Made available in DSpace on 2014-12-17T13:53:20Z (GMT). No. of bitstreams: 1 RanieryCQP.pdf: 4763460 bytes, checksum: 2187b7f5a46c8651f28aaf67ab624659 (MD5) Previous issue date: 2008-08-25 / Each two years the amount of available information in the world double. This is the Information Age, where the success depends on what one knows, not on what one has. A new economy appears with the capacity to generate, to store, to process and to apply effectively the knowledge, based on information, determining the companies productivity and competitiveness.The objective of this work is to understand the information management model of a technological research institute - CTG?S (Gas Technology Center). The research has been done focused on the 5 main processes and the 15 support processes of the organization value chain , aiming to understand the information management in the organization based on Davenport?s Information Management model (1998). Therefore, it was necessary to identify how the necessary information for the organizational processes accomplishment are determined, obtained, distributed and used by the organization. The research can be classified as descriptive, regarding to its aims, and as a case study, related to the research ways. Interviews with the managers of the organization value chain processes have been carried through, with the objective to identify how they perceive the Information Management process that circulates in the organizational processes. Complementarily, a documentary research has been carried through, associated to the direct observation and procedures and actions follow up, involving the Information Management. The data treatment and analysis have been done from the authors theoretical support and from the managers interviews analysis, documents and processes observed by the researcher in the organization. It was noticed that the organization has raised its level of information needs that are not difficult to be determined and are satisfactorily obtained and distributed, although the majority of them are not structuralized, automatized or even classified regarding to its confidence. These peaces of information have good quality and are important, however they reflect a medium dependence on external and informal information, besides being used only in its great majority for people to know what and how to do something / A cada dois anos a quantidade de informa??o dispon?vel no mundo dobra. Essa ? a Era da Informa??o em que o sucesso depende daquilo que se sabe e n?o daquilo que se tem. Uma nova economia surge com capacidade para gerar, armazenar, processar e aplicar efetivamente o conhecimento, baseada em informa??es, determinando a produtividade e competitividade das empresas. O objetivo deste trabalho ? compreender o modelo da gest?o da informa??o de um instituto de pesquisa tecnol?gica O CTG?S (Centro de Tecnologias do G?s). A investiga??o se deu com foco nos 5 processos fim e nos 15 processos meio da cadeia de valor da organiza??o, buscando compreender a gest?o da informa??o na organiza??o com base no modelo de Gest?o da Informa??o de Davenport(1998). Desta forma, foi necess?rio identificar como as informa??es necess?rias para realiza??o dos processos organizacionais s?o determinadas, obtidas, distribu?das e usadas pela organiza??o. A pesquisa pode ser classificada como descritiva, quanto aos seus fins, e como estudo de caso, quanto aos meios de investiga??o. Foram realizadas entrevistas com os gestores dos processos da cadeia de valor da organiza??o, com o objetivo de identificar como eles percebem o processo de Gest?o da Informa??o que circula nos processos organizacionais. Complementarmente foi realizada uma pesquisa documental, associada ? observa??o direta e ao acompanhamento de a??es e procedimentos envolvendo a Gest?o da informa??o. O tratamento e an?lise dos dados foram feito a partir do suporte te?rico dos autores e da an?lise das entrevistas com gestores, documentos e processos observados pelo pesquisador na organiza??o. Constatou-se que a organiza??o tem elevado n?vel de necessidades de informa??o que n?o s?o dif?ceis de serem determinadas e que s?o satisfatoriamente obtidas e distribu?das, apesar de a maioria delas n?o serem estruturadas, automatizadas ou mesmo classificadas quanto ? confidencialidade. Estas informa??es t?m boa qualidade e s?o importantes, contudo refletem uma depend?ncia mediana por informa??es do tipo externa e do tipo informal, al?m de serem usadas em sua grande maioria apenas para que indiv?duos saibam o que e como fazer algo

Made available in DSpace on 2014-12-17T13:53:29Z (GMT). No. of bitstreams: 1 GabrielARO_DISSERT.pdf: 1143900 bytes, checksum: 8256306f625e33c9e6ce65bec903d081 (MD5) Previous issue date: 2010-08-27 / The transformations economical, cultural and social that happen in world ambit they are associated to the intense progress and expansion of new technologies, forcing governments, people, companies and nations to the introduction of new patterns of behavior, forcing, in that way, to the continuous renewal of products and technological processes to maintain the competitiveness, so much among nations, as in the managerial world. In that matter, the technological innovation is recognized as basic factor of maintainable economical competitiveness, being the responsible for the breaking and/or improvement of the techniques and production processes, what presupposes the systematization varied institutional arrangements that they involve firms, interaction nets among companies, government