In all past research, iconic memory shows a significant benefit over visual working memory for storage capacity of visual items. However, this effect has only been studied on simple items such as colors and letters. The goal of this thesis was to determine whether an iconic benefit also exists for visual stimuli with higher visual complexity, such as shapes and faces. Five experiments tested iconic and working memory capacity for complex face stimuli, intermediate-complexity shape stimuli, and simple color stimuli, as well as examining feature binding of objects in iconic memory. Results from these five experiments indicated that increased visual complexity of stimuli negatively impacts the iconic capacity benefit. High- and intermediate-complexity items had little to no iconic benefit, unlike all previously tested simple stimuli. Iconic memory may only be able to represent simple features, or may not be able to transfer complex information into visual working memory as quickly as simple information. Additionally, results showed that feature representations in iconic memory were sometimes bound into complex objects. The results of these five experiments challenge the traditional characterization of visual sensory memory as a precise snapshot; this early memory store may be more complex than a simple visual icon.

Research Doctorate - Doctor of Philosophy / It is well established that there are changes in cognition and in peripheral sensory mechanisms that occur with age. However, there is much less known about the cause of either change or indeed the relationship between age-related change in sensory processing and age-associated cognitive decline. Understanding these mechanisms could improve our capacity to devise strategies which could assist older adults in aging successfully. In this thesis, I aim to bridge a gap in our knowledge concerning the relationship between age-related change in sensory processing and age-associated cognitive decline by studying the effect of age on what can be considered an intermediary process, sensory memory (in the auditory modality). I continue this line of research by examining the relationship between auditory sensory memory and other types of memory for auditory information in young and older adults. To address these goals, I adopted a cognitive neuroscience approach, relating electrophysiological data to data derived from behavioural memory assessments. In the following thesis, I present a literature review, four studies, and a general discussion of results. Several waveforms of the auditory event-related potential (ERP), including N1, P2, repetition positivity (RP), and mismatch negativity (MMN) were studied. More specifically, in study 1, we looked at the effect of age on N1 and P2 amplitude. In study 2, we examined the conditions eliciting two repetition effects, RP and the MMN memory trace effect, in the auditory ERP of young adults. Studies 3 and 4 concerned the effect of age on RP and the relationship between RP and implicit memory for contextual information as well as explicit memory for auditory information. We concluded that i) age affects auditory sensory memory, ii) the potential relationship between auditory sensory memory and implicit memory for auditory information requires re-investigation, and iii) there is a relationship between auditory sensory memory and explicit memory for auditory information that is altered with age. That is, we concluded that RP occurring in the N1/P2 and MMN latency period indicates memory trace formation and that age affects RP amplitude (restricted to an anterior RP generator). In addition, we showed that RP may be related to implicit memory (priming) in both young and older adults. Across two studies, we found a positive correlation between the response to repetition in the ERP (due to RP activity) and explicit auditory verbal memory in young adults but a negative correlation in older adults. Therefore, although age-related change in RP could reflect the capacity of older adults to encode the context of auditory stimulation, this is potentially due to compensatory activity. We argue it is possible that implicit memory changes with age as a result of age-related change in explicit episodic memory. As a result of well established changes that occur in episodic memory with age, older adults may begin to rely on implicit memory as a source of memory more so than young adults. Our data shows that the implicit memory system may, as a result, favour content over contextual information. An important theme outlined in the discussion of results involves the idea that age-related changes in cognition that are commonly interpreted as cognitive deficits may in fact be beneficial in certain circumstances. We review our results in relation to cognitive theories of aging and find that several theories are applicable to the data, including the frontal hypothesis (incorporating the inhibitory deficit hypothesis), the information degradation hypothesis, and the speed of processing hypothesis. Future research in this area could focus on exploring whether top-down or bottom-up or influences primarily contribute to the age effect on auditory sensory memory and RP, as well as evaluating our hypothesis that the age-related change in RP may be beneficial for explicit item memory but detrimental for implicit contextual memory in older adults (i.e. compensatory mechanisms). While the studies presented in this thesis have provided the foundations guiding our understanding of these issues, researchers in the field of cognitive neuroscience are well equipped to resolve such questions in the future.

