Inflammatory bowel disease (IBD) is a group of diseases in the gastrointestinal field that is becoming more commonly diagnosed among patients. IBD is usually characterized as a group of chronic diseases affecting the digestive tract that are caused by a multitude of factors including genetic, environmental, mucosal, and immune contributors. One of the subgroups of IBD is very early onset IBD (VEO-IBD), which is diagnosed in children under the age of 6. VEO-IBD is a rare yet unique case of IBD, which reports poor response to conventional adult-onset IBD treatments. Nutrition is an alternative treatment that can decrease inflammation and allow IBD patients to achieve remission. This proposed study explores whether formula-based diets, which have been strongly correlated with reduced IBD inflammation and symptoms, will impact VEO-IBD patients. A mouse model will be set up with one control group of healthy mice and two variable groups of VEO-IBD characteristic mice, with 60 mice in each group. The mice will be fed three formula-based dietary regiments including camel’s milk, Pediasure, and liquid vitamin D3 twice daily for 90 days. All three of these dietary treatments have been proven to decrease inflammation in adult-onset IBD patients. The inflammation and severity of symptoms will be monitored every two days through Western blotting protein levels of IL10 (a genetic marker for VEO-IBD) and physiological tests. If nutrition has a positive effect on the VEO-IBD induced mice, then a decrease in inflammation and VEO-IBD symptoms should be observed. This study is vital to future treatment plans by determining the influence of formula-based diets in alleviating symptoms of VEO-IBD patients.

Attention-deficit/hyperactivity disorder (ADHD) is a well-known and much debated neurological disorder. The core symptoms consist of a lacking ability to maintain focus, hyperactivity and a motoric restlessness. It is a neurological disorder, with its causes under much debate, although this essay identifies some important brain areas and transmitter systems. The aim of this essay is to give an overview of the available treatments for children with ADHD in the form of the two largest groups of treatments; pharmacological treatments and psychosocial treatments. The conclusion found is that pharmacological treatments are more effective at reducing the core symptoms of ADHD, while psychosocial treatments are more effective at improving the development of social functioning, suggesting a combination to be the superior choice.

Field trials were conducted in 1988 to evaluate the effectiveness of Steinernema (=Neoaplectana) carpocapsae (Weiser) in controlling the fire ant. Infective juveniles (IJ) of the nematode were applied as drench on 235 and 422 mounds, respectively for 2-month summer and 6-week fall evaluation periods. In comparative trials, amidinohydrazone (Amdro) was applied to 249 (summer) and 65 (fall) active mounds, with 245 (summer) and 78 (fall) untreated active as controls. Nematode treatments resulted in an average of 47% control (Abbott's formula) in summer trials and 19-88% control in the fall trials, compared with 39% and 47% control, respectively with amidinohydrazone. Active mounds treated with nematodes or amidinohydrazone had significantly fewer individuals than control mounds in summer trials.

Master of Science / Food Science Institute / Fadi M. Aramouni / Fresh cut fruits are products with minimal processing, modified by cutting, washing, packaging and refrigeration. The objective of this review is to present an overview of the available technologies for processing fresh cut fruits and technologies that could have some potential to be used in the future due to the increased consumption of fresh cut fruits. Fresh cut products are ready to eat, have high moisture content, have lack of lethal step to eliminate microbial pathogens and have the potential for temperature abuse; all these factors make quality and safety a priority. Fresh cut products sales have increased as a consequence of increased consumption of fruits and consumer attitudes toward convenience. Fresh cut fruit differ from fresh fruits in that the tissue and cell integrity have may been disrupted resulting in consequences such as changes in ethylene production, respiration, membrane degradation, metabolite accumulation, water loss and microba spoilage. However, the response to cutting depends on other variables such as cultivars, maturity and raw material quality, shape of cut, sharpness of blade, temperature and atmospheric composition. Consequently, there are enzymatic changes that impact the shelf life and quality of these products. In addition to quality and safety the nutritional value is an important factor too because consumers demand products as close to fresh as possible. The evaluation of the nutrient losses and how to reduce them through different treatments such as the introduction of vitamins and minerals in coating treatments or other treatment has become a priority too. There is a real need to find alternatives for preservation of fresh-cut fruit in order to minimize the changes that occur in the fruit tissues as a consequence of wounding. Alternatives, combined or modified methods have been proposed such as the use of alternative antibrowning, ethylene scrubbing, heat treatments, alternative antimicrobials, alternative packaging films, vacuum impregnation, osmotic dehydration, high hydrostatic pressure, use of edible coatings, radiation, bio preservation and other technologies.

