Η παρούσα διπλωματική εργασία έχει ως στόχο την αντιμετώπιση των ηλεκτρομηχανικών ταλαντώσεων οι οποίες εμφανίζονται σε μία σύγχρονη γεννήτρια παραγωγής Ηλεκτρικής Ενέργειας μετά από διαταραχές. Ο συμβατικός έλεγχος για τη διατήρηση της μηχανής σε συγχρονισμό μετά από ξαφνικές αλλαγές φορτίου, βραχυκυκλωμάτων, κλείσιμο διακοπτών ή οποιασδήποτε κατάστασης που μπορεί να προκαλέσει αστάθεια στο Σύστημα της Ηλεκτρικής Ενέργειας, γίνεται με χρήση ελεγκτικών διατάξεων Σταθεροποιητών Συστημάτων Ισχύος σε συνδυασμό με τον Αυτόματο Ρυθμιστή Τάσης (ΑΡΤ/ΣΣΙ). Σκοπός της εργασίας αυτής είναι να σχεδιαστούν και να ρυθμιστούν κατάλληλα οι διατάξεις αυτές, ώστε να εξασφαλίζεται η απόσβεση των ηλεκτρομηχανικών ταλαντώσεων που εμφανίζονται ανάμεσα στην γεννήτρια και το υπόλοιπο σύστημα. Στην εργασία αυτή, αρχικά γίνεται μια εισαγωγή στα είδη των ηλεκτρομηχανικών ταλαντώσεων και την ευστάθεια για δυναμικά Συστήματα Ηλεκτρικής Ενέργειας. Στη συνέχεια αναπτύσσεται το δυναμικό μοντέλο ενός απλού συστήματος μιας γεννήτριας άπειρου ζυγού βασισμένο στο απλοποιημένο μοντέλο 4ης τάξης της σύγχρονης μηχανής. Επειδή το μοντέλο αυτό είναι μη γραμμικό προχωράμε στην εξαγωγή του γραμμικοποιημένου μοντέλου που θα μας βοηθήσει για τον σχεδιασμό του κατάλληλου ελεγκτή. Αξιοποιώντας ιδιότητες του μοντέλου παρουσιάζεται μια συστηματική μέθοδος σχεδίασης του Σταθεροποιητή Συστήματος Ισχύος που είναι βασισμένη στη λογική των ολοκληρωτικών υπολοίπων. Τέλος με τη βοήθεια του λογισμικού SIMULINK του MATLAB προσομοιώνεται το σύστημα σύγχρονης γεννήτριας συνδεδεμένης σε άπειρο ζυγό, που ελέγχεται με την χρήση του Αυτόματου Ρυθμιστή Τάσης και του Σταθεροποιητή Συστήματος Ισχύος σε κατάσταση τυπικής φόρτισης. Εφαρμόζοντας διαταραχές στο σύστημα παρατηρείται η απόκριση του συστήματος και εκτιμάται η λειτουργία του ελεγκτή. / This thesis aims to address the electromechanical oscillations which appear in a synchronous generator after disturbances. The conventional control for maintaining the machine synchronized after sudden load changes, short circuits, switching or any condition which may cause instability phenomena, is achieved by the use of control circuits such as Power System Stabilizers combined with the Automatic Voltage Regulator ( PSS / AVR). The purpose of this work is to design and configure properly these control circuits to ensure the reduction of electromechanical oscillations that occur between the generator and the rest of the system. In the beginning this thesis, an introduction of the types of power system electromechanical oscillations and stability is being discussed. Afterwards, the dynamic model of a simple system of a generator infinite-bus based on simplified 4th order of synchronous machine is being developed. Due to the model nonlinearities, we export the linearized model which helps us to design a suitable controller. Taking into account the model properties, we provide a systematic method for designing a Power System Stabilizer based on the residues method. Finally, using the MATLAB-SIMULINK software, the synchronous generator infinite-bus system is simulated which is controlled by an Automatic Voltage Regulator and a Power System Stabilizer. After applying disturbances, the system response is driven and analyzed along with the controller functioning.

