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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
101

That half of the room is yours: conflict behavior systems in a university residence hall

Mueller, Christopher January 1900 (has links)
Master of Arts / Department of Communication Studies / Sarah Riforgiate / College residence halls house thousands of students every year. This provides students an opportunity to live closely with new people and develop social skills sought by employers (Myers & Larson, 2005). Living with new people also provides the opportunity for anxiety and conflict (Ingalls, 2000). Many residents reject the idea of initiating or processing their own conflicts, often turning to destructive conflict management behaviors such as avoidance (De Cecco & Richards, 1974; Sillars, 1980). A clearer understanding of influences on student conflict behaviors will help colleges and universities assist students in having positive experiences living on campus. While attempts to understand student conflict management are varied, few consider behavior patterns as systems (Duran & Zakahi, 1988, Kiernan & Gray, 2013, Martin & Anderson, 1995). This qualitative study applies an organizational communication framework and structuration theory (Giddens, 1984; Poole & McPhee, 2005; Sewell, 1992) as a lens to address conflict behavior systems and structures within post-secondary residence halls. Theoretically, this research adds to existing scholarship by applying structuration theory to a non-business context, extending the theory beyond the employer/employee dynamic it is often constrained to. Additionally this study uses structuration theory in a practical manner (Sewell, 1992) in the hopes of informing and improving roommate pairing and conflict approaches. Twenty-three student residents participated in in-depth interviews to answer research questions designed to address communication practices that relate to rules and resources of conflict structures as well as how the dimensions of structuration, power, meaning, and norms, influence the use of rules and resources (Poole & McPhee, 2005). The study identifies resources of authority, space, favor reciprocity, mutual respect, routines, external others, and time and discusses the associated rules within college residence hall rooms. These rules and resources are informed by systems of “coexistent” and “engaged” harmony. Additionally the study identifies how the dimensions of structuration shape systems within the residence hall room and between the roommates by influencing the way rules and resources are used. Largely, this study contributes to the field of structuration research while attempting to incorporate pieces of Sewell’s (1992) critique in the form of practical implications.
102

The impact of social enterprise on labor market structure: A case study of social enterprises in Nairobi

Mwaniki, Joy Muthanje January 2018 (has links)
Magister Artium (Development Studies) - MA(DVS) / Social entrepreneurship has spread worldwide, as social entrepreneurs seek the solutions to developmental challenges. This is especially true in Nairobi, Kenya, as social entrepreneurship has established itself in the labor market. However, there is limited knowledge regarding the impact of social enterprises in African countries, especially with regards to the labor market. It is for this reason that this study aims at highlighting the impact of social enterprises on the labor market in Nairobi, Kenya. It also provides an outline of the labor market structure in Nairobi. The study employed a mixed methods approach, using both qualitative and quantitative approaches, collected concurrently as part of a concurrent triangulation design. Five social enterprises located in Nairobi were involved in the study, and were chosen through snowball sampling. These social enterprises offered direct employment, training programmes or support for beneficiaries to start their own businesses. The research instruments used in this study were as follows; 10 interviews (5 interviews with beneficiaries and 5 with social entrepreneurs), 50 questionnaires distributed to beneficiaries through random sampling, field work observations and a literature review. The results of this study were that social enterprises in Nairobi have a significant impact on the livelihoods of beneficiaries by directly employing them, providing necessary skills for later employment or supporting them to start their own businesses. However, these increases in income are often either inadequate or inconsistent as most beneficiaries are forced to diversify their livelihoods. Social enterprises also fail to reduce the gender wage gap among their beneficiaries. Social enterprises also increase market access among their beneficiaries by providing them with advice and training, as well as, direct access to customers. In the same vein, they increase the level of training of beneficiaries. This helps beneficiaries improve their relations with customers, produce high quality goods, hone their skills, gain employment, gain experience, build a repertoire, earn profits and start businesses. The subject of training also affects the income levels of beneficiaries, as many of those who study entrepreneurship, quality training and customer service earn above minimum wage.
103

