• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 7
  • 1
  • Tagged with
  • 10
  • 10
  • 7
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

The Lived Experiences of Black Women Faculty in the Instructional Technology Professoriate

Richardson, Valora 10 January 2013 (has links)
Black women currently and historically have faced challenges as faculty in higher education. The problem the study addressed was the lack of intellectual study and resulting literature about Black women faculty in the field of Instructional Technology. This research sought to gain better insight into experiences of Black women professors in Instructional Technology. Specifically, the purpose of this research was to identify and describe the lived experiences of Black women who are tenure-track faculty in the Instructional Technology professoriate. A review of literature regarding faculty work, Black faculty in the Academy, Women in the Academy and Black women in the Academy provide groundwork for the investigation. The study employed a phenomenological methodology to answer the research questions. Siedman’s (2005) “three-interview series model” was used to collect data from the participants. The researcher facilitated three 90 minute interviews with each participant – the life history interview, the current experience interview and the meaning-making interview. The findings of this research indicate that the support of their parents and attendance at integrated grade schools prepared the participants to work in their current positions. As they worked in the professoriate, these Black women realized that they had to self-advocate and set their own boundaries. They made meaning of their experiences by connecting it to their faith and realizing that they were not in the position for themselves. The implications of this study are also indicated in the advice the participants gave to Black women who wish to pursue careers in the Instructional Technology professoriate.
2

Rheological model influence on pipe flow predictions for homogeneous non-Newtonian fluids

Van Den Heever, Emile January 2013 (has links)
Dissertation submitted in fulfilment of the requirements for the degreerequirements Master of Technology: Civi Engineering in the Faculty of Engineering at the Cape Peninsula University of Technology Supervisor: APN. Sutherland Co-supervisor: Prof. R. Haldenwang Cape Town October 2013 / The reliable prediction of pressure drop versus flow rate for non-Newtonian pipe flow is important in many industrial processes. In laminar flow scale up is straightforward, but transitional velocity and turbulent flow predictions remain a practical problem. Various theoretical models exist, but nothing in literature shows conclusively which of these is the most reliable and consistent, nor is it evident what effect the choice of rheological model has on the predictions. The aim of this work was to i) evaluate the influence of different rheological models when used in existing prediction techniques for non-Newtonian flow ii) characterise each material type using selected (commonly used) rheological models and iii) predict laminar, transitional and turbulent pipe flow characteristics for each material type using existing prediction techniques, for comparison with experimental results. Only time-independent, homogeneous, non-Newtonian fluids in pipe sizes from 13mm to 200mm were investigated. Rheological models and laminar flow predictions used only the power law, Bingham plastic, Herschel-Bulkley, Casson and Hallbom yield plastic models. The techniques used to predict transitional velocity were Ryan & Johnson, Metzner-Reed, Hedström intersection method, Slatter and Hallbom. For turbulent flow the Newtonian approximation, Dodge & Metzner, Wilson & Thomas, Slatter, Hallbom modified Wilson & Thomas and the Bowen correlation methods were used. The study documents the relevant theory and presents an assessment of the influence of rheology on pipe flow predictions, summarised in terms of the practical performance of the various rheological model/prediction method combinations for the different materials. In laminar flow at practical pseudo shear rates (8V/D; taken as 40s-1) the choice of rheological model does not significantly influence pressure drop predictions. For yield-pseudoplastic materials (eg. kaolin) the Hedström intersection and the Slatter Reynolds number method with Bingham plastic or Casson rheology predicted transitional velocity most accurately. For Bingham plastic materials (eg. bentonite) the best predictions were obtained using the Metzner & Reed Reynolds number with Bingham plastic rheology, although similar results were observed for this technique with all rheologies. The transitional velocity for pseudoplastic materials (eg. CMC) was best predicted by the Slatter and Metzner & Reed Reynolds number methods, using power law or Casson rheology. For turbulent flow of yield pseudoplastic materials the Slatter method using the Casson rheology gave the most accurate predictions overall. Turbulent flow of Bingham plastic materials was best predicted by the Slatter, Hallbom pseudo fluid Nikuradse and Dodge & Metzner methods, using Bingham plastic, Casson or yield plastic rheology. For pseudoplastic materials the Slatter and Wilson & Thomas methods were the most accurate, when used with yield plastic or power law rheology. Transitionalal velocity and turbulent flow predictions for materials with a yield stress vary significantly with rheological model. Laminar data should therefore be examined thoroughly and rheological models fitted with care. For pseudoplastic fluids there is little difference in predictions between the various techniques as long as power law rheology is used.
3