Orientador: Percival Bueno de Araujo / Resumo: Neste trabalho, uma técnica baseada na Busca em Vizinhança Variável Básica é apresentada para realizar o ajuste coordenado dos parâmetros dos controladores suplementares de amortecimento Thyristor Controlled Series Capacitor - Power Oscillation Damping e Estabilizadores de Sistemas de Potência, a fim de garantir a estabilidade a pequenas perturbações de sistemas elétricos de potência. A estratégia do método de ajuste proposto consiste em explorar sistematicamente estruturas de vizinhança atrelada a uma etapa de busca local, tornando possível a obtenção de soluções ótimas e a manutenção da capacidade de evitar a estagnação em um ótimo local. Um modelo do TCSC por injeção de corrente é apresentado e seus coeficientes de sensibilidade de corrente são deduzidos para incorporação ao Modelo de Sensibilidade de Corrente, que é utilizado para representar o sistema elétrico de potência. Com a inclusão da modelagem dos controladores de amortecimento, simulações são realizadas em dois sistemas testes, conhecidos como sistema Simétrico de Duas Áreas e sistema New England. Os resultados obtidos são analisados para melhor compreensão do comportamento do sistema elétrico de potência quando submetido a uma pequena perturbação e da influência dos controladores de amortecimento neste cenário. Os parâmetros dos controladores são ajustados pelo algoritmo Particle Swarm Optimization, por um Algoritmo Genético e, também, pelo método proposto neste trabalho. Os desempenhos individuais dos métodos d... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: In this work, a technique based on Basic Variable Neighborhood Search is presented to perform the coordinated tuning of the parameters of the supplementary damping controllers Thyristor Controlled Series Capacitor - Power Oscillation Damping and Power System Stabilizers in order to guarantee the small-signal stability of the electric power systems. The strategy of the proposed tuning method consists in systematically exploring neighborhood structures followed by a local search stage, making it possible to obtain optimal solutions and to maintain the ability to avoid stagnation in a local optimum. A current injection model for the TCSC is presented and its current sensitivity coefficients are deduced for incorporation into the Current Sensitivity Model, which is used to represent the electric power system. With the inclusion of the damping controllers modeling, simulations are performed on two test systems, known as the Two-Area Symmetric system and New England system. The results obtained are analyzed to better understand the behavior of the electric power system when subjected to a small disturbance and the influence of the damping controllers in this scenario. The controllers parameters are tuned by the Particle Swarm Optimization algorithm, by a Genetic Algorithm and also by the method proposed in this work. The individual performances of the tuning methods are compared in order to conclude on the technique best suited for this type of problem, including the analysis of a ... (Complete abstract click electronic access below) / Doutor

Mood disorders are serious diseases. Nevertheless, their pathophysiology is not sufficiently clarified. Biological markers that would facilitate the diagnosis or successful prediction of pharmacotherapy are still being sought. The aim of the study was to find out whether mitochondrial functions are affected by antidepressants, mood stabilizers and depression. Our research is based on recent hypotheses of mood disorders, the advanced monoamine hypothesis, the neurotrophic hypothesis, and the mitochondrial dysfunction hypothesis. We assume that impaired function of mitochondria leads to neuronal damage and can be related to the origin of mood disorders. Effects of antidepressants and mood stabilizers on mitochondrial functions can be related to their therapeutic or side effects. In vitro effects of pharmacologically different antidepressants and mood stabilizers on the activities of mitochondrial enzymes were measured in mitochondria isolated from pig brains (in vitro model). Activity of monoamine oxidase (MAO) isoforms was determined radiochemically, activities of other mitochondrial enzymes were measured spectrophotometrically. Overall activity of the system of oxidative phosphorylation was measured electrochemically using high- resolution respirometry. Methods were modified to measure the same...

