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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
101

Estudo dos efeitos do monossialogangliosídeo (GM1) administrado pela via transdérmica por laser a baixa temperatura, após lesão medular experimental em ratos / Study the effects of monossialoganglioside (GM1) administered by transdermal laser at low temperature, the spinal cord injuries in rats

Fabiano Inácio de Souza 24 January 2012 (has links)
Objetivo: avaliar os efeitos do monossialogangliosídeo (GM1) administrado pela via de transdérmica por laser a baixa temperatura, após lesão medular experimental em ratos. Métodos: o estudo incluiu 40 ratos Wistar, machos, com idade entre 20 e 21 semanas, submetidos à lesão medular contusa pelo equipamento NYU Impactor, a altura de 25 mm, de acordo com o protocolo MASCIS. Foram formados 4 grupos de 10 animais. No grupo 1, os ratos receberam diariamente 0,2 ml de soro fisiológico, via intraperitoneal; no grupo 2, GM1 via intraperitoneal, na concentração 30 mg/kg por dia; no grupo 3, sessão diária de laser a baixa temperatura na topografia da lesão; no grupo 4 sessão diária de laser contendo GM1 na concentração de 30 mg/kg pela via transcutânea por Laser Ice. Todos os animais foram tratados por 42 dias. Foram avaliados por meio da escala de avaliação funcional Basso, Baettie e Bresnahan (BBB) em 7, 14, 21, 28, 35 e 42 dias após a lesão, pelo exame histopatológico e por potencial evocado motor após 42 dias da lesão. Resultados: os animais do grupo 4 apresentaram os escores da escala BBB superiores aos demais grupos até a quarta semana, sendo equiparado aos demais na sexta semana. Não houve diferença estatisticamente significante entre os grupos e as semanas. A avaliação histológica não demonstrou resultados com significância estatística. Os exames de potencial evocado motor demonstraram maior latência média no grupo 1, sem significância estatística. Conclusão: o emprego de GM1 associado a laser em baixa temperatura demonstra resultados funcionais superiores nas primeiras semanas, mas sem evidenciar diferença estatisticamente significante / Objective: To evaluate the effects of monossialoganglioside (GM1) administered transdermally, and laser at low temperature, in the functional and histological recovery of spinal cord injury in rats. Methods: Forty male Wistar rats, aged between 20 and 21 weeks, underwent spinal cord contusion at NYU Impactor, according to the MASCIS protocol. They were divided into four groups: in Group 1, rats received 0.2 ml of saline intraperitoneally daily; in Group 2, GM1 was administered intraperitoneally at a concentration 30 mg/kg per day; in Group 3, rats were treated with laser at low temperature on the skin, daily and in Group 4, the daily laser session also contained GM1. All the groups were treated for 42 days. The animals were evaluated by the Basso, Baettie and Bresnahan (BBB) functional scale on days 7, 14, 21, 28, 35 and 42 after injury, and by histopathology and motor evoked potentials after 42 days of injury. Results: The animals in Group 4 had higher BBB scores compared to the other groups, until the 4th week. There were no statistically significant differences between the groups, or in the comparisons over time, i.e. from one week to the next. Histological evaluation showed no statistically significant results, and no significant differences were found in the motor evoked potential tests either. Conclusion: GM1 associated with the use of low-temperature laser shows no superior functional, neurological or histological results in the treatment of spinal cord lesions in rats
102

Avaliação do efeito do estrógeno na lesão medular experimental em ratos / Evaluation of the effect of estrogen on experimental spinal cord injury in rats