Transcranial direct current stimulation (tDCS) is a non-invasive form of brain stimulation which uses a very weak constant current to temporarily excite or inhibit activity in the brain area of interest via electrodes placed on the scalp, depending on the polarity and strength of the current. Presently, tDCS is being used as a tool to investigate frontal cognition in healthy controls and to improve symptoms in neurological and psychiatric patients. Relatively little research has been conducted with respect to tDCS and the auditory cortex (AC). The primary aim of this thesis was to elucidate the effects of tDCS on auditory sensory discrimination, assessed with the mismatch negativity (MMN) event-related potential (ERP). In the first pilot study, healthy participants were assessed in a randomized, double-blind, sham-controlled design, in which participants received anodal tDCS over the primary AC (2 mA for 20 minutes) in one session and ‘sham’ stimulation (i.e. no stimulation) in the other. Pitch MMN was found to be enhanced after receiving anodal tDCS, with the effects being evidenced in individuals with relatively low (vs. high) baseline amplitudes. No significant effects were seen with sham stimulation. A second study examined the separate and interacting effects of anodal and cathodal tDCS on MMN measures. MMN was assessed pre- and post-tDCS (2 mA, 20 minutes) in 2 separate sessions, one involving sham stimulation, followed by anodal stimulation, and one involving cathodal stimulation, followed by anodal stimulation. Only anodal tDCS over the AC increased pitch MMN in baseline-stratified groups, and while cathodal tDCS decreased MMN, subsequent anodal stimulation did not significantly alter MMNs. As evidence has shown that tDCS lasting effects may be dependent on N-methyl-D-aspartate (NMDA) receptor activity, a pharmacological study investigated the use of dextromethorphan (DMO), an NMDA antagonist, to assess possible modulation of tDCS’ effects on both MMN and working memory (WM) performance. The study involved four test sessions that compared pre- and post-anodal tDCS over the AC and sham stimulation with both DMO (50 mL) and placebo administration. MMN amplitude increases were only seen with anodal tDCS with placebo administration, not with sham stimulation, nor with DMO administration. In the sham condition, DMO decreased MMN amplitudes. Anodal tDCS improved WM performance in the active drug condition. Findings from this study contribute to the understanding of underlying neurobiological mechanisms mediating tDCS-sensory and memory improvements. As cognitive impairment has been proposed to be the core feature of schizophrenia disorder (Sz) and MMN is a putative biomarker of Sz, a pilot study was conducted to assess the effects of pre- and post-tDCS on MMN measures in 12 Sz patients, as well as WM performance. Temporal, frontal and sham tDCS were applied in separate sessions. Results demonstrated a trend for pitch MMNs to increase with anodal temporal tDCS, which was significant in a subgroup of Sz individuals with auditory hallucinations, who had low MMNs at baseline. Anodal frontal tDCS significantly increased WM performance, which was found to positively correlate with MMN-tDCS effects. The findings contribute to our understanding of tDCS effects for MMN-indexed sensory discrimination and WM performance in healthy participants and individuals with Sz disorder and may have implications for treatment of sensory processing deficits in neuropsychiatric illness.

Recently, research has begun to pay more attention to the cognitive functions associated with auditory perception. In this study, two tests are performed to investigate the correlation between the ability to recognise speech-in-noise and the performance of sensory memory, as well as to investigate whether the performance would improve during the sensory memory test. For measuring speech-in-noise, the Hagerman test was used. A random noise test to detect deviant noises was used to measure sensory memory. In total 16 participantstook part in the study (mean age=24.8125, SD=3.14), half of the group began with the Hagerman test, and the other half with the random noise test. Two different statistical analyses were performed on the data. For examining the correlation between the performance on the Hagerman test and the random noise test, a Pearson correlation was used. The results were as follows: p = 0.4962, r = -0.1835734. Observing the results, the tests did indicate a slight negative correlation regarding the r-value, but not a significant correlation. Thus, the analysis did not derive any significant results. The second analysis was a dependent t-test to examine whether there was an improvement in performance during the random noise test, as it was divided into four separate blocks. The analysis showed the following results: t = 1.0266, df = 28.943, p = 0.3131. These results were not significant, though observing the block graph might indicate a tendency for improvement. For further studies, the random noise test should perhaps be modified into an easier version. This is based upon the data, as many of the participants merely got a score above, or even below, chance. Further studiesshould also use a higher number of participants as well to increase the chance of receiving significant results from the tests.

