Submitted by JORGE ESTEBAN BLANCO RODRIGUEZ null (lobogris87@msn.com) on 2016-06-01T14:53:04Z No. of bitstreams: 1 Jorge Esteban Blanco Rodriguez.pdf: 3365866 bytes, checksum: edf247c26e3f44cc20ef44607e947f0e (MD5) / Rejected by Ana Paula Grisoto (grisotoana@reitoria.unesp.br), reason: Solicitamos que realize uma nova submissão seguindo as orientações abaixo: O mês informado na capa do documento está diferente da data de defesa que consta na folha de aprovação. Corrija esta informação no arquivo PDF e realize uma nova submissão contendo o arquivo correto. Agradecemos a compreensão. on 2016-06-02T13:45:11Z (GMT) / Submitted by JORGE ESTEBAN BLANCO RODRIGUEZ null (lobogris87@msn.com) on 2016-06-02T14:37:35Z No. of bitstreams: 1 Jorge Esteban Blanco Rodriguez 30-03-2016.pdf: 2668564 bytes, checksum: 75234917c13bea3285297fb6aeb7f0ec (MD5) / Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-06-02T16:43:57Z (GMT) No. of bitstreams: 1 blancorodriguez_je_me_ilha.pdf: 2668564 bytes, checksum: 75234917c13bea3285297fb6aeb7f0ec (MD5) / Made available in DSpace on 2016-06-02T16:43:57Z (GMT). No. of bitstreams: 1 blancorodriguez_je_me_ilha.pdf: 2668564 bytes, checksum: 75234917c13bea3285297fb6aeb7f0ec (MD5) Previous issue date: 2016-03-30 / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Implementou-se um estimulador elétrico funcional para uso na reabilitação de pacientes hígidos e paraplégicos e que não necessita de alimentação simétrica. O equipamento é constituído por dois estágios, o formador de onda, no qual se define os parâmetros do sinal de estimulação, e o de potência. No formador de onda foi utilizado uma placa Raspberry pi e uma interface de usuário, desenvolvida em Python. O estágio de potência é composto por um espelho de corrente que possibilita a utilização de transistores não casados, e uma estrutura em ponte H, para formar o sinal de eletroestimulação bifásico, sem a necessidade de fonte simétrica, diminuindo assim pela metade a diferença de potencial aplicada na alimentação do circuito. Com o estimulador implementado gerou-se correntes com forma de onda retangular, amplitude de até 120 mA e características adequadas para utilização na reabilitação dos membros inferiores e superiores de pacientes. / A functional electrical stimulator for use in the rehabilitation of paraplegic and healthy patients was implemented. It does not need symmetrical power supply. The equipment consists of two stages, the wave generator, which defines the stimulation signal parameters, and the power stage. In the wave generator we have used a Raspberry Pi board and a user interface, developed in Python. In the power stage we have used a current mirror which enables the use of unmarried transistors and a H-bridge circuit to generate a biphasic signal. With the implemented stimulator, currents with rectangular waveform, range of up to 120 mA, and suitable characteristics for using in rehabilitation of the lower and upper limbs of patients were generated.

