. / Abstract --- p.i / Acknowledgement --- p.iii / Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Synchronization of Master-slave Systems --- p.1 / Chapter 1.2 --- Output Regulation --- p.2 / Chapter 1.3 --- Typical Nonlinear Systems --- p.4 / Chapter 1.4 --- Organization --- p.4 / Chapter 2 --- Synchronization of Chua's Circuit and Van der Pol Oscillator via Inter- nal Model Approach --- p.6 / Chapter 2.1 --- Introduction --- p.6 / Chapter 2.2 --- Problem Formulation --- p.8 / Chapter 2.3 --- Preliminaries --- p.10 / Chapter 2.4 --- Solvability of the Problem --- p.13 / Chapter 2.4.1 --- The solution of the regulator equations --- p.14 / Chapter 2.4.2 --- Steady-state generator --- p.15 / Chapter 2.4.3 --- Internal model --- p.19 / Chapter 2.4.4 --- Stabilization --- p.20 / Chapter 2.4.5 --- Simulation --- p.22 / Chapter 2.5 --- Conclusions --- p.27 / Chapter 3 --- Robust Output Regulation of Output Feedback Systems with Nonlinear Exosystems --- p.28 / Chapter 3.1 --- Introduction --- p.28 / Chapter 3.2 --- Assumptions and Preliminaries --- p.29 / Chapter 3.3 --- Solvability of the Synchronization Problem --- p.33 / Chapter 3.4 --- Comparing Two Approaches for Output Regulation --- p.42 / Chapter 3.4.1 --- Differences between the two approaches for the output regulation problem --- p.42 / Chapter 3.4.2 --- Solvability of the regulator equations --- p.43 / Chapter 3.4.3 --- Solvability of stabilization --- p.47 / Chapter 3.5 --- Conclusions --- p.49 / Chapter 4 --- Applications of Robust Regional Synchronization via Output Regulation Techniques --- p.50 / Chapter 4.1 --- Problem Formulation --- p.50 / Chapter 4.2 --- Duffing Oscillator Synchronizes with Chua's Circuit --- p.51 / Chapter 4.2.1 --- Transfer the synchronization problem into the stabilization problem --- p.53 / Chapter 4.2.2 --- Boundedness of Chua's circuit --- p.57 / Chapter 4.2.3 --- Stabilization --- p.59 / Chapter 4.2.4 --- Simulation Results --- p.64 / Chapter 4.3 --- The Chaotic SMIB Power System Synchronizes with Van der Pol Oscillator --- p.64 / Chapter 4.3.1 --- Transfer the synchronization problem into the stabilization problem --- p.68 / Chapter 4.3.2 --- Stabilization --- p.71 / Chapter 4.3.3 --- Simulation Results --- p.74 / Chapter 4.4 --- Conclusions --- p.76 / Chapter 5 --- Conclusions --- p.77 / Bibliography --- p.79

O presente experimento foi realizado com o objetivo de avaliar o impacto da inseminação artificial em tempo fixo (IATF) na eficiência reprodutiva de vacas de leite de alta produção inseminadas no período pós-parto. Vacas Holandesas com média de 50 dias pós-parto foram distribuídas homogeneamente em um de dois grupos experimentais, levando em consideração a presença ou ausência de corpo lúteo (CL), o escore de condição corporal e a produção de leite. No grupo Controle (G-Controle; n = 490), as vacas foram submetidas à observação do comportamento de aceitação de monta (duas vezes ao dia por uma hora) e inseminadas 12 horas após a primeira detecção. No grupo IATF (G-IATF; n = 495), as vacas receberam um implante auricular de norgestomet, mantido por oito dias, e 2 mg de benzoato de estradiol IM no dia 0 (D0; dia aleatório do ciclo estral). No momento da retirada do implante (D8) foram administrados 150 µg de prostaglandina F2α, 400 UI de gonadotrofina coriônica eqüina e 1 mg de cipionato de estradiol. A IATF foi realizada de 54 a 56 h após a retirada do implante auricular, concomitante à administração de 100 µg de gonadorelina. Após a IATF, as vacas foram submetidas à observação de cio com subseqüente inseminação, seguindo os mesmos critérios descritos para o G-Controle. Amostras de sangue foram colhidas de um subgrupo de animais (G-Controle, n = 50; G-IATF, n = 58) 5 e 11 dias após a primeira inseminação artificial (IA) para dosagem de progesterona (P4) circulante. Todos os animais foram mantidos no experimento até a terceira IA ou 150 dias após o parto e os tratamentos foram realizados no inverno e no verão. O diagnóstico de gestação foi realizado aos 30 dias pós-IA por ultrassonografia e aos 60 dias pós-IA por palpação transretal. Os dados binomiais foram analisados por regressão logística utilizando o PROC GLIMMIX e as variáveis contínuas por ANOVA utilizando PROC GLM do SAS. Não se verificou interação entre estação do ano e tratamento na análise das taxas de concepção, perda gestacional, intervalo entre IAs, intervalo parto-concepção (IPC) e taxa de prenhez aos 150 dias pós-parto. Os resultados são