Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-04-17T23:38:51Z No. of bitstreams: 1 LeticiaStreck_TESE.pdf: 2733282 bytes, checksum: a29543b300520c0b87fa69110b9016dc (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-04-21T00:04:14Z (GMT) No. of bitstreams: 1 LeticiaStreck_TESE.pdf: 2733282 bytes, checksum: a29543b300520c0b87fa69110b9016dc (MD5) / Made available in DSpace on 2017-04-21T00:04:14Z (GMT). No. of bitstreams: 1 LeticiaStreck_TESE.pdf: 2733282 bytes, checksum: a29543b300520c0b87fa69110b9016dc (MD5) Previous issue date: 2017-02-02 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Doen?as negligenciadas, incluindo a doen?a de Chagas, representam um problema de sa?de mundial devido ao desinteresse da ind?stria na pesquisa por novos f?rmacos. Benznidazol (BNZ), f?rmaco dispon?vel no Brasil para o tratamento da doen?a de Chagas, e distribu?do pelo Minist?rio da Sa?de, apresenta algumas limita??es quanto ao seu uso, em especial na fase cr?nica da doen?a. A tecnologia farmac?utica proporciona o desenvolvimento de sistemas que aumentam a solubilidade do f?rmaco ou aumento de sua concentra??o nas c?lulas/tecidos infectados o que reflete diretamente no aumento da biodisponibilidade e efici?ncia terap?utica do BNZ. Assim, sistemas l?quidos tais como os sistemas coloidais lip?dicos (SCL), como emuls?es, microemuls?es, nanoemuls?es s?o uma alternativa interessante para o aumento da biodisponilidade oral e parenteral do BNZ. Este trabalho tem como objetivo o desenvolvimento de nanoemuls?es biocompat?veis contendo triglicer?deo de cadeia m?dia (Miglyol?812) estabilizados por uma mistura adequada de tensoativos (fosfatidilcolina de soja e oleato de s?dio), al?m de avaliar o efeito tripanocida. As condi??es ideais para obten??o dos sistemas de interesse foi avaliada pelo estudo da temperatura de invers?o de fases (TIF) e da adi??o de um novo componente. Nanoemuls?es foram formadas com adi??o de 2-metilpirrolidona (NMP) com tamanho de got?cula uniforme e menor que 162,66 nm. Os sistemas permaneceram est?veis at? 60 dias quando armazenados a temperatura de 25 ?C. As propriedades reol?gicas mostraram comportamento dependente com a quantidade de co-solvente adicionada ao sistema. As imagens de microscopia de luz polarizada e espalhamento de raios-X a baixo ?ngulo confirmaram a forma??o de sistemas isotr?picos quando o co-solvente est? em concentra??o superior a 5%. A libera??o de BNZ nos sistemas contendo ?cido si?lico em diferentes concentra??es, foi at? 3 (tr?s) vezes mais r?pida que os sistemas sem a subst?ncia. Os sistemas apresentaram biocompatibilidade em diferentes linhagens celulares (Vero, SiHa e LLC-MK2). Nanoemuls?es apresentaram capacidade de veicular o BNZ em sistemas biocompat?veis e com excelente atividade tripanocida, representando assim um futuro promissor no tratamento da doen?a de Chagas, considerando que at? o presente n?o existem formas farmac?uticas l?quidas de administra??o, o que impossibilita o ajuste da dose e a redu??o de efeitos colaterais. / Neglected diseases, including Chagas disease, represent a global health problem due to the industry's lack of interest in research for new drugs. Benznidazole (BNZ), a drug available in Brazil for the treatment of Chagas disease, and distributed by the Health Ministery, presents some limitations regarding its use, especially in the chronic phase of the disease. Pharmaceutical technology provides the development of systems that increase drug solubility or increase its concentration in infected cells / tissues which directly reflects the increased bioavailability and therapeutic efficacy of BNZ. Thus, liquid systems such as lipid colloidal systems (LCS), such as emulsions, microemulsions, nanoemulsions are an interesting alternative for increasing oral and parenteral bioavailability of BNZ. This work aims to develop biocompatible nanoemulsions containing medium chain triglycerides (Miglyol?812) stabilized by a suitable mixture of surfactants (soybean phosphatidylcholine and sodium oleate), and to evaluate the trypanocidal effect. The ideal conditions for obtaining the systems of interest were evaluated by the study of phase inversion temperature (PIT) and the addition of a new component. Nanoemulsions were formed with addition of 2-methylpyrrolidone (NMP) with uniform droplet size and less than 162.66 nm. The systems remained stable for up to 60 days when stored at 25 ? C. The rheological properties showed a behavior dependent on the amount of co-solvent added to the system. The polarized light microscopy and low angle X-ray scattering images confirmed the formation of isotropic systems when the cosolvent is in a concentration greater than 5%. The release of BNZ in systems containing sialic acid at different concentrations was up to 3 (three) times faster than systems without the substance. The systems showed biocompatibility in different cell lines (Vero, SiHa and LLCMK2). Nanoemulsions were able to transport BNZ in biocompatible systems with excellent trypanocidal activity, thus representing a promising future in the treatment of Chagas' disease, considering that to date there are no liquid dosage forms of administration, which makes it impossible to adjust the dose and decrease of side effects.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-06-13T20:29:52Z No. of bitstreams: 1 AndreLuizSilvaDavim_TESE.pdf: 2927049 bytes, checksum: c70bf3fe6cd0580d21ea07690845a8e8 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-06-19T14:43:48Z (GMT) No. of bitstreams: 1 AndreLuizSilvaDavim_TESE.pdf: 2927049 bytes, checksum: c70bf3fe6cd0580d21ea07690845a8e8 (MD5) / Made available in DSpace on 2017-06-19T14:43:48Z (GMT). No. of bitstreams: 1 AndreLuizSilvaDavim_TESE.pdf: 2927049 bytes, checksum: c70bf3fe6cd0580d21ea07690845a8e8 (MD5) Previous issue date: 2017-02-23 / Atualmente os custos no tratamento de pacientes com doen?as inflamat?rias que progridem de forma sist?mica, com destaque para a sepse, s?o muito elevados e representa a maior causa de morte em unidades de terapia intensiva, n?o cardiol?gica, em todo o mundo. No Brasil, a incid?ncia de pacientes com sepse ? cada vez mais frequente. Apesar dos avan?os farmacol?gicos, tecnol?gicos e cir?rgicos, a mortalidade por sepse e/ou doen?as associadas continua alta em todo o mundo, e por isso se busca alternativas terap?uticas de f?cil acesso e baixo custo para conter o avan?o dessa doen?a. Os produtos naturais v?m desempenhando importante papel na ind?stria farmac?utica, pois algumas dessas subst?ncias agem de forma ben?fica sobre o sistema imunol?gico humano. Nos ?ltimos tempos, h? uma crescente investiga??o das poss?veis propriedades biol?gicas e terap?uticas atribu?das ao ?leo de r?