Olavo Biraghi Letaif 07 July 2014 (has links)
Este estudo teve como objetivo avaliar a influência do tratamento com estrógeno em ratos submetidos à lesão medular aguda experimental. A lesão foi produzida por meio de um equipamento computadorizado para impacto medular, o NYU Impactor, que promoveu a queda de um peso de altura de 12,5 mm sobre a medula do animal. Utilizamos 20 ratos Wistar que foram separados em dois grupos de 10 animais cada: Grupo 1, com ratos submetidos a lesão medular e depois a terapia com 17-beta estradiol ainda sob anestesia, o grupo experimental; Grupo 2, com ratos submetidos apenas à lesão medular, o grupo controle. Os animais foram observados por 42 dias. A recuperação funcional motora foi avaliada pela escala de Basso, Beattie e Bresnahan (BBB) nos dias 2, 7, 14, 21, 28, 35 e 42 após a lesão, e pelo exame de potencial evocado motor no dia 42. Foi também realizada avaliação histopatológica da área da lesão medular após eutanásia, no dia 42. Os resultados das avaliações da escala BBB evidenciaram que o grupo experimental apresentou melhora significativamente superior em relação ao outro grupo desde o 28o dia até o 42o dia de observação. Os resultados das avaliações por exame de potencial evocado revelaram que o grupo experimental apresentou melhora estatisticamente significante em relação ao grupo controle. Os resultados das avaliações anatomopatológicas pela histomorfometria mostraram melhor recuperação neurológica do grupo experimental com relação à proporção numérica e ao diâmetro das fibras nervosas contadas. A conclusão é que a administração de estrógeno em ratos submetidos à lesão medular mostrou benefícios na recuperação neurológica e funcional motora dos animais tratados / This study aimed to evaluate the influence of estrogen treatment in rats with experimental acute spinal cord injury. The injury was produced using a computerized device for spinal cord impact, the NYU Impactor, which promoted the injury by the falling of a weight on the animal\'s spine from a 12.5 mm-height. Twenty male Wistar rats were divided into two groups of 10 animals each: Group 1, rats with spinal cord injury and undergoing estrogen therapy with 17-beta estradiol, while still anesthetized, the experimental group; Group 2, rats that underwent spinal cord injury only, the control group. Animals were observed for 42 days. The neurological recovery was verified by assessing functional motor recovery by the scale of Basso, Beattie and Bresnahan (BBB) on the 2nd, 7th, 14th, 21st, 28th, 35th and 42nd days after injury, and by quantifying motor evoked potential in the 42nd day. Histopathological evaluation of the area of spinal cord injury was performed after euthanasia in the 42nd day. Results of the BBB scale evaluation showed that the experimental group had significantly greater improvement compared to the other group since the 28th day until the 42nd day of observation. The results of evaluations by the evoked potential test revealed that the experimental group showed statistically significant improvement compared to the control group. The results of the histomorphometry evaluations showed better neurological recovery in the experimental group with respect to the numerical proportion and diameter of nerve fibers counted. The conclusion is that the administration of estrogen in rats with spinal cord injury showed benefits in neurological and functional motor recovery of the treated animals
103

Avaliação clínica e cinemática da função manual de pessoas com tetraplegia com a utilização de EENM e sistema híbrido = Clinical and kinematic analysis of the hand function of persons with tetraplegic using NMES and hybrid system / Clinical and kinematic analysis of the hand function of persons with tetraplegic using NMES and hybrid system

