Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-05-10T22:28:10Z No. of bitstreams: 1 LudmilaDeMeloAlvesDamasio_DISSERT.pdf: 1997584 bytes, checksum: 375ff6f5e4cd5f8032fbc09944492828 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-05-17T19:21:21Z (GMT) No. of bitstreams: 1 LudmilaDeMeloAlvesDamasio_DISSERT.pdf: 1997584 bytes, checksum: 375ff6f5e4cd5f8032fbc09944492828 (MD5) / Made available in DSpace on 2016-05-17T19:21:21Z (GMT). No. of bitstreams: 1 LudmilaDeMeloAlvesDamasio_DISSERT.pdf: 1997584 bytes, checksum: 375ff6f5e4cd5f8032fbc09944492828 (MD5) Previous issue date: 2015-02-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Nas ?reas pobres em dados, o conhecimento dos pescadores tem sido ?til para complementar lacunas atuais e no passado de dados cient?ficos sobre v?rios temas da pesca. Aqui foi verificado se as informa??es dos pescadores costeiros (N = 82), a partir de duas comunidades no NE brasileiro, ? apoiada por dados oficiais de desembarque e se o seu conhecimento poderia ser usado de forma confi?vel para reconstruir as capturas e CPUE (captura por unidade de esfor?o) para 1993, 2003 e 2013. Os registros de desembarque confirmaram a premissa dos pescadores de que as capturas n?o se alteraram ao longo de 2003 a 2013, em ambas as comunidades (C1: t = 0,1; p = 0,2; C2: t = 1,6; p = 0,1). Estimativas dos pescadores para a sua captura m?dia por esp?cies concordaram estatisticamente com os dados de desembarque para tr?s esp?cies (bonito, bagre mar de coco e tubar?es) de um total de 22 esp?cies. Para outros 13, as informa??es fornecidas pelos pescadores e pelos dados de desembarque foram semelhantes, embora estatisticamente n?o significativa. Os pescadores superestimaram a CPUE de esp?cies capturadas usando linhas ou redes de emalhar (? exce??o de Cynoscion jamaicensis, que foi subestimado). Por outro lado, os pescadores deram estimativas precisas da abund?ncia que foram congruentes com os dados de desembarque para as 11 esp?cies mais importantes (correla??o de Spearman: r 2013 = 0,8; r2003 = 0,9; p = 0,000). Por isso, os pescadores eram mais capazes de perceber mudan?as na abund?ncia em vez de mudan?as em seu esfor?o, o que sugere que as informa??es relativas CPUE devem ser mais cuidadosamente interpretadas, como pode haver uma ligeira sobreestimativa para algumas esp?cies. No futuro, devemos tratar porque os pescadores podem dar informa??es detalhadas sobre as suas capturas e esfor?o para algumas esp?cies, mas n?o para outros. / Despite all importance, the small-scale fisheries lives in a condition of limited data. To generate scientific knowledge of these fisheries, the researchers have used increasingly, the local ecological knowledge. The great advantage in using the LEC for evaluation of small-scale fishing is able to access past information not reported in the literature and require considerable investment in time and financial resources to be sampled. In this dissertation sought to increase information available on small-scale fishing in Rio Grande do Norte. In the first article we use information of the fishers to estimate the CPUE of current catches of 10 and 20 years ago and identify the species most captured in the same period and compare this information with landing records and data obtained from expert fishers. In the second article we analyze the information of the boats used in artisanal fisheries to check for a fleet operating on the same species exploited or are different fleets operating on different species. In the first article as stated by fishers, the results do not suggest any change in CPUE between 2003 and 2013. In addition to being good informants to establish ranks of species abundance for the target species, fishers also provided accurate estimates for the CPUE of the best catches in the current period (2013).The approach used in this study showed, once again, that fishers have an important