Orientador: Dennys Esper Corrêa Cintra / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Aplicadas / Made available in DSpace on 2018-08-25T14:56:46Z (GMT). No. of bitstreams: 1 Lazari_VanessadeOliveira_M.pdf: 4172597 bytes, checksum: 62cbaf2cfa729f497e7b3cc4cdf3e7a1 (MD5) Previous issue date: 2013 / Resumo: A obesidade é uma doença metabólica absolutamente fora de controle. As condições primárias associadas são hipertensão arterial, dislipidemias, diversos tipos de câncer, resistência à insulina (RI) e principalmente o diabetes mellitus tipo 2 (DM2). Dentre as características secundárias, esteatose hepática e síndrome do ovário policístico figuram entre as principais. Tais doenças acometem número cada vez maior de indivíduos e sobrecarregam sistemas públicos mundiais de saúde. A inflamação crônica e de baixo grau, designada "meta-inflamação", por acometer todo o organismo, parece ser o pano de fundo principal do processo obesogênico, resultando no descontrole da ingestão alimentar e na predisposição ao surgimento da RI podendo progredir para o DM2. Diante da ineficiência de terapêuticas farmacológicas atuais para o controle da obesidade, o investimento em estratégias anti-inflamatórias tem sido incentivado. Nesse intuito, ácidos graxos insaturados (AGIs), especialmente os ômega-3 (?3) e ômega-9 (?9) têm-se mostrado eficientes em atenuar a inflamação por meio da ativação do receptor GPR120, e em recuperar a sensibilidade à insulina em diversos tecidos. O objetivo deste trabalho foi avaliar as ações e mecanismos anti-inflamatórios dos AGIs ?-linolênico (?3) e oléico (?9), presentes em elevadas concentrações no óleo de semente de linhaça e oliva respectivamente, em tecidos periféricos metabolicamente ativos de animais obesos e diabéticos induzidos por dieta rica em gordura (HF), e suas repercussões na regulação glicêmica do organismo. O tratamento via dieta HF com substituição em 10% da fração saturada pelos respectivos óleos, foi eficiente em restabelecer o controle da fome dos animais que consequentemente ganharam menos peso em relação aos seus controles obesos. Dados fisiológicos obtidos por meio de medições de glicemia de jejum e dos testes de tolerância à insulina (ITT) e à glicose (GTT) evidenciaram melhoras na homeostase glicêmica, confirmado em nível molecular pelo aumento da atividade das principais proteínas envolvidas na via da insulina como o IR, IRS-1 e Akt. Possivelmente esses resultados deram-se em virtude da redução da expressão de peptídeos pró-inflamatórios como TNF-?, IL-6 e IL-1?, seguidos pelo aumento da expressão da IL-10, de caráter anti-inflamatório. No fígado, a melhora na sensibilidade à insulina, resultou em inibição da enzima GSK-3 propiciando o restabelecimento do controle hepático sobre o metabolismo da glicose. Análises por hematoxilina/eosina (HE) e imunohistoquímica evidenciaram menor acumulação lipídica e redução da infiltração de macrófagos M1 no parênquima hepático, resultando em melhora do fenótipo de esteatose hepática macrovesicular e recuperação funcional deste tecido. Houve diminuição da hipertrofia dos adipócitos, fato que contribuiu com a remissão da inflamação. Foi verificada a presença do receptor GPR120 nestas células, permitindo, portanto a entrada dos AGIs. A técnica de espectrometria de massa atestou a incorporação dos AGIs de interesse no fígado, sustentando a hipótese de que os efeitos benéficos encontrados ocorreram em decorrência das ações destes nutrientes. Esses achados permitem concluir que fontes alimentares dos AGs ?3 e ?9 modulam de forma potente a resposta inflamatória no organismo. Tais ações são controladas pelo GPR120, receptor comum a esses AGs, e parecem ocorrer de maneira tecido-específica com repercussões sistêmicas, positivas para o controle glicêmico / Abstract: Obesity is characterized as a metabolic disease absolutely out of control which nowadays reaches epidemic levels. The diseases associated to thiscomorbid as hypertension, dyslipidemia, several kinds of cancer, insulin resistance (IR), type 2 diabetes (DM2) and secondary conditions as hepatic steatosis and polycystic ovary syndrome affect a large number of people,burdening the public health system. The low grade chronic inflammation seems to be the main cause of the obesogenic processes, resulting in an uncontrolled food intake and the predisposition for insulin resistance (IR), which can lead to type II diabetes. Once there is no effective pharmacological therapy to treat obesity so far, the investment in anti-inflammatory approaches has been encouraged. In this regard, unsaturated fatty acid, mostly 3-omega (?3) and 9-omega (?9) have been shown effective in decreasing the inflammatory process by activating its common receptor, the GPR120, by recuperating the insulin sensibility in several tissues resulting in improvements in the systemic glucose homeostasis. The purpose of this study was to evaluate the potential antiinflammatory effects of the fatty acids ?