Ferreira, Vanessa Maria de Vargas, 1986- 06 December 2012 (has links)
Orientador: Alberto Cliquet Junior / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-20T15:29:18Z (GMT). No. of bitstreams: 1 Ferreira_VanessaMariadeVargas_M.pdf: 2494774 bytes, checksum: 74419f732c2e800ecd68ccd1416acbcf (MD5) Previous issue date: 2012 / Resumo: Pacientes com lesão medular cervical apresentam disfunção dos membros superiores com grande perda de funcionalidade. A eletroestimulação neuromuscular (EENM) é considerada uma ferramenta importante para a reabilitação desses pacientes. O presente estudo tem como objetivo avaliar a função de pacientes tetraplégicos na tarefa mimética de beber e comparar com a utilização de EENM e um sistema híbrido (órtese dinâmica e EENM) para membros superiores, por meio de análise clínica e cinemática. Participaram desta pesquisa 14 pacientes com tetraplegia com nível motor entre C4 a C7 e 5 voluntários saudáveis. Foram aplicadas escalas clínicas para definir o nível de acometimento neurológico e funcional do paciente (AIS e MIF) e foi realizada avaliação cinemática da tarefa mimética de beber, sendo que os pacientes realizaram a atividade em 3 situações: movimento livre, com EENM e com o sistema híbrido. As variáveis cinemáticas utilizadas foram: tempo do movimento, razão do pico de velocidade máxima, índice de curvatura, trajetória do esterno, distância punho-esterno e abertura da mão. Também foi computado o número de acertos para a realização da tarefa. Os resultados indicam que pacientes que realizam a preensão por tenodese possuem maior independência funcional pela MIF (p=0,0008). Na tarefa mimética de beber houve 60% de acertos no movimento livre, 72,8% com EENM e apenas 47,6% com o sistema híbrido. Pela análise cinemática o uso da EENM não foi diferente do movimento livre, no entanto, os pacientes apresentaram maior tempo e menor suavidade no movimento e realizaram maior trajetória do punho e esterno durante a atividade quando comparado com o controle. O uso do sistema híbrido alterou o padrão de movimento dos pacientes, apresentando um aumento na trajetória do esterno e diminuição da suavidade do movimento. Em suma, a EENM promoveu uma melhor atividade funcional para os pacientes com nível C5, no entanto, o uso do sistema híbrido não parece facilitar a manipulação de objetos por pessoas com tetraplegia / Abstract: Patients with cervical spinal cord injury have dysfunction of the upper limbs with great loss of motor function. Neuromuscular electrical stimulation (NMES) is considered an important tool in rehabilitation. The aim of the present study is to evaluate the function of patients with tetraplegia in the mimetic task of drinking and compare with the use of NMES and a hybrid system (NMES and dynamic orthosis) through clinical evaluation and kinematic analysis. Fourteen patients with tetraplegia level C4 to C7 and 5 able-bodied volunteers participated in the study. Clinical tests were applied to verify the neurological and functional impairment (AIS and FIM) and the mimetic task of drinking was assessed with kinematic during three situations: free movement, with NMES and with the hybrid system. The kinematic variables used were: movement time, peak velocity ratio, index of curvature, sternum trajectory, wrist-sternum distance and hand opening. We also computed the number of successes to perform the task. The results indicate that patients that are able to perform tenodesis grip have greater functional independence through FIM (p=0.0008). The rate of success of the free movement was 60%, 72.8% with NMES and only 47.6% with the hybrid system. In the kinematic analysis the NMES was not different from the free movement, however, patients performed the task in a longer time, the movement was less smooth and the sternum and wrist trajectories were greater than the control group. The use of the hybrid system modified the pattern of movement of the patients, with an increase of the sternum trajectory and decrease of the smoothness. In conclusion, NMES improved the functional activity of patients with C5 level; on the other hand, the use of the hybrid system does not appear to facilitate the prehension of persons with tetraplegia / Mestrado / Fisiopatologia Cirúrgica / Mestre em Ciências
104

Trauma raquimedular : aspectos epidemiológicos, de recuperação funcional e de biologia molecular