Yes / The goal of this study was to investigate the reference frames used in perceptual encoding and storage of visual motion information. In our experiments, observers viewed multiple moving objects and reported the direction of motion of a randomly selected item. Using a vector-decomposition technique, we computed performance during smooth pursuit with respect to a spatiotopic (nonretinotopic) and to a retinotopic component and compared them with performance during fixation, which served as the baseline. For the stimulus encoding stage, which precedes memory, we found that the reference frame depends on the stimulus set size. For a single moving target, the spatiotopic reference frame had the most significant contribution with some additional contribution from the retinotopic reference frame. When the number of items increased (Set Sizes 3 to 7), the spatiotopic reference frame was able to account for the performance. Finally, when the number of items became larger than 7, the distinction between reference frames vanished. We interpret this finding as a switch to a more abstract nonmetric encoding of motion direction. We found that the retinotopic reference frame was not used in memory. Taken together with other studies, our results suggest that, whereas a retinotopic reference frame may be employed for controlling eye movements, perception and memory use primarily nonretinotopic reference frames. Furthermore, the use of nonretinotopic reference frames appears to be capacity limited. In the case of complex stimuli, the visual system may use perceptual grouping in order to simplify the complexity of stimuli or resort to a nonmetric abstract coding of motion information.

Yes / The Atkinson-Shiffrin modal model forms the foundation of our understanding of human memory. It consists of three stores (Sensory Memory (SM), also called iconic memory, Short-Term Memory (STM), and Long-Term Memory (LTM)), each tuned to a different time-scale. Since its inception, the STM and LTM components of the modal model have undergone significant modifications, while SM has remained largely unchanged, representing a large capacity system funneling information into STM. In the laboratory, visual memory is usually tested by presenting a brief static stimulus and, after a delay, asking observers to report some aspect of the stimulus. However, under ecological viewing conditions, our visual system receives a continuous stream of inputs, which is segmented into distinct spatio-temporal segments, called events. Events are further segmented into event-segments. Here we show that SM is not an unspecific general funnel to STM but is allocated exclusively to the current event-segment. We used a Multiple-Object Tracking (MOT) paradigm in which observers were presented with disks moving in different directions, along bi-linear trajectories, i.e., linear trajectories, with a single deviation in direction at the mid-point of each trajectory. The synchronized deviation of all of the trajectories produced an event stimulus consisting of two event-segments. Observers reported the pre-deviation or the post-deviation directions of the trajectories. By analyzing observers' responses in partial- and full-report conditions, we investigated the involvement of SM for the two event-segments. The hallmarks of SM hold only for the current event segment. As the large capacity SM stores only items involved in the current event-segment, the need for event-tagging in SM is eliminated, speeding up processing in active vision. By characterizing how memory systems are interfaced with ecological events, this new model extends the Atkinson-Shiffrin model by specifying how events are stored in the first stage of multi-store memory systems.