-touro, pois esse ?leo vem sendo utilizado de forma indiscriminada pela popula??o no tratamento de diversas doen?as como bronquite, asma, l?quem escleroso, furunculose, cisto seb?ceo e para cicatriza??o de pele e mucosas. Por?m as poss?veis consequ?ncias no consumo excessivo desse ?leo s?o, o aumento da produ??o de eicosanoides derivados do ?cido araquid?nico proinflamat?rio e a defici?ncia na regula??o hep?tica, predispondo ? esteatose podendo progredir para inflama??o hep?tica e fibrose. Muitas hip?teses se baseiam na atua??o dos compostos presentes no ?leo de r?-touro na modula??o da resposta inflamat?ria, impedindo assim a instala??o de inj?rias teciduais. Dessa forma, a microemuls?o apresenta-se como uma poss?vel alternativa para um novo sistema de libera??o de f?rmacos, com o intuito de diminuir a incid?ncia de hepatoxicidade e protegendo o organismo contra instala??o de les?es teciduais em fun??o do quadro s?ptico. Assim, o presente estudo teve como objetivo avaliar o potencial anti-inflamat?rio do ?leo de r?-touro puro e em um sistema microemulsionado em modelo experimental. Neste estudo, foi preparado e caracterizado um sistema microemulsionado (WIV) e, aplicado em ensaios biol?gicos a fim de avaliar o potencial antiinflamat?rio do ?leo puro e em microemuls?o. Foram utilizados o modelo de sepse, induzida pela t?cnica da CLP (cecal ligant puncture), e a les?o muscular induzida pela formalina. Os ensaios foram realizados em modelos murinos, onde os animais foram separados aleatoriamente em grupos e tratados com o ?leo de r?-touro puro e em microemuls?o, atrav?s da t?cnica de gavage para posterior avalia??o do potencial hepatot?xico e anti-inflamat?rio. Para a an?lise do potencial antiinflamat?rio em modelo de sepse, foram realizadas lavagens bronco alveolares com posterior contagem de c?lulas inflamat?rias e an?lises histopatol?gicas do tecido pulmonar. Para a an?lise no modelo de les?o muscular, foi avaliado extens?o horizontal da pata dos animais, bem como feita a an?lise histopatol?gica do tecido muscular. Para a an?lise do potencial hepatot?xico das subst?ncias, foram avaliados a taxa de sobrevida dos animais p?s-sepse e as an?lises histopatol?gicas dos tecidos hep?ticos dos animais. Quando avaliado a toxicidade do ?leo de r?-touro puro e em sistema microemulsionado, foi observado que no grupo em que foi administrado a microemuls?o (ME), o f?gado teve a arquitetura preservada, mas com sinais cl?nicos de esteatose hep?tica, diferentemente do grupo ?leo de r?-touro puro (OR), que apresentou m?ltiplos focos de necrose hepatoc?tica acompanhado de infiltrado de polimorfonucleares. Esses achados evidenciam um quadro de esteatohepatite, ou seja, um est?gio mais avan?ado e um precursor do carcinoma hep?tico. Quando avaliada a sobrevida dos animais, foi observado que no grupo ME a taxa foi significativamente maior quando comparado ao grupo OR. Quando avaliado o potencial antiinflamat?rio da ME e OR em modelo de sepse, foi observado em ambos os grupos potencial de modula??o da resposta inflamat?ria, visto a capacidade de reduzir de forma significativa (P?0.01) a migra??o de leuc?citos para os pulm?es ap?s a indu??o da sepse. Quando analisado a histologia dos tecidos pulmonares dos animais dos dois grupos, foi verificado intenso desgaste nos animais do grupo OR quando comparados com o grupo ME, onde evidenciou-se pouco comprometimento tecidual. No ensaio de les?o muscular, foi observado que o grupo ME e OR apresentaram bom potencial antiedematog?nico at? a segunda hora da indu??o da les?o, quando comparados ao grupo controle (P?0.01), mas n?o sendo observado diferen?as significativas entre os dois grupos at? a vig?sima quarta hora p?s-les?o. Nas an?lises histol?gicas foram observadas maior desgaste no tecido muscular do grupo OR, com intensa presen?a de infiltrado celular (edema) e comprometimento de fibras musculares, n?o sendo observado a mesma intensidade de inj?ria no grupo ME. Assim, conclui-se que o ?leo de r?-touro puro e em sistema microemulsionado apresentam bom potencial anti-inflamat?rio nos modelos avaliados, embora o ?leo puro tenha apresentado alto potencial hepatot?xico, caracterizando que este em um sistema microemulsionado, se mostra com um poss?vel novo sistema de libera??o de f?rmacos (NSLF). / Current costs of treating patients with systemically progressing inflammatory diseases, especially sepsis, are the leading cause of death in non-cardiological intensive care units worldwide. In Brazil, the incidence of sepsis in patients is becoming more frequent. Despite pharmacological, technological and surgical advances, mortality due to sepsis and/or associated diseases remains high worldwide, hence the search for easily accessible and inexpensive therapeutic alternatives to contain the progression of this disease. Natural products have played an important role in the pharmaceutical industry because some of these substances act in a beneficial way on the human immune system. In recent times, there is a growing investigation of the possible biological and therapeutic properties attributed to bullfrog oil, since this oil has been used indiscriminately by the population in the treatment of various diseases, such as bronchitis, asthma, lichen sclerosus, furunculosis, sebaceous cyst, and for healing of skin and mucous membranes. However, the possible consequences of excessive consumption of this oil are increased production of eicosanoids derived from proinflammatory arachidonic acid and deficiency in hepatic regulation, predisposing to steatosis, which may progress to hepatic inflammation and fibrosis. Many hypotheses are based on the performance of the compounds present in bullfrog oil in the modulation of the inflammatory response, thus preventing the onset of tissue injuries. The microemulsion is presented as a possible alternative to a new drug delivery system, in order to reduce the incidence of hepatotoxicity and protect the organism against the installation of tissue lesions as a function of the septic condition. The present study is aimed to evaluate the anti-inflammatory potential of pure bullfrog oil and a microemulsion system in an experimental model. In this study, a microemulsified system (WIV) was determined and characterized, and applied in biological tests to evaluate the anti-inflammatory potential of pure oil and microemulsion. We used the sepsis model, induced by cecal ligant puncture (CLP) technique, and the formalin-induced muscle injury. The tests were performed in murine models, where the animals were randomly separated into groups and treated with pure bullfrog oil and microemulsion, using the gavage technique for further evaluation of the hepatotoxic and anti-inflammatory potential. For the analysis of the anti-inflammatory potential in