and sometimes unique information. However, when this knowledge was compared with formal data, showed major differences. This heterogeneity of informants and data sources (data of fishermen and official data) may be the single best source of information for fishing in areas where there lack of scientific data and abundance of skilled fishers. In the second article, the results indicate that there are two different fleet acting on the same species. The division between small and large boats showed that small boats are the best option for small-scale fishers. Since there is no difference in the amount of captured species and obtained income and expenses of the vessels these categories are much smaller, generating more profits than the big boats.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-08-09T23:58:08Z No. of bitstreams: 1 AdrianaSoeiroDeFariasSilvaJunqueiraAyres_TESE.pdf: 4492005 bytes, checksum: 363e585cddc1b3b004eb5170356b575b (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-08-15T23:16:31Z (GMT) No. of bitstreams: 1 AdrianaSoeiroDeFariasSilvaJunqueiraAyres_TESE.pdf: 4492005 bytes, checksum: 363e585cddc1b3b004eb5170356b575b (MD5) / Made available in DSpace on 2016-08-15T23:16:31Z (GMT). No. of bitstreams: 1 AdrianaSoeiroDeFariasSilvaJunqueiraAyres_TESE.pdf: 4492005 bytes, checksum: 363e585cddc1b3b004eb5170356b575b (MD5) Previous issue date: 2015-12-11 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / As plantas medicinais constituem uma rica fonte de compostos biologicamente ativos com seu potencial terap?utico para o tratamento de diversos transtornos psiqui?tricos, como os transtornos de ansiedade e depress?o. O transtorno de ansiedade generalizada tem aumentado de forma significativa, sendo o segundo transtorno mais prevalente em locais de assist?ncia ? sa?de p?blica. A depress?o ? considerada um transtorno psiqui?trico cr?nico e comum que afeta 350 milh?es de indiv?duos de todas as idades ao redor do mundo. Neste contexto as condutas de interven??o farmacol?gica que v?m sendo empregadas, embora eficazes, deixam a desejar, quando observados seus efeitos adversos. A Passiflora ? uma variedade comumente conhecida comercialmente, mas tamb?m ? usada na medicina tradicional brasileira. A Passiflora edulis exibe consider?vel variabilidade morfol?gica. Esta planta produz dois tipos de fruto: o roxo (P. edulis var. edulis) e o amarelo (P. edulis var. flavicarpa). O presente estudo investigou os efeitos centrais do extrato aquoso das folhas de duas variedades da esp?cie Passiflora edulis em testes comportamentais utilizados para avaliar comportamentos relacionados ? ansiedade e depress?o, bem como investigou o potencial efeito do tipo antidepressivo das subfra??es da Passiflora edulis var. edulis e os mecanismos neurofarmacol?gicos respons?veis por essa a??o. Para a realiza??o desse estudo foram utilizados camundongos Swiss machos (2 meses de idade, pesando 30-35 g). Os animais receberam o extrato aquoso das folhas das duas esp?cies de Passiflora: Passiflora edulis Sims var. edulis (PEE - 100, 300, 1000 mg/Kg) e subfra??es AcOet, BuOH e residual (25, 50, 75, 100 mg/Kg), e a P. edulis var. flavicarpa (PEF - 30, 100, 300, 1000 mg/Kg) ou solu??o salina, por gavagem, 60 minutos antes dos testes do labirinto em cruz elevado (LCE), teste de campo aberto (TCA), teste de nata??o for?ada (TNF) e teste de seda??o induzido por tiopental. Para investigar o mecanismo de a??o da atividade do tipo antidepressiva das subfra??es foram utilizadas as seguintes drogas: PCPA (inibidor da s?ntese de 5-HT), AMPT (inibidor da s?ntese de catecolaminas), DSP-4 (neurotoxina noradren?rgica) e Sulpiride (antagonista seletivo de receptor dopamin?rgico D2). Foram utilizados como controle positivo padr?o, a fluoxetina e a nortriptilina. Os resultados do perfil fitoqu?mico demonstram caracter?sticas bem distintas para o extrato aquoso das variedades