Rieder, Marcelo de Mello January 2014 (has links)
Introdução: O Traumatismo Raquimedular (TRM) é um evento catastrófico súbito e inesperado que traz consequências drásticas nos âmbitos de saúde e social de um indivíduo. Os estudos que avaliam as causas e recuperação funcional de TRM no nosso meio são escassos. Não há estudos que utilizem o emprego de biomarcadores séricos como prognosticadores da recuperação funcional. Os objetivos deste estudo são: descrever as Causas das Lesões Medulares de um hospital especializado em trauma na cidade de Porto Alegre e comparar com outros centros no Brasil; avaliar as taxas de mortalidade, tempo de ventilação mecânica, tempo de internação destes pacientes; avaliar e funcionalidade mediante o emprego da MIF no momento da alta e 6 meses após a lesão medular; avaliar os Niveis Séricos dos Biomarcadores: Neuronio Específico Enolase, Irterleucina-6, e Fator Neurotrófico Derivado das Celulas Gliais em pacientes com Trauma Raquimedular Isolado; avaliar o comportamento destes Biomarcadores nas primeiras 48 horas e comparar com o grupo controle, correlacionando as alterações clínicas e o prognóstico nos pacientes com TRM. Material e Métodos: Estudo de coorte prospectivo com pacientes com TRM de várias etiologias. Foram incluídos no estudo todos os pacientes que sobreviveram de TRM isolado que foram atendidos no nosso hospital Cristo Redentor no período de 2010 a 2013. Devido ao considerável número de pacientes com TRM devido a lesões por arma de fogo, estudamos prospectivamente a reabilitação funcional deste grupo de pacientes. Durante a hospitalização, todos os pacientes foram submetidos a uma intensiva reabilitação e a mesmo continuou após a alta hospitalar. Foram avaliadas as escalas da American Spinal Injury Association (ASIA) e a Medida de Indepencência Funcional (MIF) no momento a alta hospitalar e após 6 meses de lesão. Ainda, foram estudados biomarcadores da fase aguda da lesão com objetivo de entender melhor a fisiopatologia das lesões medulares e pesquisar marcadores de prognóstico nesses pacientes. Resultados: A Coorte foi composta de 81 pacientes com média (DP) de 32.6 (±12.2) anos, sendo 76 (93.8%) homens. Na nossa coorte, lesão por arma de fogo foi a maior causa de TRM (x%), enquanto que TRM em acidente de trânsito foram obersvadas em x% e as provocadas por quedas em x%. Os pacientes com TRM causado por lesão por arma de fogo apresentaram menor grau de comprometimento na escala ASIA motora de membro superior, em função de estas lesões afetarem mais porções mais caudais da medula. Entretanto, não observamos diferenças na MIF entre os grupos. Após seis meses, os pacientes apresentaram uma significativa melhora nas escalas ASIA e MIF. O grau de melhora foi similar nas lesões causadas por arma de fogo e de outras etiologias. Nas 48 horas após o TRM observamos elevação significativa de interleucina 6 (IL-6) e enolase neurônio-específica (NSE). No entanto, essa elevação não pôde ser correlacionada com a causa, tipo, severidade da lesão ou prognóstico dos pacientes. Conclusôes: As lesões por arma de fogo são importantes causas de TRM e déficits neurológicos no nosso meio, sendo essse cenário possivelmente reflexo da panorama do TRM no Brasil. A recuperação funcional do TRM severo provocado por armas de fogo é pequena, mas similar aos traumas provocados por queda e acidentes automobilísticos. Nas primeiras 48 horas IL-6 e NSE aumentam significativamente nesses pacientes, embora esse amento não tenha uma correlação clínica mais direta. / Introduction: The Spinal Cord Injury (SCI) is a sudden and unexpected catastrophic event that brings drastic consequences in the areas of health and welfare of an individual. Studies assessing the causes and functional recovery of TRM in our environment are lacking in literature. No studies using the employment of serum biomarkers as predictors of functional recovery. The objectives of this study are to describe the Causes of Spinal Injuries of a specialized trauma hospital in the city of Porto Alegre and compare with other centers in Brazil. We assessed the rates of mortality, duration of mechanical ventilation and length of stay of these patients and evaluated the functionality through the use of the FIM at discharge and 6 months. We also evaluated levels of serum biomarkers : Neuron Specific Enolase , Interleukin -6 -Derived Neurotrophic Factor and Glial Cells from patients with Spinal Cord Trauma Isolated and the behavior of these biomarkers in the first 48 hours and compared with the control group correlating the clinical findings and prognosis in patients with SCI . Material and Methods: Prospective cohort study conducted in patients with severe TSCI with different etiologies. All survivals patients of isolated acute TCSI who were attended in our center from 2010 to 2013 were included in this study. Patients were divided in two groups if TSCI, those with lesions provoked by firearms was provoked by firearm or other causes. During hospitalization all patients were submitted to intensive rehabilitation and followed in a rehabilitation program after discharge. They were evaluated with ASIA and FIM at the time of the hospital discharge and six mounts latter. Sorological biomarkers were evaluated in the first 48 hours. Results: The cohort was composed by 81 patients, mean age (±S.D.) of 32.6 (±12.2) years, being 76 (93.8%) males. Patients with TSCI caused by firearms showed lower degree of impairment than other patients in ASIA motor superior, because a larger number of patients in the group of firearm lesions showed lumbar woods. However, in the other scales we did not observed this difference. After six months, patients showed significant improvement in ASIA and FIM scales. The degree of improvement was similar between patients with TSCI caused by firearms or others. There was an increase of biomarkers IL-6, NSE and GDNF. Conclusions: TSCI provoked by firearms are an important cause of spinal lesion and neurological deficits in Brazil. Functional recovery in severe TSCI provoked by firearms is limited but similar than severe TSCI provoked by falls or automobilist accidents.
105