Perceived Effectiveness of Faculty Development Programs for Full-Time Occupational-Technical Faculty in Virginia Community Colleges

Sprenger, Kurt William 11 April 1999 (has links)
The purpose of this study was to identify faculty perceptions of the personal and student benefits deriving from participation in faculty development activities. Faced with the challenge of keeping up-to-date with technology in order to keep their students up-to-date, faculty participate in many different activities. The perceived effectiveness of faculty development activities varies depending on the knowledge and interest of each faculty member. This study was descriptive, using a two-part survey to collect both quantitative and qualitative data. First, a mail survey was used to collect data on the perceptions of faculty members regarding 12 professional development activities. The survey was sent out to 407 faculty in Business Technology and Engineering and Industrial Technology at the 23 colleges in the Virginia Community College System. Second, selected participants were contacted for a follow-up phone interview which elucidated some of the information from the mail survey. The surveys were designed based upon a review of the literature and through interviews with professionals. The survey was pilot tested on community college faculty. Major findings from the study included the following: 1. The three most participated in activities were training in computer skills, professional conferences, and college-sponsored presentations and workshops. 2. Professional conferences and college-sponsored presentations and workshops were the highest rated in terms of participation, but rated the lowest in terms of personal and student benefit. 3. Females, on average, participate in more activities and have higher ratings for personal and student benefit. 4. Many faculty reported that funding for professional development activities is limited and that they have a limited amount of time to participate in activities. It is not uncommon for a faculty member to pay out of their own pocket for a worthwhile activity. 5. Activities that deal the most with learning new technologies, such as training in computer skills, retraining for fields in technology, and internships in business or industry, were given the highest ratings of personal and student benefit. Based on the findings several recommendations and suggestions for future research were made: 1. Additional research is needed on the actual measures of student benefit, not just perceptions 2. Community college faculty need to carefully select professional development activities that will benefit not only themselves and their student as well. 3. Community college administrators should encourage faculty members to participate in internships in business and industry. Administrators need to do all they can to provide funding for these activities. 4. Additional research is needed on the differences in how males and females rate their perceptions. / Ph. D.
4

Development of a food knowledge test for first-year students at a University of Technology in the Western Cape, South Africa

van der Vyver, Rache January 2013 (has links)
Thesis submitted in fulfillment of the requirements for the degree Master of Technologiae: Consumer Science: Food and Nutrition in the Faculty of Applied Sciences at the Cape Peninsula University of Technology Supervisor: Dr I Venter Co-supervisor: Ms L du Toit Cape Town September 2013 / Objective: To develop a valid and reliable test to determine the food knowledge of first-year students at a university of technology (UOT) in the Western Cape, South Africa. Design: Two preliminary food knowledge tests were developed covering the content domains, namely fruit and vegetables and fats and oils, as these topics attend to the areas of concern in the dietary intake of young adults. Both tests consisted of multiple-choice questions and incomplete statements compiled following the test item construction rules. The items of both tests were evaluated by experts in the field of food science and nutrition to ensure item content and face validity. Both tests were independently administered to two sample groups represented by knowledgeable students (having food-orientated subjects as part of their course) and less knowledgeable students (not having food-orientated subjects as part of their course syllabus) at a UOT in the Western Cape, SA for the item analysis and test construct validity and reliability determinations. The second preliminary test incorporating three response alternatives was developed as the number of items retained after the item analysis of the first preliminary test incorporating four alternatives was less than the envisaged number of about 20 items. Results: After the item analysis of the first preliminary test (n = 72 items) only 10 and 13 items were respectively retained after two administrations to two sample groups. The second preliminary test (n = 135 items) completed by knowledgeable (n=119) and less-knowledgeable (n=91) student sample groups delivered 74 items after its item analysis across the two content domains, namely fruit and vegetables (n=49) and fats and oils (n=25). The test was found valid, with a significant difference (p < 0.001) in the knowledge scores between the two sample groups (Mann-Whitney test, z = 9.74) and highly reliable (KR20 and Cronbach's alpha= 0.934). Conclusions: The test being a valid and reliable assessment tool can be used to determine the food knowledge of first-year students at a UOT in the Western Cape, SA, across the two content domains to establish if guidance and possible teaching is necessary to equip them with basic food knowledge to support them in their food provision. / Cape Peninsula University of Technology
5