-linolenic(?3) and oleic (?9), found in high concentrations in flaxseed and olive oil respectively on active metabolic tissue as liver, skeletal muscle and white adipose tissue of obese and diabetic animals induced by high fat diet, as well as its effects on insulin signaling and glycemic regulation. The high fat treatment with 10% replacement of the saturated portion by ?3 or ?9 oil was effective in restoring the control of food intake in the animals, which consequently gained less weight compared to the obese group. Physiological data from fasting glycemic measure, insulin and glucose tolerance test (ITT and GTT) have showed improvements in the glycemic homeostasis, which was molecularly confirmed by the increase in the activity of the main proteins involved in the insulin signaling pathway as the IR, IRS-1 and AKT. We believe that these results are due to the decrease in proinflammatory peptides expression as TNF-?, IL-6 and IL-1? and increase in the IL-10 expression, known by its anti-inflammatory effects. Improvements in insulin sensitivity in liver resulted in GSK-3 inhibition culminating in the glucose hepatic metabolic reestablishing which contributes to restore the control of plasma glucose levels. Hematoxilin/Eosin (HE) and Immunohistochemistry analysis showed lower lipid accumulation and decreased macrophage infiltration in hepatic parenchyma corroborating the reducing in macrovesicular steatosis and functional recovering of this tissue. There was reduction in adipocyte size, which contributed to "meta-inflammation" remission. We could note the presence of GPR120 receptor in membrane of these cells probably allowing the ?3 and ?9 entry. Mass spectrometry technique attested high incorporation of these fatty acids in liver suggesting the beneficial effects found were due to these nutrients actions. These findings allow us to conclude that alimentary sources of ?3 and ?9 fattty acids modulate effectively the systemic inflammatory response, resulting in the insulin sensibility restoration and in the glucose tolerance improvement. Such nutrients have shown to be important therapeutic nutrigenomic tools against obesity and its associated comorbidities / Mestrado / Nutrição / Mestra em Ciências da Nutrição e do Esporte e Metabolismo

Bakgrund: Typ 2-diabetes är en folksjukdom som är utspridd över hela världen och förutses bli allt mer förkommande. Sjukdomen och dess komplikationer innebär en livsstilsförändring för de som drabbas men även en stor kostnad för samhället. Egenvård är en stor del i behandlingen av typ 2-diabetes och sjukvården har en viktig roll i att genom patientutbildning, råd och stöd motivera patienter till att genomföra egenvården.                                                                       Syfte: Syftet var att beskriva typ 2-diabetespatienters upplevelser av egenvård.                         Metod: Litteraturstudie som baserades på 12 artiklar med kvalitativ metod. Artikelsökning gjordes i databaserna PubMed, CINAHL, SveMed+ och PsycINFO.                                                   Resultat: Resultatet visade att god kontakt med kunnig vårdpersonal och tillgång till patientutbildningar som bidrar till kunskap hos patienterna främjar egenvården vid typ 2-diabetes. Även stöd och motivation från familj och andra personer i sin närhet ökar patienternas motivation till att utföra egenvård. Faktorer som hindrar eller gör det svårare för patienter att utföra egenvård är bland annat brist på stöd från vårdpersonal, familj och vänner. Egenvårdsbrist är också en konsekvens av vilken kultur patienten tillhör samt vilken socioekonomisk status patienten har.                                                                            Slutsats: Grundläggande för god egenvård är en individanpassad vård där både vårdpersonalens och patientens kunskap om typ 2-diabetes och dess behandling ska vara hög. / Background: Type 2 diabetes is a widespread disease and is expected to become increasingly prevalent. The disease and its complications mean a lifestyle change for the people that are afflicted but it also implies to a great cost on society. Self care is a major part in diabetes treatment and healthcare plays an important role in motivating patients to carry out self-care through patient education, counseling and support.                                                                     Aim: The aim of this study was to describe the experiences of self-care by type 2 diabetes patients.                                                                                                                                  Method: Literature study based on 12 articles with qualitative method. Article search was made in the databases PubMed, CINAHL, SveMed + and PsycINFO.                                             Results: The result showed that good contact with skilled healthcare professionals and access to patient education that contributes to knowledge promotes self-care in type 2 diabetes. Also support and motivation from family and other people in their vicinity increases the patient's motivation to perform self-care. Factors that prevent or make it more difficult for patients to perform self-care are lack of support from healthcare professionals, family and friends. Self-deficiency is also a consequence of the culture and the socio-economic status of the patient.                                                                        Conclusion: The foundation for good self-care is individualized care where both the healthcare professional's and the patient's knowledge about type 2 diabetes and its treatments is high.