Estudo dos efeitos do monossialogangliosídeo (GM1) administrado pela via transdérmica por laser a baixa temperatura, após lesão medular experimental em ratos / Study the effects of monossialoganglioside (GM1) administered by transdermal laser at low temperature, the spinal cord injuries in rats

Souza, Fabiano Inácio de 24 January 2012 (has links)
Objetivo: avaliar os efeitos do monossialogangliosídeo (GM1) administrado pela via de transdérmica por laser a baixa temperatura, após lesão medular experimental em ratos. Métodos: o estudo incluiu 40 ratos Wistar, machos, com idade entre 20 e 21 semanas, submetidos à lesão medular contusa pelo equipamento NYU Impactor, a altura de 25 mm, de acordo com o protocolo MASCIS. Foram formados 4 grupos de 10 animais. No grupo 1, os ratos receberam diariamente 0,2 ml de soro fisiológico, via intraperitoneal; no grupo 2, GM1 via intraperitoneal, na concentração 30 mg/kg por dia; no grupo 3, sessão diária de laser a baixa temperatura na topografia da lesão; no grupo 4 sessão diária de laser contendo GM1 na concentração de 30 mg/kg pela via transcutânea por Laser Ice. Todos os animais foram tratados por 42 dias. Foram avaliados por meio da escala de avaliação funcional Basso, Baettie e Bresnahan (BBB) em 7, 14, 21, 28, 35 e 42 dias após a lesão, pelo exame histopatológico e por potencial evocado motor após 42 dias da lesão. Resultados: os animais do grupo 4 apresentaram os escores da escala BBB superiores aos demais grupos até a quarta semana, sendo equiparado aos demais na sexta semana. Não houve diferença estatisticamente significante entre os grupos e as semanas. A avaliação histológica não demonstrou resultados com significância estatística. Os exames de potencial evocado motor demonstraram maior latência média no grupo 1, sem significância estatística. Conclusão: o emprego de GM1 associado a laser em baixa temperatura demonstra resultados funcionais superiores nas primeiras semanas, mas sem evidenciar diferença estatisticamente significante / Objective: To evaluate the effects of monossialoganglioside (GM1) administered transdermally, and laser at low temperature, in the functional and histological recovery of spinal cord injury in rats. Methods: Forty male Wistar rats, aged between 20 and 21 weeks, underwent spinal cord contusion at NYU Impactor, according to the MASCIS protocol. They were divided into four groups: in Group 1, rats received 0.2 ml of saline intraperitoneally daily; in Group 2, GM1 was administered intraperitoneally at a concentration 30 mg/kg per day; in Group 3, rats were treated with laser at low temperature on the skin, daily and in Group 4, the daily laser session also contained GM1. All the groups were treated for 42 days. The animals were evaluated by the Basso, Baettie and Bresnahan (BBB) functional scale on days 7, 14, 21, 28, 35 and 42 after injury, and by histopathology and motor evoked potentials after 42 days of injury. Results: The animals in Group 4 had higher BBB scores compared to the other groups, until the 4th week. There were no statistically significant differences between the groups, or in the comparisons over time, i.e. from one week to the next. Histological evaluation showed no statistically significant results, and no significant differences were found in the motor evoked potential tests either. Conclusion: GM1 associated with the use of low-temperature laser shows no superior functional, neurological or histological results in the treatment of spinal cord lesions in rats
106

The Influence of Self-Efficacy Expectations on Rehabilitation Outcome in Spinal Cord Injured Individuals

Belanus, Anne 08 1900 (has links)
This study examined the relationship between Bandura' s theory of self-efficacy and the rehabilitation outcome of spinal cord injured persons. The study elicited selfefficacy expectations from fifteen subjects on three occasions: admission and two and four weeks later. Patients rated how they expected to perform six weeks after admission on fifteen rehabilitation behaviors. Patients' ratings were compared to actual performance ratings made by the medical staff on the Barthel Index. Results reveal that subjects' predictions two weeks and four weeks after admission were accurate (r = .74, < .01; r = .89, p < .001, respectively). Findings support the limited applicability of Bandura's theory of spinal cord injury rehabilitation. Recommendations for future research include examining variables which enhance self-efficacy and using a larger, more homogeneous sample.
107