Using Student Response System in Higher education: teachers' perception of influential factors and challenges

Huang, Rong January 2019 (has links)
Information and communication technologies have changed the traditional concept of education and improved existing educational methods. Student Response System is a new teaching system that combines technology and education. Student Response System encourages immediate feedback on teaching content, which not only improves student engagement, learning, and satisfaction but also enhances their understanding of course materials. The purpose of this paper is to study the reasons and motivations that affecting the use of SRS also the challenges that are faced by teachers from technology faculty at Linnaeus University. In this study, a qualitative research method is used to conduct a semi-structured interview with eight teachers who have the experience of using the Student Response System and collect data as well. Data analysis and identification of three major themes based onresearch questions and related literature. According to the interview results, the reasons why teachers use such a system is that it can promote students' participation, learning and provide timely feedback, but they still face problems such as insufficient software functions, network instability, teaching time constraints. The study may provide suggestions for improving teaching methods and help other Swedish universities and departments to use SRS better.Also software designers can get some advice.
6

Application of zirconium-coated titanium wires as restorative orthodontic materials

Ali, Khaled Abedela Mahdi January 2013 (has links)
Thesis submitted in fulfillment of the requirements for the degree Magister of Technology: Dental Technology In the Faculty of Health & Wellness Sciences At the Cape Peninsula University of Technology 2013 / Orthodontic archwires are made from different alloys. It is now possible to match phases of treatment with orthodontic archwires according to its mechanical properties. On this basis, the titanium molybdenum alloys (TMA) in its beta phase have an excellent combination of strength and flexibility when used as archwires to apply biomechanical forces that affect tooth movement. It has recently gained increased popularity in orthodontic treatment. There are, however, disadvantages associated with the use of orthodontic archwires, such as high surface roughness, which increases friction at the archwire-brackets interface during the sliding process. The surface roughness of dental materials is of utmost importance. Properties such as desirable tensile strengths, load deflection, hardness and low modulus of elasticity and resistance against corrosion & wear determine the area of the contact surface, thereby influencing the friction. The main object of this study was to improve the strength and surface roughness of the beta-titanium orthodontic archwires (β-Ti III) and timolium archwires (TIM), taking into account of retention of the archwires strength. The following tasks were performed. Layers of Zr were deposited on the β-Ti archwires and compared with the archwire strength before and after Zr deposition. The structure of selected archwires and its composition and surface roughness was investigated before and after Zr deposition, using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The force of selected archwires before and after deposition with layers of Zr by Hounsfield deflection testing was studied. Two commercially available orthodontic archwires were used in this study, namely, β-Ti III and TIM orthodontic archwires. The archwires were cut into 25 mm long specimens. In this study, the electron beam-physical vapour deposition (EB-PVD) technique was applied to deposit pure Zr (thicknesses of 5, 10, 25 and 50 nm) on selected archwires and the effects thereof were investigated using AFM, SEM and the Hounsfield deflection test. Results of SEM and AFM analysis and deflection tests showed significant differences between Zr-coated archwires compared with uncoated archwires. Zr-coated archwires (5, 10, 25 and 50 nm depositions) had reduced surface roughness compared with uncoated archwires. A high load deflection rate was exhibited by the coated β-Ti III archwires and a low load deflection rate was exhibited by the coated TIM archwires. There was a difference in load deflection rate between the coated and uncoated archwires. Deposition of 5, 10, 25 and 50 nm Zr on both types of β-Ti orthodontic archwires is recommended for even sliding mechanics due to resulting reduced surface roughness with a good load deflection rate compared with uncoated β-Ti orthodontic archwires. KEYWORDS Surface roughness Zirconium Titanium Deflection test Beta titanium orthodontic archwires Orthodontic archwires alloys Coated materials Electron beam-physical vapour deposition Scanning electron microscopy Atomic force microscopy
7