Proposer une relecture du sensible par le palimpseste est s'intéresser avant tout au temps de l'expérience. Il s'agit d'appréhender ce dernier en tant que matière dans la conception de la ville. Étant définie comme une stratification temporelle par la superposition des couches d'écriture, l'introduction de la métaphore palimpseste dans une réflexion sur les ambiances ajoute une épaisseur temporelle aux phénomènes sensibles. La figure «ambiance-palimpseste» montre comment la quotidienneté de l'expérience sensible s'inscrit dans une durée. Cette vision redéfinit l'ambiance comme une incarnation du passé dans le présent à travers un processus continu de sédimentation des traces. Le couplage «ambiance-palimpseste » incarne une puissance du temps dans laquelle le passé se recompose différemment avec la superposition de chaque présent. Entre la production des villes mémorielles et - ou - des villes artefacts, la pensée urbaine contemporaine marque une crise par rapport au temps où le présent fonctionnait comme une étanchéité temporelle, voire un tampon temporel entre le passé et le futur. Le terme « ambiance-palimpseste» resitue le présent dans son emplacement - l'entre-deux -, comme un interface à travers lequel les liens entre le futur et le passé sont rétablis. L'étude du sensible en épaisseur offre une nouvelle perspective dans la conception des villes et propose une autre approche temporelle où il s'agit de « faire avec » le temps, celui du passé et celui du futur. Elle propose une recompositions des valeurs sensibles du passé tout en se projetant vers le futur. Elle mêle la rétrospectivité et la prospectivité dans une approche qui vise à penser et à concevoir l'avenir de la ville autrement. Avec un tel objectif, cette thèse propose un dispositif de lecture du sensible en épaisseur, « la coupe temporelle », comme moyen de considérer l'expérience dans le temps et de déplier les couches des mémoires sédimentées. La coupe temporelle donne à lire les reliefs temporels de l'expérience. Elle marque un tournant dans la représentation de la ville, allant de la cartographie vers la stratigraphie. / Proposing a rereading of the sensory experience by the term palimpsest is above all focusing on « time ».This approach introduces time as a main material for designing cities. Being defined as a stratification of time by a continual re-writing, the metaphorical coupling of terms « ambiance-palimpsest » adds a temporal depth to the sensory phenomena. It point out how everyday life experience reflects a maintain over time. This vision redefines the ambience as an incarnation of the past in the present through a continuous process of sedimentation of traces. Ambience-palimpsest embodies a power of time in which the past is reconstructed differently with each time a new present is overlaid upon territory. Between the production of memorial cities and artifacts ones, the current contemporary urban thinking marks a crisis in dealing with time, in which the present functions as a buffer, isolating the past from the futur. The introduction of term palimpsest in the field of ambiences relocates the present as a connecting interface between the two temporal entities. Taking into consideration the temporal depth when analyzing the sensory experience, offers a new perspective of designing cities by recomposing the past sensory values in a projection to the future. It mixes a retrospective and prospective approaches for rethinking the future of cities. In such an interest, this thesis proposes an architectural reading tool « the temporal section » as a way to stroll in time and to unfold the layers of sediment memories. This architectural section, to which we add time as vertical dimension of place, helps reading the temporal configuration of the experience, thus marking a turning point in the representation of cities form cartography to stratigraphy.

Cette thèse a pour objet d’étude la mémoire urbaine du centre-ville de Beyrouth. L’objectif de cette recherche est de reconstituer in situ, le fil historique et mémoriel urbanistique du centre-ville de Beyrouth depuis sa reconstruction d’après-guerre : de sa mutation à sa métamorphose. Ce travail se base sur soixante-et-un entretiens semi-directifs menés auprès de la population libanaise, de professionnels (architectes, avocats, hommes politiques) et d’enseignants-chercheurs (géographes, sociologues, littéraires). Cette recherche s’inscrit dans une démarche qualitative. Elle s’appuie également sur des études socio-anthropologiques, historiques et géographiques menées sur la reconstruction du centre-ville de Beyrouth et son histoire urbaine retraçant ainsi trois périodes temporelles : l’avant, le pendant et l’après-guerre, fondatrices des évolutions du centre-ville de Beyrouth. Elle explore grâce à l’outil de comparaison les processus de reconstruction d’autres villes détruites lors de conflits armés. En croisant les différents questionnements et choix urbains liés à la reconstruction et à la conservation de la mémoire des villes détruites, cette recherche cerne ainsi les spécificités de la reconstruction libanaise. Ce travail repose également sur un recueil de données ethnographiques mettant en lumière la mémoire urbaine du centre-ville à travers les récits mémoriaux des habitants, privilégiant ainsi un urbanisme sensible focalisé sur une mémoire sensorielle et sur des sensations passées, éprouvées et disparues avec la métamorphose des lieux du centre-ville beyrouthin. / This thesis aims to study the urban memory of downtown Beirut. The objective of this research is to reconstitute in situ, the historical and memory line of downtown Beirut since its post-war reconstruction: from its transformation to its metamorphosis. This work is based on sixty-one semi-structured interviews with the Lebanese population, professionals (architects, lawyers, politicians) and research professors (geographers, sociologists, literarys). This research is part of a qualitative approach. It also relies on socio-anthropological, historical and geographical studies carried out on the reconstruction of downtown Beirut and its urban history retracing three time periods: before, during and after the war, founders of evolutions of downtown Beirut. Through the comparison tool, it explores the reconstruction processes of other cities destroyed during armed conflicts. By crossing the different questions and urban choices related to the reconstruction and preservation of the memory of the destroyed cities, this research identifies the specificities of the Lebanese reconstruction. This work is also based on a collection of ethnographic data highlighting the urban memory of the city center through the memorial narratives of the inhabitants, favoring a sensitive urban planning focused on a sensory memory and on past sensations, proven and disappeared with the metamorphosis places downtown Beirut.