de P. edulis ?flavicarpa? e ?edulis?. Os extratos aquosos de ambas as variedades de P. edulis compartilham atividade do tipo ansiol?tica (PEE 300 mg/Kg; PEF 300 e 1000 mg/Kg) e antidepressiva (PEE 300 mg/Kg; PEF 1000 mg/Kg), enquanto o efeito hipolocomotor/sedativo s? foi visto para a PEE (1000 mg/Kg). Ambas subfra??es AcOet e BuOH do extrato aquoso da PEE apresentaram atividade do tipo antidepressiva na dose de 50 mg/Kg no TNF. Os dados sugerem que o efeito do tipo antidepressivo das subfra??es da P. edulis envolve a neurotransmiss?o serotonin?rgica e catecolamin?rgica, principalmente dopamin?rgica, haja visto que o pr?-tratamento com DSP-4 n?o afetou a a??o antidepressiva das subfra??es, enquanto que mostrou ser dependente da ativa??o de receptores dopamin?rgicos D2. / The medicinal plants constitute a rich source of biologically active compounds used for the treatment of many psychiatric disorders, such as anxiety disorders and depression. Generalized anxiety disorder has increased significantly, being the second most prevalent disorder in care facilities to public health. Depression is considered a chronic and common psychiatric disorder that affects 350 million people of all ages around the world. In this context, the pharmacological intervention conduits have been employed, effective, although leave to be desired when observed adverse effects. The genus Passiflora is commonly commercially known by its fruit, but is also widely used in traditional Brazilian medicine. Passiflora edulis displays considerable morphological variability. This plant produces two types of fruit: Purple (Passiflora edulis Sims fo. edulis) and yellow (Passiflora edulis fo. flavicarpa Degener). This study investigated the central effects of aqueous extract of the leaves of the two varieties of the species Passiflora edulis in tests used to assess behavior related to anxiety and depression, as well as investigating the potential effect of the antidepressant-like fractions of edulis fo. edulis and neuropharmacological mechanisms responsible for this action. To conduct this study used male Swiss mice (2 months old, weighing 30-35 g). The animals received the aqueous extract of the leaves of the two species of Passiflora: edulis fo. edulis (100, 300, 1000 mg / kg) and fractions ethyl acetate, butanol and aqueous waste (25, 50, 75, 100 mg / kg) and edulis fo. flavicarpa (30, 100, 300, 1000 mg / kg) or saline by gavage 60 minutes prior to the maze tests at high cross the open field test, test forced swim test and sedation induced by thiopental. To investigate the mechanism of action of the activity of antidepressant type of fractions the following drugs were used: PCPA (inhibitor of 5-HT synthesis) AMPT (inhibitor of catecholamine synthesis), DSP-4 (noradrenergic neurotoxin) and Sulpiride (antagonist selective dopamine D2 receptor). They were used as a standard positive control, fluoxetine and nortriptyline. The results of the phytochemical profile show very different characteristics to the aqueous extract of the varieties of Passiflora edulis "flavicarpa" and "edulis". The aqueous extracts of both varieties of Passiflora edulis share anxiolytic activity type (edulis fo. edulis 300 mg/kg; edulis fo. flavicarpa 300 and 1000 mg/kg) and antidepressant (edulis fo. edulis 300 mg/kg; edulis fo flavicarpa 1000 mg/kg), while the effect hipolocomotor/sedative was only seen for edulis fo. edulis (1000 mg/kg). Both fractions ethyl acetate, butanol aqueous extract edulis fo. edulis showed activity type antidepressant at a dose of 50 mg/kg in the forced swim test. The data suggest that the effect of antidepressant-like fractions edulis fo. edulis involves catecholaminergic and serotonergic neurotransmission, particularly dopaminergic, there is seen that pre-treatment DSP-4 is not affected antidepressant action of fractions as was dependent activation of dopamine D2 receptors.

