<p>In this dissertation, I study medicalization, a wide spread phenomenon in this world but understudied in the current literature. The main theoretical focus of this dissertation is on expanding the medicalization theories. Questioning the breadth of conceptualization, the feasibility of measurement, and the depth of empirical implications in the extant medicalization theories, this dissertation proposes a new conceptual model of medicalization and further develops a quantitative measure of medicalization by disaggregating it into empirically valid dimensions that could be used to examine how degree of medicalization is related to social outcomes. Specifically, I conceptualize medicalization as an institutionalization process whereby the medical model becomes increasingly dominant in the explanation of health, illness, and other human problems and behavior. Medicalization is multidimensional and is represented by expansions in the three major components of the health care system: increasing medical investment, medical professionalization/specialization, and the relative size of the pharmaceutical industry. </p><p>Based on this new conceptual model and measurement, I probe three research questions: (1) how medicalization may impact population health in the context of recent epidemiologic transitions and how this impact may differ by the stages of epidemiologic transition and socioeconomic development; (2) what are the mechanisms that reproduce medicalization; and (3) how the lay public may respond to medicalization, the institution of medicine, and the medical profession.</p><p>This dissertation links several lines of theoretical and empirical research from medical sociology, demography, epidemiology, health economics and management, and medical science, and extensively employs OECD Health Data, World Development Indicators, the World Values Survey, the European Values Study data, the U.S. General Social Survey, and the U.S. National Health Interview Survey. It uses several advanced statistical methods, e.g., multiple imputations, latent variable analysis, mixed models, generalized estimating equations models, generalized method of moments models, difference-in-difference models, and hierarchical-age-period-cohort models.</p><p>Results for the first research question suggest that various dimensions of medicalization vary in importance on population health and these effects also differ by the stages of epidemiologic transition and socioeconomic development. I discuss the mechanisms linking various dimensions of medicalization to population health and then discuss these findings in the context of epidemiologic transition, fundamental causes of disease and death, and global health movement. </p><p>Results for the second research question suggest that medicalization at both the societal and individual levels negatively affect individual subjective health, which leads to increasing health care utilization. These social processes function together to promote and reproduce medicalization at societal level. I discuss several pathways linking medicalization to lower subjective health and other agents of medicalization.</p><p>Results for the third research question suggest that American's "confidence in the medical institution and profession" has continuously declined in the last three decades and groups with higher socioeconomic status report lower obedience to doctors' authority, but are more likely to trust doctors' ethics than their counterparts. I discuss the mechanisms for the changes in public confidence in the medical institution and profession, the status of medicine and the medical profession in the era of medicalization, the paradox of opposite trends in attitudes toward medicine and health utilization behavior, and group differences in obedience and trust.</p> / Dissertation

This dissertation investigates how economically-comparable peer firms can be used to obtain inferences about a company’s accounting quality in two different research settings. The first Chapter examines whether auditor industry specialization, measured using auditor market share by industry, improves audit quality. After matching clients of specialist and non-specialist auditors according to industry, size and performance, there are no significant differences in audit quality between these two groups of auditors. In addition, this Chapter uses two analyses that do not rely primarily on matched samples. First, examining a sample of Arthur Andersen clients that switched auditors in 2002, there is no evidence of industry-specialization effects following the auditor change. Second, using a simulation approach, this study shows that client characteristics, and particularly client size, influence the observed association between auditor industry specialization and audit quality. Overall, these findings do not imply that industry knowledge is not important for auditors, but that the methodology used in extant studies examining this issue may not fully parse out the effects of auditor industry expertise from client characteristics. The second Chapter examines whether account-level expectation models for analytical audit procedures can be enhanced by using information from economically-comparable peer firms. This Chapter assesses the effectiveness of three main types of expectation models, with and without including information from peer firms: heuristic, time-series, and industry cross-sectional models. Information from peer firms improves the accuracy of all models and improves the detection power of time-series and industry cross-sectional models. Comparing between models, one-period heuristic models are generally unreliable, and industry cross-sectional models can be more effective than time-series models. These findings may help auditors of public companies and financial analysts in selecting expectation models and finding peer firms to assess the reasonability of a company’s financial information at the account-level.

This dissertation investigates how economically-comparable peer firms can be used to obtain inferences about a company’s accounting quality in two different research settings. The first Chapter examines whether auditor industry specialization, measured using auditor market share by industry, improves audit quality. After matching clients of specialist and non-specialist auditors according to industry, size and performance, there are no significant differences in audit quality between these two groups of auditors. In addition, this Chapter uses two analyses that do not rely primarily on matched samples. First, examining a sample of Arthur Andersen clients that switched auditors in 2002, there is no evidence of industry-specialization effects following the auditor change. Second, using a simulation approach, this study shows that client characteristics, and particularly client size, influence the observed association between auditor industry specialization and audit quality. Overall, these findings do not imply that industry knowledge is not important for auditors, but that the methodology used in extant studies examining this issue may not fully parse out the effects of auditor industry expertise from client characteristics. The second Chapter examines whether account-level expectation models for analytical audit procedures can be enhanced by using information from economically-comparable peer firms. This Chapter assesses the effectiveness of three main types of expectation models, with and without including information from peer firms: heuristic, time-series, and industry cross-sectional models. Information from peer firms improves the accuracy of all models and improves the detection power of time-series and industry cross-sectional models. Comparing between models, one-period heuristic models are generally unreliable, and industry cross-sectional models can be more effective than time-series models. These findings may help auditors of public companies and financial analysts in selecting expectation models and finding peer firms to assess the reasonability of a company’s financial information at the account-level.