a sepsis model, bronchoalveolar lavage was performed with subsequent inflammatory cell counts and histopathological analyzes of lung tissue. For the analysis in the muscle injury model, the horizontal extension of the limbs of the animals was evaluated, as well as the histopathological analysis of the muscle tissue. For the analysis of the hepatotoxic potential of the substances, the post-sepsis survival rate and the histopathological analyzes of the hepatic tissues of the animals were evaluated. When evaluating the toxicity of pure bullfrog oil and in a microemulsion system, it was observed that in the group that received the microemulsion (ME), the liver had the architecture preserved, but with clinical signs of hepatic steatosis, unlike the pure bullfrog oil group, which presented multiple outbreaks of hepatocytic necrosis accompanied by polymorphonuclear infiltrates. These findings indicate a picture of steatohepatitis, that is, a more advanced stage and a precursor of hepatic carcinoma. When evaluating the survival of the animals, it was observed that the ME group survival rate was significantly higher when compared to the oil group. When evaluating the anti-inflammatory potential of the ME and the oil group in a sepsis model, the potential for modulation of the inflammatory response was observed in both groups, since the leukocyte migration to the lungs was significantly reduced (P<0.01) after the induction of sepsis. When analyzing the histology of the lung tissues of the animals of both groups, intense wear was observed in the animals of the oil group, when compared with the ME group, where there was little tissue compromise. In the muscle injury test, it was observed that the ME and oil group had good anti-nematode potential until the second hour of injury induction, when compared to the control group (P<0.01), but no significant differences were observed between the two groups until twenty-fourth hour post-injury. In the histological analyzes, greater wear was observed in the oil group muscle tissue, with an intense presence of cellular infiltrate (edema) and muscle fibers involvement, and the same intensity of injury was not observed in the ME group. Thus, it is concluded that pure bullfrog oil and microemulsion system present good anti-inflammatory potential in the evaluated models, although the pure oil showed high hepatotoxic potential, characterizing that in a microemulsified system, it is shown with a possible new drug delivery system (NSLF).

Submitted by Ricardo Cedraz Duque Moliterno (ricardo.moliterno@uefs.br) on 2018-01-25T23:14:34Z No. of bitstreams: 1 DISSERTA??O - MARCOS VIN?CIUS SANTOS SILVA.pdf: 1867351 bytes, checksum: def26bc9b7fc279cafbb180af8d67b58 (MD5) / Made available in DSpace on 2018-01-25T23:14:34Z (GMT). No. of bitstreams: 1 DISSERTA??O - MARCOS VIN?CIUS SANTOS SILVA.pdf: 1867351 bytes, checksum: def26bc9b7fc279cafbb180af8d67b58 (MD5) Previous issue date: 2016-04-27 / The research aims to analyze the interface between humanization and technological resources in hospitals. It was the result of an investigation under a qualitative approach, while the data were analyzed in addition to the quantifiable dimensions, but a universe embraced by signs, senses and meanings attributed to the object in focus. The empirical universe of the study was two hospital equipments linked to the Department of Health of the State of Bahia, administered under different legal and administrative systems. The choice of these hospitals met the criteria: broad flow demand of massive technological development and that were allocated near the university in which the study is linked. Empirical research showed with the application of semi-structured interviews scripts together professionals from both units. Discussions necessary researches are categorized in the debate on hospital care, specifying on its structure and the adjacent and constituent subjects in defendants processes. The results of this study reflect issues to the very interface between humanization and technological resources in health, converging on the antagonistic character attributed to technology, now seen as making it humanizes, sometimes as dehumanizing mechanism. Also, the data also indicate on the various meanings attributed to humanization, converging with its polysemous attribute. Although, all the undertaken theoretical basis points directives that establish with the ideal of restructuring hospital care, with a focus to their practice. With regard, it urges the need to safeguard the qualities inherent in the principle of ethics, as they stand up for human values in much needed. Therefore, the discussions related to the paradigm of execution of humanization in the health field by the driver of technological resources, are recurrent. Thus, it points out the need to build care environments conducive to the introduction of targeted practices and demarcated by the complementarity between categories humanization and technology. Therefore, the need to adopt and reflect on an integrative approach is argued between them, facilitating the humans values to scale on the technologic practices, proceduralists, as combated. / A pesquisa tem como objetivo analisar a interface entre a humaniza??o e a incorpora??o tecnol?gica em unidades hospitalares. Foi fruto de uma investiga??o com abordagem qualitativa, ao passo que os dados foram analisados al?m das dimens?es quantific?veis, mas num universo abarcado por signos, sentidos e significados atribu?dos ao objeto em foco. O universo emp?rico do estudo foi dois equipamentos hospitalares vinculados ? Secretaria Estadual de Sa?de do Estado da Bahia, administrados sob diferentes regimes jur?dico-administrativos. A escolha desses hospitais se deu devido aos seus amplos fluxos demandat?rios, ? maci?a incorpora??o tecnol?gica em ambos e ao fato de estarem alocados pr?ximos ? universidade em que esse estudo est? vinculado. A pesquisa emp?rica evidenciou-se com a aplica??o de roteiros semiestruturados de entrevistas junto aos profissionais de ambas as unidades. As discuss?es necess?rias ? pesquisa categorizam-se no debate sobre o cuidado hospitalar, especificando sua estrutura e os sujeitos adjacentes e constituintes nos processos demandados. Os resultados desse estudo refletem quest?es referentes ? pr?pria interface entre a humaniza??o e a incorpora??o tecnol?gica em sa?de, convergindo quanto ao car?ter antag?nico atribu?do ? tecnologia, ora vista como fazer que humaniza, ora como mecanismo desumanizador. Igualmente, os dados indicam os v?rios sentidos atribu?dos ? humaniza??o, confluindo com seu atributo poliss?mico. Conquanto, todo o aporte te?rico empreendido aponta diretivas que coligem com o ideal de reestruturar o cuidado hospitalar, com enfoque ao campo das pr?ticas. A pesquisa incita a necessidade de resguardar as qualidades inerentes ao princ?pio da ?tica, ? medida que ressalta os valores humanos, em muito carecidos. Logo, as discuss?es relacionadas ao paradigma da efetiva??o da humaniza??o no campo da sa?de, mediante o fator condicionante da incorpora??o tecnol?gica, s?o recorrentes. Assim, aponta-se para a necessidade de se construir ambientes de cuidado prop?cios ? instaura??o de pr?ticas direcionadas e demarcadas pela complementariedade entre as categorias ?humaniza??o? e ?tecnologia?. Portanto, defendeu-se a necessidade de adotar e refletir acerca de uma abordagem integradora entre ambas, possibilitando aos valores humanos dimensionarem-se sobre as pr?ticas tecnicistas, em geral, muito combatidas.