Le diabètes mellites de type 2 (T2DM) est caractérisé par une hyperglycémie provenant d’une dérégulation de la sécrétion d’insuline combinée avec une altération de l’action de l’insuline. CaMK1D est un nouveau gène identifié, dont le rôle reste à explorer. Dans l’étude exposée ici, j’ai montré que CaMK1D a un effet majeur sur la régulation du glucose. J’ai observé une réduction exceptionnelle des taux de glucose sanguins à jeun, ce qui entraine une amélioration globale de la tolérance au glucose. Les souris mutantes montrent une augmentation conséquente dans les niveaux sanguins d’insuline. Les souris invalidées pour CaMK1D présentent des ilots pancréatiques de taille plus importante due à une hypertrophie des cellules béta. De plus, les souris mutantes sont protégées contre la stéatose hépatique. Dans l’ensemble, mon travail met en évidence le nouveau rôle clé de CaMK1D chez les cellules béta et apporte plus de compréhension quant à son rôle lors du développement du T2DM. / Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from defects in insulin secretion in combination with impaired insulin action. CaMK1D represents one potential candidate gene, the in vivo function remained elusive. In this work, I have found that CaMK1D plays a central role in blood glucose regulation. Pancreas-specific CaMK1D knockout mice display dramatically reduced fasting blood glucose levels leading to an overall improved glucose tolerance. CaMK1D knockout mice show markedly higher ad libitum and fasting insulin levels. Interestingly, pancreas-specific CaMK1D knockout mice display islet hyperplasia caused by beta-cell hypertrophy. Furthermore, conditional knockout mice are protected against high-fat feeding-induced hepatic steatosis. Overall, my work establishes an essential role of CaMK1D in pancreatic beta-cells and provides further understanding about its role in the development of T2DM.

Introduction: Type 2 diabetes mellitus (T2DM) is a worldwide spread disease of affluence which prevalence has been growing. Although, the probability of its manifestation is being linked above all with environmental factors, genetic susceptibility plays an important role too. The aim of this thesis was to find out the association of four polymorphisms with the risk of T2DM manifestation in Czech population. Polymorphisms rs10203174 THADA, rs6819243 MAEA, rs849135 JAZF1 and rs1552224 ARAP1 (CENTD2) were chosen based on their risk in British population. Methodology: We studied groups of 712 Czech patients with T2DM and 752 healthy controls selected as a random sample of Czech population in the post-MONICA study. For a genotypisation rs10203174 and rs6819243 we used the PCR-RFLP method. For an analysis of genotypes rs849135 and rs1552224 was used the real-time PCR method. The results were analysed via odds ratio (OR) a chi-square test. Results: In case of the rs1552224 variant, the risk was proved with statistical significance (P = 0,01). The value of OR for the risk allele T is 1,37 (95% CI 1,07-1,75). In case of the polymorphisms rs10203174, rs6819243 and rs849135 no significant association with the disease was proved. For rs10203174 the value of OR of the allele C is 1,20 (95% CI 0,91-1,56, P = 0,20), OR of...