agencies, universities, research institutes, laboratories of companies and scientists and engineers activities. Those arrangements, to the if they articulate with the educational system, with the industrial and managerial section and, also, with the financial institutions, they take the form that Freeman (1987) it coined of national system of innovation, promoted through public politics of CT&I, which seek to induce and to support innovative initiatives in the companies, as well as to establish demands and to prioritize vocations and regional potentialities. In that context of government support to the technological innovation interferes this study, that it looked for to know the reasons of the fragility innovative in the pharmaceutical industry of State of Par? in Brazil, pointed for PINTEC (2005), starting from the point of view of the businessmen of that section. For such, the qualitative approach was used - with interviews directing semi and the technique of the content analysis. The results of the research pointed that the fragilities innovative of the section links to the ignorance of the government support to the technological innovation on the part of the businessmen of the pharmaceutical industry of State of Par? in Brazil / As transforma??es econ?micas, culturais e sociais que ocorrem em ?mbito mundial est?o associadas ao intenso avan?o e expans?o de novas tecnologias, for?ando governos, pessoas, empresas e na??es ? introdu??o de novos padr?es de comportamento, obrigando, desse modo, ? renova??o cont?nua de produtos e processos tecnol?gicos para manter a competitividade, tanto entre na??es, como no mundo empresarial. Nesse particular, a inova??o tecnol?gica ? reconhecida como fator b?sico de competitividade econ?mica sustent?vel, sendo a respons?vel pelo rompimento e/ou aperfei?oamento das t?cnicas e processos de produ??o, o que pressup?e a sistematiza??o de variados arranjos institucionais que envolvem firmas, redes de intera??o entre empresas, ag?ncias governamentais, universidades, institutos de pesquisa, laborat?rios de empresas e atividades de cientistas e engenheiros. Esses arranjos, ao se articularem com o sistema educacional, com o setor industrial e empresarial e, tamb?m, com as institui??es financeiras, tomam a forma que Freeman (1987) cunhou de sistema nacional de inova??o, promovido por meio de pol?ticas p?blicas de CT&I, as quais visam induzir e apoiar iniciativas inovadoras nas empresas, como tamb?m estabelecer demandas e priorizar voca??es e potencialidades regionais. Nesse contexto de apoio governamental ? inova??o tecnol?gica se insere este estudo, que buscou conhecer as raz?es da fragilidade inovativa na ind?stria farmac?utica paraense, apontada pela PINTEC 2005, a partir do ponto de vista do empresariado desse setor. Para tal, utilizou-se a abordagem qualitativa - com entrevistas semi diretivas e a t?cnica da an?lise de conte?do. Os resultados da pesquisa apontaram que as fragilidades inovativas do setor se relacionam ao desconhecimento do apoio governamental ? inova??o tecnol?gica por parte do empresariado da ind?stria farmac?utica paraense

Made available in DSpace on 2014-12-17T13:53:36Z (GMT). No. of bitstreams: 1 AlinnePCQ_DISSERT.pdf: 1893742 bytes, checksum: 7e97cee14efe2142e77ccf54ef3f0ba1 (MD5) Previous issue date: 2013-08-19 / O advento das novas tecnologias e a dinamicidade das mudan?as que estas provocam, impactam diretamente em v?rios aspectos da sociedade, dentre estes, na educa??o. Novas metodologias e mudan?as no processo de ensino-aprendizagem tornam-se pr?ticas cada vez mais frequentes neste campo. O elemento basilar desta nova constitui??o ? o docente, capaz de transformar a utiliza??o desses recursos em ferramentas que favore?am o processo educativo. Essa readequa??o do comportamento exigida por essas constantes mudan?as ? orientada pelos valores pessoais dos sujeitos que vivenciam a situa??o. Os valores s?o idealizados como crit?rios que interferem diretamente nas atitudes, prefer?ncias e at? mesmo no comportamento humano, influenciando no modo como o indiv?duo interpreta as suas pr?prias atitudes e as dos outros, inclusive no ?mbito profissional. Dessa forma, o objetivo geral da presente pesquisa ? analisar as rela??es entre o perfil de uso da tecnologia e os valores dos docentes da UFRN Universidade Federal do Rio Grande do Norte, baseado na escala de valores de Schwartz. Para isso foram utilizados os tipos motivacionais que comp?em a teoria de valores de Schwartz, atrav?s de question?rio aplicado junto aos docentes. Trata-se de uma pesquisa de enfoque anal?tico quantitativo que utiliza um question?rio da escala de valores desenvolvida por Schwartz et al. (2001) conhecida como PVQ (Portrait Values Questionnaire). A pesquisa foi desenvolvida a partir de uma amostra de 200 docentes entre atuantes da modalidade presencial e/ou na modalidade de ensino a dist?ncia. A estrat?gia de an?lise dos dados utilizou t?cnicas de estat?stica descritiva, an?lise de gr?ficos, an?lise das frequ?ncias relativas e a t?cnica estat?stica MANOVA (An?lise Multivariada de Vari?ncia). Os resultados apontaram que os docentes utilizam moderadamente os recursos tecnol?gicos avaliados nesta pesquisa, como ferramenta de apoio pedag?gico. Com rela??o ao perfil de valores, os docentes apresentaram prioridade entre os tipos motivacionais Autodetermina??o, Benevol?ncia e Universalismo, enquanto os menos priorizados foram os de Tradi??o, Realiza??o e Poder, respectivamente. Contudo, n?o foram identificadas rela??es significativas entre o perfil de valores e o perfil de uso da tecnologia entre os docentes estudados nesta pesquisa