indicativos de que não existem diferenças nas taxas de concepção entre os diferentes grupos após as IAs (primeira, segunda e terceira). A perda gestacional relativa à primeira IA foi maior nas vacas do G-IATF. Os intervalos parto-primeira IA, parto-segunda IA e parto-concepção foram inferiores para as vacas do G-IATF. Entretanto, o intervalo entre a primeira e a segunda IA foi maior para o G-IATF. Não houve diferença na taxa de prenhez aos 150 dias entre os grupos. Ainda, a taxa de serviço (TS) nos primeiros 21 dias após o período voluntário de espera (PVE) foi maior para o grupo IATF. Entretanto, a TS entre 21 e 42 dias após o PVE foi maior para o G-Controle. As concentrações circulantes de P4 não diferiram entre os grupos e as estações do ano. Concluiu-se que o emprego da IATF 60 dias pós-parto foi eficiente para diminuir o IPC. Contudo, a porcentagem de vacas prenhes aos 150 pós-parto foi semelhante entre os dois tratamentos (Controle e IATF) / The aim of the present study was evaluate the impact of fixed-time artificial insemination (FTAI) on reproductive efficiency of high-producing dairy cows inseminated during the postpartum period. Holstein cows with average 50 days in milk were allocated to one of two groups considering the presence or absence of corpus luteum (CL), body condition score and milk production. On Control group (Control-G; n = 490), the cows were submitted to estrus detection twice per day for one h and were inseminated 12 hours after the first detection. On FTAI group (FTAI-G; n = 495), the cows received a norgestomet ear implant (kept for eight days) plus administration of 2 mg of estradiol benzoate i.m. on Day 0 (random day of the estrous cycle). The implant was removed on Day 8 followed by FTAI 54 to 56 h later and the administration of 100 µg of gonadorelin. On Day 8, cows received 400 IU eCG, 150 &micro:g of prostaglandin F2α and 1 mg of estradiol cypionate. After FTAI, cows were submitted to estrus detection and artificial insemination (AI) 12 h after. Blood samples were collected from a subset of animals (Control-G, n = 50; FTAI-G, n = 58) on Day 5 and 11 after the first AI to investigate serum progesterone concentration (P4). All animals were maintained on the experiment until 150 days post-partum and the treatments were conducted during the winter and summer. Pregnancy diagnosis was performed by ultrasonography 30 days after AI (Day 30) and by rectal palpation 60 days after AI (Day 60). Binomial data were analyzed by logistic regression using the PROC GLIMMIX and continuous variables by ANOVA using PROC GLM of SAS. No interaction was found between season and treatment when conception rate, pregnancy loss, interval between inseminations, interval from calving to conception and pregnancy rate 150 post-partum were analysed. The results indicate no differences on conception rate among both experimental groups after AI (first, second and third). However, the interval from calving to first and second AI and interval from calving to conception were lower on FTAI-G. No difference on pregnancy rate 150 days post-partum was found among groups. Pregnancy loss after first AI was greater on FTAI-G. The interval from calving to first AI, from calving to second AI and the interval from calving to conception were shorter on FTAI-G. However, the interval between first and second AI was longer on FTAI-G. There was no difference on pregnancy rate 150 days post-partum among treatments. Also, the service rate (SR) 21 days after the voluntary waiting period (VWP) was greater on FTAI-G compared to Control-G. Conversely, the SR was lower between 21 and 42 days after the VWP on FTAI-G. No difference was found in serum concentration of P4 among treatment groups and season. Thus, the use of FTAI 60 days post-partum was efficient to anticipate the conception of high-producing dairy cattle by reducing the interval from calving to conception, but did not increase the pregnancy rate 150 days post-partum