Časoprostorová strukturace Pražské metropolitní oblasti / Time-space structuration of the Prague Metropolitan Area

Zevl, Jiří-Jakub January 2019 (has links)
This diploma thesis focuses upon mobility which structures time and space of Prague's hinterland. The time-space regions are conceptualised and serve to explore the structure of suburban space. The positioning data from mobile phones are used to investigate tangential mobility throughout suburban municipalities. It happened in two time-sections which distinguish the working and the service commute. The method of the time-space regionalisation was introduced for this purpose. In total, 45 local centres were found. Moreover, their regions were delimited and two regions without cores were delimited as well. The resulting time-space regions are distinguished into three types: small inner regions, large outer regions and river regions. The case study in Dolní Břežany municipality seeks causes and consequences of centrality in local scale. The significance of the thesis lies in partial, but highly interconnected contributions in all three dimensions: theory, methodology and empirics. Key words: mobility, suburbanisation, structuration, regionalisation, mobile data, Prague, Dolní Břežany
104

Architecture multi-échelle de matériaux polymères : de l’auto-assemblage à l’assemblage forcé / Multi-scale architecture of polymeric materials : from self-assembly to forced assembly

Montana garcia, Juan 18 December 2017 (has links)
Les copolymères à blocs (BCP) sont des macromolécules capables de s’auto-assembler produisant des morphologies bien définies à l’échelle nanométrique. Un certain nombre de leurs propriétés macroscopiques peuvent être largement modifiées par des effets de confinement à l’échelle moléculaire, mais aussi par des effets de cisaillement (l’orientation des structures et donc un comportement mécanique fortement anisotrope). L’une des technologies permettant d’étudier ces effets sur la structuration des BCP est la coextrusion multinanocouches, qui permet de produire à grande échelle des matériaux sous forme de films possédant deux ou plusieurs constituants organisées en milliers de couches alternées ayant chacune une épaisseur nanométrique. À l’aide de ce procédé, des films constitués du tribloc poly(méthacrylate de méthyle-b-butyle acrylate-b-méthacrylate de méthyle) et des homopolymères polyméthacrylate de méthyle, polystyrène et polycarbonate (ayant donc différentes interfaces) ont été fabriqués en variant la composition du mélange et les conditions de coextrusion afin d’obtenir différentes épaisseurs du film (et donc différentes épaisseurs de couche). Une caractérisation multi-échelle a été effectuée en couplant différentes techniques, notamment AFM, MET (après une étape préalable de marquage) et SAXS. Elle a permis d’identifier les structures locales au sein des couches et de mieux comprendre la relation procédé-structure-propriétés suite à des essais en traction uni-axiale montrant de meilleures propriétés dans le cas de structures multicouches. Une faible stabilité thermique, à de temps comparables à ceux du procédé, a montré une influence sur la structuration de ce type de BCP. Nous avons mis en évidence un changement dans la morphologie du tribloc à partir d’une structure lamellaire, lorsque le matériau se trouve dans un état proche de l’équilibre thermodynamique, vers une structure cylindrique au sein du système multicouche et maintenue, quelle que soit l’épaisseur de couche, à grande distance. La maitrîse des procédés de transformation de matériaux à base de polymère à l’échelle micro ou nanométrique prend ainsi toute son importance afin de mieux contrôler, dans le cas des BCP, la structuration lors d’une production à grande échelle de matériaux hiérarchisés constitués de ces matériaux, ce qui influence fortement leurs propriétés macroscopiques. / Block copolymers (BCP) have proven to be of great interest, especially for their ability to spontaneously self-assemble in ordered and well-defined nanostructures. Some of their macroscopic properties can be altered by physical effects such as confinement (constraining domains at molecular scale) or shear (predominant orientation of domains with anisotropic mechanical response). Here, the study of these effects over the BCP structuration is achieved by using an industrially scalable technique, nanolayer coextrusion, which allows fabrication of macroscopic films made of thousands of alternating layers with individual thickness tuned down to a few tens of nanometers. Films are then coextruded using the triblock : poly(methyl methacrylate-b-butyl acrylate-b-methyl methacrylate) and the polymers : polymethyl methacrylate, polystyrene and polycarbonate (having different interfaces) by varying weight proportions and process parameters to target different layer thicknesses. A multi-scale characterization by coupling different technics as AFM, TEM (after samples staining) and SAXS allowed the local identification of nano-domains and the better understanding of process-structures-properties relation as a result of tensile tests showing improved mechanical behavior for these films. A low thermic stability for comparable process times showed a clear influence over structuration of this kind of BCP. We have observed a change in the triblock morphology from lamellar structures, when it is a close to thermodynamic equilibrium state, to cylindrical structures within the multilayer system which is maintained over long distances indistinct of layer thickness. The well understanding of the forming process parameters to create polymer-based materials at micro- or nanoscale scale is therefore an important factor in order to control nano-structures during a large-scale production of hierarchized materials consisting of BCP, which could strongly influence their macroscopic properties.
105