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-04-08T23:04:24Z No. of bitstreams: 1 PauloVitorSilva_TESE.pdf: 16564605 bytes, checksum: d1310555faa2a858e9c72cbd78a64731 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-04-11T22:58:46Z (GMT) No. of bitstreams: 1 PauloVitorSilva_TESE.pdf: 16564605 bytes, checksum: d1310555faa2a858e9c72cbd78a64731 (MD5) / Made available in DSpace on 2016-04-11T22:58:46Z (GMT). No. of bitstreams: 1 PauloVitorSilva_TESE.pdf: 16564605 bytes, checksum: d1310555faa2a858e9c72cbd78a64731 (MD5) Previous issue date: 2015-05-11 / A necessidade constante de novas fontes de energias renov?veis vem promovendo cada vez mais o aumento de investimentos nessa ?rea. Dentre essas fontes, a energia e?lica vem tomando grande destaque. Torna-se importante promover a busca pelo aprimoramento das tecnologias envolvidas nas topologias de aerogeradores, buscando alternativas que aumentem o rendimento obtido, apesar da irregularidade da velocidade do vento. Este trabalho apresenta um novo sistema para controle de velocidade, aqui aplicado em aerogeradores, o Regulador Eletromagn?tico de Frequ?ncia (REF). Um dos dispositivos mais utilizados em algumas topologias s?o as caixas de engrenagens mec?nicas que, al?m de uma vida ?til curta, representam frequentemente, fontes de ru?do e defeitos. O REF dispensa essas caixas de transmiss?o, representando um avan?o tecnol?gico, utilizando para isso uma m?quina de indu??o adaptada, na qual o estator passa a ser m?vel, solid?rio ao eixo da turbina. Na topologia utilizada neste trabalho, o REF tamb?m permite dispensar o uso de conversores eletr?nicos para estabelecer o acoplamento entre o gerador e a rede el?trica, raz?o pela qual tamb?m proporciona a possibilidade de obten??o de gera??o em corrente alternada, com tens?o e frequ?ncia constantes, onde n?o exista a rede el?trica. Respons?vel pelo controle da velocidade mec?nica do gerador, o REF pode ser ?til em outros sistemas de transmiss?o onde o controle de velocidade mec?nica de sa?da seja o objetivo. Al?m disso, por operar atrav?s da combina??o de duas entradas, uma mec?nica e outra el?trica, o REF multiplica as possibilidades de aplica??es por ser apto ao acoplamento sin?rgico entre energias de matrizes diferentes, e, por tais motivos, possibilita que as diversas fontes de energia envolvidas sejam desacopladas da rede, sendo o gerador s?ncrono o respons?vel pela conex?o do sistema com a rede el?trica, simplificando as estrat?gias de controle quanto ? pot?ncia injetada na mesma. Resultados de simula??o e experimentais s?o apresentados no decorrer do trabalho, voltados a um aerogerador, validando a proposta em rela??o a efici?ncia no controle de velocidade do sistema para diferentes condi??es de vento. / The constant necessity for new sources of renewable energy is increasingly promoting the increase of investments in this area. Among other sources, the wind power has been becoming prominent. It is important to promote the search for the improvement of the technologies involved in the topologies of the wind turbines, seeking for alternatives which enhance the gotten performance, despite the irregularity of the wind speed. This study presents a new system for speed control, in this case applied to the wind turbines - the Electromagnetic Frequency Regulator (EFR). One of the most used devices in some topologies is the mechanical gearboxes which, along with a short service life, often represent sources of noise and defects. The EFR does not need these transmission boxes, representing a technological advancement, using for that an adapted induction machine, in which the stator becomes mobile, supportive to the axis of the turbine. In the topology used in this study, the EFR also allows us to leave out the usage of the eletronic converters to establish the coupling between the generator and the electrical grid. It also the reason why it provides the possibility of obtaining the generation in alternating current, with constant voltage and frequency, where there is no electrical grid. Responsable for the mechanical speed control of the generator, the EFR can be useful in other transmission systems in which the mechanical speed control output is the objective. In addition, the EFR operates through the combination of two inputs, a mechanical and other electrical. It multiplies the possibilities of application because it is able to synergistic coupling between different arrays of energy, and, for such reasons, it enables the various sources of energy involved to be uncoupled from the network, being the synchronous generator responsible for the system connection with the electrical grid, simplifying the control strategies on the power injected in it. Experimental and simulation results are presented through this study, about a wind turbine, validating the proposal related to the efficience in the speed control of the system for different wind conditions.