CHAPTER I: INTRODUCTION The purpose of this study is to explore the practice, significance, and development over time of ‘traditional’ home cooking for the descendants of Lebanese immigrants in Argentina and greater Latin America. This is an exploratory paper suggestive of themes that could be examined more deeply through more localized research (Rowe 2012). Nonetheless, this study supports a number of conclusions about this dynamic diasporic group and its relationship to traditional food practices. Narratives and responses about meaning in memory, kinship, and tradition tell an important story about motivations for engaging in food and cooking practices among the descendants of the Lebanese diaspora in Latin America. My study shows that my participants and respondents engage in food and cooking practice as a largely unselfconscious reproduction of cultural identity motivated primarily by a desire to connect with their kin, to evoke memories of their past, and to preserve the gastronomic heritage taught to them—whether directly or indirectly—by their immigrant ancestors. [TRUNCATED]

La schizophrénie (SZ) est une pathologie psychiatrique chronique et invalidante dont les conséquences fonctionnelles sont principalement liées à des déficits cognitifs. Ceux-ci sont étroitement associés à des déficits de perception auditive précoce d’informations de bas niveaux telle que la hauteur sonore. La perception auditive précoce peut s’évaluer avec un paradigme comportemental simple appelé « tone-matching » (appariement tonal AT), dans le lequel les sujets doivent discriminer activement entre deux sons courts (300-ms) d’une même paire séparés par un intervalle bref (500-ms). Les performances d’AT reflètent un processus cognitif de comparaison préattentionnelle se déroulant au sein du système auditif central (SAC). Le SAC est constitué du noyau géniculé médian du thalamus (MGN), de l’aire corticale auditive précoce (EA) et de l’aire corticale auditive associative (AA). Cependant, les dysfonctionnements du SAC sous-tendant les déficits d’AT dans la SZ restent mal connus. De plus, ces déficits sont élevés mais hétérogènes selon les cohortes. Ce travail de thèse propose de caractériser le fonctionnement du SAC associé aux performances d’AT chez les sujets SZ afin de mieux comprendre la physiopathologie du trouble et de développer des traitements ciblés. L’hypothèse guidant les 4 études expérimentales de ce travail est que des altérations psychophysiques et neurophysiologiques spécifiques du SAC sont impliquées dans les déficits d’AT dans la SZ. Nos études psychophysiques utilisant différents paradigmes de « tone-matching » ont montré 1) un déficit d’AT de magnitude croissante pour l’intensité, la hauteur et la longueur des stimuli auditifs chez les sujets SZ (n=29), 2) un déficit d’appariement de trios de sons médiant une corrélation entre les déficits d’appariement de paires de sons (AT proprement dit) et l’identification de phrases émotionnelles (n=27). Ces résultats démontrent que les sujets SZ présentent différents niveaux de déficits d’AT selon le type de caractéristique acoustique, ainsi que des niveaux de déficits hiérarchiquement organisés entre les types de complexité des stimuli auditifs perçus. 3) Nos approches neurophysiologiques ont montré une distribution bimodale des performances d’AT chez les sujets atteints de SZ (n=310) avec un 1er groupe présentant une réduction significative de ces performances associée à une réduction de la connectivité fonctionnelle de repos à l’IRM entre les différentes régions du SAC (MGN-EA, MGN-AA et EA-AA impliquant particulièrement des sous-régions AA adjacentes à l’EA) et un 2nd ne présentant pas de déficits d’AT mais une réduction plus modérée de la connectivité uniquement entre EA-AA. Ces résultats démontrent que les performances d’AT permettent de séparer deux sous-types de SZ présentant des patterns topographiques spécifiques de dysconnectivité fonctionnelle de repos au sein du SAC. 4) Les résultats préliminaires de l’étude de l’effet d’une procédure de stimulation électrique transcrânienne non invasive (tES) ciblant le SAC gauche (2mA, 10x20min) montrent une modulation significative des performances d’AT après la procédure de stimulation chez les sujets SZ (n=2). Cela suggère que les déficits d’AT pourraient être dépendants de mécanismes d’excitabilité et de plasticité des neurones du SAC modulables par tES. Pris ensembles, ces résultats