Introduction: Class II Division 1 malocclusions are characterized by a retrusive mandible and prominent upper incisors. Despite Class II malocclusions being one of the most frequently treated cases in orthodontists' office, there is no uniform consensus in the orthodontic community on the best treatment modality and biomechanical approach to use in treating patients with Class II malocclusions. Purpose: This paper examines the end-of-treatment outcomes of severe Class II Division I malocclusion patients treated with surgical versus non-surgical approaches. Study Design: This is a retrospective study of consecutively treated severe Class II Division I patients at the University of Iowa. Initial and deband lateral cephalometric radiographs were compared between 45 non-surgical and 21 surgical patients. All patients that were debanded between the ages of 13 to 19 years were included. Multivariable regression analyses were used to examine differences in outcomes between treatment groups. Results: Following adjustment for patient level confounders (age, gender, and race), those treated surgically had better end of treatment cephalometric outcomes. Those treated surgically had a more balanced skeletal profile, greater reduction in overjet, and improvement in ANB angle (p Conclusion: Orthodontic treatment in conjunction with orthognathic surgery is a more ideal treatment for patients with severe Class II Division I malocclusion. When treated surgically, a greater amount of overjet can be reduced while keeping lower incisors in a more stable position in bone.

Behavioral researchers have investigated procedures for identifying preferred items for individuals with varying levels of developmental disabilities. Some researchers in this area have reported difficulties in identifying preferred items for individuals with severe to profound multiple disabilities (SPMD), in part because the individuals may not possess the motor skills needed to select and manipulate the items included within the assessment. The purpose of the current study was to address three research questions: Would differences in preference patterns be observed if individuals with SPMD could activate toys with a motor response that is within their repertoire (i.e., press a large microswitch to activate the toy) versus when they are required to perform a motor response that may not be within their repertoire (e.g., sliding knobs, twisting dials to activate a toy)? Would teaching specific skills to activate a toy result in increased toy engagement and a shift in preference toward directly operating the toy? Would teaching the participant a motor response to activate the toy directly affect the levels of microswitch engagement observed? Data were collected within a combination multiple baseline (across 2 participants) and multielement (across conditions) design. The results of this study showed that (a) differences in preference were observed when different measures of assessing preferences were conducted, (b) acquisition of specific motor skills resulted in an increase in preference toward directly manipulating items, and (c) acquisition of motor skills also resulted in a decrease in activating items via microswitches. These results extend the preference assessment literature by showing that the motor skills present within an individual's current repertoire may affect the results of preference assessments for individuals with SPMD.