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-05-31T20:39:36Z No. of bitstreams: 1 IrisUcellaDeMedeiros_TESE.pdf: 1627038 bytes, checksum: abacbae1a6fa2f0ce88c897b540dedc4 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-03T00:28:56Z (GMT) No. of bitstreams: 1 IrisUcellaDeMedeiros_TESE.pdf: 1627038 bytes, checksum: abacbae1a6fa2f0ce88c897b540dedc4 (MD5) / Made available in DSpace on 2016-06-03T00:28:56Z (GMT). No. of bitstreams: 1 IrisUcellaDeMedeiros_TESE.pdf: 1627038 bytes, checksum: abacbae1a6fa2f0ce88c897b540dedc4 (MD5) Previous issue date: 2015-08-14 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq) / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / Durante as ?ltimas d?cadas t?m sido demonstrado que existe uma rela??o entre a depress?o maior e a ativa??o do sistema imunol?gico. Nociceptina/orfanina FQ (N/OFQ) ? o ligante natural do receptor acoplado ? prote?na Gi chamado NOP, ambos constituem um sistema pept?dico que est? envolvido na regula??o do humor e de respostas inflamat?rias. Considerando essas a??es, a presente tese teve como objetivo investigar as consequ?ncias do bloqueio da sinaliza??o do receptor NOP nos comportamentos doentio e do tipo depressivo induzidos pela administra??o de lipopolissacar?deo (LPS) em camundongos. A administra??o sist?mica de doses de LPS, que n?o causam sepse, induzem altera??es nos comportamentos de camundongos relacionadas com a atividade das citocinas pr?-inflamat?rias fator de necrose tumoral-? (TNF-?) e interleucinas 6 (IL-6) e 1? (IL- 1 ?). Ap?s 2 a 6 h e 24 h da inje??o intraperitoneal, camundongos tratados com LPS apresentam, respectivamente, o comportamento doentio e o comportamento do tipo depressivo. No presente trabalho, a administra??o de LPS (0,8 mg/kg, ip) induziu sinais de doen?a em camundongos Swiss e CD-1, como perda de peso, redu??o transit?ria da temperatura retal e diminui??o da ingest?o de ra??o e ?gua. Al?m disso, nas 24 h ap?s a inje??o de LPS, essas mesmas linhagens de camundongos mostraram aumento no tempo de imobilidade durante os 6 min que foram submetidos ao teste de suspens?o pela cauda (TSC). O tratamento com nortriptilina (30 mg/kg, ip, 60 minutos antes do TSC) reduziu o tempo de imobilidade dos camundongos controle e tratados com LPS, e foi utilizado como antidepressivo padr?o. A administra??o pr?via ao LPS do antagonista do receptor NOP SB-612111 (10 mg/kg, ip), n?o alterou os comportamento doentio e do tipo depressivo induzidos pelatoxina. No entanto, quando injetado 24 h ap?s o tratamento com LPS, SB-612111 (ip, 30 minutos antes do TSC), como tamb?m o antagonista pept?dico do receptor NOP UFP-101 (10 nmol/2ul, icv, 5 min antes do TSC), inverteram significativamente os efeitos da toxina. O protocolo de indu??o do comportamento do tipo depressivo pela administra??o intraperitoneal de LPS tamb?m foi testado em camundongos nocautes para o receptor NOP (NOP(-/-)) e seus respectivos wild types (NOP(+/+)). O tratamento com LPS provocou altera??es significativas, como a redu??o tempor?ria da temperatura retal nos camundongos NOP(-/-) e perda de peso corporal e redu??o no consumo de ra??o e ?gua em ambos os camundongos NOP(+/+) e NOP(-/-). O consumo de ?gua foi significativamente diferente entre os gen?tipos. A inje??o de LPS induziu altera??es transit?rias nas citocinas pr?-inflamat?rias. Nas 6 horas ap?s o tratamento com LPS, os n?veis s?ricos de TNF-? mostraram-se aumentados significativamente nos camundongos NOP (+/+) e NOP (-/-), j? os n?veis de IL-6 mostraram-se significativamente aumentados apenas no soro dos camundongos NOP (+/+). Nas 24 horas ap?s a inje??o de LPS, os n?veis s?ricos das citocinas pr?-inflamat?rias retornaram ? linha de base. O tratamento com LPS provocou efeitos de tipo depressivo nos camundongos NOP (+/+), mas foi ineficaz nos camundongos NOP (-/-). Os dados obtidos nesta tese mostram que o bloqueio farmacol?gico e gen?tico da sinaliza??o mediada pelo receptor NOP n?o previne os comportamentos doentio e do tipo depressivo induzidos por LPS, no entanto revertem o comportamento do tipo depressivo. Em conclus?o, esses resultados evidenciam o envolvimento do sistema pept?dico N/OFQ - receptor NOP na modula??o dos comportamentos relacionados ao humor e ? ativa??o do sistema imunol?gico. / During the last decades, it has been established that there is a relationship between major depression and activation of immune system. Nociceptin/orphanin FQ (N/OFQ) is the natural ligand of a Gi-protein coupled receptor named NOP, both compose the peptidergic system wich is involved in the regulation of mood states and inflammatory responses. Considering these actions, the present thesis aimed to investigate the consequences of blocking NOP signaling in lipopolysaccharide (LPS)-induced sickness and depressive-like behaviors in mice. Systemic administration of LPS doses, that do not cause sepsis in mice, induce changes in their behaviors related with activity of pro-inflammatory cytokines tumor necrosis factor-? (TNF-?) and interleukins 6 (IL-6) and 1? (IL-1 ?). At the time points of 2 to 6 h and 24 h after intraperitoneal injection, mice treated with LPS displayed, respectively, sickness and depressive-like behaviors. In the present work the administration of LPS 0.8 mg/kg (ip) significantly induced sickness signs in Swiss and CD-1 mice, such as weight loss, transient reduction in rectal temperature and decrease of food and water intake. Moreover at 24 h after LPS injection these same mice strains displayed significantly increased immobility time on the tail suspension test (TST) when compared with control mice, this alteration was not related with possible locomotion impairments as verified on the open field test. Treatment with Nortriptyline 30 mg/kg (ip, 60 min prior the TST) reduced the immobility time of control and LPS-treated mice and was used as standard antidepressant. The NOP receptor antagonist SB-612111 (10 mg/kg, ip), 30 min prior LPS, did not modify LPS-induced sickness signs and depressive-like behavior. However, when injected 24 h after LPS treatment, SB-612111 (ip, 30 min prior the TST) as well as the