O objetivo deste trabalho foi determinar a eficiência do LH suíno, em dosagens reduzidas em relação à dose tradicional de 5,0mg, no processo de sincronização da ovulação em fêmeas cíclicas. Foram tratadas 115 fêmeas das raças Landrace e Large White, com ordem de parto variando de 1 a 6 e escore corporal acima de 2 dentro de uma escala de 1-5, com variação de meio ponto. A detecção do cio foi realizada duas vezes ao dia, no início da manhã e no final da tarde, através do reflexo positivo de tolerância ao macho. As fêmeas foram divididas aleatoriamente em três tratamentos, com 600UI de eCG ao desmame e 2,5 (T1), 1,25 (T2) e 0,625mg (T3) de LH, 56 horas após a injeção de eCG. O grupo controle não recebeu a administração de LH. A ocorrência da ovulação foi determinada pela ultra-sonografia trans-retal. Os dados foram reavaliados de acordo com o número de inseminações em 1 e 2 inseminações. As fêmeas foram abatidas 96 horas após a ovulação, com a finalidade de proceder com a contagem do número de corpos lúteos e a colheita de embriões. O intervalo entre a aplicação do LH e a ocorrência da ovulação (IA-OV), nos três tratamentos foi de 41,0±5,9, 56,0±17,0, 58,2±18,8 respectivamente e 62,9±14,8 para o grupo controle. A melhor sincronização da ovulação (p<0,05, teste de Bartlett), ocorreu no T1, o qual corresponde a dose de LH de 2,5mg. Os resultados quanto ao número de inseminações, taxa de fertilização e viabilidade embrionária, não diferiram estatisticamente entre os tratamentos, porém, quando o intervalo (IA-OV) foi maior que 24 horas, a taxa de fecundação e viabilidade embrionária sofreram uma diminuição em comparação com os intervalos menores do que 24 horas (p<0,05). Os protocolos hormonais não influenciaram quanto ao número de cistos ovarianos (p<0,05, teste de Tukey). Conclui-se que a utilização da dose de LH de 2,5mg sincroniza a ovulação e pode ser aplicada em programas de IATF e que a realização de 1 inseminação artificial até 24 horas antes da ovulação em tempo fixo não deprecia a taxa de fecundação e o número de embriões viáveis / This work had as purpose the determination of the efficiency of the LH swine, in reduced dosage against the traditional 5,0mg dose, in the process of synchronization of the ovulation in cyclical females. There were treated 115 females of Landrace and Large White races, with average parity number varying from 1 to 6 and corporal sustain above 2 among 1 to 5 scale, with variation of half point. The detection of the heat was accomplished twice a day, in the beginning of the morning and at the end of the afternoon, through the positive reflex of tolerance to the male. The females were randomly divided in three treatments, with 600UI of eCG by the weaning and 2,5 (T1), 1,25 (T2) and 0,625mg (T3) of LH, 56 hours after the eCG injection. The control group didn\'t receive the LH administration. The occurrence of the ovulation was determined by the trans-rectal ultrasonography. The data were revalued according to the number of inseminations in 1 and 2 inseminations. The females were slaughtered 96 hours after the ovulation, with the purpose of proceeding with the counting of the number of corpora lutea and the recovered embryos. The interval between the LH application and the occurrence of the ovulation (IA-OV), in the three treatments was of 41,0±5,9, 56,0±17,0, 58,2±18,8 respectively and 62,9±14,8 for the control group. The best ovulation synchronization (p <0,05, test of Bartlett) happened in T1, which corresponds to the LH 2,5mg dose. The results concerning the number of inseminations, fertilization rate and embryonic viability, didn´t differ statistically among the treatments, however, when the interval (IA-OV) was over 24 hours, the fecundation rate and embryonic viability decreased if compared with the intervals shorter than 24 hours (p<0,05). The hormonal protocols didn´t cause influence as to the ovarian cysts number (p<0,05, test of Tukey). It´s conclusive that the use of the LH 2,5mg dose synchronizes the ovulation and it can be applied in IATF programs, and that accomplishment of 1 artificial insemination up to 24 hours before the ovulation in fixed time doesn´t depreciate the fecundation rate and the number of viable embryos

Synchronization of an ensemble of oscillators is an emergent phenomenon present in several complex systems, ranging from biological and physical to social and technological systems. The most successful approach to describe how coherent behavior emerges in these complex systems is given by the paradigmatic Kuramoto model. For decades, this model has been traditionally studied in globally coupled topologies. However, besides being intrinsically dynamical, complex systems exhibit very heterogeneous structure, which can be represented as complex networks. This thesis is dedicated to the investigation of fundamental problems regarding the collective dynamics of Kuramoto oscillators coupled in complex networks. First, we address the effects on network dynamics