O presente trabalho se propõe a elaborar algoritmos para controle robusto de sistemas de potência. O modelo de sistema de potência multimáquinas utilizado é o de pequenas perturbações, e o objetivo principal é aumentar o amortecimento dos autovalores críticos do sistema, garantindo sua estabilidade e desempenho em diversas condições operativas. Para isso, são utilizadas as Desigualdades Matriciais Lineares (ou LMI\'s), muito adequadas ao tratamento de problemas de controle robusto por sua flexibilidade e possibilidade de agrupamento de diversos requisitos de desempenho. São propostos, entre outros, três algoritmos fundamentais para controle robusto: dois estão relacionados ao controle descentralizado e com controladores de estrutura fixa, o que é muito comum na indústria de potência atualmente, e o outro está relacionado ao controle hierarquizado, que consiste na integração de várias camadas de controle utilizando sinais remotos. Os algoritmos de controle descentralizado propostos são inovadores, pois ambos os métodos permitem a utilização de controladores de estrutura fixa (qualquer que seja ela), e o algoritmo de controle hierarquizado propõe uma estrutura de controle inédita que utiliza aproximações de Padé de diversas ordens para representar os atrasos de comunicação no sistema. Durante a fase de projeto, pode-se escolher o atraso de comunicação, bem como a ordem da aproximação de Padé desejada. Nos algoritmos de controle robusto descentralizado, realizamos uma minimização da norma da matriz de ganhos estáticos do controlador, o que impede que o resultado do algoritmo sejam parâmetros de valores muito elevados e infactíveis para os controladores. A técnica utilizada para os três controladores propostos é o posicionamento de pólos, o que garante que os autovalores do sistema de potência em malha fechada estejam numa dada região do plano complexo, relacionada ao amortecimento mínimo desejado para os autovalores do sistema. Os testes e simulações realizados para validação dos algoritmos de controle robusto foram feitos em ambiente MATLAB, e foram utilizados diversos sistemas de potência: sistema New England de 39 barras e 9 geradores, sistema New England de 69 barras e 16 geradores e sistema New England de 39 barras utilizando modelos de termogeradores. Os testes sugerem que as técnicas propostas são eficazes, pois todas elas garantem boas taxas de amortecimento para os sistemas de potência utilizados. Ao final, simulações não-lineares comprovam a eficácia e a eficiência de um dos controladores projetados para o sistema New England de 39 barras. / The aim of this work is to elaborate robust control algorithms to power systems. The mathematical model employed to describe the multimachine power system is that used in small signal studies, and the main goal is to increase the damping of the critical eigenvalues of the system, guaranteeing its stability and performance in various operating conditions. To do this, we apply the Linear Matrix Inequalities (or simply LMI\'s), suitable to deal with robust control problems due to its flexibility and possibility to group many performance requisites. We propose three robust control algorithms: two of them are related to decentralized control with controllers of predefined structure, which are commonly used in the power industry, and the other one is related to the hierarchized control, which consists on the integration of various controllers layers using remote signals. The decentralized robust control algorithms proposed are novel, because both methods make possible the development of controllers of pre-defined structure, and the hierarchized control algorithm suggests a novel control structure that uses Padé approximations of different orders to represent the communication delays in the system. During the design, we can choose the communication delay, as well as the order of the Padé approximation desired. The decentralized robust control algorithms solve minimization problems over the controller gain matrix norm, which guarantees that the final values of the controller\'s parameters will not be much high and impracticable. The technique employed for the three types of controllers proposed is the pole placement, which ensures that the eigenvalues of the closed loop power system will be in a certain region of the complex plane, related to the minimum damping required for the system. Tests and simulations are done in MATLAB to validate the robust control algorithms, and we apply these algorithms to various power systems: 39-bus 9-machine New England power system, 69-bus 16-machine New England power systems and 39-bus New England power system with thermo machine models. The tests suggest that the proposed techniques work well, once all of them guarantee good damping rates to the power systems considered. To complete the tests round, nonlinear simulations proof the efficiency of the controllers designed for the 39-bus New England power system.

Small disturbances occur continuously in electrical systems mainly due to load and generation variations. This ends up causing low frequency voltage fluctuations that are usually observed in systems whose lines have weak connections. In addition to damaging loads connected to the same bus, they can even damage equipment and incurring in costs to the energy distributors. Moreover, such oscillations can resonate with the system parameters and cause a general collapse in energy supplies. In the literature, there are methods for the development of stabilizers for power systems that are implemented to counteract these perturbations. In this dissertation, we compared some objective functions and identified points that can be optimized for parameterization of power system stabilizers IEEE models: PSS2B, PSS4B and conventional Delta w PSS, by computer simulations. The adjustment methodology used in this dissertation is based on the genetic algorithm (GA) held in Simulink® with the aid of the Matlab toolbox Gatool®. The effectiveness of the suggested technique and stabilizers are checked using simulation results, where it is noticeable that the PSSs managed to dampen oscillations in almost all cases. The only one who did not realize the optimization was the Delta W PSS with ITSE objective function in the hydraulic turbine, which failed to dampen oscillations even for the best results. Moreover, it was also possible to notice that the same Delta W PSS with ITAE objective function had the best results for the two types of turbine. / Pequenas perturbações ocorrem continuamente em sistemas elétricos principalmente devido às variações de cargas e da geração. Isto acaba acarretando oscilações de tensão de baixa frequência que são normalmente observadas em sistemas cujas linhas possuem conexões fracas. Além de prejudicar as cargas conectadas no mesmo barramento, elas podem até danificar aparelhos e incorrer em ônus para as distribuidoras de energia. Além do mais, tais oscilações podem entrar em ressonância com os parâmetros do sistema e causar um colapso geral no abastecimento de energia. Na literatura encontram-se metodologias para o desenvolvimento de Estabilizadores para Sistemas de Potência que são implantadas para se contrapor a estas perturbações. Nesta dissertação, foram comparadas algumas funções objetivo para a parametrização dos estabilizadores de sistemas de potência modelos IEEE: PSS2B, PSS4B e convencional Delta w PSS, a partir de simulações computacionais. A metodologia de ajuste utilizada nesta dissertação é baseada no algoritmo genético (AG) realizada em Simulink® com auxílio do toolbox Gatool® do Matlab®. A eficácia da técnica sugerida e dos estabilizadores é verificada com os resultados de simulação, em que é possível perceber que os PSSs conseguiram amortecer oscilações em quase todos os casos. O único que não realizou a otimização foi o Delta W PSS com a função objetivo ITSE na turbina hidráulica, o qual não conseguiu amortecer as oscilações com seu melhor resultado encontrado. Por outro lado, foi possível perceber também que o mesmo Delta W PSS com a função objetivo ITAE teve o melhor resultado para os dois tipos de turbina.