peptidergic NOP receptor antagonist UFP-101 (10 nmol/2?L, icv, 5 min prior the TST) significantly reversed the toxin effects. The protocol of LPS-induced depressive-like states was also tested in NOP receptor knockout mice (NOP(-/-)) and their respective wild types (NOP(+/+)). LPS evoked transient rectal temperature reduction in NOP(-/-) mice and loss of body weight, food and water intake reduction in both NOP(+/+) and NOP(-/-) mice. The consumption of water was significantly different due to the genotype. LPS injection induced transient changes in pro-inflammatory cytokines. At 6 h after LPS injection, serum levels of TNF-? were significantly increased in NOP(+/+) and NOP(-/-) mice, as the IL-6 levels were significantly increased just in NOP(+/+) serum. At 24 h after LPS treatment the pro-inflammatory cytokines had returned to the baseline levels in both genotypes. LPS treatment elicited depressive-like effects in NOP(+/+) but not in NOP(-/-) mice. The data obtained during the execution of this doctoral thesis reveal that pharmacological and genetic blockade of NOP signaling does not affect LPS evoked sickness signs while reversing depressive-like behavior. In conclusion, these results highlight the involvement of the peptidergic system N/OFQ - NOP receptor in the modulation of behaviors related to mood and activation of the immune system.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-06-21T19:57:35Z No. of bitstreams: 1 FatimaDuarteFreire_TESE.pdf: 3248766 bytes, checksum: 8e2bf08690970bd4823d71ff58b8c29f (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-23T17:44:50Z (GMT) No. of bitstreams: 1 FatimaDuarteFreire_TESE.pdf: 3248766 bytes, checksum: 8e2bf08690970bd4823d71ff58b8c29f (MD5) / Made available in DSpace on 2016-06-23T17:44:50Z (GMT). No. of bitstreams: 1 FatimaDuarteFreire_TESE.pdf: 3248766 bytes, checksum: 8e2bf08690970bd4823d71ff58b8c29f (MD5) Previous issue date: 2015-03-30 / A infec??o causada pelo Helicobacter pylori tem sido associado a v?rias doen?as g?stricas, inclusive o c?ncer g?strico. Esta bact?ria coloniza a mucosa g?strica de metade da popula??o do mundo, e os tratamentos dispon?veis s?o mal sucedidos em praticamente um em cada cinco pacientes. Pol?meros mucoadesivos, tais como quitosana, s?o usados como sistemas de libera??o g?stricos para uma melhor libera??o do f?rmaco nos locais de atua??o. Neste trabalho, part?culas de quitosana contendo amoxicilina foram obtidas pelo m?todo de coacerva??o/precipita??o visando uma libera??o controlada do f?rmaco no ambiente do est?mago, no intuito de melhorar a efic?cia terap?utica da amoxicilina no tratamento do Helicobacter pylori. A incorpora??o da amoxicilina foi feita utilizando duas t?cnicas diferentes: durante a forma??o das part?culas e por adsor??o das part?culas formadas .As part?culas foram caracterizadas quanto ao tamanho m?dio, potencial zeta, DSC, FTIR, efici?ncia de encapsula??o e libera??o in vitro em HCl 0,1N. As part?culas apresentaram uma efici?ncia de encapsula??o de 83%, tamanho m?dio de part?cula nanom?trica e potencial zeta positivo (20 mV). A amoxicilina encapsulada nas micropart?culas teve libera??o in vitro de apenas 40 % em 120 minutos. / The infection caused by Helicobacter pylori (H. pylori) is associated with gastroduodenal inflammation can lead to the development of gastritis, gastric or duodenal ulcer and gastric cancer (type 1 carcinogen for stomach cancer). Amoxicillin is used as first-line therapy in the treatment of H. pylori associated to metronidazole or clarithromycin, and a proton pump inhibitor. However, the scheme is not fully effective due to inadequate accumulation of antibiotics in gastric tissue, inadequate efficacy of ecological niche of H. pylori, and other factors. In this context, this study aimed to obtaining and characterization of particulate systems gastrorretentivos chitosan - amoxicillin aiming its use for treatment of H. pylori infections. The particles were obtained by the coacervation method / precipitation using sodium sulfate as precipitating agent and crosslinking and two techniques: addition of amoxicillin during preparation in a single step and the sorption particles prior to amoxycillin prepared by coacervation / precipitation and spray drying. The physicochemical characterization of the particles was performed by SEM, FTIR, DSC, TG and XRD. The in vitro release profile of amoxycillin free and incorporated in the particles was obtained in 0.1 N HCl (pH = 1.2). The particles have higher encapsulation efficiency to 80% spherical shape with interconnected particles or adhered to each other, the nanometric diameter to the systems obtained by coacervation / precipitation and fine for the particles obtained by spray drying. The characterization by FTIR, DSC and XRD showed that the drug was incorporated into the nanoparticles dispersed in the polymeric matrix. Thermal analysis (TG and DSC) indicated that encapsulation provides greater heat stability to the drug. Amoxicillin encapsulated in nanoparticles had slower release compared to free drug. The particles showed release profile with a faster initial stage (burst effect) reaching a maximum at 30 minutes 35% of amoxicillin for the system in 1: 1 ratio relative to the polymer and 80% for the system in the ratio 2: 1. Although simple and provide high encapsulation efficiency of amoxicillin, the process of coacervation, precipitation in one step using sodium sulfate as precipitant / cross-linker must be optimized in order to adjust the release kinetics according to the intended application.