Orientador: Aparecido Augusto de Carvalho / Resumo: Implementou-se um estimulador elétrico funcional para uso na reabilitação de pacientes hígidos e paraplégicos e que não necessita de alimentação simétrica. O equipamento é constituído por dois estágios, o formador de onda, no qual se define os parâmetros do sinal de estimulação, e o de potência. No formador de onda foi utilizado uma placa Raspberry pi e uma interface de usuário, desenvolvida em Python. O estágio de potência é composto por um espelho de corrente que possibilita a utilização de transistores não casados, e uma estrutura em ponte H, para formar o sinal de eletroestimulação bifásico, sem a necessidade de fonte simétrica, diminuindo assim pela metade a diferença de potencial aplicada na alimentação do circuito. Com o estimulador implementado gerou-se correntes com forma de onda retangular, amplitude de até 120 mA e características adequadas para utilização na reabilitação dos membros inferiores e superiores de pacientes. / Abstract: A functional electrical stimulator for use in the rehabilitation of paraplegic and healthy patients was implemented. It does not need symmetrical power supply. The equipment consists of two stages, the wave generator, which defines the stimulation signal parameters, and the power stage. In the wave generator we have used a Raspberry Pi board and a user interface, developed in Python. In the power stage we have used a current mirror which enables the use of unmarried transistors and a H-bridge circuit to generate a biphasic signal. With the implemented stimulator, currents with rectangular waveform, range of up to 120 mA, and suitable characteristics for using in rehabilitation of the lower and upper limbs of patients were generated. / Mestre

Esta dissertação se propõe a estudar o tema do duplo a partir da produção fílmica de Hanns Heinz Ewers, O estudante de Praga, e o conto de Mário de Sá-Carneiro, A confissão de Lúcio, ambos de 1913. Asduas narrativas se organizam em torno de um triângulo amoroso e compartilham o mesmo destino trágico. Tomando como suporte, inicial, de leitura os textos de Freud e Rank, de 1914, Sobre o narcisismo: uma introdução e O duplo, respectivamente, o artigo de Lacan, O estádio do espelho como formador da função do eu (1949) e seu seminário sobre a angústia, pretende-se estabelecer um diálogo entre literatura e psicanálise, considerando a questão do desdobramento do eu e suas variantes, a cisão do eu em múltiplos eus e o desaparecimento da imagem. A imagem no espelho, a princípio fonte de júbilo, escamoteia um drama: o drama de um sujeito que se constitui a partir de uma ficção / This dissertation proposes to study the theme of the double from the filmic production by author Hanns Heinz Ewers called The student of Prague, as well as Mário de Sá-Carneiros tale named Lúcios confession. Ewers and Sá-Carneiros works are both from 1913. These narratives are organized around a love triangle and share the same tragic fate. Taking as a starting-readable texts by authors Freud and Rank in 1914, called On narcissism: an introduction and The double respectively, Lacan s article, The Mirror Stage as formative of the function of the I (1949) and his seminar on anxiety, thus we intend to establish a dialogue between literature and psychoanalysis, considering the issue of deployment of the self and its variants, ego splitting into multiple selves and the disappearance of the image. The image in the mirror, originally source of joy, hides a drama: the drama of an individual who is built up from a fiction

My graduation thesis is called {\clq}qCrocks of Safari`` and it is divided into two main segments. The First part is theoretical which explains my inspiration, choice of theme and material, method of working - starting with design, ending with final artwork and its installation. It also considers the techniques of mosaic creation. It includes image documentation, which enriches and completes the text. The Second part is practical which includes its own graphic creation. That is two mosaic images made out of combined material {--} ceramics and glass (mirror) inserted into a metal frame. It features graphic structures and elements of an African fauna. It specifically interprets cut outs from herd of zebras and their typical stripes. My goal was to create abstract images where you can feel the character of used material and harmony of natural structures.