L’asthme équin est une maladie obstructive récurrente des voies respiratoires. De nombreux facteurs étiologiques ontété déterminés comme pouvant initier ou maintenir l’asthme équin sévère (AES), cependant l’exposition au foin restele facteur de risque principal. L’utilisation de traitements à base de corticoïdes sont efficaces en cas de crise maisinefficaces en l’absence de mesures sanitaires. Ainsi, depuis quelques années un dispositif permettant de « purifier »le foin à la vapeur a été développé, afin de diminuer la teneur en poussières et les antigènes microbiologiques présentsdans le foin. La physiopathologie de l’AES est complexe. Parmi les principaux acteurs de cette réponse immunitaire,les macrophages alvéolaires ont un rôle prédominant dans l’initiation et l’orientation de la réponse immunitaire. Ainsiétudier le rôle des macrophages des chevaux AES permettrait de mieux comprendre l’initiation de la réponseimmunitaire dans l’AES. Dans ce contexte, nous nous sommes interrogés sur l’influence du foin « à la vapeur » surla réponse immunitaire des chevaux AES lors d’un challenge in vivo et lors de la stimulation in vitro des macrophagesalvéolaires. Ainsi nous avons d’abord étudié la réponse systémique et locale des chevaux soumis à un challenged’exposition in vivo à du foin sec ou « à la vapeur ». La première partie de ce travail nous a permis d’observer uneffet bénéfique du foin « à la vapeur » sur le score de mucus trachéal des chevaux CTL et AES cependant nousn’avons pas observé un effet bénéfique significatif du foin « à la vapeur » sur la réponse cytologique et immunitaire.La deuxième partie du travail a permis d’étudier la réponse au foin « à la vapeur » à l’échelle des macrophagesalvéolaires. La microscopie en temps réel a mis en évidence des différences dans le comportement des macrophagesen réponse (1) à différents stimuli, (2) entre les chevaux AES et CTL, (3) entre les HDS provenant de foin sec ou defoin « à la vapeur ». La concentration en IL-1β était significativement plus élevée et la concentration en IL-10significativement plus faible chez les MA des chevaux AES comparés aux chevaux CTL. Une concentration en TNF-α plus élevée après stimulation in vitro a été observée chez les MA des chevaux AES et CTL. Cet état des lieux surla réponse des macrophages alvéolaires stimulés in vivo et in vitro pourra servir de base aux études futures nécessairespour conclure sur le rôle des MA dans le cas de l’AES. Cette triple approche à l’échelle du cheval, du poumon et dela cellule permet une vision globale de la réponse à un challenge d’exposition à du foin sec ou « à la vapeur » etpermet tout de même d’avoir un regard optimiste sur l’utilisation du foin « à la vapeur » pour les chevaux atteintsd’AES. / Equine asthma is a recurrent obstructive disease of respiratory tract. Several aetiologic factors are known to induceor maintain the severe equine asthma (sEA), however the hay exposure is the main risk factor. The use of treatmentswith corticoids are effective in case of crisis, but ineffective in the absence of sanitary measures. So, since severalyears a device allowing to purify the hay with steam was developed, in order to decrease the dust content and themicrobiological antigens within the hay. The pathophysiology of sEA is complex. Among the main actors of thisimmune response, the alveolar macrophages have an important role in the intiatiation and orientation of the immuneresponse. So, investigating the role of the equine alveolar macrophages of sEA horses would allow to betterunderstand the initiation of the immune response in the sEA. In this context, we focused on the influence of steamedhay on the immune response of sEA horses during an in vivo challenge and an in vitro stimulation of the alveolarmacrophages. First, we studied the systematic and local responses of horses submitted to an in vivo challengeexposure to dry and steamed hay. The first part of this work allowed us to show a beneficial effect of the steamedhay on the mucus tracheal score of sEA horses, however we did not observe any beneficial effect of the steamed hayon the cytological and immune response. The second part of the study allowed us to investigate the response of thealveolar macrophages to steamed hay. The real time microscopy showed differences in the behavior of macrophagesin response (1) to various stimuli, (2) between sEA and CTL horses (3) between HDS resulting from dry hay or fromsteamed hay. Moreover, the protein quantification of IL-1β was signifantly higher and the concentration of IL-10significantly lower in AM supernatant of sEA horses compared to CTL. The TNF-α concentration was higher on AMafter in vitro stimulation in sEA and CTL horses. These results on the alveolar macrophages reponse after both invivo challenge and in vitro stimulation, can be used as a basis for future studies in order to further characterize therole of AM in case of sEA. This triple approach on the horse, the lung and the cell scale allows a global vision of theresponse to an exposure challenge to dry or steamed hay and allows having an optimistic preliminary look on the useof the steamed hay for sEA horses.

This text for early childhood special education pre-service and in-service teachers provides a unique and much needed focus on how to collaborate effectively with the wide variety of professionals who work with young children who have developmental delays.

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<div><div><div><p>Objectives: Previous research suggests an association between working alliance, the collaborative and affective bond between patient and therapist, and improved therapeutic treatment outcomes within treatment of severe mental illness (SMI). However, little is known about the mechanisms through which working alliance improves outcomes in this population. Through investigating key elements of recovery within SMI, two possible mediators—patient activation and hope—appear particularly relevant to the relationship between working alliance and improved treatment outcomes. The current study aimed to examine patient activation and hope as potential mediators in the relationship between working alliance and improved depression in individuals with SMI. Additionally, the current study investigated whether or not the patient’s evaluation of which provider is most important to their recovery significantly moderated the relationship between working alliance and patient activation/hope.</p><p>Methods: The current study was a secondary analysis of longitudinal (baseline, 6-month, and 12-month) data comparing two interventions aimed at reducing treatment provider burnout in community mental health settings primarily serving individuals with SMI. Participants (maximum N for analyses = 346) completed measures of working alliance with a linked provider on their treatment team, patient activation, hope, and depression at baseline, 6 months, and 12 months. Using moderated mediation analysis, 6-month patient activation and 6-month hope were examined as mediators in the relationship between baseline working alliance and 12-month improved depression (change score between 12-month and baseline depression). Additionally, whether or not the patient deemed their linked provider as most important to their recovery was tested as a moderator in the relationship between baseline working alliance and 6-month patient activation/hope.</p><p>Results: Overall, the current study’s hypothesized model was not supported. Baseline working alliance did not significantly predict improved depression 12 months later. Further, both patient activation and hope measured at month 6 in the study did not significantly mediate the relationship between working alliance quality at baseline and improved depression at month 12. Additionally, whether or not the patient believed their linked provider was most important to their recovery did not significantly moderate the relationship between baseline working alliance and 6-month patient activation or 6-month hope. However, results indicate that better quality working alliance at baseline did significantly predict higher patient activation at 6 months. Lastly, the current study found a significant positive correlation between importance of provider and baseline working alliance.</p></div></div></div><div><div><div><p>Discussion: Results suggest that improvement in depression may not be a key SMI treatment outcome that relates to working alliance, patient activation, and hope. Further, fostering a positive working alliance (e.g., collaboratively developing goals/tasks in-session) may increase patient’s ability, willingness, and confidence in managing their own mental health care. Additionally, a positive working alliance may also contribute to how important the patient believes the provider is to their recovery. However, those that have seen their provider for longer (e.g., more chronically ill) may be less active in managing their own mental health care. Limitations and possible future directions are discussed.</p></div></div></div>