Made available in DSpace on 2014-12-17T14:52:50Z (GMT). No. of bitstreams: 1 JosianaFVR_DISSERT.pdf: 4062433 bytes, checksum: 07efe5a289d33a87d6e4d3ebf39cb0e2 (MD5) Previous issue date: 2009-12-22 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / The study examines the process of Knowledge Management and Technological Innovation in Small and Micro Enterprises (SME) in Rio Grande do Norte, Brazil, and proposes actions that can contribute to regional development and competitiveness of SME. Presents as technological innovation can help to make the SME entrepreneurial activities with innovative and competitive. Defines the phases and activities of the construction of knowledge in small organizations. Examines the process of Innovation, Research and Development (R & D) in SME. Identifies the use of knowledge management and technological innovation in management practices and social interaction to influence the competitiveness of SME. Covers the communities of practice as a diffuser of knowledge and learning. To obtain the data were used questionnaires with closed questions with multiple choice, direct observations and interviews with companies. The questionnaires and interviews covered the topics of Innovation, Knowledge Management and Competitive Intelligence on SME. The sample consisted of a total of 13 Small and Micro Enterprises Award winning MPE Brazil Competitiveness, sponsored by SEBRAE in the State of Rio Grande do Norte. The assessment questionnaires dealing with the Knowledge Management (KM Diagnostics - Model Bukowitz and Williams, 2002) and the process of Technological Innovation (Adaptation of ANPEI - National Association for Research, Development and Engineering of Innovative Companies). With the analysis, we concluded that the SME perceive knowledge management, but not formalized management practices so as to facilitate the dissemination of information. Soon, these companies need additional supports to direct them to the innovative activities that generate added value and competitiveness in the market / O estudo analisa o processo de Gest?o do Conhecimento e Inova??o Tecnol?gica nas Micro e Pequenas empresas no Rio Grande do Norte e prop?e a??es que possam contribuir para o desenvolvimento regional e a competitividade das MPEs. Apresenta como a Inova??o Tecnol?gica pode contribuir para tornar as MPEs empreendedoras com atividades inovadoras e competitivas. Define as fases e atividades do processo de constru??o do conhecimento nas organiza??es de pequeno porte. Examina o processo de Inova??o, Pesquisa e Desenvolvimento (P&D) nas MPEs. Identifica o uso da Gest?o do Conhecimento e inova??o tecnol?gica nas pr?ticas administrativas e de intera??o social ao influenciar a competitividade das MPEs. Aborda as comunidades de pr?tica como difusoras do conhecimento e da aprendizagem. Para a obten??o dos dados foram utilizados question?rios com perguntas fechadas de m?ltipla escolha, entrevistas e observa??es diretas com as empresas. Os question?rios e as entrevistas abordaram os temas de Inova??o, Gest?o do Conhecimento e Intelig?ncia competitiva nas MPEs. A amostra constituiu-se por um total de 13 Micro e Pequenas empresas vencedoras do Pr?mio MPE Brasil de Competitividade, promovido pelo SEBRAE no Estado do Rio Grande do Norte. Os question?rios de avalia??o versam sobre a Gest?o do Conhecimento (Diagn?stico de GC - Modelo de Bukowitz e Williams, 2002) e o processo de Inova??o Tecnol?gica (Adapta??o da ANPEI Associa??o Nacional de Pesquisa, Desenvolvimento e Engenharia das empresas Inovadoras). Com a an?lise dos resultados, conclui-se que as MPEs percebem a gest?o do conhecimento, por?m n?o formalizam as pr?ticas gerenciais de forma que facilitem a dissemina??o das informa??es. Logo, estas empresas precisam de suportes adicionais que as direcionem para as atividades inovativas que gerem um valor agregado e competitividade no mercado