Made available in DSpace on 2015-04-14T14:49:12Z (GMT). No. of bitstreams: 1 417384.pdf: 1342446 bytes, checksum: 4858f19c27a2781bf9df32e176deb4f3 (MD5) Previous issue date: 2009-07-06 / O Governo Eletr?nico (e-Gov) deve servir de base para a gest?o de Tecnologia da Informa??o e Comunica??o do Governo Federal e tem como requisitos fundamentais a promo??o da cidadania, a prioriza??o da inclus?o digital, o uso da gest?o do conhecimento, a racionaliza??o de recursos, a padroniza??o de normas, pol?ticas e padr?es e a integra??o com os demais entes federativos. As grades computacionais, por sua vez, fornecem um ambiente para execu??o de aplica??es paralelas no qual recursos distribu?dos podem ser utilizados de forma transparente. Este ambiente possibilita o processamento de grandes volumes de dados, compartilhamento de recursos e a redu??o de custos. Dessa forma, as grades computacionais podem ajudar os ?rg?os p?blicos a alcan?ar seus objetivos. Neste estudo os requisitos do Governo Eletr?nico s?o analisados sob a perspectiva de utiliza??o de grades computacionais para execu??o aplica??es de e-Gov, verificando como as grades podem ser ?teis aos ?rg?os governamentais. Uma aplica??o de e-Gov ? modelada e testada em ambiente de grades para mostrar o potencial desta plataforma de execu??o em tais condi??es.

Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2015-09-02T14:24:03Z No. of bitstreams: 1 474447 - Texto Completo.pdf: 2284764 bytes, checksum: 96a5bca2a4ec18ab595cb869947e7ccc (MD5) / Made available in DSpace on 2015-09-02T14:24:03Z (GMT). No. of bitstreams: 1 474447 - Texto Completo.pdf: 2284764 bytes, checksum: 96a5bca2a4ec18ab595cb869947e7ccc (MD5) Previous issue date: 2015-04-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Given the population growth and increasing urbanization problems the need to search for creative solutions to improve the quality of life arises, which often are supported by the use of technology: thus the smart city initiatives come up. It is in this context that the present study aims to contribute by proposing to analyze a smart city initiative, to identify the challenges and success factors of its implementation, therefore contributing to the description of the phenomenon in the Brazilian scenario. The initiative chosen was the implementation of the Integrated Center of Command (CEIC) in Porto Alegre, because it is a service integration that uses technology. Hence, this study aims to answer the following research question: How is happening CEIC deployment in Porto Alegre? To answer this question, the Smart City Initiatives Framework in Chourabi et al. (2012) was used. To better understand the phenomenon under study, a qualitative approach with the case study method was used. Data were collected through semi-structured interviews in various organizational levels. Subsequently, to obtain the results the data were categorized. Thus, this research allowed to analyze the CEIC deployment and identified that the main contribution of the CEIC to the service integration was the implementation of a common, centralizedtechnology infrastructure through the development of a city monitoring infrastructure with the integration of cameras, images and information sharing with bodies that are part of CEIC and partners who work in special operations. In the study, the use of technology as a key element that helps to generate information to qualify the decision-making of municipal management, especially in emergencies and large events is highlighted. The key success factors identified were investment in technology, common technology infrastructure, training and collaboration. The main challenges evidenced were the scarcity of financial resources and the public procurement procedure. / Diante do crescimento populacional e dos crescentes problemas de urbaniza??o surge a necessidade de busca de solu??es criativas para melhorar a qualidade de vida dos cidad?os, as quais, muitas vezes, s?o apoiadas pelo uso de tecnologia: assim surgem as iniciativas de smart city. ? dentro deste contexto que o presente estudo pretende contribuir, buscando analisar uma iniciativa de smart city, identificar os desafios e fatores de sucesso de sua implanta??o, contribuindo, destarte, com a descri??o do fen?meno no cen?rio brasileiro. A iniciativa escolhida foi a implanta??o do Centro Integrado de Comando (CEIC) da cidade de Porto Alegre, por tratar-se de uma integra??o de servi?os atrav?s da utiliza??o da tecnologia. Assim, este estudo busca responder ? seguinte quest?o de pesquisa: como est? ocorrendo a implanta??o do CEIC em Porto Alegre? Para respond?-la, foi utilizado o Framework Integrativo de Iniciativas de Smart Cities de Chourabi et al. (2012). Visando um melhor entendimento do fen?meno em estudo, buscou-se utilizar uma abordagem qualitativa, tendo como m?todo o estudo de caso. O levantamento dos dados ocorreu atrav?s de entrevistas semiestruturadas em diversos n?veis organizacionais. Posteriormente, para obten??o dos resultados, os dados foram categorizados. Assim, esta pesquisa permitiu analisar a implanta??o do CEIC e identificar que a principal contribui??o do CEIC para a integra??o dos servi?os foi implantar uma infraestrutura tecnol?gica comum e centralizada atrav?s do desenvolvimento de uma infraestrutura de monitoramento da cidade, com a integra??o de c?meras, compartilhando as imagens e informa??es com ?rg?os que integram o CEIC e parceiros que atuam em opera??es especiais. No estudo, destaca-se a utiliza??o da tecnologia como elemento fundamental que auxilia a gerar informa??es para qualificar a tomada de decis?o da gest?o municipal, principalmente em situa??es emergenciais e eventos de grande porte. Os principais fatores de sucesso identificados foram investimento em tecnologia, infraestrutura tecnol?gica comum, treinamento e colabora??o. Os principais desafios evidenciados foram a car?ncia de recursos financeiros e o processo de aquisi??o p?blica.