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-06-21T19:57:35Z No. of bitstreams: 1 NayaraPereiraSoares_TESE.pdf: 2308575 bytes, checksum: f4c0d7842d74893a5b09526959d9ced3 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-23T17:55:53Z (GMT) No. of bitstreams: 1 NayaraPereiraSoares_TESE.pdf: 2308575 bytes, checksum: f4c0d7842d74893a5b09526959d9ced3 (MD5) / Made available in DSpace on 2016-06-23T17:55:53Z (GMT). No. of bitstreams: 1 NayaraPereiraSoares_TESE.pdf: 2308575 bytes, checksum: f4c0d7842d74893a5b09526959d9ced3 (MD5) Previous issue date: 2015-12-11 / Introdu??o: S?ndrome dos Ov?rios Polic?sticos (SOP), segundo o crit?rio de Rotterdam, est? presente em 6-12% das mulheres em idade reprodutiva, ? caracterizada pelo hiperandrogenismo, resist?ncia ? insulina (RI) e por seu estado inflamat?rio, fatores comumente exacerbados pela presen?a da obesidade e associados com o aumento da genotoxicidade. Alimenta??o saud?vel com implica??o na perda de peso atua restabelecendo as fun??es reprodutivas e metab?licas na SOP, entretanto sua influ?ncia na redu??o da genotoxicidade ? desconhecida. Objetivos: investigar se existem diferen?as entre os marcadores de genotoxicidade e de risco cardiometab?licos em mulheres com SOP e controle, e avaliar a efetividade da interven??o diet?tica nos marcadores de genotoxicidade e de risco cardiometab?licos em mulheres com SOP sobrepeso ou obesas. Metodologia: as participantes tinham faixa et?ria entre 18 e 35 anos. No primeiro estudo transversal foram inclu?das 27 mulheres com diagn?stico de SOP e 20 controles que tiveram seus marcadores antropom?tricos, hormonais, bioqu?micos e inflamat?rios avaliados, al?m da genotoxicidade. O segundo estudo foi um ensaio cl?nico de interven??o diet?tica, com dieta de restri??o cal?rica de 500 Kcal/dia por 12 semanas com 22 mulheres com SOP sobrepeso ou obesas. Dados antropom?tricos, de consumo alimentar, hormonais e bioqu?micos foram avaliados e a genotoxicidade, de ambos os estudos, foi verificada pelo teste do cometa. Resultados: n?o houve diferen?as significativas entre o marcador de genotoxicidade tail intensity (p= 0,18), tail moment (p= 0,76) e tail length ( p=0,109) na SOP quando comparado ao grupo controle. Mulheres com SOP apresentam um pior perfil de risco cardiometab?lico. A interven??o diet?tica reduziu os marcadores genotoxicidade: tail intensity (24,35 ? 5,86 ? pr?-dieta vs. 17,15 ? 5,04 -pos-dieta) e tail moment (20,47 ? 7,85 ? pr?-dieta vs. 14,13 ? 6,29 -p?s-dieta) com p =0,001 para ambos os marcadores. Sem diferen?as no tail length (p=0,07). Provocou tamb?m a perda de peso (3,5%) e redu??o dos marcadores de risco cardiometab?licos, como a RI e o hiperandrogenismo. Conclus?o: mulheres com SOP apresentam pior perfil de risco cardiometab?lico comparado com mulheres controles, entretanto genotoxicidade semelhante. A interven??o diet?tica reduz a genotoxicidade de mulheres com SOP sobrepeso ou obesas, assim como reduz os fatores de risco cardiometab?licos. / Introduction: Polycystic Ovary Syndrome (PCOS), present in 6-12% of women of reproductive age, the criterion of Rotterdam, is characterized by hyperandrogenism, insulin resistance (IR) and its inflammatory state, exacerbated by obesity and factors associated with the increase in damage DNA. Weight loss, combined with healthy eating, acts restoring the reproductive and metabolic functions in the SOP, though its influence in reducing DNA damage in PCOS are unknown. Aim: To investigate whether there are differences between DNA damage markers and factors of cardiometabolic risk in women with PCOS and control, and evaluate the effectiveness of nutritional intervention in DNA damage markers and cardiometabolic risk markers in overweight and obese women with PCOS. Methods: the study was conducted in two studies and the participants were aged between 18 and 35 years. In the first study, a prospective case-control, were included 27 women diagnosed with PCOS and 20 controls. In the second study, clinical trial of nutritional intervention with 12-week calorie-restricted diet 500Kcal / day. The genotoxicity, DNA damage (intensity tail, tail moment and tail length) was evaluated by the comet assay. Anthropometric data, dietary intake, hormonal, biochemical and inflammatory were evaluated in different studies. Results: there was no significant difference between the DNA damage marker tail intensity (p = 0.18), tail moment (p = 0.76) and tail length (p = 0.109) in PCOS when compared to the control group. Data after nutritional intervention in PCOS women with overweight and obesity showed a decrease in DNA damage markers: tail intensity (24.35 ? 5.86 - pre-diet vs. 17.15 ? 5.04 -Post-diet) and tail moment (20.47 ? 7.85 - pre-diet vs. 14.13 ? 6.29 -post-diet) (p <0.001). Reduction of weight (3.5%) and decreased cardiometabolic markers IR and hyperandrogenism. Conclusion: women with PCOS have a worse cardiometabolic risk profile compared to control however similar genotoxicity identified by DNA damage. Nutritional intervention reduced the genotoxicity of overweight and obese women with PCOS, and reduce the factors of cardiometabolic risk.