New technologies of components assembling in car and aircraft industries and requests on improved mechanical and corrosion properties of metallic materials in the packing industry activate the utilization of highly innovative and unconventional manufacturing processes. There are only a limited number of processing, that retain the original material thickness and in an appropriate manner modify material properties. These are different types of annealing, severe plastic deformation methods or combination of both. In recent years constrained groove pressing (CGP) was devoloped with this method the grain size can be reduced from tens of micrometers to sub-micrometers. The present work is focused on a study of evolution of microstructure and mechanical properties of two alloys based on EN AW 3003 after CGP deformation and subsequent annealing.

Title: Study of ultrafine-grained materials prepared with different methods of severe plastic deformation Author: RNDr. Tomáš Krajňák Department: Department of Physics of Materials, Faculty of Mathematics and Physics, Charles University in Prague Supervisor: Doc. RNDr. Kristián Máthis, PhD., Department of Physics of Materials, Faculty of Mathematics and Physics, Charles University in Prague Abstract: Interstitial free steel with ultrafine-grained (UFG) structure was prepared by high-pressure torsion (HPT). The development of the microstructure as a function of the number of HPT turns was studied at the centre, half-radius and periphery of the HPT-processed disks by X-ray line profile analysis (XLPA), positron annihilation spectroscopy (PAS) and electron microscopy. The dislocation densities and the dislocation cell sizes determined by XLPA were found to be in good agreement with those obtained by PAS. The evolution of the dislocation density, the dislocation cell and grain sizes, the vacancy cluster size, as well as the high-angle grain boundary (HAGB) fraction was determined as a function of the equivalent strain. It was found that first the dislocation density saturated, then the dislocation cell size reached its minimum value and finally the grain size got saturated. For very high strains after the...

Title: Microstructure and mechanical properties of lightweight structural AZ31 alloy prepared by twin-roll casting method Author: Mariia Zimina Abstract: Microstructure of AZ31 twin-roll cast magnesium alloy was studied using light optical, electron and atomic force microscopy. The effect of annealing temperature on the microstructure was tested. Mechanical properties of a thin magnesium strip were investigated by means of microhardness tests and tensile tests at a relatively low strain rate 10-3 s-1 . Results show that the ductility of the twin roll cast strip increases with increasing deformation temperature, however, a remarkable decrease was observed at about 200 řC. This effect appears also in a conventionally cast ingot of a master alloy and is caused by a change of a deformation mode occurring at this temperature. Moreover, the effect of severe plastic deformation on the microstructure and mechanical properties was studied. Equal channel angular pressing was applied on magnesium strip samples and lead to a significant grain refinement accompanied by an unfavorable strengthening of the initial basal texture, which is effectively suppressed by a subsequent annealing. A constrained groove pressing was for the first time successfully applied on AZ31 twin-roll cast strip leading to an increase of...

The aim of this diploma thesis is to investigate microstructure and thermal stability of ultra fine grained magnesium alloys. The thesis first summarises methods using plastic deformation in order to achieve ultra fine grained structure that are used to process metals. Then experimental methods employed in the experimental part including microhardness testing, scanning electron microscopy and positron annihilation spectroscopy are described. Brief summary of previous research on MgZnY alloys strengthened by quasicrystalline phases and Mg22Gd alloys is given. Finally, results of experimental investigation of MgZnY alloys with various Zn/Y ratios and Mg22Gd alloy are discussed. These results suggest that presence of phases in MgZnY alloys depend on Zn/Y ratio, hardness of these alloys depends on Zn content and that rapid cooling of MgZnY alloys annealed at 500 řC lead to significant increase in volume fraction of quasicrystalline icosahedral phase. In the second section of the experimental part thermal behaviour of Mg22Gd alloy is investigated. Furthermore, formation of GdH2 particles in Mg22Gd is examined and attributed to reaction of hydrogen decomposed from water vapour with gadolinium in areas rich in gadolinium. Finally, significant hardening of Mg22Gd alloy processed by high pressure torsion has been...