This dissertation modifies the model of Yang and Ng (1995) to investigate the condition of the emergence of the firm from a specialized exchange economy. It is assumed in this dissertation that there are fixed costs involved in the operation of a firm. After taking into account of this factor, I re-examine its effects on the division of labor and the structure of firm following Yang and Ng¡¦s framework. The model adopts an inframarginal framework to analyze the subject, in which a firm demonstrates diminishing returns, while both the final labor input and the intermediate labor input demonstrates increasing returns defined upon individuals. However, it is assumed that only the final labor input has the economies of specialization. It is argued in this dissertation that the existence of fixed learning costs may stimulate the economy to undergo structural changes if suitable conditions are met, which are largely related to relative market efficiency between markets.

Business cycle is an important issue for economist. Because the fluctuations of product and employment have deep influences on people¡¦s life and social stability, almost every government tries to reduce the volatility of national business cycles. If we want to make it, we must realize it first. Since countries communicate with each other more frequently in recent decades, the volatility of national product cycles is not only influenced by domestic economic variables but also foreign ones. The purpose of this paper is to analyze the effect of transmission mechanism on international business cycles synchronization (BCCs). The major purpose of this paper is to analyze the effect of international vertical specialization on BCCs among industrial countries. There are two kinds of effect. One is indirect effect. Vertical specialization happens between industrial countries and developing countries, so it can reduce bilateral trade intensity among industrial countries. Through this way, BCCs among industrial countries will reduce. The other one is direct effect. Vertical specialization changes the economic structure of industrial countries. Industrial countries can focus on product development and market research. This kind of economic structure is less capital intensive, which lessens the effect of common shocks to industrial country¡¦s business cycles. BCCs among industrial countries will reduce. We measured the effect using the data from G6 (Canada, France, Germany, Japan, UK and US). The result is consistent with our inferance. Vertical specialization can reduce BCCs by reducing bilateral trade intensive among industrial countries. There is a negative relation between Vertical specialization and BCCs among industrial countries.

<p>Denna uppsats analyserar om det finns ett samband mellan den snabbt växande tyska exporten och produktutveckling. Genom en segmentering av den tyska tillverkningsindustriexporten i relation till olika produktgruppers internationella konkurrenskraft ges en möjlighet att undersöka skillnader mellan produktsegment med olika internationell konkurrenskraft. Analysen visar att i tidsperioden 2000 till 2002 definierades 76 av 240 produktgrupper ha haft en ökande internationell konkurrenskraft genom en relativ prishöjning. Detta är fler produktgrupper än i någon annan undersökt tidsperiod. De 76 produktgrupperna motsvarar 29,5 procent av det totala tyska exportvärdet, marginellt högre än i någon annan tidsperiod.</p><p>Produkter med ökande internationell konkurrenskraft genom en relativ prishöjning är också av ett högre värde per kilo export än andra konkurrenssegment. Analysen visare vidare att den internationella efterfrågan på dessa produktgrupper är signifikant högre än för produktgrupper med minskad internationell konkurrenskraft. Dock kunde inga generella skillnader mellan olika konkurrenssegment i relation till avståndskänslighet, kulturell och språklig affinitet samt EU-medlemskap på importandelen av tyska varor påvisas.</p> / <p>In this thesis the relationship between product development of the German manufacturing industry and the rapid German export growth is analyzed. By a segmentation of the German export according to international competitiveness, differences in characteristics of the different segments are analyzed. Positive for Germany is that in the time-period 2000 to 2002, 76 out of 240 analyzed product groups were defined as experienced increased export competi-tiveness through relative price increase; more than in any other analyzed time-period. These 76 product groups constituted 29.5 percent of Germany’s total export value, marginal higher than in any other time-period.</p><p>The analysis also shows that German product groups with increasing international competitiveness through relative price increase are of higher value than products in other competitive segments. The international demand for product groups with increasing international competitiveness through relative price increase is also higher than for other competitive segments. However, no general significant differences could be shown between different competitive segments in respect to distance sensitiveness, importance of cultural and linguistic affinity and EU-membership on the import share of German products.</p>

