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Dermal Vγ4+ γδ T cells possess a migratory potency to the draining lymph nodes and modulate CD8+ T cell activity through TNF-α production / 真皮Vγ4陽性γδT細胞はリンパ節へ遊走しTNF-αを産生することによりCD8陽性T細胞を活性化させるNakamizo, Satoshi 23 March 2015 (has links)
Journal of Investigative Dermatology (2015) 135, 1007–1015; doi:10.1038/jid.2014.516; published online 8 January 2015 / 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第18890号 / 医博第4001号 / 新制||医||1009(附属図書館) / 31841 / 京都大学大学院医学研究科医学専攻 / (主査)教授 生田 宏一, 教授 髙折 晃史, 教授 河本 宏 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia / 抗HIV薬アバカビルは、TDP1が欠損している成人T細胞白血病を標的とするTada, Kohei 24 November 2015 (has links)
京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19363号 / 医博第4040号 / 新制||医||1011(附属図書館) / 32377 / 新制||医||1011 / 京都大学大学院医学研究科医学専攻 / (主査)教授 小柳 義夫, 教授 河本 宏, 教授 松岡 雅雄 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T cells / 生理的胸腺退縮は加齢に伴う老化関連CD4+T細胞増加の一因であるSato, Kyosuke 26 March 2018 (has links)
京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13160号 / 論医博第2147号 / 新制||医||1029(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 生田 宏一, 教授 杉田 昌彦, 教授 椛島 健治 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM
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Glucocorticoids drive diurnal oscillations in T cell distribution and responses by inducing interleukin-7 receptor and CXCR4 / グルココルチコイドはインターロイキン7受容体とCXCR4を誘導することでT細胞の分布と応答の日内変動を制御するShimba, Akihiro 26 March 2018 (has links)
京都大学 / 0048 / 新制・課程博士 / 博士(医科学) / 甲第21027号 / 医科博第88号 / 新制||医科||6(附属図書館) / 京都大学大学院医学研究科医科学専攻 / (主査)教授 杉田 昌彦, 教授 濵﨑 洋子, 教授 河本 宏 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
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TNF Antagonism Stifles Host Response to Pulmonary Pathogen through Gut/lung Immunoregulatory AxisTweedle, Jamie L. 30 October 2018 (has links)
No description available.
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Inflammation in plexiform neurofibroma development and growth.Fletcher, Jonathan S. January 2018 (has links)
No description available.
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Role of ETS-1 and Histone Methylation Patterns in Rapid Recall Ability of Memory T CellsEymard, Eric D. 01 April 2021 (has links)
No description available.
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Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity / T細胞受容体シグナルの障害が腸内細菌叢と全身性自己免疫に及ぼす影響Taguchi, Mirei 23 March 2023 (has links)
京都大学 / 新制・論文博士 / 博士(医学) / 乙第13536号 / 論医博第2276号 / 新制||医||1065(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 河本 宏, 教授 妹尾 浩, 教授 中川 一路 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM
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Inhibition of a Chicken B-Cell Lymphoma by Suppressor T-Cells From Agammaglobulinemic ChickensChi, D. S., Sharma, J. M. 01 January 1990 (has links)
The growth of B-cell lymphoma, LSCC-RP9, in culture was inhibited by spleen cells from bursa-immunized agammaglobulinemic (A-gamma) chickens. This inhibition was mediated by suppressor T-cells. The growth of transplantable LSCT-RP6 B-cell lymphoma was suppressed in A-gamma chickens, while that of the control SPCT-RP11 T-cell tumor was not affected. Furthermore, the incidence and growth of the LSCT-RP6 tumor in normal recipients were decreased when it was co-transplanted with spleen cells from bursa immunized A-gamma chickens. The results suggest that suppressor T-cells inhibit the growth of B-cell lymphoma.
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The Regulatory Role Of Matrix Metalloproteinases In T Cell ActivationBenson, Heather Lynette 08 December 2009 (has links)
Indiana University-Purdue University Indianapolis (IUPUI) / Introduction: Matrix metalloproteinases (MMPs) are known for their role in extracellular matrix remodeling, but their role in regulating intracellular immune cell function is unknown. We reported that MMP inhibition down regulated T cell proliferation in response to alloantigens and autoantigens; but the direct role of MMP involvement in T cell activation has not been reported. Methods: MMP deficient or MMP sufficient wild-type CD4+ or CD8+ T cells from C57BL/6 mice were treated with SB-3CT, a specific inhibitor of MMP2 and MMP9, stimulated with anti-CD3 Ab, alone, or with IL-2 or CD28. Cellular activation and cytokine profiles were examined. A mouse model of antigen specific T cell mediated lung injury was used to examine MMP inhibition in antigen-specific T cell mediated lung injury. Results: SB-3CT (1-25μM) induced dose-dependent reductions in anti-CD3 Ab-induced proliferation (p<0.0001). Compared to wild-type, MMP9-/- CD4+ and CD8+ T cells proliferated 80-85% less (p<0.001) in response to anti-CD3 Ab. Compared to untreated or wild-type cells, anti-CD3 Ab-induced calcium flux was enhanced in SB-3CT-treated or MMP9-/- CD4+ and CD8+ T cells. Cytokine transcripts for IL-2, TNF-α and IFN-γ were reduced in both CD4+ and CD8+ MMP9-/- T cells, as well as in SB3CT treated CD4+ T cells. MMP inhibition dampened antigen-specific T cell mediated lung injury. Conclusions: Although known to be functional extracellularly, the current data suggest that MMPs function inside the cell to regulate intracellular signaling events involved in T cell activation. T cell targeted MMP inhibition may provide a novel approach of immune regulation in the treatment of T cell-mediated diseases. - David S. Wilkes, M.D., Chair.
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