Made available in DSpace on 2015-04-14T14:52:21Z (GMT). No. of bitstreams: 1 437118.pdf: 1810013 bytes, checksum: 80cf27556031120483224b5ecd4c1090 (MD5) Previous issue date: 2012-01-16 / In a context of growing Information and Communication Technologies (ICT) in organizations, has grown the need for adoption of technology also on governments to improve administrative procedures, the provision of public services and the social participation through e-governance practices. The use of IT in public institutions enables the promotion of transparency in government actions, improving the relationship between citizens and government through a broader interaction between them, besides to expands and improves the quality in service delivery. The institutional perspective was used under theoretical lens. The present study seeks to answer the following research question: How do institutional factors influence the governance of IT organizations to implement e-governance practices? To answer it, a conceptual model that seeks to identify the influence of coercive pressures, mimetic and normative practices in implementing e-governance was proposed through research propositions. A qualitative research approach was used, with the method of single case study in a public e-service provider organization (CAPES Journals Portal). The finding results corroborate the propositions of the conceptual model of this research, suggesting that there is influence of institutional factors in the form of coercive, normative and mimetic mechanisms in the governance structure of the IT organization, characterized as a business monarchy regarding IT decisions to implementation of a public e-service. The work allowed to identified that the public organization is dependent on several factors of the field in which it is inserted, as dependence on resources, the need to supply a demand from the scientific community, the federal government encouragement, the need to expand the service`s reach and cost reduction and the existence of similar successful models, under isomorphic pressure from other organizations and the environment itself. Furthermore, the present study identifies that the environment, through institutional factors, determines the organizational behavior to implementing e-governance practices. / Em um contexto de crescimento das Tecnologias de Informa??o e Comunica??o (TIC) nas organiza??es surgiu a necessidade de ado??o de tecnologia tamb?m nos governos, para a melhoria dos processos administrativos, da presta??o de servi?os p?blicos e da participa??o social, atrav?s de pr?ticas de governan?a eletr?nica. O uso de TIC nas institui??es p?blicas permite a promo??o de transpar?ncia nas a??es do governo, a melhoria do relacionamento entre cidad?o e governo atrav?s de uma maior intera??o dos mesmos, al?m da amplia??o e aumento da qualidade na presta??o de servi?os. Como lente te?rica da investiga??o foi utilizada a perspectiva institucional. Este estudo busca responder a seguinte quest?o de pesquisa: Como os fatores institucionais influenciam na Governan?a de TI (Tecnologia de Informa??o) das organiza??es para implementa??o de pr?ticas de governan?a eletr?nica? Para respond?-la, foi proposto um modelo conceitual que busca identificar a influ?ncia de press?es coercitivas, normativas e mim?ticas na implementa??o de pr?ticas de governan?a eletr?nica, atrav?s de proposi??es de pesquisa. Utilizou-se uma abordagem qualitativa de pesquisa, tendo como m?todo o estudo de caso ?nico em uma organiza??o prestadora de um e-servi?o p?blico, sendo este o Portal de Peri?dicos da CAPES. Os resultados encontrados corroboram as proposi??es do modelo conceitual da pesquisa, sugerindo que existe influ?ncia de fatores institucionais, na forma de mecanismos coercitivos, normativos e mim?ticos, na estrutura de Governan?a de TI da organiza??o, caracterizada como uma monarquia de neg?cios com rela??o ?s decis?es de TI, para implementa??o do e-servi?o p?blico. O trabalho permitiu identificar que a organiza??o p?blica ? dependente de fatores do campo em que est? inserida como a depend?ncia de recursos, a necessidade de atendimento de uma demanda da comunidade cient?fica, o incentivo do governo federal, a necessidade de amplia??o do alcance do servi?o e da redu??o de custos e a exist?ncia de modelos semelhantes de sucesso, sofrendo press?es isom?rficas de outras organiza??es e do pr?prio ambiente. Al?m disso, permitiu identificar que o ambiente, atrav?s de fatores institucionais, condiciona o comportamento organizacional para implementa??o de pr?ticas de governan?a eletr?nica.

Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-05-09T20:17:02Z No. of bitstreams: 2 MarliAlvesFloresdeMeloTese2016.pdf: 2866717 bytes, checksum: ded487e445cc5b3ce25965551908312d (MD5) MarliAlvesFloresdeMeloTeseAnexoD2016.pdf: 2501968 bytes, checksum: 0460450c595e2baabeb90212217e95f7 (MD5) / Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2017-05-09T20:17:28Z (GMT) No. of bitstreams: 2 MarliAlvesFloresdeMeloTese2016.pdf: 2866717 bytes, checksum: ded487e445cc5b3ce25965551908312d (MD5) MarliAlvesFloresdeMeloTeseAnexoD2016.pdf: 2501968 bytes, checksum: 0460450c595e2baabeb90212217e95f7 (MD5) / Made available in DSpace on 2017-05-09T20:17:28Z (GMT). No. of bitstreams: 2 MarliAlvesFloresdeMeloTese2016.pdf: 2866717 bytes, checksum: ded487e445cc5b3ce25965551908312d (MD5) MarliAlvesFloresdeMeloTeseAnexoD2016.pdf: 2501968 bytes, checksum: 0460450c595e2baabeb90212217e95f7 (MD5) Previous issue date: 2016-12-19 / This thesis aims to identify the possible causes for the gap between theoretical conceptions and trends that resulted from academic studies and public policies applied to professional, scientific, and technological education. In order to achieve this, we searched, in 28 doctoral dissertations in the field of education and similar fields, the conceptions of professional, scientific, and technological education extracted from their results, analyses, and discussions, observing the parameters in technical, methodological, theoretical, and epistemological levels, and the paradigmatic assumptions. As a differential, a pilot study was carried out, in the templates of an empirical ???pre-research,??? aiming to consubstantiate the whole decision process that preceded the dissertation structuring???this topic being inserted in the justification and relevance of the study. As for its characterization, this study is exploratory and its methodology was divided in two large blocks: theoretical dimension, with the part for the fundamentals, and the procedural dimension, with the components that involve the research practice. As for the approach, it meets the principles of the essentially qualitative research, having as basis the comprehension, although it has used numerical and statistical representativeness. It has adopted as fundamentals for methodology, procedures, and instruments the S??nchez Gamboa paradigmatic scheme, a scheme which, for its nature, is also acknowledged as an epistemological approach of method. It has also used the state of the art as the most appropriate for meta-research. The data-generating process encompassed bibliographic research, documental research, and the registration sheet, with adaptations. The results indicated, on what concerns the conceptions of the researched dissertations??? authors, that the dualism and disconnection between what supports the theoretical and methodological dimension of studies and the reality, as well as the strict vision on training for the labor market, constitute the three factors that have impacted the most the causes for the gap between academic studies and public policies in professional, scientific, and technological education. Among other causes, what stood out was also the divergence of conceptions with geographically distinct vision of domains for which the theoretical trends would be destined, on state and federal levels. On theoretical trends and the benefits of including local productive arrangements in the offer of courses of technical and professional education, the results have steered to a new understanding: Paulo Freire???s context of ???unheard-viable.??? We concluded with the implications for further studies and a report on pending matters in this study. / O objetivo geral desta tese foi identificar as implica????es do distanciamento entre as concep????es e tend??ncias te??ricas provenientes dos estudos acad??micos e as pol??ticas p??blicas aplicadas ?? Educa????o Profissional, Cient??fica e Tecnol??gica (EPCT). Para alcan????-lo, buscouse, em vinte e oito teses de doutorado em educa????o e ??reas afins, as concep????es de educa????o profissional, cient??fica e tecnol??gica obtidas na parte dos resultados, das an??lises e discuss??es, observando-se os par??metros nos n??veis t??cnico, metodol??gico, te??rico e epistemol??gico, bem como nos pressupostos paradigm??ticos. Como diferencial, realizou-se um estudo-piloto nos moldes de uma ???pr??-pesquisa??? emp??rica, com o objetivo de consubstanciar todo o processo de decis??o que antecedeu a estrutura????o da tese, sendo este t??pico inserido como parte da justificativa e relev??ncia do estudo. Quanto ?? carateriza????o, o estudo ?? de natureza explorat??ria e a metodologia foi dividida em dois grandes blocos, assim denominados: dimens??o te??rica, com a parte dos fundamentos; e dimens??o procedimental, com os componentes que envolveram a pr??tica da pesquisa. Quanto ?? abordagem, atendeu aos princ??pios da pesquisa essencialmente qualitativa, tendo por base a compreens??o, embora se tenha feito uso de representatividade num??rica e estat??stica. Adotou-se como fundamentos da metodologia, procedimentos e instrumentos, o esquema paradigm??tico de S??nchez Gamboa, esquema que, por sua natureza, ?? reconhecido tamb??m como uma abordagem epistemol??gica do m??todo. Utilizou-se, ainda, o estado da arte, como um recurso complementar, quando se faz metapesquisa. O processo de gera????o dos dados abrangeu a pesquisa bibliogr??fica, a pesquisa documental e a ficha de registro, com adapta????es. Os resultados, no que tange ??s concep????es dos autores das teses pesquisadas, indicaram que o dualismo, a desconex??o entre o que fundamenta a dimens??o te??rica e metodol??gica dos estudos e a realidade, bem como a vis??o restrita sobre treinamento para o mercado de trabalho, constituem os tr??s fatores que mais exerceram impacto no distanciamento entre estudos acad??micos e pol??ticas p??blicas na ??rea da EPCT. Entre outros, destacou-se, ainda, a diverg??ncia de concep????es com vis??o geograficamente distinta dos dom??nios para as quais se destinariam as tend??ncias te??ricas, nas esferas estadual e federal. Sobre as implica????es entre tend??ncias te??ricas e benef??cios da inclus??o dos arranjos produtivos locais (APL) na oferta de cursos, no ensino t??cnico e profissional, os resultados direcionaram para um novo entendimento: o contexto de ???in??ditovi??vel???, de Paulo Freire. Finalizou-se com as implica????es para futuras pesquisas e um relato das pend??ncias deste estudo.

Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2018-03-15T12:12:02Z No. of bitstreams: 1 2016 - Celia Regina de Souza Caldas.pdf: 2562125 bytes, checksum: 963804d7cc59b2a3215a6dfd314fe5b0 (MD5) / Made available in DSpace on 2018-03-15T12:12:02Z (GMT). No. of bitstreams: 1 2016 - Celia Regina de Souza Caldas.pdf: 2562125 bytes, checksum: 963804d7cc59b2a3215a6dfd314fe5b0 (MD5) Previous issue date: 2016-12-14 / The avalanche of new services available on platforms that enable voice-over-data technologies such as Internet TV, streaming technology videos and WhatsApp communication have become part of consumers' daily lives, which overwhelm telecommunications and wireless carriers Competitiveness in the market. The scenario refers to a necessary change of behavior in the sector, parallel to an essential revision of the existing regulation. This study analyzes the impacts of the regulated telecommunications market in the process of convergence with the IT industry, where regulation has a dual influence on the industry: ensuring order in telecommunication services and, on the other hand, an offensive risk of disadvantage in the Competitiveness and restraint of innovation in a digital economy. Based on the contributions of the VBM and VBR theories, an exploratory research was developed, carried out through a single case study and bibliographic review, under the lens of the regulatory impacts on competitiveness. Data were collected through semi-structured interview of the strategic body of a telecom operator, being treated in a qualitative way. The analysis pointed to a finding: regulation as a strong influencer in strategic positioning can be harmful to the competitiveness and deflagration of the industry when it can not keep up with the evolution and dynamism of the sector. With this, the operator under study proposes a new business model based on a strategy of aggregation of IT services over telecom, indicating an alternative to innovate within a regulated market. It is understood that an operator model, lighter, agile and digital, is necessary in the consolidation of a "Telco Digital". It is hoped, with the strategy outlined, to successfully face the process of transformation of the industry and to maintain in the market a viable and sustainable model of operator in the digital economy. / A avalanche de novos servi?os disponibilizados em plataformas que viabilizam tecnologias de voz sobre dados, como a TV por internet, v?deos em tecnologia streaming e a comunica??o WhatsApp passaram a fazer parte do cotidiano dos consumidores, o que sobrecarregam as redes das operadoras de telecomunica??es e acirra a competitividade no mercado. O cen?rio remete a uma necess?ria mudan?a de comportamento no setor, paralelo a uma essencial revis?o da regulamenta??o existente. Este estudo analisa os impactos do mercado regulado das telecomunica??es em pleno processo de converg?ncia com a ind?stria de TI, onde a regulamenta??o exerce dupla influ?ncia sobre a ind?stria: garantir a ordem nos servi?os de telecomunica??es e, por outro lado, um risco ofensor de desvantagem na competitividade e freio da inova??o em uma economia digital. Com base nos aportes das teorias de VBM e VBR, desenvolveu-se uma pesquisa de car?ter explorat?rio, realizada atrav?s de estudo de caso ?nico e revis?o bibliogr?fica, sob a lente dos impactos regulat?rios na competitividade. Os dados foram coletados atrav?s de entrevista semiestruturada do corpo estrat?gico de uma operadora de telecom, sendo tratados de forma qualitativa. As an?lises apontaram para uma descoberta: a regulamenta??o como forte influenciadora no posicionamento estrat?gico, pode ser nociva ? competitividade e deflagra??o da ind?stria quando n?o consegue acompanhar a evolu??o e o dinamismo do setor. Com isso, a operadora em estudo prop?e um novo modelo de neg?cio pautado numa estrat?gia de agrega??o de servi?os de TI sobre telecom, indicando uma alternativa de inovar dentro de um mercado regulado. Entende-se que um modelo de operadora, mais leve, ?gil e digital, ? necess?rio na consolida??o de uma ?Telco Digital?. Espera-se, com a estrat?gia delineada, enfrentar com ?xito o processo de transforma??o da ind?stria e manter no mercado um modelo vi?vel e sustent?vel de operadora na economia digital

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-12-12T19:38:30Z No. of bitstreams: 1 ReginaCarmenEsposito_TESE.pdf: 1609404 bytes, checksum: bbff08f10f8b71c6162cfba459bc5243 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-12-14T19:40:52Z (GMT) No. of bitstreams: 1 ReginaCarmenEsposito_TESE.pdf: 1609404 bytes, checksum: bbff08f10f8b71c6162cfba459bc5243 (MD5) / Made available in DSpace on 2017-12-14T19:40:52Z (GMT). No. of bitstreams: 1 ReginaCarmenEsposito_TESE.pdf: 1609404 bytes, checksum: bbff08f10f8b71c6162cfba459bc5243 (MD5) Previous issue date: 2017-09-29 / O aumento benigno da pr?stata, mais conhecido como hiperplasia benigna da pr?stata (HBP), leva a sintomas do trato urin?rio inferior (STUI), que contribuem para diminuir a qualidade de vida dos homens acima da quarta d?cada. O mesmo vem sendo tratado, na sua maioria, por medicamentos alop?ticos do grupo dos inibidores da 5-alfa-redutase e/ou alfa-bloqueadores e/ou fitoter?picos. A literatura cient?fica apresenta uma escassez de ensaios cl?nicos randomizados, controlados com cegamento sobre a efic?cia de medicamentos homeop?ticos que j? tenham mat?ria m?dica para esta doen?a, bem como de novos rem?dios homeop?ticos. O presente estudo visou a avaliar a efic?cia do produto homeop?tico, contendo Momordica charantia 12CH, no controle dos STUI, devido ? HBP em ensaio cl?nico, randomizado, duplo cego e placebo controlado. Foram aleatorizados 81 pacientes em grupo A - Placebo e grupo B - Momordica charantia 12CH e avaliados a cada consulta pela anamnese, com o Escore Internacional de Sintomas Prost?ticos (IPSS), pelos exames de imagem com mensura??o do Volume Prost?tico (PV) e do Volume de Urina Residual P?s-esvaziamento (PVR) e laboratoriais pelo Ant?geno Prost?tico Espec?fico (PSA), Prote?na C Reativa quantitativa (PCR) e Interleucina-6 (IL-6). Em 72 amostras, foram realizados imunofenotipagem de linf?citos e subpopula??es por citometria de fluxo. Tanto a vari?vel principal (IPSS) quanto as vari?veis secund?rias (PSA, PV, PVR e PCR) e acess?rias (IL-6, linf?citos totais, linf?citos B, linf?citos T, linf?citos T helper, linf?citos T citot?xico e rela??o CD4/CD8 e c?lulas Natural Killer) n?o apresentaram signific?ncia estat?stica nas m?dias entre os grupos tratado e Placebo. Quanto ?s vari?veis de seguran?a, o uso da medica??o homeop?tica, pelos