Interrogating student and lecturer perspectives of professional knowledge delivery in the initial teacher-education programmes in South Africa within a context of quality

Phillips, Heather Nadia January 2013 (has links)
Thesis in fulfilment of the requirements for the degree Doctor of Education in the Faculty of Education at the Cape Peninsula University of Technology Supervisor: Professor Rajendra Chetty Co-supervisor: Associate Professor Janet Condy November 2013 / In South Africa, the quality of teachers working in our current education system has been put under a looking glass by the Department of Education (DoE) (2006) since the systemic results, indicating national literacy and numeracy levels in primary schools, were issued. These results place South African literacy and numeracy skills far below those of many countries in the rest of Africa. This has been viewed by the South African school sector as one of the symptoms of the breakdown in the culture of learning in the education system in our country. As a result, the South African school system has been characterised as a ‘high- cost, high-participation, low-quality system’ Taylor (2008). Taylor (2008) concludes from his research that the challenges which undermine effective teaching and learning in South African schools include the quality of teacher knowledge and teaching practices. The relationship between teacher quality and teacher productivity is key to the development of a high-quality educational system. It is argued that teacher quality impacts greatly on student achievement, which, in turn, impacts on the development and transformation of that society. Rowe (2003) and Morrow’s (2007) key findings in their research on educational success indicate that ‘what matters most’ is the quality teacher. The historical and social change in South Africa has pioneered transformation with regard to curriculum change and has redefined the aims of teacher education in this country. Over the last few years we have been faced with a myriad of changes in policy frameworks that are supposed to guide change within the educational system, as well as within teacher education (Guskey, 2002:381-391). This study, therefore, aims to interrogate the missing links between teacher education institutions and pre-service teachers’ experience, while incorporating school and learner needs. Since quality is the critical factor, there is an urgent need to re-conceptualise how we can prepare a generation of teachers equipped to meet the demands of the 21st-century student. The key objective in this study, therefore, is the interrogation of the following components in the initial teacher-training programmes in South Africa: • Professional development and knowledge of teachers. • Delivery of that knowledge from a pedagogical perspective. • Quality of current teacher-training programmes. This research project is geared towards understanding the challenges that face final-year teacher-training students as they prepare themselves to enter the ‘real world of teaching’. The study cross-examines the quality of learning and teaching in higher education institutions, the pedagogy applied and the degree of its success. In order to examine the initial teacher-training programmes there was a need to interrogate: • students’ perceptions of the quality of their training; • lecturers’ responses to the quality of training provided; and • pre-service teachers’ notions of the quality of the ‘product’ they experience in the field during practice teaching and in their experience with newly qualified teachers. The search for an alternative pedagogy, which aims to promote the transformation and reconstruction of education in South Africa, has placed this research project within a conceptual framework of critical pedagogy, which holds the view that learning is self-generated and not just accessible. The theoretical underpinnings were derived from the works of Paulo Freire and Henry Giroux. This project is situated within an interpretivist paradigm and is qualitative in nature. A sample of four faculties of education, nationally, has been used in the project. Semi-structured interviews and focus-group interviews were used to collect data from all the fourth-year BEd students and their lecturers at each of the four universities, as well as from in-service teachers who host students during practice teaching sessions. The interview questions were concerned with the delivery of the teacher-training programmes and whether the needs of students were being met with regard to their training. Students commented on the development of the following areas: delivery of knowledge, acquisition of adequate teaching skills, and their readiness to enter the teaching field. The findings of this research indicate that students, lecturers and in-service teachers believe that many components within the current teacher-training programme need to be transformed. This could be attributed to, amongst others, the inadequate pedagogical practices used in knowledge delivery, lack of actual classroom experience, and the ineffective organisation and supervision of teaching practice which results in students feeling ill-equipped to enter the teaching arena. These impact the quality of teachers who are exiting the current system. Suggestions to improve the organisation of teacher experience, the on-going professional development of teacher educators, and mentorship ofteachers,as well as the development of recruitment and selection criteria for students wishing to enter teacher education are made.
8