Análise dos diferentes modelos de estruturação de procurement em empresas de real estate / Analysis of different stucturation models of procurement in real estate companies.

Neves, Mauricio Bertoldi Sanchez 06 May 2016 (has links)
Percebe-se no mercado brasileiro que a área de suprimentos - Procurement - nas empresas do segmento de real estate de construção civil se apresenta, tanto em termos de estrutura quanto em procedimentos, de diferentes formas. É possível observar estruturas centralizadas responsáveis por toda a gestão na companhia, enquanto há outras em que as obras são autônomas com suporte corporativo. Para cada estrutura, as formas de atuação das áreas diferem, objetivando satisfazer as premissas gerenciais de cada companhia. A análise do espectro existente resulta em razoável incerteza para se afirmar quais práticas são mais eficazes em termos de desempenho e geração de resultado. Enquanto estruturas mais centralizadas conduzem para menos autonomia para as obras com sistemas corporativos mais robustos, estruturas autônomas possibilitam maior agilidade e rapidez nas tomadas de decisão. Neste cenário, o objetivo desta dissertação é analisar as diferentes composições estruturais das áreas de suprimentos existentes nos subsetores de construção civil: infraestrutura e edificações a fim de propor um modelo adequado de estruturação e atuação, visando proporcionar uma melhor forma de atuação das áreas de suprimentos no setor de construção brasileiro. Para tanto, foi realizado uma revisão bibliográfica a respeito dos temas: estruturas e procedimentos de suprimentos em real estate e riscos e oportunidades das vertentes estruturais. Em seguida foi realizada uma enquete com algumas das principais empresas de ambos subsetores objeto deste estudo. Tal pesquisa permitiu identificar os principais aspectos de cada vertente estrutural de procurement em construção civil e assim identificar as caraterísticas necessárias para a proposição do modelo. Dessa forma, foi proposto o modelo de atuação adequado para as empresas desse setor, onde se espera contribuir para que a gestão de suprimentos nessas empresas de construção brasileiras seja tratada de forma estratégica, adicionando valor e competitividade às organizações a qual fazem parte. / It is perceived in Brazilian market that procurement in real estate companies is presented differently both in terms of structure and procedures. It is possible to observe centralized structures responsible for all management in the company, while there are structures in which the works are basically autonomous with corporate support. For each structure, the procedures of the areas differ, aiming to meet the managerial assumptions of each company. The analysis of existing spectrum results in reasonable uncertainty to assert what practices are most effective in terms of performance and result generation. While more centralized structures lead to less autonomy for works with more robust enterprise systems, autonomous structures enable greater agility and quickness in decision-making. In this scenario, the goal of this dissertation is to analyze the different structural compositions of existing supplies areas in the subsectors of civil construction: infrastructure and building in order to propose a suitable model of organization and operation. Still, this works aims to provide a better way of operation of the supply areas in the Brazilian construction sector. Therefore, a literature review was conducted on the themes: infrastructure and supply procedures in real estate and risks & opportunities of the structural aspects. Then a survey had been done in some of leading companies in both subsectors object of this study. This research allowed recognizing the main aspects of each structural procurement component in construction and consequently identifying the characteristics necessary for the model proposition. Finally, it was proposed the appropriate operational model for companies in this sector, which expects to contribute to supply management be treated in a strategic manner from now on in Brazilian construction companies and adding value and competitiveness to organizations to which they belong.
106