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-03-09T22:56:49Z No. of bitstreams: 1 KyviaBezerraMota_TESE.pdf: 5202658 bytes, checksum: 44dd9aeba607843c325d09b4d48f945d (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-03-13T23:39:17Z (GMT) No. of bitstreams: 1 KyviaBezerraMota_TESE.pdf: 5202658 bytes, checksum: 44dd9aeba607843c325d09b4d48f945d (MD5) / Made available in DSpace on 2017-03-13T23:39:17Z (GMT). No. of bitstreams: 1 KyviaBezerraMota_TESE.pdf: 5202658 bytes, checksum: 44dd9aeba607843c325d09b4d48f945d (MD5) Previous issue date: 2016-10-07 / Essa tese trata de duas pesquisas com diferentes naturezas conceituais no campo da modelagem molecular, por?m baseadas em semelhantes princ?pios te?ricos da f?sica qu?ntica e da qu?mica computacional. No primeiro estudo, as estabilidades dos sistemas ER?-OHT (Receptor ? de Estr?geno-Hidroxitamoxifeno), ER?-RAL (Receptor ? de Estr?geno-Raloxifeno) e Integrina ?v?3-Cilengitide foram determinadas em termos energ?ticos a partir da t?cnica de fracionamento molecular com capuzes conjugados (MFCC) e no escopo da teoria do funcional da densidade (DFT) seguindo o esquema GGA-PBE-Grimme para calcular a intera??o energias dos sistemas estudados. No primeiro estudo, foi poss?vel predizer a relev?ncia individual dos amino?cidos Glu, Asp, Arg, Lys no sistema com o Tamoxifeno e Glu, Asp e Lys com o Raloxifeno. Para isso ser poss?vel, as for?as de atra??o e repuls?o dos res?duos que comp?em os sistemas foram calculadas. Cada um desses res?duos apresentou uma energia de intera??o que variou dependendo da natureza qu?mica da sua cadeia lateral, do ambiente de microsolvata??o que o envolve e dos contatos intermoleculares que estabelece. O estudo pioneiro da estabilidade conformacional em termos energ?ticos de uma regi?o livre de amino?cidos incitar? pesquisas centradas no desenvolvimento e s?ntese de novos antagonistas utilizados no tratamento de diversas patologias comuns na popula??o geral. No segundo estudo, foram determinadas as propriedades energ?ticas do sistema Integrina ?V?3-Cilengitide, cuja estrutura cristalogr?fica apresenta c?tions Mn+2. Observou-se a import?ncias dos amino?cidos Ser, Asp, Leu, Arg, Lys, Ala e Pro na intera?ao da integrina com o fragmento RGD (R: arginina; G: glicina; D: ?cido asp?rtico) do cilengitide. A import?ncia da integrina com o fragmento RGD no mecanismo de ades?o de diversas c?lulas envolvidas nas doen?as cancer?genas e tamb?m na implanta??o embrion?ria permitir? o desenvolvimento de novas terapias impactantes na sobrevida de pacientes portadores de diversas neoplasias e na reprodu??o humana. / This thesis deals with two researches with different conceptual nature in the field of molecular modeling based on similar theoretical principles of quantum physics and computational chemistry. In the first study the stabilities of ER?-OHT (Receptor ? Estrogen co-crystalyzed with Hydroxytamoxifen), ER?-RAL (?-Estrogen Receptor co-crystalyzed with Raloxifene) and integrin ?v?3 co-crystalyzed with cilengitide systems were determined in terms of energy from the Molecular Fractionation Technique Caps Conjugates (MFCC), and the scope of the Density Functional Theory (DFT) following GGA-PBE-Grimme scheme for calculating the interaction energy of the systems studied. In the first study, it was possible to predict the relevance of individual amino acids Glu, Asp, Arg, Lys in the system with Tamoxifen and Glu, Asp and Lys in Raloxifene system. For this to be possible, the attraction and repulsion forces of the residues that comprise the systems were calculated. Each of these residues had an energy of interaction that varied depending on the chemical nature of the side chain, the microsolvation environment that surrounds and intermolecular contacts establishing. The pioneer study of conformational stability in terms of energy of free amino acid region will encourage research focusing on the development and synthesis of new antagonists used in the treatment of several common diseases in the general population. In the second study, we determined the energetic properties of Integrin ?V?3-cilengitide system, whose crystallographic structure has Mn+2 cations. It was noted the importance of amino acids Ser, Asp, Leu, Arg, Lys, Ala and Pro in integrin interaction with the RGD fragment (R: arginine; G: glycine; D: aspartic acid) of cilengitide. The importance of integrin with the RGD fragment in the adhesion mechanism of various cells involved in cancers and in embryo implantation allows the development of new therapies impacting on survival of patients with various forms of neoplasms and in human reproduction.