Introdução O espelho de Glatzel (EG) é correntemente utilizado em consultórios fonoaudiológicos para a avaliação rápida da permeabilidade nasal. O mesmo foi descrito inicialmente em 1898 por Zwaardemaker. Porém, estudos de validação inexistem na literatura. Este estudo teve por objetivos verificar a reprodutibilidade do EG e a correlação intra-sujeito entre área de condensação e percepção subjetiva de permeabilidade nasal. Material e Métodos Vinte e cinco sujeitos foram avaliados com o EG por cinco minutos consecutivos (475 medidas por sujeito); cada meia hora por quatro horas; cada dia no início da tarde, por cinco dias e toda a quinta-feira por cinco semanas consecutivas. Utilizou-se uma escala análoga visual para avaliar a percepção de respiração nos períodos de horas, dias e semanas. Resultados O coeficiente de correlação total (área direita mais esquerda) encontrado entre área de condensação e percepção subjetiva foi de r=0,04 (p=0,3761). No lado esquerdo foi de r=0,08 (p=0,0984) e no lado direito de r=0,05 (p=0,2862). Os coeficientes de variação unilaterais medianos foram menores que 15% e os totais menores que 12%, independente do intervalo de tempo entre teste e re-teste. Conclusão Não se evidenciou correlação significativa entre a percepção subjetiva e a área de condensação nasal. A variabilidade unilateral foi maior do que quando considerados os valores totais (direito mais esquerdo) e não houve diferença na variabilidade das medidas de área de condensação nasal nos diferentes momentos do tempo. / Objective The Glatzel mirror (Gm) is used at speech therapy offices for a prompt evaluation of the nasal patency. It has been described in 1898 by Zwaardemarker. However, there is no literature of validation studies. This study aimed the verification of the reproducibility of the Gm and the correlation between the condensation area and the subjective perception of nasal patency. Methods Twenty-five individuals were evaluated for five consecutive minutes (475 measurements per individual), every half-an-hour during four hours, every day, in the beginning of the afternoon, for five days, and every Thursday during five consecutive weeks. A visual analog scale was used to evaluate the breathing perception within the hour, day and week periods. Results The coefficient of correlation between the subjective perception of the nasal patency and the condensation area of the right and left areas sumed was r=0.04 (p=0.3761). The left was r=0.08 (p=0.0984) and the right was r=0.05 (p=0.2862). The medium unilateral and total coefficients of variation were, respectivelly, less then 15% and 12%, independently of the interval of test-retest timing. Conclusion No significant correlation has been noticed between the subjective perception and the nasal condensation area. The unilateral variability was higher than the total values (right + left) and there was no difference in the variability of nasal condensation areas on different moments in time.

Soluções computacionais desenvolvidas para dispositivos móveis são cada vez mais comuns. A popularização de aplicativos móveis possibilitou o desenvolvimento de soluções para diversas áreas de grande potencial, como a área da saúde, entre ela a Terapia Ocupacional. Entre essas soluções, trabalhos apresentaram diversos métodos computacionais para o apoio a Terapia do Espelho. A terapia do espelho é um método que consiste na execução de exercícios com um membro saudável refletido em um espelho de modo que a visualização auxilie na redução da dor e na reabilitação do membro afetado. Essa terapia tem apresentado resultados, entre outros, na reabilitação para indivíduos que reportam dor do membro fantasma ou em recuperação pós-Acidente Vascular Cerebral (AVC). A literatura apresenta soluções computacionais para, entre outros, permitir a visualização do membro saudável a partir de tecnologias de realidade aumentada e de dispositivos vestíveis. Essas soluções muitas vezes são de difícil acesso e economicamente inviáveis. Um trabalho anterior, realizado em colaboração com equipe multidisciplinar, resultou na definição de um modelo de acompanhamento remoto que emprega dispositivos móveis para permitir o monitoramento de pacientes em tratamento por meio da terapia do espelho. Uma das limitações encontradas naquele trabalho foi o fato do terapeuta não conseguir acompanhar de maneira automática se o paciente está executando a terapia de maneira correta. Explorando essas contribuições e limitações, este trabalho teve como objetivo propor um modelo que permita o acompanhamento remoto da terapia do espelho com apoio de recursos de realidade aumentada. Como apoio computacional ao modelo, foi desenvolvida a aplicação para smartphones TEIRA (Terapia do Espelho Interativa com Realidade Aumentada) que, utilizada em conjunto com a tecnologia Google Cardboard, permite a execução da terapia do espelho com realidade aumentada. Além disso, com a integração do sistema TEIRA com o sistema de planejamento de intervenções ESPIM (Experience Sampling and Programmed Intervention Method), foi possível proporcionar um método de acompanhamento remoto com coleta de dados e vídeo. Consulta a especialistas indica que a solução apresenta benefícios potenciais para o monitoramento do paciente durante o acompanhamento