Exploring Organizational Structures for Women in Academe: A Feminist Exploration of Career and Care

Ashton M. Mouton (5930072) 10 June 2019 (has links)
In 2008, Women’s Studies in Communication released a special issue entitled “Conversations and Commentary on Redefining the Professor(iate): Valuing Commitments to Care and Career in Academe” where the authors discussed how a lack of support for multiple and competing roles related to care and career responsibilities negatively impacted the careers of women faculty members. Today, women faculty members still experience more challenges associated with advancement, tenure, and promotion compared to their male counterparts and are also more likely to leave academia as leaks in the pipeline. Previous research has demonstrated that these challenges are due to organizational barriers rather than individual choices and abilities (McMurtrie, 2013; Slaughter, 2012). As such, this study employs two theoretical frameworks to explore career challenges in more detail: structuration theory (Giddens 1979; 1984) and feminist intersectional theory (Crenshaw, 1988; 1989/1993; 1991). Coupled together, structuration theory and feminist intersectional theory enable the researcher to understand what structures enable and constrain tenure/promotion and care needs/responsibilities and to be critical of those structures and who they privilege along the way. Semi-structured interviews (n=49), in combination with document collection (n=433) and logging, were used to assess the organizational structure and the movement of participants through the structure. Analysis of the documents and interviews illustrate rules and resources that both enable and constrain tenure, promotion, and care work for female faculty.
107

Exploring educators experiences implementing open educational practices

Paskevicius, Michael 17 December 2018 (has links)
This research focuses on how educators are using openly accessible sources of knowledge and open-source tools in ways that impact their pedagogical designs. Using a phenomenological approach with self-identifying open education practitioners, I explore how open educational practices (OEP) are being actualized in formal higher education and impacting learning design. Specifically, I examine how educators are bringing elements of openness into their everyday teaching and learning practice using educational technologies. I draw upon Giddens (1986) structuration theory, further developed for use in technology adoption research most notably by DeSanctis and Poole (1994) and Orlikowski (2000). This approach positions technologies as being continually socially constructed, interpreted, and put into practice. In an organizational context, the use of technology is intrinsically linked with institutional properties, rules and norms, as well as individual perceptions and knowledge. The findings suggest that OEP represents an emerging form of learning design, which draws from existing models of constructivist and networked pedagogy. Open technologies are being used to support and enable active learning experiences, presenting and sharing learners work in real-time, allowing for formative feedback, peer review, and ultimately, promoting community-engaged coursework. By designing learning in this way, faculty offer learners an opportunity to consider and practice developing themselves as public citizens and develop the knowledge and literacies for working with copyright and controlling access to their online contributions, while presenting options for extending some of those rights to others. Inviting learners to share their work widely, demonstrates to them that their work has inherent value beyond the course and can be an opportunity to engage with their community. Dataset available: https://doi.org/10.5683/SP2/CA77BB / Graduate
108

O setor de cachaça artesanal da região do Litoral Norte Gaúcho : processo de estruturação?