<p>Spinoffs are an increasing phenomenon on the Swedish stock market. In this report one can read about factors that trigger spinoffs as well as about the short and medium term risk and return that spinoffs yield. I have observed 17 pre-spinoff companies that become 34 post-spinoff companies which continued to be traded on the stock market.</p><p>For the purpose of the investigation I use time-series regression, and my model is the sin-gle-factor market model. I use this model to estimate the beta and the firm specific factor. Supporting theories are: efficiency, portfolio theory, valuation method and asymmetry all those topics are central parts in a spinoff.</p><p>From my research I can not prove that spinoffs increase shareholders wealth. That means that the new units created through a spinoff are not more worth than the old corporation as such the new units do not outperform the old conglomerate structures expected return. However, the new units beta is not equal the old conglomerate structures beta, and this may due to change in capital structure. The weighted beta increase in half of the times, as such, it suggests a higher level of debt financing.</p><p>By comparing the spinoff company and the parent company in the post-spinoff scenario it can be concluded that the company who is performing the best is also the riskier alternative and the spinoff performs better than the parent company in eleven out of seventeen times. There is also a correlation between risk and return - when higher return is observed it also brings higher risk, and it holds true in all samples except one.</p><p>Further, at group level the spinoff group performs better than the market return and the spinoff group performs on average better than the parent group. Thus, if an outside inves-tor is to invest in either a spinoff company or a parent company one should buy the spinoff company at preferred weight according to the investors risk preferences.</p>

Thesis (Ph.D.)--University of Alabama at Birmingham, 2009. / Title from PDF title page (viewed on Feb. 3, 2010). Includes bibliographical references (p. 69-75).

This dissertation expands on the economic geography literature on how and why innovation clusters spatially by taking a closer look at two correlated phenomena: regional specialization and firm clustering. While existing studies note that innovative regions are often highly specialized and highly clustered, further research is needed on the relative contributions of specialization and clustering to regional innovation. I examine these contributions by focusing on one key element of any regional innovation project: the labor market for scientific and technical professionals. The foundation for this study is a typology of regions based on regional specialization and firm clustering. I use this typology to answer one key research question: how specialization and clustering affect wages and recruitment methods in science-based industries. I create my typology using firm location data from the Photonics Buyers’ Guide, a leading trade publication in the photonics industry; I use the standardized location quotient and the average nearest neighbor distance as metrics of regional specialization and firm clustering, respectively. I investigate small firms’ labor market strategies using job search and wage data from the 2011 and 2012 SPIE salary surveys of employees in the photonics industry. I also examine how people-based and place-based policies for strengthening scientific and technical labor markets change when viewed through the lens of specialization and clustering. I selected the photonics industry as an example of a science-based industry for three reasons: its diversity of applications, its policy importance, and its unique colocation of design and manufacturing. Regional specialization and firm clustering, while correlated, do not always go hand in hand. By disentangling the effects of specialization versus clustering, this dissertation contributes to the literature on the spatial analysis of innovation. It also offers policymakers a heuristic for deciding on the importance of being known for a particular industry (regional specialization) and creating dense innovation districts (firm clusters) through preferential zoning or other mechanisms.

The Sertoli cell ectoplasmic specialization is a specialized domain of the calcium-dependent Sertoli-spermatid adherens junction. Structurally abnormal or absent Sertoli ectoplasmic specializations are associated with spermatid sloughing and subsequent oligospermia in conditions associated with reduced fertility potential, although the junctional strength between these cells is not known. Adjudin is a potential male contraceptive agent thought to interrupt testicular binding dynamics of adherens junctions, resulting in controlled spermatid sloughing.It was hypothesized that the mechanism of action of Adjudin, pertinent to its putative contraceptive effect, is the disruption of the Sertoli cell-spermatid junction. This was tested in vitro using primary isolates of germ cells and both primary and immortal Sertoli cells.This dissertation presents the examination of Sertoli-germ cell interactions in three parts, which address the overall aims of this dissertation project: (1) measurement of the junctional strength between Sertoli cells and spermatids in vitro, (2) determination of the efficacy of sk Sertoli cell lines in Sertoli-germ cell binding studies in vitro, and (3) assessment of Adjudin as a potential male contraceptive, by measuring the junctional binding strength between Sertoli cells and spermatids exposed to this chemical in vitro.For the first time, the strength of the Sertoli-spermatid junction has been measured, using a micropipette pressure transducing system (MPTS). Results reported in this dissertation demonstrate that the junctional strength between Sertoli cells and germ cells can be measured in vitro, support long held speculations regarding Sertoli-spermatid junctional interactions, and provide a technology to test proposed mechanisms of junctional binding dynamics between cells of the seminiferous epithelium (Chapter 2). Although the sk cell lines initially expressed mRNA for the FSH receptor, coculture results determined that these cell lines have limited value for investigating Sertoli-germ cell binding dynamics in vitro (Chapter 3). By utilizing the MPTS and primary cell isolates, Adjudin was determined to reduce the junctional strength between Sertoli cells and step-8 spermatids. In conclusion, results support the use of Adjudin as a potential reversible male contraceptive agent by a mechanism which alters the adhesion properties between the step-8 spermatid and the Sertoli cell (Chapter 4).