Use of food-buying practices within different socio-economic classes in the city of Cape Town

Harper, Crystal January 2013 (has links)
Thesis submitted in fulfilment of the requirements for the degree Master of Technology Consumer Science: Food and Nutrition in the Faculty of Applied Sciences at the Cape Peninsula University of Technology 2013 / Consumer debt has escalated in South Africa ever since the country sank into a recession in early 2009. One of the many consequences of this economic downturn has been a major increase in energy, transport and food prices. Food-buying strategies can be used by consumers to help to reduce the amount of money, which is spent on food, and increase funds that are available for other household expenses. The main objective of this study was to determine the use of four pre-selected food-buying practices by consumers who reside in different socio-economic status (SES) areas in the City of Cape Town. Residents of lower SES areas have been found to have purchasing patterns that are different to those who live in higher SES areas. The subsidiary objectives were to further establish whether there is a difference in the use of food-buying practices by consumers who reside in different SES areas, and to ascertain whether shopper and demographical characteristics have an influence on the use of food-buying practices among consumers in general as well as among consumers within the same SES area. A consumer intercept survey was conducted after being granted ethics approval. Three groups of respondents that represent a low, middle and high SES area were systematically sampled. A total of 1 200 consumers (95% response rate) who are older than 18 years anonymously and voluntarily participated in the study, which was conducted at pre-selected stores in the suburban areas of Delft (low SES area), Maitland (middle SES area) and Meadowridge (high SES area) in the City of Cape Town. These areas and stores were selected to represent the SES of households or consumers, respectively, based on the demographic and employment profile that was provided for each by Statistics South Africa‟s 2001‟s census profiles. The data was collected by using a pilot tested structured, self-administered questionnaire consisting of mainly multiple-choice questions, which gathered information from the respondents regarding their shopper and demographic characteristics, as well as their frequency of use of the four food-buying practices (represented by six structured questions each) as: (i) use of a shopping list; (ii) use of advertisements to plan shopping; (iii) comparison of prices amongst different brands; and (iv) avoidance of impulse buying. These food-buying practices were selected based on available consumer education literature, which focused on the use of these food-buying practices and a pilot study that was conducted in 2011, which indicated that these four practices were most frequently used by the consumers who were surveyed. Within each SES area most of the Cronbach‟s alpha coefficients that were obtained were >0.9 among the six questions, which represented each food-buying practice, and reflected strong internal consistencies among the questions. The Generalised Linear Model analysis of variance utilising the Wald statistic, which is based on the chi- square distribution and Bonferroni pair-wise comparisons, were used to determine significant differences between respondents‟ use of the food-buying practices and their SES area group, as well as their shopper and demographic characteristics. A significant level of p<0.001, as well as p<0.05 was used. Most (60 to 80%) of the respondents in each SES area are female. Within the total sample, low and middle SES areas a majority (62 to 73%) of the respondents were between 26 to 55 years of age, whereas in the high SES area a majority (63.5%) of the respondents were 46 years and older. In general, more than half (52 to 56%) of the respondents were married and most (38 to 55%) were employed full-time and had household sizes, which mainly (18 to 23%) consist of two to four members. Regarding highest level of education attained, most of the respondents in the total sample either had a Grade 8 to 11 (37.6%) or a Grade 12 (24.7%), whereas most (54%) respondents in the high SES had either acquired a post-matric diploma or certificate, degree or post-graduate degree. Most (67 to 89 %) of the respondents within the total sample, middle and low SES area associated themselves with the Coloured population group, whereas most (56.7%) of the respondents in the high SES area associated themselves with the White population group. Concerning household monthly