confirment l’influence d’altérations mécanistiques du SAC sur les déficits d’AT dans la SZ, dont les spécificités anatomo-fonctionnelles seront à confirmer par des études de validation et des explorations neurophysiologiques « temps réel » du SAC en situation d’AT. En perspective, comme les paradigmes de « tone-matching » peuvent être implémentés facilement en pratique clinique, ces nouvelles donnés pourront permettre de différencier facilement des sous-types physiopathologiques de patients, et de développer des approches thérapeutiques ciblées sur le SAC à la fois en tES et en entraînement cognitif sensoriel / Schizophrenia (SZ) is a chronic brain disorder with outcome primarily driven by deficits in cognition. These have been related to impaired discrimination of basic auditory information such as pitch, as assessed in tone-matching behavioral paradigms in which subjects are asked to actively discriminate between two short pure tones (300-ms) following a brief delay (500-ms). More specifically, tone-matching indexes early, pre-attentive comparison mechanisms occurring in the central auditory system (CAS, divided into thalamic medial geniculate nucleus (MGN), early auditory (EA) and association auditory (AA) cortical areas). Therefore, characterisations of the CAS functioning associated with tone-matching abilities in SZ individuals may be useful drivers for pathophysiology understanding and therapeutic development. First, we aimed at exploring tone-matching abilities in SZ across major acoustic features (length, pitch, intensity) and different levels of complexity (2-tones, 3-tones, emotional sentences) using psychophysical testing. We predicted that patients would display differential deficits across acoustic features, and present a mediated relationship between tone-matching levels of complexity. Second, we investigated the CAS functioning associated with tone-matching at a neurophysiological level, using resting-state functional connectivity MRI (rsFC-MRI) and CAS-targeted transcranial electrical stimulation (left fronto-temporal tES, 2mA, random noise current, ten 20-min twice-daily sessions). We predicted that functional dysconnectivity within the CAS would be associated with tone-matching impairments, and that tES would significantly modulate these impairments in patients. As complementary, we reviewed historical aspects of basic auditory explorations in SZ and studies investigating basic auditory-training approaches as a potential remediative treatment. Psychophysical studies demonstrated more prominent deficits for length than pitch and, in turn, than intensity (n=29), and showed that 3-tones discrimination mediates the correlation between 2-tones and auditory emotion recognition deficits (n=27). Neurophysiological approaches showed that tone-matching performances are bimodally distributed across SZ subjects (n=310), with one group (SZ-) showing significant reductions in both tone-matching and rsFC-MRI in regions of the bilateral CAS (i.e., between MGN and both EA and AA, as well as reductions between EA and AA, particularly involving parcels which are immediately adjacent to EA), and one group (SZ+) showing intact tone-matching and significant reductions only in EA-AA connectivity. The investigation of CAS-targeted tES impact on tone-matching abilities in patients is still ongoing, but preliminary results demonstrated significant modulations of tone-matching scores after the tES procedure (n=2). Our results demonstrate that SZ individuals present with different patterns of tone-matching deficits across acoustic features, but similar yet hierarchical levels of impairments for processing of simple vs. more complex auditory stimuli. Nevertheless, both feature- and complexity- dependant tone-matching deficits might be associated with different types of anatomo-functional underpinnings in the CAS. In addition, we showed that tone-matching measure segregates between discrete SZ subgroups presenting distinct topographic patterns of functional dysconnectivity in the CAS. Finally, tone-matching deficits might be related to neuronal excitability and plasticity mechanisms in the SAC that are modulated by tES. As tone-matching paradigms can be readily implemented within routine clinical settings, these experimental results may be useful to permit differentiation of discrete subtypes of SZ and to develop both non-invasive brain stimulation and remediative approaches