caused by the presence of triangles, which are structural patterns that permeate real-world networks but are absent in random models. By extending the heterogeneous degree mean-field approach to a class of configuration model that generates random networks with variable clustering, we show that triangles weakly affect the onset of synchronization. Our results suggest that, at least in the low clustering regime, the dynamics of clustered networks are accurately described by tree-based theories. Secondly, we analyze the influence of inertia in the phases evolutions. More precisely, we substantially extend the mean-field calculations to second-order Kuramoto oscillators in uncorrelated networks. Thereby hysteretic transitions of the order parameter are predicted with good agreement with simulations. Effects of degree-degree correlations are also numerically scrutinized. In particular, we find an interesting dynamical equivalence between variations in assortativity and damping coefficients. Potential implications to real-world applications are discussed. Finally, we tackle the problem of two intertwined populations of stochastic oscillators subjected to asymmetric attractive and repulsive couplings. By employing the Gaussian approximation technique we derive a reduced set of ODEs whereby a thorough bifurcation analysis is performed revealing a rich phase diagram. Precisely, besides incoherence and partial synchronization, peculiar states are uncovered in which two clusters of oscillators emerge. If the phase lag between these clusters lies between zero and π, a spontaneous drift different from the natural rhythm of oscillation emerges. Similar dynamical patterns are found in chaotic oscillators under analogous couplings schemes. / Sincronização de conjuntos de osciladores é um fenômeno emergente que permeia sistemas complexos de diversas naturezas, como por exemplo, sistemas biológicos, físicos, naturais e tecnológicos. A abordagem mais bem sucedida na descrição da emergência de comportamento coletivo em sistemas complexos é fornecida pelo modelo de Kuramoto. Durante décadas, este modelo foi tradicionalmente estudado em topologias completamente conectadas. Entretanto, além de ser intrinsecamente dinâmicos, tais sistemas complexos possuem uma estrutura altamente heterogênea que pode ser apropriadamente representada por redes complexas. Esta tese é dedicada à investigação de problemas fundamentais da dinâmica coletiva de osciladores de Kuramoto acoplados em redes. Primeiramente, abordamos os efeitos sobre a dinâmica das redes causados pela presença de triângulos padrões que estão omnipresentes em redes reais mas estão ausentes em redes gerados por modelos aleatórios. Estendemos a abordagem via campo-médio para uma variação do modelo de configuração tradicional capaz de criar topologias com número variável de triângulos. Através desta abordagem, mostramos que tais padrões estruturais pouco influenciam a emergência de comportamento coletivo em redes, podendo a dinâmica destas ser descrita em termos de teorias desenvolvidas para redes com topologia local semelhante a grafos de tipo árvore. Em seguida, analisamos a influência de inércia na evolução das fases. Mais precisamente, generalizamos cálculos de campo-médio para osciladores de segunda-ordem acoplados em redes sem correlação de grau. Demonstramos que na presença de efeitos inerciais o parâmetro de ordem do sistema se comporta de forma histerética. Ademais, efeitos oriundos de correlações de grau são examinados. Em particular, verificamos uma interessante equivalência dinâmica entre variações nos coeficientes de assortatividade e amortecimento dos osciladores. Possíveis aplicações para situações reais são discutidas. Finalmente, abordamos o problema de duas populações de osciladores estocásticos sob a influência de acoplamentos atrativos e repulsivos. Através da aplicação da aproximação Gaussiana, derivamos um conjunto reduzido de EDOs através do qual as bifurcações do sistema foram analisadas. Além dos estados asíncrono e síncrono, verificamos a existência de padrões peculiares na dinâmica de tal sistema. Mais precisamente, observamos a formação de estados caracterizados pelo surgimento de dois aglomerados de osciladores. Caso a defasagem entre estes grupos é inferior a π, um novo ritmo de oscilação diferente da frequência natural dos vértices emerge. Comportamentos dinâmicos similares são observados em osciladores caóticos sujeitos a acoplamentos análogos.