Functional Electrical Stimulation Post-Spinal Cord Injury Improves Locomotion and Increases Afferent Input Into the Central Nervous System in Rats

Beaumont, Eric, Guevara, Edgar, Dubeau, Simon, Lesage, Frederic, Nagai, Mary, Popovic, Milos 01 January 2014 (has links)
Background: Functional electrical stimulation (FES) has been found to be effective in restoring voluntary functions after spinal cord injury (SCI) and stroke. However, the central nervous system (CNS) changes that occur in as a result of this therapy are largely unknown. Objective: To examine the effects of FES on the restoration of voluntary locomotor function of the CNS in a SCI rat model. Methods: SCI rats were instrumented with chronic FES electrodes in the hindlimb muscles and were divided into two groups: (a) FES therapy and (b) sedentary. At day 7 post-SCI, the animals were assessed for locomotion performance by using a Basso, Beattie and Bresnahan (BBB) scale. They were then anesthetized for a terminal in vivo experiment. The lumbar spinal cord and somatosensory cortex were exposed and the instrumented muscles were stimulated electrically. Associated neurovascular responses in the CNS were recorded with an intrinsic optical imaging system. Results: FES greatly improved locomotion recovery by day 7 post-SCI, as measured by BBB scores (P < 0.05): (a) FES 10 ± 2 and (b) controls 3 ± 1. Furthermore, the FES group showed a significant increase (P < 0.05) of neurovascular activation in the spinal cord and somatosensory cortex when the muscles were stimulated between 1 and 3 motor threshold (MT). Conclusion: Hind limb rehabilitation with FES is an effective strategy to improve locomotion during the acute phase post-SCI. The results of this study indicate that after FES, the CNS preserves/acquires the capacity to respond to peripheral electrical stimulation.
108

THE EFFECTS OF OSTEOPATHIC TREATMENT ON COMMON FEMORAL ARTERY BLOOD FLOW AND SKIN TEMPERATURE IN SPINAL CORD INJURED AND ABLE-BODIED INDIVIDUALS

Murray, David J.G. 04 1900 (has links)
<p><h1>ABSTRACT</h1> <h1>Individuals with spinal cord injuries (SCI) are prone to significant alterations in vascular structure and function. This study was designed to examine the effects of osteopathic treatment on mean leg (MLBF) blood flow and skin temperature in the lower extremities of individuals with chronic SCI compared to able-bodied (AB) individuals. Methods: Nine individuals (age 44 ± 17.5 years) with a chronic SCI (C6-T12; AIS A-B; 3.7 ± 4.6 years post-injury) and six AB individuals (38.3 ± 9.7 years) participated. The protocol consisted of 1 interview session and 3 osteopathic treatment sessions. Doppler ultrasound measured the diameter and mean blood velocity in the CFA before (Pre) and after (Post) each session. Skin temperatures were measured using skin thermistors at three different sites on the left leg. Change scores were calculated and measured as post-treatment minus pre-treatment. Results: A two-way ANOVA revealed an increase in flow of 16±2 ml/min within the SCI group and a decrease in flow of 25±2 ml/min in the AB group (p = 0.04). There was also a smaller reduction in skin temperature in individuals within the SCI versus AB (left thigh: SCI, -0.5±0.2° C; AB, -1.2±0.2°C, p(left foot: SCI, -0.1±0.4°C; AB, -1.8±0.4°C, pAll treatments resulted in small increases in MLBF in the SCI group versus small decreases in the able-bodied group and smaller skin temperature decreases in the SCI versus the decreases in the AB group, potentially indicating reduced skin temperature reactivity. These findings emphasize the potential for different physiological responses to interventions in individuals with SCI compared to AB individuals.</h1></p> / Master of Science in Kinesiology
109

Cellular and molecular characterization of inflammation in the injured spinal cord

Ghasemlou, Nader. January 2008 (has links)
No description available.
110

Ocorrência de traumatismo raquidiano em doentes em coma decorrente de traumatismo cranioencefálico / Spine injuries in patents presenting coma due to head injury