income, two thirds (65%) of the respondents within the high SES area had an income of R12 801 upward; most (77.5%) of the respondents within the middle SES area had an income of R801 to R12 800 per month; and more than half (57%) of the respondents in the low SES area received an income of R800 to R3 200 per month. In general, most respondents indicated that they shopped for food once a week (33 to 48%); took less than half an hour to shop for food (40 to 52%); and usually shopped alone for food (68.9%). Cash was the most prevalent means of payment among respondents within the total sample (66.7%), middle (70.5%) and low (93%) SES areas, while most (43.2%) respondents in the high SES area paid by means of a debit card. Among the respondents who reside in the different SES suburban areas, differences in the use of food-buying practices were revealed. Respondents within the high (p<0.001) and middle (p<0.05) SES areas displayed a higher propensity to use a shopping list, yet a lower propensity to use advertisements compared to respondents within the low SES area. Respondents within the low and particularly middle SES area displayed a higher propensity to compare prices (p<0.05) compared to respondents within the high SES area. No differences (p>0.05) for the avoidance of impulse buying as a food-buying practice were found among respondents within a low, middle and high SES area. A largely low propensity to avoid impulse buying was found. Regarding shopper characteristics, the respondent payment method influenced the use of a shopping list (p<0.05), use of advertisements (p<0.05 and p<0.001 between the payment methods) and propensity to avoid impulse buying (p<0.05) as food-buying practices within the low SES area. Among respondents, in general, the payment method influenced the avoidance of impulse buying (p<0.05) as a food-buying practice. The length of time that it took to shop influenced the use of a shopping list (p<0.05) as a food-buying practice within the low SES area and the propensity to compare prices of different brands (p<0.05) as a food-buying practice within the middle SES area. Shopping frequency influenced the use of advertisements (p<0.05) as a food buying practice within the low SES area and co-shopping influenced the propensity to avoid impulse buying (p<0.05 and p<0.001 between the various co-shoppers) as a food-buying practice within the low SES area, as well as the propensity to use advertisements (p<0.05) as a food-buying practice within the high SES area. Gender influenced the use of a shopping list (p<0.05) as a food-buying practice within the high SES area and the use of advertisements (p<0.05), as well as the propensity to avoid impulse buying (p<0.001) as food-buying practices within the middle SES area. Gender also affected the propensity to compare the prices of different brands (p<0.05) as a food-buying practice within the low SES area and among respondents, in general, the propensity to avoid impulse buying (p<0.05), as well as the use of advertisements (p<0.001) as food-buying practices. Employment status affected the use of a shopping list (p<0.05) as a food-buying practice within the high SES area. Population group affected the propensity to use advertisements as a food-buying practice within the low SES area (p<0.05 and p<0.001 between the population groups) and among the respondents, in general, (p<0.05). Household monthly income affected the propensity to compare the prices of different brands (p<0.05) as a food-buying practice within the high SES area. Among the respondents, in general, household monthly income affected the propensity to compare the prices of different brands (p<0.05 and p<0.001 between the income groups) and the use of advertisements (p<0.05) as food-buying practices. The study confirmed that there are differences in the use of food-buying practices among consumers who reside in different SES areas, and further identified specific shopper and demographic characteristics that have an effect on consumers‟ (in general, as well as within the same SES area) use of food-buying practices. Since food-buying practices can be used by consumers to manage their household income expenditure on food, consumer awareness of these practices, in particular the avoidance of impulse buying should be promoted through educational efforts ideally by food retail companies. These companies have the resources and capability to communicate with consumers regularly (while shopping in-store), and can inform their customers about food-buying practices that would help them to save money and/or make additional funds available for other essential household expenses.
9