Electronic gadgets such as touchpads and smartphones are becoming more popular in business and everyday life. The main advantage of mobile devices over personal computers is their portability. Cellular data plans allow Internet access without having permanent access point. There is a number of web-based applications available for gadgets. The primary goal of these apps is to provide their services through constant Internet access. However, it may affect the operation of both devices and applications. The objective of this thesis is to find a better way of client/server data synchronization in iOS development that can reduce the negative consequences of constant Internet access such as Internet traffic consumption, reduced battery life and cover area limitation of cellular services. As the result of the conducted research, the "FollowQTM" application was developed. Despite the fact, that the application is synchronized with web server, it does not require constant Internet access to operate.

We describe a set of fundamental contributions to the design, analysis and implementation of distributed MIMO techniques in wireless networks. The main idea behind distributed MIMO is to organize groups of wireless transmitters and receivers into distributed antenna arrays to cooperatively achieve beamforming and spatial multiplexing gains in ad-hoc wireless networks. This technique promises orders-of-magnitude increases in wireless data rates, however it presupposes very stringent timing, carrier frequency and phase synchronization of the RF signals between the cooperating nodes in the array. Specifically in this dissertation, we consider a sub-class of distributed MIMO systems called distributed MISO systems. In other words, we focus on distributed transmit arrays, wherein a group of N transmitters organize themselves into a virtual antenna array (VAA) to talk to a single-antenna receiver. While distributed MIMO involves virtual arrays on both transmit and receive ends, transmit arrays require real-time coordination, and therefore present unique challenges as compared to receive arrays. We explore two specific MISO techniques: i) distributed beamforming and ii) distributed nullforming in this work. Beamforming involves focusing transmitted energy selectively in the direction of an intended receiver, and nullforming involves forming a "null" i.e. having the transmissions of the different array nodes cancel each other completely at a desired location. Beamforming has the potential of substantially increasing the energy efficiency of wireless communications, while nullforming allows multiple nodes to communicate simultaneously over the same frequency band by carefully canceling the resulting interference. Beamforming and nullforming can also be thought of as basic building blocks for more sophisticated MIMO techniques. In this work, we present a set of frequency synchronization and phase control algorithms to establish and maintain a VAA for distributed beamforming and nullforming. For frequency-locking, we propose a novel distributed consensus-based algorithm. For a VAA with two nodes, we show that our algorithm achieves frequency lock globally and exponentially with a residual phase disparity that is either 0 or pi. This is in contrast to PLL-like algorithms that only achieve lock locally. Next, we describe in detail the key ideas behind an implementation of distributed beamforming on a GNU-radio/USRP based software-defined radio (SDR) platform. We introduce a novel DSP-centric Master-Slave (MS) architecture that enables the use of low-rate DSP algorithms for synchronization of high frequency RF signals. We describe the evolution of our implementation from initially using analog signaling with Costas loops/PLLs for frequency offset estimation and compensation, to a digital signaling scheme that uses extended Kalman filters (EKF) to track and compensate for frequency offsets. The EKF-based frequency locking scheme is well-suited for packet wireless networks, e.g., WiFi, ZigBee. We next consider phase control algorithms for forming beams and nulls with a VAA. In our experimental implementation, we have used several variants of classical 1-bit feedback control algorithm during different stages of our work. 1-bit feedback algorithm is an iterative gradient-ascent algorithm which causes the VAA nodes' signals to add constructively at a designated receiver. We present results to demonstrate the gains in the RSS at the receiver due to beamforming in the real-time settings. We also describe a distributed gradient-descent based algorithm that causes VAA nodes to achieve a null at a designated null target. We provide detailed convergence analysis for the proposed null-steering algorithm. This analysis shows that the algorithm always achieves practical null at null-target; moreover, all the spurious stationary points are locally unstable. Finally, we conclude by providing suggestions for future work.