remoto, que ajudem o paciente a executar a terapia de maneira correta. / Computational solutions developed for mobile devices are increasingly common. The popularization of mobile applications enabled the development of solutions for several areas of great potential, such as the health area, including Occupational Therapy. Among these solutions, papers presented several computational methods to support Mirror Therapy. Mirror therapy is a method that involves performing exercises with a healthy limb reflected in a mirror so that visualization helps in reducing pain and in rehabilitating the affected limb. This therapy has shown results, among others, in rehabilitation for individuals who report phantom limb pain or in post-stroke recovery. The literature presents computational solutions to, among others, allow visualization of the healthy limb from technologies of augmented reality and wearable devices. These solutions are often difficult to access and economically unfeasible. Previous work, conducted in collaboration with a multidisciplinary team, resulted in the definition of a remote monitoring model that uses mobile devices to allow the monitoring of patients being treated by means of mirror therapy. One of the limitations found in this work was that the therapist was unable to automatically follow up if the patient was performing the therapy correctly. Exploring these contributions and limitations, this work aimed to propose a model that allows remote monitoring of mirror therapy with the support of augmented reality resources. As a computational support to the model, the application was developed for TEIRA (Interactive Mirror Therapy with Augmented Reality) which, used in conjunction with the Google Cardboard technology, allows the execution of mirror therapy with reality increased. In addition, with the integration of the TEIRA system with the ESPIM (Experience Sampling and Programmed Intervention Method) intervention system, it was possible to provide a remote monitoring method with data and video collection. Expert consultation indicates that the solution has potential benefits for patient monitoring during remote monitoring, which will help the patient perform the therapy correctly.

L'objectif de mon travail a été d'étudier les bases génétiques de deux maladies du mouvement, les mouvements miroirs congénitaux (CMM) et les dyskinésies paroxystiques kinésigéniques (PKD). Nous avons tout d'abord mis en évidence le deuxième gène impliqué dans les CMM, RAD51, et commencé à explorer quelques hypothèses physiopathologiques. Nous avons ensuite recueilli les ADN de 26 cas index de CMM isolés, et montré que près de 50% d'entre eux avaient un variant possiblement pathogène dans RAD51 ou dans le premier gène de CMM décrit, DCC. Nous avons ensuite écarté l'implication d'un troisième gène possiblement causal, DNAL4, dans 17 cas index. Enfin, nous avons collaboré avec une équipe néo-zélandaise et mis en évidence par séquençage de l'exome un nouveau gène, NTN1, codant pour le ligand de DCC, dans deux familles et un cas sporadique. En ce qui concerne les PKD, nous avons analysé le premier gène impliqué dans cette pathologie, PRRT2, dans une cohorte de 42 cas index. Nous avons ainsi montré que PRRT2 est un gène majeur de PKD dans la population européenne, impliqué dans 65% des cas typiques. Nous avons ensuite contribué à mettre en évidence l'implication de PRRT2 dans la migraine hémiplégique, et effectué une revue de la littérature montrant que les mutations de PRRT2 peuvent être responsables de phénotypes multiples de mouvements anormaux paroxystiques. Nous avons ensuite réalisé un séquençage d'exomes chez une famille et 10 trios, malheureusement sans résultat probant. Enfin, chez deux patients avec PKD atypiques, nous avons mis en évidence des mutations du gène ADCY5, récemment impliqué dans des formes complexes de dyskinésies paroxystiques. / The objective of my work was to study the genetic bases of two movement disorders, congenital mirror movements (CMM) and paroxysmal kinesigenic dyskinesia (PKD). First we uncovered the second gene implicated in CMM, RAD51, and started to explore pathophysiological hypotheses. Then we collected DNA of 26 index cases of isolated CMM, and showed that almost 50% of them had a possibly pathogenic variant in RAD51 or in the first described gene of CMM, DCC. We subsequently ruled out the implication of a possible third gene, DNAL4, in 17 cases. Finally, we collaborated with a team from New Zealand to implicate a novel gene, NTN1, coding for the ligand of DCC, in two families and one sporadic case. Concerning PKD, we analyzed the first causative gene described, PRRT2, in a cohort of 42 index cases. We showed that PRRT2 is a major gene of PKD in the European population, involved in 65% of typical cases. We then contributed to show the implication of PRRT2 mutations in hemiplegic migraine, and conducted a review of the literature concluding that PRRT2 mutations can induce multiple types of paroxysmal disorders. We sequenced the exomes of one family and 10 trios negative for PRRT2, but were unable to uncover another causative gene. Finally, in two patients with atypical PKD, we found mutations in ADCY5, a gene recently implicated in complex forms of paroxysmal dyskinesia.