Die Bedeutung des Immunsystems in der Pathophysiologie von bipolaren Erkrankungen und Epilepsie ist ein aktueller Gegenstand der neuropsychoimmunologischen Forschung. Eine erhöhte Produktion von Zytokinen aufgrund von oxidativem Stress wurde dabei wiederholt als für die Pathophysiologie von Epilepsie und Bipolarer Störung relevant angesehen. In Hinblick auf Veränderungen der Zytokine Interleukin (IL)-1ß, IL-2, IL-4, IL-6 und Tumornekrosefaktor-alpha (TNF-α) wurden z. T. überlappende Ergebnisse bei beiden Erkrankungen beschrieben. Inwiefern diese Zytokine durch Stimmungsstabilisierer und Antiepileptika beeinflusst werden, wurde bisher jedoch nicht systematisch untersucht. In dieser Studie wurden systematisch in-vitro die Konzentrationen von IL-1ß, IL-2, IL-4, IL-6, IL-17, IL-22 und TNF-α im stimulierten Blut 14 gesunder Frauen mittels Vollblutverfahren (whole blood assay) nach Zugabe von Stimmungsstabilisierern bzw. Antiepileptika gemessen. Es wurden dabei die Stimmungsstabilisierer bzw. Antiepileptika Primidon, Carbamazepin, Levetiracetam, Lamotrigin, Valproat, Oxcarbazepin, Topiramat, Phenobarbital und Lithium untersucht. Die Ergebnisse lassen darauf schließen, dass der Mechanismus von erwünschter und unerwünschter anderer Wirkung von Stimmungsstabilisierern und Antiepileptika mit der Regulation von IL-1ß, IL-2, IL-22 und TNF-α in Zusammenhang stehen könnte. Getrennt nach den im Vollblutverfahren verwendeten Stimulanzien – Toxic-Shock-Syndrome-Toxin-1 (TSST-1) vs. monoklonaler Antikörper gegen das CD3-Oberflächenantigen (OKT3) in Kombination mit dem 5C3-Antikörper gegen CD40 (OKT3/CD40) – wurden die Ergebnisse in zwei unterschiedlichen Publikationen berichtet, die dieser Promotion zugrunde liegen.

In the Nordic power network, the existence of poorly damped low-frequency inter-area oscillations (LFIOs) has long affected stability constraints, and thereby, limited power transfer capacity. Adequate damping of inter-area modes is, thus, necessary to secure system operation and ensure system reliability while increasing power transfers. Power system stabilizers (PSS) is a prevalent means to enhance the damping of such modes. With the advent of phasor measurement units (PMUs), it is expected that wide-area damping control (WADC), that is, PSS control using wide-area measurements obtained from PMUs, would effectively improve damping performance in the Nordic grid, as well as other synchronous interconnected systems. Numerous research has investigated one ``branch'' of the problem, that is, PSS design using various control schemes. Before addressing the issue of controller design, it is important to focus on developing proper understanding of the ``root'' of the problem: system-wide oscillations, their nature, behavior and consequences. This understanding must provide new insight on the use of PMUs for feedback control of LFIOs. The aim of this thesis is, therefore, to lay important concepts necessary for the study of power system small signal stability analysis that considers the availability of synchrophasors as a solid foundation for further development and implementation of ideas and related applications. Particularly in this study, the focus is on the application addressed damping controller design and implementation. After a literature review on the important elements for wide-area damping control (WADC), the thesis continues with classical small signal stability analysis of an equivalent Nordic model; namely, the KTH-NORDIC32 which is used as a test system throughout the thesis. The system's inter-area oscillations are identified and a sensitivity analysis of the network variables directly measured by synchrophasors is evaluated. The concept of network modeshapes, which is used to relate the dynamical behavior of power systems to the features of inter-area modes, is elaborated. Furthermore, this network modeshape concept is used to determine dominant inter-area oscillation paths, the passageways containing the highest content of the inter-area oscillations. The dominant inter-area paths are illustrated with the test system. The degree of persistence of dominant paths in the study system is determined through contingency studies. The properties of the dominant paths are used to construct feedback signals as input to the PSS. Finally, to exemplify the use of the dominant inter-area path concept for damping control, the constructed feedback signals are implemented in a PSS modulating the AVR error signal of a generator on an equivalent two-area model, and compared with that of conventional speed signals.