The current study evaluated the performance of traditional versus modern MDTs in the estimation of fixed-effects and variance components for data missing at the second level of an hierarchical linear model (HLM) model across 24 different study conditions. Variables manipulated in the analysis included, (a) number of Level-2 variables with missing data, (b) percentage of missing data, and (c) Level-2 sample size. Listwise deletion outperformed all other methods across all study conditions in the estimation of both fixed-effects and variance components. The model-based procedures evaluated, EM and MI, outperformed the other traditional MDTs, mean and group mean substitution, in the estimation of the variance components, outperforming mean substitution in the estimation of the fixed-effects as well. Group mean substitution performed well in the estimation of the fixed-effects, but poorly in the estimation of the variance components. Data in the current study were modeled as missing completely at random (MCAR). Further research is suggested to compare the performance of model-based versus traditional MDTs, specifically listwise deletion, when data are missing at random (MAR), a condition that is more likely to occur in practical research settings.

This study investigated depth of hypnosis self-reported by subjects on the Field Inventory of Hypnotic Depth (FIHD) after experiencing one of two formal hypnotic inductions. The 68 subjects (41 females and 27 males) ranged in age from 17 to 47 (mean 25.3) and were placed into a high susceptibility group or a low susceptibility group based on their scores on the Harvard Group Scale of Hypnotic Susceptibility (HGSHS:A). Both the low susceptibility group and the high susceptibility group were further divided randomly so that half of each group received an indirect induction treatment and the other half received a direct induction treatment.

abstract: There are federal mandates attached to funding for behavioral health programs that require the use of evidence-based treatments (EBTs) to treat mental health disorders in order to improve clinical outcomes. However, these EBTs have not been constructed with American Indian/Alaskan Native (AI/AN) populations. There are over 340 EBTs, and only two outcome controlled studies have demonstrated effectiveness with AI/AN populations to treat mental health disorders. AI/AN communities often have to select an EBT that is not reflective of their culture, language, and traditions. Although EBTs are frequently used in AI/AN communities, little is known about the adaptation process of these interventions with the AI/AN population. For this study, a qualitative design was used to explore how American Indian behavioral health (AIBH) organizations in the Southwest adapted EBTs for cultural relevancy and cultural appropriateness. One urban and two tribal AIBH programs were recruited for the study. Over a six-week period, 24 respondents (practitioners and cultural experts) participated in a semi-structured interview. Transcripts were analyzed using the constant comparative analysis approach. As a result, four themes emerged: 1) attitudes towards EBTs, 2) how to build culturally competent clinical skills, 3) steps to adapt EBTs, and 4) internal and external organizational factors required to adopt EBTs. The four themes identify how to build a culturally responsive behavioral health program in Indian country and are the purview of this dissertation. / Dissertation/Thesis / Doctoral Dissertation Social Work 2020

Parkinson’s disease (PD) impairs the quality of life of patients and causes substantial social and economic burden. However the currently available symptomatic treatments, although initially effective, do not satisfactorily control the progressive disability experienced by patients with PD in the long run. In order to develop effective treatments for patients that aim to attain the desired effect with as few adverse events as possible, it is crucial to be able to follow and understand the biological mechanisms underlying the continued neural degeneration and treatment failure. The efforts to understand the precise pathway by which neurodegenerative processes proceed and the development of approaches to modulate them offers the promise to eventually enable the prevention of these neurodegenerative diseases. This dissertation focused on two potential synthetic methods to produce pharmaceutical grade Fluorodopa, ultimately to be able to produce positron emitting 18Fluorodopa in South Africa with its potential for studying neuronal mechanisms in the brain. 18Fluorodopa allows a unique almost non-invasive in vivo approach to the evaluation of neurochemical function in the human brain and its local introduction will be a valuable addition to medical research within South Africa’s borders. The successful implementation of safe and efficient non-radioactive models for Fluorodopa synthesis was achieved. The successful demonstration of locally synthesised Fluorodopa safety, as well as a low toxicity profile, both in vitro using cell cultures and in vivo in mouse models was achieved. These were both positive outcomes of objectives set out for this study. Copyright / Dissertation (MSc)--University of Pretoria, 2010. / Pharmacology / unrestricted

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Previous studies in Native American ethnobotany on the shared use of medicinal and cultural plants between communities fail to clearly reveal if these shared uses are part of changing culture or remain a stabilizing connection between old and new tribes. During the late 1700's to early 1800's, various factions of the Creek tribes of Georgia migrated into Florida, forming a new tribe called the Seminoles. This event provides the unique opportunity to study the changing cultural and medicinal uses of plants by a new tribe in a new geographic location, revealing if cultural purposes were passed from one group to another. A list of plants used for medicinal purposes by the Creek and Seminole tribes was produced from previous studies. Utilizing these lists, comparisons were drawn to determine if cultural practices were carried on between tribes as they changed locations and lifestyles. This study examines the use of 465 plants in 125 plant families. Of these, 39 plants were found to be used by both tribes for different treatment purposes. In contrast, only 15 plants where used by both tribes for similar treatments. The small number of shared use of plants indicates the newly formed Seminole tribe developed new cultural and medicinal practices. These findings indicate that the plants used for medicinal purposes by the Native American tribes of the southeast were a part of a changing culture, not a stabilizing connection between old and new tribes as previously thought.