Oscillators are components providing clock signals. They are widely required by low-cost on-chip applications, such as biometric sensors and SoCs. As part of a sensor, a relaxation oscillator is implemented to provide a clock reference. Limited by the sensor application, a clock reference outside the sensor is not desired. An RC implementation of the oscillator has a balanced accuracy performance with low-cost advantage. Hence an RC relaxation oscillator is chosen to provide the clock inside the sensor. This thesis proposes a current mode relaxation oscillator to achieve low frequency standard deviation across different supplies, temperatures and process corners. A comparison between a given relaxation oscillator and the proposed design is made as well. All oscillators in this thesis use 0.18 μm technology and 1.8 V nominal supply. The proposed oscillator manages to achieve a frequency standard deviation across all PVT variations less than ±6.5% at 78.4 MHz output frequency with a power dissipation of 461.2 μW. The layout of the oscillator's core area takes up 0.003 mm2.

Dans cette thèse, nous établissons un résultat de symétrie miroir dans une gamme de cas pour lesquelles les techniques habituelles reposant sur la concavité ou sur la convexité ne fonctionnent pas. Plus précisément, nous travaillons sur la théorie quantique des singularités développée par Fan,Jarvis, Ruan et Witten, et vue comme un analogue de la théorie de Gromov--Witten via la correspondance LG/CY. Notre résultat principal donne une formule explicite pour le cycle virtuel de Polishchuk et Vaintrob en genre zéro. Dans les cas non-concaves des polynômes dits inversibles, elle nous procure un théorème de compatibilité entre le cycle virtuel de Fan--Jarvis--Ruan--Witten et celui de Polishchuk--Vaintrob. Pour les polynômes qui sont de plus de type chaine, nous obtenons une preuve d'un théorème de symétrie miroir pour la théorie FJRW. Enfin, nous généralisons notre résultat principal et calculons le produit d'intersection entre la classe de Chern maximale du fibré de Hodge et le cycle virtuel en genre quelconque. Spécifié au cas de la théorie des courbes $3$-spin, ceci mène à la preuve d'une conjecture de Buryak sur l'équivalence entre la hiérarchie DR et la hiérarchie $3$-KdV. / In this thesis, we provide a mirror symmetry theorem in a range of cases where the state-of-the-art techniques relying on concavity or convexity do not apply. More specifically, we work on a family of FJRW potentials named after Fan, Jarvis, Ruan, and Witten's quantum singularity theory and viewed as the counterpart of a non-convex Gromov--Witten potential via the physical LG/CY correspondence. The main result provides an explicit formula for Polishchuk and Vaintrob's virtual cycle in genus zero. In the non-concave case of the so-called chain invertible polynomials, it yields a compatibility theorem with the FJRW virtual cycle and a proof of mirror symmetry for FJRW theory. At last, we generalize our main theorem to the computation of intersection numbers between the top Chern class of the Hodge bundle and the virtual cycle in arbitrary genus. In the case of $3$-spin theory, it leads to a proof of Buryak's conjecture on the equivalence between double ramification hierarchy and $3$-KdV hierarchy.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / This article is about the problem and development of a fashion virtual assistant proposed by using a Kinect v2 camera and image processing, for fashion retail stores. It comes up mainly as a response to the inability of providing unique experiences during the shopping process through the use of diverse devices. Because of this, similar virtual assistant solutions, oriented to provide clothing recommendations, were analyzed to be able to provide software that could give a more personalized suggestion for the users based on their physical characteristics. / Revisión por pares