Rosi Junior, Jefferson 05 April 2012 (has links)
Foi realizado estudo prospectivo com o objetivo de se determinar a ocorrência de traumatismo raquidiano (TR) em 355 doentes em coma decorrente de traumatismo cranioencefálico (TCE) resultante de acidente de tráfego atendidos no Pronto Socorro de Neurocirurgia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (PSNCHCFMUSP) de 1° de setembro de 2003 a 31 de dezembro de 2009. Todos os doentes foram submetidos ao exame físico e neurológico e à tomografia computadorizada (TC) do corpo inteiro para diagnosticar-se e avaliar-se a gravidade das lesões traumáticas encefálicas, vertebrais ou de outras regiões no momento da admissão ao PSNCHCFMUSP. Em 69 (19,4%) doentes, foi(ram) diagnosticada(s) lesão(ões) na coluna vertebral com o exame de TC da coluna vertebral. As idades dos doentes variaram de 12 a 55 anos (média de 29,0 anos). Eram do sexo masculino 57 (82,6%) doentes. As causas do(s) traumatismo(s) foi(ram) acidente(s) envolvendo motocicleta em 28 (40,6%) casos, atropelamento em 21 (30,5%), colisão de automóvel, caminhão ou caminhonete, em 18 (26,1%) ou acidente com bicicleta em dois (2,9%). Hemorragia subaracnóidea traumática foi a anormalidade intracraniana traumática mais evidenciada no exame de TC do crânio; ocorreu em 57 (82,6%). O(s) processo(s) transverso(s) foi(ram) o(s) segmento(s) vertebral(is) mais acometido(s) pela(s) fratura(s). A sétima vértebra cervical foi a mais lesada; nela identificaram-se fraturas em 24 (34,8%) doentes. Evidenciou-se que a distribuição das fraturas foi similar ao longo das demais vértebras da coluna cervical, quatro primeiras vértebras torácicas e vértebras lombares. Em oito (11,6%) doentes a(s) lesão(ões) neurológica(s) foi(ram) classificada(s) como Frankel A, e nos demais 61(88,4%), como Frankel não-A. Houve necessidade de cirurgia espinal em 24 (34,8%) doentes e de neurocirurgia craniana em 18 (26,0%) doentes. A Escala de Recuperação de Glasgow foi aplicada para avaliar-se as condições neurológicas do doente no momento da alta hospitalar e revelou ocorrência de óbito em dois (2,9%) doentes. Concluiuse que é recomendada a avaliação clínica e também com métodos de imagem da coluna vertebral nos doentes em coma decorrente de TCE / The author presents a prospective study aiming the evaluation of coexistence of spinal injury (SI) in 355 patients presenting coma due to craniocerebral trauma assisted at the Emergency Room of the Hospital das Clínicas of the University of São Paulo Medical School, from September, 1st, 2003 to december, 31th,2009. All patients underwent physical and neurological examination and had computed tomography (CT) scanning of the entire body to diagnose and evaluate the severity of brain and spinal injury at the time of admission. Traumatic lesions of the spine were diagnosed in 69 (19.4%) patients. The ages of patients ranged from 12 to 55 years (mean = 29,0 years).The SI predominated in males, corresponding to 57 (82.6%) patients. The causes of the trauma were motorcycle accident in 28 (40.6%) cases, running over in 21(30.5%), car collision 18 (26.1%) cases and bicycle accident in two (2.9%). Traumatic subarachnoid hemorrhage was the most common traumatic intracranial abnormality in the CT images; it was identified in 57 (82.6%) patients. The transverse process was the most common vertebral part presenting fracture(s). The 7th cervical vertebra was individually the most commonly affected; traumatic lesion of this vertebra presented in 24 (34.8%) patients. The diagnosis of fracture(s) was similar in the other cervical vertebrae and occurred also in the first four thoracic and in the lumbar vertebrae. Severe neurological deficit secondary to spine fracture was diagnosed in eight (11.6%) patients, classified as Frankel A. The others 61(88.4%) patients did not present complete spinal cord or spinal roots neurological deficits were classified as Frankel non A. The Recovery Scale of Glasgow was used to evaluate the neurological status at discharge from hospital. Two (2.9%) patients died. Spinal surgery was necessary in 24 (34.8%) patients and cranial surgery in 18 (26.0%). It was concluded that in addition to clinical evaluation, the CT imaging of the spine is recommended in patients in coma due to mechanical traumatic head injury

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