Mood disorders are serious diseases. Nevertheless, their pathophysiology is not sufficiently clarified. Biological markers that would facilitate the diagnosis or successful prediction of pharmacotherapy are still being sought. The aim of the study was to find out whether mitochondrial functions are affected by antidepressants, mood stabilizers and depression. Our research is based on recent hypotheses of mood disorders, the advanced monoamine hypothesis, the neurotrophic hypothesis, and the mitochondrial dysfunction hypothesis. We assume that impaired function of mitochondria leads to neuronal damage and can be related to the origin of mood disorders. Effects of antidepressants and mood stabilizers on mitochondrial functions can be related to their therapeutic or side effects. In vitro effects of pharmacologically different antidepressants and mood stabilizers on the activities of mitochondrial enzymes were measured in mitochondria isolated from pig brains (in vitro model). Activity of monoamine oxidase (MAO) isoforms was determined radiochemically, activities of other mitochondrial enzymes were measured spectrophotometrically. Overall activity of the system of oxidative phosphorylation was measured electrochemically using high- resolution respirometry. Methods were modified to measure the same...

Psychopharmaca are a large group of drugs widely used not only in psychiatry. Their systemic administration affects both the main diagnosis and the organism as a whole. The subject of our experiments is the effect of psychopharmaca on the changes in mitochondrial functions, which is beneficial for understanding of molecular mechanisms of therapeutic and adverse effects of drugs. The aim of this thesis was to study the in vitro effects of selected drugs on the cell energy metabolism. Selected antipsychotics (chlorpromazine, levomepromazine, haloperidol, risperidone, ziprasidone, zotepine, aripiprazole, clozapine, olanzapine, and quetiapine), antidepressants (bupropion, fluoxetine, amitriptyline, imipramine) and mood stabilizers (lithium, valproate, valpromide, lamotrigine, carbamazepine) were tested. In vitro effects of selected psychopharmaca were measured on isolated pig brain mitochondria. The activities of citrate synthase (CS) and electron transport chain (ETC) complexes (I, II+III, IV) were measured spectrophotometrically. Drug-induced changes of mitochondrial respiration rates linked to complex I (supported by malate and pyruvate) and complex II (supported by succinate) were evaluated by high resolution respirometry. Complex I was significantly inhibited by lithium, carbamazepine, fluoxetine,...

Vanliga fenoliska antioxidanter som används i polymerer orsakar färgändringar i polymeren. Detta arbete berör antioxidanter med jämförelsevis begränsad färgändring, med fokus på att utveckla metoder för analys av dessa. UV-stabilisatorerna UV2, UV5, UV1, UV4, UV3 och UV6 är också inkluderade i detta arbete. Metodutvecklingen involverade både kapillärelektrofores och ”matrix assisted laser desorption ionization-time of flight mass spectrometry” (MALDI-TOF). Den bästa metoden för analys av de flesta av additiven inkluderade MALDI-TOF med 2’,6’-dihydroxyacetophenon (10 mg/ml) i TA50 som matris och hexafluoroisopropanol som lösningsmedel. När en metod för detektion av analyterna hade tagits fram, så inleddes utveckling av en metod för extraktion av additiv från polymera material. Extraktion av UV5 var framgångsrik vid användning av toluen vid 80 °C i ultraljudsbad i tre timmar. Det extraherade UV5 detekterades sedan med metoden som hade utvecklats för det rena additivet. / Ordinary phenolic antioxidants used in polymers give rise to color formations. This work concerns antioxidants with limited color-formations in comparison, with the focus being development of methods for analysis of these. Also included in this work are the high molecular weight UV-stabilizers UV2, UV5, UV1, UV4, UV3 and UV6. The method development involved both capillary electrophoresis and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF). The best method for analysis of most additives involved using MALDI-TOF with a matrix consisting of 2’,6’-dihydroxyacetophenone (10 mg/ml) in TA50 and with hexafluoro isopropanol as the solvent. When a method for detection of the analytes had been obtained, a method for extraction of the additives from polymers was developed. UV5 was successfully extracted using toluene as the extracting solvent at 80 °C under sonication for three hours. The extracted UV5 was then detected using the method developed for the pure additive.