The nematode Caenorhabditis elegans is a model organism for understanding sensory molecules of multicellular organisms. Ovulating hermaphrodites produce putative pheromone(s) that cause male attraction. Because pheromones are produced in such small quantities, adult conditioned-media from large-scale synchronous culture is necessary to analyze these pheromones. Current protocols for culture synchronization have volume constraints that limit large-scale synchronous cultures and current methodology for adult conditioned-media production is impractical. Modification of Tangential Flow Filtration (TFF) systems was investigated for use as a method to increase the volume limits of bleach egg harvest for C. elegans culture synchronization. Also, an adult retention device built within the culture vessel was investigated to optimize the environment for aseptic conditioned-media production from dense large-scale C. elegans cultures. During this investigation, we have shown that synchronous C. elegans cultures for adult conditioned-media production can be grown at scales larger than reported before, with potential for further scale up. Our growth methodologies have also yielded denser cultures than previously achieved at large scales. Since rapid bleach harvesting appears to be the bottleneck for large-scale production of synchronous C. elegans cultures, our approach of using modified TFF systems with mesh to retain C. elegans eggs increased the amount of eggs that could be bleach harvested at one time. Using this method we have been able to achieve up to 5x103 synchronous C. elegans per mL at a 50L scale. Since scale-up of TFF is straightforward, our results suggest that the technique reported here can easily be applied to larger scale systems for production of adult conditionedmedia from C. elegans. Further, the adult retention device within the culture vessel can ensure that the whole process remains aseptic.

Estrous synchronization and artificial insemination (ESAI) are reproductive technologies that cattlemen can use to improve the reproductive performance of their herds. Controlling the gender ratio of the calf-crop can also improve the opportunity for increased revenue and profit. Producers are able to shift and/or control the gender ratio of their calf crop by incorporating sex-sorted semen into their AI programs. However, decreased conception rates to AI have been previously observed when sex-sorted semen was used in comparison to conventional semen of the same sires. The objective of the first study was to determine if conception rates will differ in females inseminated with conventional semen or SexedULTRA™ sex-sorted semen when estrus is synchronized using an industry-standard, 7-d CO-Synch + Controlled Internal Drug Release (CIDR) protocol for fixed-time artificial insemination (FTAI). The objective of the second study was to determine if conception rate to FTAI differs between SexedULTRA™ sex-sorted and conventional semen when yearling beef heifers are synchronized using a 14-d controlled internal drug release (CIDR) - PGF2α (PGF) protocol modified to optimize the control of ovulation and timing of insemination.

No description available.

Contexte : […], le mode d'interaction entre les signaux corticaux et striataux reste flou. Dans la présente thèse, nous avons d’abord saisi l’opportunité d’enregistrements stéréoélectroencéphalographiques chez des patients atteints d’épilepsie pharamcorésistante pour analyser qualitativement et quantitativement l’activité ictale du striatum. Deuxièmement, nous avons créé un modèle primate de crises motrices focales sous-corticales induites par des injections striatales antagonistes GABAergiques. Première étude : Patients et méthode : onze patients ayant subi une évaluation SEEG ont été inclus prospectivement s'ils remplissaient deux critères d'inclusion: i) au moins un contact explorait le striatum, ii) au moins deux crises avaient été enregistrées. Les régions d'intérêt corticales et sous-corticales ont été définies et différentes périodes d'intérêt ont été analysées. Les signaux SEEG ont été inspectés visuellement et une analyse de corrélation non linéaire h2 a été réalisée pour étudier la connectivité fonctionnelle entre les régions corticales d’intérêt et le striatum. Résultats : Deux patterns principaux d'activation striatale ont été enregistrés : le plus fréquent était caractérisé par une activité alpha / bêta précoce débutant dans les cinq premières secondes suivant le début de la crise. Le second était caractérisé par une activité thêta / delta tardive plus lente. Une différence significative des indices de corrélation h2 a été observée au cours de la période préictale et début de crise par rapport au tracé de fond pour l'indice striatal global, l'indice mésio-temporal / striatal, l'index latérotemporal / striatal, l'index insulaire / striatal, l'index préfrontal / striatal. En outre, une différence significative des indices de corrélation h2 a été observée pendant la période de fin de crise par rapport à toutes les autres périodes d’intérêt. Deuxième étude : Matériel et méthode : Des injections antagonistes aiguës de GABAergic (bicuculline) ont été réalisées sur trois Macaca fascicularis dans la partie sensorimotrice du striatum. Les modifications comportementales ont été enregistrées et scorées selon une échelle de Racine