Fernandes, Elieti Biques January 2010 (has links)
Esta dissertação tem por foco analisar e compreender o processo de estruturação do setor de produção de cachaça artesanal da região do Litoral Norte do Rio Grande do Sul. Com o objetivo de delinear o processo de estruturação do setor e desvelar as práticas que estão sendo construídas, incluindo o modo como o são e a que(m) favorecem, buscou-se elementos da teoria da estruturação proposta por Giddens (2009) que traz a interação ação-estrutura que dinamiza as articulações iniciais de um processo de institucionalização. Outros insights são advindos de conceitos desenvolvidos por Berger e Luckmann (2009) na obra “A construção social da realidade” e da teoria neo-institucionalista (ZUCKER, 1977, DIMAGGIO; POWELL, 1999, DiMAGGIO, 1988, 1991, TOLBERT; ZUCKER, 1999, MEYER; ROWAN, 1999, SCOTT; MEYER, 1999, SCOTT, 1999, 2001). O esforço de análise e compreensão desse processo de estruturação, considerando uma correlação entre a ação dos atores do setor e sua estruturação, foi apoiada pela perspectiva da análise de discurso através do modelo discursivo de institucionalização proposto por Phillips et al. (2004). Esse modelo é composto por 7 proposições teóricas e considera uma relação mutuamente constitutiva entre discurso, texto e ação, e objetiva demonstrar a importância dos textos e dos discursos no processo de institucionalização. A partir da aplicação parcial desse modelo, proposições anteriores ao processo de institucionalização, foram analisadas as ações e textos dos atores que compõem o setor e prospectados seus respectivos discursos. Dentro do escopo desse trabalho, o modelo discursivo de institucionalização sinalizou as ações e textos indicativos de um processo de estruturação e revelou as relações desiguais de forças entre os atores que compõem o setor. A pesquisa de campo revelou que o processo de estruturação está sendo delineado por dois discursos: um discurso que se destaca em que um conjunto de atores, que detém interesses específicos e recursos dentro do setor, desenvolve ações estratégicas para se distinguirem das demais organizações através do produto cachaça artesanal; e, um discurso em que um conjunto de atores busca minimizar a relação de dependência das organizações informais e garantir a sobrevivência dos produtores rurais através do desenvolvimento de alternativas de produção para a região em que estão inseridos. Perceber o delineamento desse processo de estruturação e as possíveis conseqüências para o setor de cachaça artesanal permitiu desvelar relações construídas a partir de interesses específicos de algumas organizações. Esta pesquisa apresenta insights que podem ser úteis sobre as possibilidades de um eminente processo de institucionalização do setor. Fato que pode resultar na construção de uma legitimidade limitada ao entendimento de alguns propósitos específicos, acarretando em um enrijecimento nas relações entre os atores que, seguramente, trará implicações, econômicas, sócio-culturais e organizativas para a totalidade dos atores envolvidos, representando um “risco” a demandas mais particulares das comunidades onde se inserem as organizações. / This work focuses on the analysis and comprehension of the structuring process of the craft cachaça’s productive sector that is located in the region of the North Coast of Rio Grande do Sul. In order to delineate this sector’s structuring process and unveil the practices that are being built, including how and who(m) they favor, we sought evidence of the struturation theory proposed by Giddens (2009) that brings the action-structure interaction which drives the joints of an initial process of institutionalization. Other insights are coming from concepts developed by Berger and Luckmann (2009) on his work "The Social Construction of Reality" and the neo-institutional theory (ZUCKER, 1977, DIMAGGIO, POWELL, 1999, DiMaggio, 1988, 1991 TOLBERT, ZUCKER, 1999 MEYER, ROWAN, 1999, SCOTT, MEYER, 1999, SCOTT, 1999, 2001). The analysis and understanding effort of this structuring process, in which the correlation between the sector actors’ actions and its structuring process, was supported by discursive analysis perspective through the discursive model of institutionalization proposed by Phillips et al. (2004). This model consists of seven theoretical propositions and considers a mutually constitutive relationship among discourse, text and action, and aims to demonstrate the importance of texts and discourses in the institutionalization process. Departing from this model’s partial implementation, which are propositions prior to the institutionalization process; we analyzed the sector actor’s actions and texts and prospected their respective discourses. Within this work’s scope, the institutionalization’s discursive model signaled the actions and texts proper of a structuring process and revealed the unequal power relations between the sector’s actors. The research field revealed that the structuring process is outlined by two discourses. First, a discourse that stands in an actors’ group which has specific interests and resources within the sector and develops strategic actions to distinguish themselves from other organizations across the craft cachaça product, and second, a discourse in which a set of actors seeks to minimize the informal organizations’ interdependence and ensure the farmers’ survival through the development of production alternatives for the region where they live. The realization of this structuring process’ design and the possible craftwork industry’s consequences allowed us to reveal relations constructed from some organizations’ special interests. This research provides insights that can be useful on the possibility of an imminent institutionalization process of the sector. The fact, in which may result in the construction of a limited legitimacy to the understanding of some specific purposes and also may result in stiffened relations between actors, will undoubtedly bring, to all the actors involved, economic, socio-cultural and organizational implications, which mean a “risk” to more specific demands for the communities where this organizations are inserted.
109