pacientes, n?o trouxe interfer?ncia durante os seis meses do experimento, seja na taxa de glicemia de jejum, seja nas dosagens de alanina aminotransferase, aspartato aminotransferase, fosfatase alcalina, bilirrubinas totais e fra??es e creatinina, usadas para avalia??o hep?tica e da fun??o renal respectivamente. A aus?ncia de infec??o urin?ria, confirmada pelo sum?rio de urina dos pacientes, predominou em ambos os grupos A e B durante todo o per?odo do ensaio cl?nico. Pode-se concluir que o tratamento com a Momordica charantia 12CH n?o apresentou diferen?a significativa para o placebo, quanto ? efic?cia no controle dos STUI, por HBP, por?m mostrou-se seguro. Pesquisas de alta qualidade, que permitam a prescri??o, a partir da individualiza??o dos sintomas e com diferentes dinamiza??es, devem ser realizadas, para possibilitar uma interpreta??o mais decisiva. / The benign enlargement of the prostate, better known as benign prostatic hyperplasia (BPH) results in symptoms of the lower urinary tract (LUTS) that contributes to lower quality of life of men over the fourth decade, and is mostly treated by allopathic drugs of the group of 5-alpha-reductase inhibitors and / or alpha-blockers, and / or phytotherapics. The scientific literature shows lack research from randomised and doubleblind clinical trials on the efficacy of homeopathic medicinal products that already have homeopathic medical materia and new homeopathic medicinal for BPH.The present study aimed to evaluate the effectiveness of the homeopathic product containing Momordica charantia 12CH in the LUTS control caused by BPH in a clinical, randomized, double-blind and placebo-controlled trial.A total of 81 patients were randomized to group A - Placebo and group B - Momordica charantia 12CH and evaluated at each visit by anamnesis with the International Prostate Symptom Score (IPSS), by imaging tests measured prostate volume (PV) and post-void residual (PVR) and laboratory tests for prostate specific antigen (PSA), quantitative C-reactive protein (CRP) and interleukin-6 (IL-6), and in 72 samples, lymphocyte and subpopulation immunophenotyping were performed by flow cytometry.Both the main variable (IPSS) and the secondary variables (PSA, PV, PVR and CRP) and accessory variables (IL-6, total lymphocytes, B lymphocytes, T lymphocytes, T helper cells, cytotoxic T lymphocytes and CD4 / CD8 ratio and Natural Killer cells) did not present statistical significance in the means between the groups treated and Placebo.About the safety variables, the use of homeopathic medication by the patients did not interfere during the six months of research, either in the fasting glucose level, as well as in the dosages of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubins and fractions and creatinine levels used for hepatic evaluation and renal function respectively.The absence of urinary infection confirmed by urinalysis of patients predominated in both groups A and B throughout the clinical trial period. It can be concluded that treatment with Momordica charantia 12CH did not show a significant difference for placebo in the efficacy in the control of STUI by BPH, but it demostrated to be safe. High quality researchs, which allows prescription, from the individualization of symptoms and with different dynamizations, must be performed, to enable more decisiveinterpretation of its effectiveness.

Made available in DSpace on 2014-12-17T13:51:38Z (GMT). No. of bitstreams: 1 FernandoPSO_TESE.pdf: 2860613 bytes, checksum: c176b9a96ce41e332623f6fc2475170a (MD5) Previous issue date: 2014-08-11 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / This study approaches bureaucratic organizational structures with the aim to understand the adherence procedure to virtual technologies in the stricto sensu educational administrative process. Thus, the author navigates through the formation of these organizations in Brazil with the intent to demonstrate the bureaucratic organizational culture and the consequent form of domination of those who detain power. In this epistemological construction, the author explores the culture s bureaucratic environment and the organizational power. In the analyses, it was observed the technological phenomenon in the ODL s administrative environment, which can explain the adherence procedure to structures and technological instruments for stricto sensu courses that, hypothetically, dilutes the traditional inherited organizational axiom. Therefore, it was utilized as object of study the Professional Master s degree in National Scale Public Administration PROFIAP, hence analyzing the documental content and the legislation related to institutionalization as well as the positioning of professors/coordinators and of the director of CAPES/MEC. Considering this axioms, it was concluded that the bureaucratic structures can admit ODL in the stricto sensu s environment. However, this can only be done as long as the adherence does not imply in a dilution of the traditional forms of power and institutional bureaucratic inherited dominance, as well as the alleged hegemony of the governmental structure in the educational administration adopted in person by the stricto sensu courses in Brazil / O estudo aborda as estruturas organizacionais burocr?ticas, a fim de compreender a forma da ades?o ?s tecnologias virtuais no processo administrativo-educacional para o stricto sensu. Para tanto, o autor navega na forma??o das organiza??es no Brasil, visando demostrar a cultura organizacional burocr?tica e a consequente forma de dom?nio daqueles que det?m o poder. Nessa constru??o epistemol?gica, o autor explora o ambiente burocr?tico da cultura e poder organizacional. Para tal an?lise, observa-se o fen?meno da tecnologia no ambiente administrativo da EAD, o qual pode explicar a forma da ades?o ?s estruturas e instrumentos tecnol?gicos para o stricto sensu, que, em tese, dilui o axioma organizacional tradicional herdado. Portanto, foi utilizado, enquanto objeto de estudo, o caso do Mestrado Profissional em Administra??o P?blica em Rede Nacional PROFIAP, analisando o conte?do documental e da legisla??o relacionada ? institucionaliza??o e o posicionamento de professores/coordenadores e diretor da CAPES/MEC. Concluiu-se, sob tais axiomas, que as estruturas burocr?ticas podem admitir, sim, a EAD no ambiente do stricto sensu. Isso desde que a ades?o n?o conote diluir as formas tradicionais de poder e dom?nio burocr?tico institucional herdado, assim como a suposta hegemonia da estrutura de governan?a da administra??o na educa??o adotada presencialmente pelo stricto sensu no Brasil