Effects of dietary Garcinia kola supplementation and oxidative stress in isolated perfused rat hearts

Nyepetsi, Naledi Gape January 2014 (has links)
Thesis submitted in fulfilment of the requirements for the degree of Master of Technology: Biomedical Technology In the Faculty of Health and Wellness Sciences At the Cape Peninsula University of Technology Supervisors: Prof. Adriaan J Esterhuyse Dr Dirk J Bester Bellville January 2014 / Background: Oxidative stress and chronic inflammation contributes significantly to the pathogenesis of several ischaemic heart diseases, including atherosclerotic plaque rupture and myocardial infarction. It is widely demonstrated that ischaemia, followed by reperfusion, results in alterations of the mitochondrial and endothelial function through uncontrolled cascades of events characterized by free radical release and inflammation. Recent experimental evidence shows that modulation of inflammatory and antioxidant signaling mediators may determine the host outcome following myocardial ischaemia-reperfusion injury. Investigations from the past decade indicate that food supplements may play an important role in the prevention and management of chronic inflammatory diseases. Garcinia kola seeds are flavonoid rich nut from a tropical flowering, non-timber plant of the Guttiferae family. This plant is highly valued in several African cultures for its use in herbal medicine. Recently, the majority of experimental research has linked phytochemicals found in Garcinia kola nut, to its proposed beneficial effects in treatment and management of oxidative stress related-chronic diseases. Research performed in our laboratory demonstrated that kolaviron, a prominent Garcinia kola flavonoid extract, reduces myocardial apoptosis during ischaemia-reperfusion injury. Therefore, the aim of our current study was to determine the effects of Garcinia kola supplementation on cardiac inflammatory and antioxidant signaling pathways during ischaemia-reperfusion using a Wistar rat heart model. Materials and Methods: Male wistar rats were randomly divided into two groups: a control group receiving 2ml/kg corn oil and the experimental group receiving 100mg/kg Garcinia kola dissolved in corn oil, daily for 4 weeks. After the feeding period, blood samples were collected and lymphocytic DNA damage was analyzed using the alkaline comet assay. Furthermore, rat hearts were isolated and perfused with Krebs-Henseleit buffer on a working heart perfusion apparatus to measure myocardial functional parameters. Myocardial functional recovery was measured after 15 minutes global ischaemia followed by 25 minutes reperfusion. Hearts were freeze clamped at three different time points for myocardial cytokine concentration determinations using multiplex electrochemilunescent immunoassay. Nuclear factor kappa beta (NF- kβ), p38 mitogen activated protein kinases (p38 MAPK), protein kinase B/Akt (PKB/Akt), nitro-tyrosine, inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2), poly (adenosine-di-phosphate) ribose polymerase-1 (PARP-1) and caspase-3 expression and their phosphorylated forms (where applicable) were analyzed using the Western blot technique. Results: Dietary Garcinia kola supplementation significantly improved functional recovery when compared to the control group as reflected by the improved aortic output recovery (68.47 ± 6.16% versus 44.96 ± 7.00%; p<0.05). Our biochemical results supports the hypothesis that, dietary Garcinia kola supplementation modulates different cardiac proteins in terms of expression and activation at different time points when compared to the control group. We show that, before induction of ischaemia, Garcinia kola supplementation attenuates expression of inflammatory mediators and pro-apoptotic proteins when compared to the control group. The improved functional recovery was associated with a prompt inflammatory response, activation of PKB/Akt and attenuation of protein nitrosylation after 10 minutes of reperfusion. Modulation of NF-kβ and the p38 MAPK family proteins expression could have also played a significant role in myocardial functional recovery. Conclusion: We have shown that a 4 week period of dietary Garcinia kola supplementation at 100mg/kg daily improves cardiac functional recovery following ischaemia-reperfusion injury. We propose that dietary Garcinia kola supplementation protects cardiac myocytes from ischaemia-reperfusion induced oxidative stress through the induction of a prompt inflammatory response and controlled expression and/or activation of the, NF-kβ, PKB/Akt and p38 MAPK protein signaling pathways PARP-1 and caspase. Finally, we demonstrated that dietary Garcinia kola supplementation did not induce rat lymphocytic DNA damage when compared to the control group.
10

Absolventenbefragung 2013 Fakultät für Wirtschaftswissenschaften: Ergebnisbroschüre

Pawlowsky, Peter, Froß, Petra, Magnus, Therese, Beuchold, Jennifer 07 March 2016 (has links)
Im Jahr 1996 führte der Lehrstuhl Personal und Führung erstmals eine Befragung von Absolventen der Fakultät für Wirtschaftswissenschaften durch. Auch in den Jahren 1998, 2001, 2005 und 2009 konnte jeweils eine Absolventenbefragung an der Fakultät für Wirtschaftswissenschaften realisiert werden. Inhalt dieser Ergebnisbroschüre bildet die nunmehr sechste Erhebungswelle 2013, wobei eine Gegenüberstellung der Daten zu den früheren Absolventenbefragungen im Sinne eines Längsschnittvergleichs möglich ist.

Page generated in 0.0783 seconds