modifiée. L'électromyographie, l'électroencéphalographie, les potentiels de champ locaux des noyaux gris centraux ont été enregistrés au cours de chaque expérience. Une analyse de retromoyenage a été effectuée pour chaque session enregistrée. Résultats: sur les 39 injections de bicuculline, 29 (74,3%) ont produit des changements comportementaux reproductibles caractérisés par des secousses myocloniques répétitives et pseudopériodiques avec des crises tonico-cloniques généralisées. Les injections de NaCl n'ont jamais entraîné de changement de comportement. Les secousses myocloniques étaient clairement détectables sur le signal EMG sous la forme d'une courte bouffée stéréotypée concomitante de pointes épileptiques anormales enregistrées sur l'EEG. Une analyse de rétromoyennage à partir des myoclonies EMG a montré que l'activité électrophysiologique commençait significativement plus tôt dans le striatum (p <0,0001), le GPe (p <0,0003) et le GPi (p <0,0086) que dans le cortex. Conclusion : Ces modifications du niveau de synchronisation entre les activités corticales et striatales pourraient s’inscrire dans un mécanisme endogène contrôlant la durée des oscillations anormales au sein de la boucle striato-thalamo-corticale et, de fait leur terminaison. Les interneurones GABAergic de type fast-spiking pourraient jouer un rôle crucial dans la synchronisation du réseau cortico-striato-thalamique et une modification GABAergique brutale du striatum peut provoquer une crise focale. Le rôle joué par les noyaux gris centraux dans le renforcement des mécanismes sous-jacents à la cessation de la propagation ictale devrait inspirer de nouveaux schémas de stimulation cérébrale profonde chez les patients atteints d'épilepsies focales pharmacorésistantes non chirurgicales. / Background: Although a number of experimental and clinical studies have pointed out participation or an even more prominent role of basal ganglia in focal seizures, the mode of interaction between cortical and striatal signals remains unclear. In the present thesis, we first we took the opportunity of stereoelectroencephalographic recordings in drug-resistant epilepsy patients, to qualitatively and quantitatively analyse the ictal striatum activity. Secondly, we created a primate model of subcortical focal motor seizures induced by GABAergic antagonist striatal injections First study: Patients and method: eleven patients who underwent SEEG evaluation were prospectively included if they fulfilled two inclusion criteria: i) at least one orthogonal intracerebral electrode contact explored the basal ganglia, in their either putaminal or caudate part, ii) at least two SEEG seizures were recorded. Cortical and subcortical regions of interest were defined and different periods of interest were analysed. SEEG was visually inspected and h2 non-linear correlation analysis performed to study functional connectivity between cortical region of interest and striatum. Results: Two main patterns of striatal activation were recorded: the most frequent was characterised by an early alpha/beta activity that started within the first five second after seizure onset. The second one was characterised by a late slower, theta/delta activity. A significant difference in h2 correlation indexes was observed during the preictal and seizure onset period compared to background for global striatal index, mesio-temporal/striatal index, latero-temporal/striatal index, insular/striatal index, prefrontal/striatal index. In addition, a significant difference in h2 correlation indexes was observed during the seizure termination period compared to all the other periods of interest. Second study: Material and method: Experiments were performed on three fascicularis monkeys. Acute GABAergic antagonist (bicuculine) injections were performed within the sensorimotor part of the striatum. Behavioural modifications were recorded and scored according to a modified Racine’s scale. Electromyography, electroencephalography, basal ganglia local field potentials were recorded during each experiment. A backaveraging analysis was performed for each recorded session. Results: over the 39 Bicuculline injections, 29 (74.3%) produced dramatic reproducible behavioural changes characterised by repetitive and pseudo-periodic myoclonic jerks with generalised tonic-clonic seizures. NaCl injections never produced any behavioural changes. Myoclonic jerks were clearly detectable on the EMG signal as short stereotypical EMG burst concomitant from abnormal epileptic spikes recorded on EEG. Back averaging analysis from EMG myoclonia showed that electrophysiological activity started significantly earlier in the striatum (p < 0.0001), the GPe (p < 0.0003) and the GPi (p < 0.0086) than in the cortex. Conclusion: These changes in synchronisation level between cortical and striatal activity might be part of an endogenous mechanism controlling the duration of abnormal oscillations within the striato-thalamo-cortical loop and thereby their termination. GABAergic fast-spiking interneurones might play a crucial role synchronising the cortico-striato-thalamic network and a drastic GABAergic modification of the striatum can induce focal seizures. The role of the basal ganglia role in strengthening mechanisms underlying cessation of ictal propagation should inspire new rationales for deep brain stimulation in patients with intractable focal epilepsy.