Made available in DSpace on 2014-12-17T14:53:14Z (GMT). No. of bitstreams: 1 SergioRDV_DISSERT.pdf: 3253000 bytes, checksum: 6c4b82388e8ffd681cfbe825099e3577 (MD5) Previous issue date: 2013-11-11 / Technological innovation promotes the generation of economic value by creating a new product, process or organizational management model, being classified as dynamic and multidimensional. Government intervention has the role of acting through government grant programs to foster the integration of innovative processes in small companies, due to the high costs and risks of development, strengthening the country`s economy in this phase. The distribution of this grant is determined by criteria, based especially in subjective judgments, which are based on the beliefs and perceptions about the technological opportunities and market actors involved in the process, being very difficult to measure the probability of success of the project under evaluation. This study aims to identify the most relevant selection criteria that must be inserted in grants programs at Rio Grande do Norte executed by Funda??o de Pesquisa do Rio Grande do Norte (FAPERN). Initially, there was a systematization of 18 countries, covering 41 programs in foreign countries and 29 in Brazil. Based on the data collected, we conducted one survey containing four programs of FAPERN (INOVA I, INOVA II , INOVA III and INOVA IV), covering 44 companies and analyzing their responses according to the Likert scale , obtaining the degree of importance given by the respondent to each of the criteria in the questionnaire . As a result, drew up a proposal for new criteria to be used in the next FAPERN?s grants, containing 13 new criteria. It is expected, therefore, to contribute to a better spending of public funds invested in companies subsidized in Brazil / A Inova??o tecnol?gica promove a gera??o de valor econ?mico por meio da inser??o no mercado de um novo produto, processo ou modelo de gest?o organizacional, sendo classificada como: din?mica e multidimensional. A interven??o governamental tem como papel atuar por meio de programas governamentais de subven??o para fomentar a inser??o dos processos inovativos nas pequenas empresas, devido aos custos e elevados riscos de desenvolvimento, fortalecendo a economia do pa?s emergente. A distribui??o desse recurso ? determinada por meio de crit?rios, sobretudo em julgamentos subjetivos, que s?o baseados em cren?as e percep??es quanto ?s oportunidades tecnol?gicas e de mercados dos agentes envolvidos no processo, sendo muito dif?cil de mensurar as probabilidades de sucesso do projeto em avalia??o. O presente trabalho tem como objetivo identificar as pr?ticas do processo de sele??o mais relevantes que devem ser inseridas nas linhas governamentais de fomento ? inova??o a Micro e pequenas empresas de base tecnol?gica da Funda??o de Amparo ? Pesquisa do Rio Grande do Norte (FAPERN). Para conduzir esta pesquisa, realizou-se uma sistematiza??o referente a 18 pa?ses, abordando um panorama de 41 programas em pa?ses estrangeiros e 29 editais brasileiros. Com base nos dados coletados, conduziu-se uma survey contemplando quatro editais da FAPERN (INOVA I, INOVA II, INOVA III e INOVA IV), 44 empresas, analisando suas respostas por meio da escala de Likert, obtendo o grau de import?ncia dado pelo entrevistado a cada um dos processos/crit?rios presentes no question?rio. Como resultado, elaborou-se uma proposta com os novos processos a serem utilizados nos pr?ximos editais da FAPERN, apresentando 13 itens in?ditos nos editais do RN. Pretende-se, assim, contribuir para uma melhor efici?ncia dos recursos p?blicos aplicados nas empresas subvencionadas brasileiras

Made available in DSpace on 2014-12-17T15:04:47Z (GMT). No. of bitstreams: 1 FranciscodeAssisFN.pdf: 2669056 bytes, checksum: 28c22ab95b1086c5c0751fcd5ea3ff8d (MD5) Previous issue date: 2006-12-11 / The aim of the present paper is to reorganize a discipline on technological physics so that the construction site of civil engineering becomes a natural environment of learning, providing the learner with the association between theory and practice as well as allowing the subject to process, in real time, information generated from his cognitive constructions and his contextualizations. Thus, a sequence of actions was taken into account: firstly, the programme was developed in the classroom, sharing with its contextualized information through experiments done under supervision by the learners in laboratories; secondly, the data which associate physics with construction were collected and, to do so, technical visits to construction sites were realized, providing the learner the association between the theory and the practice in a suitable site to the constructivist approach. As a result, the first discipline on physics of the Curso de Tecn?logos em Ger?ncia de Obras de Edifica??es do CEFET/PB was re-structured in terms of syllabus, methodology, application and evaluation. In fact, this work deals with a dynamic process that gathers and gives emphasis to teaching, learning, technology, information, creativity, competence and abilities in a constructivist learning process and, as a consequence, having allowed institutional engagement / O nosso objetivo ? reestruturar a disciplina de f?sica tecnol?gica de maneira a tornar o canteiro de obras da constru??o civil o ambiente natural de aprendizagem, oportunizando ao aprendiz a associa??o entre a teoria e a pr?tica, permitindo ao sujeito processar em tempo real informa??es geradas entre suas constru??es cognitivas e suas contextualiza??es. Desta forma foi priorizada uma seq??ncia de a??es: em primeiro lugar, foi desenvolvido em sala de aula o conte?do program?tico, compartilhado com a sua contextualiza??o em experimentos laboratoriais presenciais executados de modo orientado pelos aprendizes. Posteriormente, foram levantados dados que associam a f?sica ? constru??o civil; para isto, foram realizadas visitas t?cnicas aos canteiros de obras possibilitando ao aprendiz a associa??o da teoria ? pr?tica em ambiente prop?cio ? abordagem construtivista. Como resultado, obtivemos uma reformula??o no programa da primeira disciplina de f?sica do Curso de Tecn?logos em Ger?ncia de Obras de Edifica??es, do Cefet/PB, fundamentada e implementada nos seguintes referentes: ementa da disciplina, metodologia trabalhada, implementa??o e an?lise. Trata-se de um processo din?mico, que re?ne e enfatiza ensino, aprendizagem, tecnologia, informa??o, criatividade, compet?ncias e habilidades, em um processo construtivista e, como conseq??ncia, tendo propiciado envolvimento institucional

Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-03-21T12:35:07Z No. of bitstreams: 1 KellySivocySampaioTeixeira_TESE.pdf: 2385798 bytes, checksum: ad5dc195f2ccb1f7300d4f04dc565b8f (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-03-23T13:54:08Z (GMT) No. of bitstreams: 1 KellySivocySampaioTeixeira_TESE.pdf: 2385798 bytes, checksum: ad5dc195f2ccb1f7300d4f04dc565b8f (MD5) / Made available in DSpace on 2018-03-23T13:54:08Z (GMT). No. of bitstreams: 1 KellySivocySampaioTeixeira_TESE.pdf: 2385798 bytes, checksum: ad5dc195f2ccb1f7300d4f04dc565b8f (MD5) Previous issue date: 2017-03-29 / O Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / A Organiza??o Mundial de Sa?de (OMS) sugere que o tratamento da tuberculose (TB) seja realizado atrav?s da terapia que consiste na associa??o de quatro f?rmacos: rifampicina, isoniazida, pirazinamida e etambutol. Com isso o tratamento ? melhor aceito tendo uma maior ades?o do paciente ? terapia prescrita. Levando-se em considera??o que a metodologia utilizada para o doseamento de um f?rmaco na presen?a de excipientes e outros f?rmacos ? a cromatografia l?quida de alta efici?ncia (CLAE) que ? sabidamente trabalhosa, de alto custo e destrutiva, foi proposta desse trabalho o desenvolvimento e valida??o de um modelo de calibra??o multivariada em associa??o com a t?cnica de espectroscopia no infravermelho pr?ximo (NIR) para determina??o simult?nea de rifampicina, isoniazida, pirazinamida e etambutol que fosse mais simples, r?pida, de baixo custo, n?o destrutiva e que n?o utilizasse solventes org?nicos, contribuindo assim com o meio ambiente. Sendo, portanto, ferramenta de otimiza??o para o controle de qualidade deste medicamento. Nesse trabalho foi utilizado o m?todo por NIR ? PLS (regress?o de m?nimos quadrados parciais) onde as misturas dos quatro f?rmacos foram realizadas com base no planejamento experimental do tipo composto central elaborado pelo programa Statistica 13 (StatSoft Inc.). Essas misturas foram lidas na faixa de 10.000 a 4.000 cm-1 utilizando um espectrofot?metro Infravermelho (IRPrestige-21 - Shimadzu) com resolu??o de 4 cm-1, 20 varreduras, temperatura e umidade controladas. As an?lises envolvendo CLAE foram realizadas em um cromat?grafo (Hitachi ? Elite Ultra), equipado com coluna C18 (15 cm x 4,6 mm ? ACE-5) e (25 cm x 4,6 mm ? Luna - Phenomenex) e detector UV (matriz de diodo), utilizando o m?todo de refer?ncia descrito na farmacopeia internacional 15? edi??o. Ao final, todos os dados foram tratados por ferramentas computacionais de an?lise multivariada, utilizando PLS atrav?s do programa pirouette 3.11 (Infometrix, Inc.). As sele??es de vari?veis foram realizadas pelo programa QSAR modeling. Foi realizada valida??o cruzada pelo m?todo leave-one-out e estimativa de figuras de m?rito como linearidade, precis?o e exatid?o foram demonstradas nos quatro modelos propostos. Na avalia??o das amostras comerciais pelos modelos de calibra??o multivariada em associa??o com a espectroscopia no infravermelho pr?ximo (NIR) desenvolvidos foram capazes de determinar simultaneamente os quatro f?rmacos, apresentando dados estatisticamente equivalentes aos obtidos por CLAE. / The World Health Organization (WHO) suggests that treatment of tuberculosis (TB) should be done through a combination of four drugs: rifampicin, isoniazid, pyrazinamide and ethambutol. With this the treatment is better accepted having a greater adhesion of the patient to the prescribed therapy. Taking into account that the methodology used for the determination of a drug in the presence of excipients and other drugs is high-performance liquid chromatography (HPLC), which is known to be laborious, expensive and destructive. Validation of a multivariate calibration model in association with the near infrared spectroscopy (NIR) technique for the simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol that was simpler, faster, low cost, non destructive and did not use organic solventes, thus contributing to the environment. Therefore, it is an optimization tool for the quality control of this medicine. In this work, the NIR - PLS (partial least squares regression) method was used where the mixtures of the four drugs were performed based on the experimental design of the central composite type elaborated by the program Statistica 13 (StatSoft Inc.). These mixtures were read in the 10,000 to 4,000 cm-1 range using an infrared (IRPrestige-21 - Shimadzu) spectrophotometer with 4 cm-1 resolution, 20 sweeps, controlled temperature and humidity. The analyzes involving HPLC were performed in a chromatograph (Hitachi - Elite Ultra) equipped with a C18 column (15 cm x 4.6 mm - ACE - 5) and (25 cm x 4.6 mm - Luna - Phenomenex) and UV detector (Diode array) using the reference method described in the International Pharmacopoeia 15th Edition. At the end, all data were treated by computational tools of multivariate analysis, using PLS through the program pirouette 3.11 (Infometrix, Inc.). The selections of variables were performed by the QSAR modeling program. Cross-validation was performed by the leave-one-out method and estimation of merit figures such as linearity, precision and accuracy were demonstrated in the four proposed models. In the evaluation of the commercial samples by the multivariate calibration models in association with the near infrared spectroscopy (NIR), they were able to simultaneously determine the four drugs, presenting data statistically equivalent to those obtained by HPLC.