Modélisation et simulation numérique de la dynamique de séparation de phase d’une solution polymère dans le cadre de la formation de membranes poreuses / Modeling the phase separation dynamics of a polymer solution for the preparation of porous polymeric membranes

Manzanarez, Hervé 29 November 2017 (has links)
Ce travail de thèse vise à modéliser et simuler la séparation de phase d’un système polymère solvant afin de comprendre, prédire et maitriser la dynamique de formation de membranes poreuses. L’équation phénoménologique proposée de Cahn-Hilliard, couplée à un champ de vitesse (Modèle H dans la classification de Hohenberg et Halperin) sera utilisée pour décrire l’inversion de phase induite par un changement de température (procédé TIPS), le système PMMA/cyclohexanol étant pris comme système de référence.Dans un premier temps, nous nous sommes attachés à étudier de façon systématique l’influence du terme de mobilité sur la dynamique de séparation de phase, sans couplage avec l’hydrodynamique en 2D. Un analyse des lois de croissance des structures formées a été réalisée via une analyse des images par transformée de Fourier et une analyse spécifique des patterns a été effectuée via l’analyse originale des descripteurs de Minkowski. Dans une seconde partie de la thèse, nous avons étudié le couplage entre la séparation de phase et l’hydrodynamique, en 2D et 3D. Enfin, nous avons intégré dans une dernière partie le couplage entre la séparation de phase, l’hydrodynamique et les phénomènes de transferts de matière aux interfaces induits notamment par l’évaporation du solvant au cours de la formation d’une membrane. / The thesis aimed at modeling and simulating the phase separation dynamics of a polymeric system (polymer/solvent or polymer/solvent/non-solvent) for better understanding and controlling the formation mechanisms of porous polymeric membranes. The equation of Cahn and Hilliard (1956)[1] was used and coupled to a hydrodynamic model (H model in the classification of Hohenberg et Halperin (1977)[2]) to simulate the phase inversion in closed system.In a first stage, hydrodynamics was not coupled to Cahn-Hilliard equation and the work focused on the mobility term in the Cahn-Hilliard equation and its influence on the phase separation dynamics (pattern evolution, growth law of the characteristic structures). The patterns were analyzed by Fourier transform and an original analysis was also performed using the Minkowski descriptors.In a second part of the thesis, we coupled the Cahn-Hilliard equations with Navier-Stokes equations and the influence of this coupling on the membrane formation dynamics was investigated.Then, in order to simulate the membrane formation in a context closer to reality, transfer phenomena were simulated at the upper interface of the domain to describe solvent evaporation during demixing process.Finally, the simulations were extended to ternary systems (polymer/solvent/non-solvent) systems since most of industrial polymer membranes involve are prepared from ternary system, with NIPS process (Non-solvent Induced Phase Separation) or dry casting process (differential evaporation between solvent and non-solvent).
110

Immunité bactérienne et épidémiologie évolutive des phages / Bacterial immunity and phages evolutionary epidemiology

Chabas, Hélène 18 September 2018 (has links)
Les êtres vivants sont confrontés à des parasites qui diminuent leur fitness et se répandent dans la population. En réponse, les hôtes ont développé de nombreuses défenses immunitaires qui sont souvent mises en défaut par l'évolution des parasites. Ces défenses sont de plus souvent extrêmement diversifiées génétiquement. Quel est donc l'apport de la diversité génétique des défenses contre l'évolution des parasites ? Répondre à cette question expérimentalement nécessite un système biologique pour lequel on peut étudier la diversité génétique de l'hôte et l'évolution et la propagation du parasite. Les systèmes bactéries/phages sont de bons candidats pour une telle étude : leur manipulation au laboratoire est aisée, leurs cycles de vie sont rapides et ils ont de forts taux de mutation. La découverte récente de l'immunité CRISPR--Cas a ouvert de nombreuses possibilités : cette dernière a la propriété unique de générer dans le même fond génétique que l'hôte sensible de nombreux allèles de résistance. De plus, son mécanisme de fonctionnement reposant sur une interférence à ARN, la cible d'une résistance est très précisément connue ainsi que les possibilités de la contourner. Ce système permet donc l'étude expérimentale de l'impact de la diversité génétique sur la propagation et l'évolution des parasites, et sur la co-évolution antagoniste. Dans cette thèse, nous cherchons à 1) déterminer l'impact de la composition de la population d'hôtes sur la probabilité qu'une épidémie créée par un virus mutant ait lieu (émergence évolutive), 2) expliciter les causes de l'hétérogénéité de durabilité des résistances et 3) étudier la dynamique co-évolutive entre population génétiquement diversifiée d'hôtes et de parasites. Nous montrons que la composition de la population d'hôtes module fortement la probabilité d'émergence évolutive : une faible diversité génétique associé à un taux intermédiaire d'hôtes sensibles maximisant la probabilité d'émergence évolutive. Dans un second temps, nous montrons que l'immunité CRISPR génère des résistances dont la durabilité est hétérogène et cette hétérogénéité ne peut pas être expliquée par une hétérogénéité des fitness des mutants contournant CRISPR. Enfin, nous montrons que la diversité des résistances est maintenue à court terme par l'hétérogénéité des populations de parasites et que la dynamique co-évolutive est accélérée en présence d'une population génétiquement diverse. Enfin, nous proposons des pistes de recherche qu'il nous parait intéressant d'étudier dans le futur. / Living organisms face parasites which decrease their fitness and spread into their population. In response, hosts have evolved countless immune defenses that are often circumvented by parasite evolution. These defenses are usually extremely diverse. What is the impact of such genetic diversity on the protection against the evolution of parasites? Answering this question experimentally requires an experimental system in which host genetic diversity and parasite evolution and spreading can be monitored. Phages and bacteria systems are ideal candidates for such studies as their handling is easy in the lab, their life cycle is short and their mutation rates is high. The recent discovery of CRISPR--Cas immunity has opened many possibilities. Indeed, this immunity has the unique property to generate in the same genetic background as the sensitive host, numerous resistant alleles. In addition, it relies on an interference--RNA-like pathway, which results in the precise understanding of phage bypassing and in the ability to predict the targeted sequence. This system hence allows the experimental study of the impact of host genetic diversity on the epidemiology and the evolution of parasites and on antagonist coevolution. In this PhD, we 1) study how the host population composition impacts the probability of an epidemic created by an escape mutant (evolutionary emergence), 2) try to understand the causes of the heterogeneity in durability of resistances and 3) monitor the coevolution dynamic between genetically diverse populations. We show that the composition of the host population impacts the probability of evolutionary emergence: a low resistances diversity with an intermediate proportion of sensitive hosts maximises the probability of evolutionary emergence. Second, we show that CRISPR--Cas resistances are heterogeneous in their durability and this is not explained by the heterogeneity of escape mutants fitness. Third, we show that resistances diversity is conserved in a short term by parasites genetic diversity and that the coevolutionary dynamic is fastened by parasite intra-specific genetic diversity. Finally, we discuss research questions that we find interesting to develop in the near future.

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