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Type 2 diabetes mellitus (T2DM) is one of the leading causes of death from worldwide non-communicable diseases. The prevalence of diabetes in the Mexico (MX)-United States border states exceeds the national rate in both countries. The economic burden of diabetes, due to decreased productivity, disability, and medical costs, is staggering and increases significantly when T2DM-related complications occur. The purpose of this study was to use a modified behavioral risk factor surveillance system (BRFSS) to describe the T2DM self-management behaviors, diabetes care, and health perception of a convenience sample of adults with T2DM in Monterrey, MX. This cross-sectional study design, with convenience sampling, was conducted with a convenience sample (n = 351) of adults in the metropolitan area of Monterrey, MX who self-reported a diagnosis of T2DM. Potential participants were recruited from local supermarkets. Twenty-six diabetes and health-related items were selected from the BRFSS and administered in face-to-face interviews by trained data collectors. Data analysis was conducted using descriptive statistics. The mean age was 47 years, and the mean length of time with T2DM was 12 years. The majority was taking oral medication and 34% required insulin. Daily self-monitoring of feet was performed by 56% of the participants; however, only 8.8% engaged in blood glucose self-monitoring. The mean number of health-care provider visits was 9.09 per year, and glycated hemoglobin level (HbA1c) was assessed 2.6 times per year. Finally, only 40.5% of the participants recalled having a dilated eye exam. We conclude the modified BRFSS survey administered in a face-to-face interview format is an appropriate tool for assessing engagement in T2DM self-management behaviors, diabetes care, and health perception. Extension of the use of this survey in a more rigorous design with a larger scale survey is encouraged.

Type 2 diabetes mellitus (T2DM) is an increasing global health concern, currently affecting an estimated 382 million individuals. There is no cure for T2DM and the search for new and improved treatments is ongoing. Presently, various pharmacological regimens are available to treat T2DM, but with varied success. Thousands of traditional herbs are also used to treat T2DM, but mainly without scientific validation. The aim of this study was to assess the polyphenolic content, antioxidant capacity, as well as in vitro toxicity and hypoglycaemic activity of a commercial ‘antidiabetic’ tea mixture (Diabetea) and its individual constituents: Achillea millefolium L. (Yarrow), Agathosma betulina Bartl. & Wendl. (Buchu), Salvia officinalis L. (Sage), Taraxacum officinalis L. (Dandelion), Thymus vulgaris L. (Thyme), Trigonella foenum-graecum L. (Fenugreek) and Urtica urens L. (Nettle). All herbs were tested as crude extracts, prepared using hot water (HW) and dichloromethane (DCM). The total polyphenolic content of each extract was determined using the Folin-Ciocalteau and aluminium trichloride methods. The non-cellular antioxidant activity was assessed using 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) methods. The cell-based antioxidant activity was measured against p-chloranil-induced generation of reactive oxygen species (ROS) in Ea.hy926 cells, using the fluorescent dye, 2',7'-dichlorfluorescein-diacetate (DCFH-DA). The effect of each extract on the viability of C2C12 myotubes, Ea.hy926 endothelial cells and human lymphocytes (HL) was determined using sulforhodamine B (SRB). The in vitro hypoglycaemic activity was assessed against α-amylase and α-glucosidase activity using 3,5-dinitrosalicylic acid (DNSA) and p-nitrophenyl-α-D-glucopyranoside (p-NPG), respectively. The type of inhibition exerted on these enzymes was determined using the Michaelis-Menten enzyme kinetics model, expressed as mixed, competitive, non-competitive and uncompetitive. Glucose uptake activity was measured using the 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-D-glucose (2-NBDG) fluorescent analogue. T. vulgaris and S. officinalis had the highest amount of polyphenols of all extracts tested. The HW extracts of T. vulgaris and S. officinalis showed significant (p < 0.05) cell-free antioxidant activity and cell-based radical scavenging activity. In addition, U. urens (HW) also limited cell-based ROS generation (p < 0.05). The Diabetea extracts presented with poor antioxidant activities, of which some had a pro-oxidant effect on Ea.hy926 cells. The positive linear relationship between antioxidant activity and polyphenolic content was shown to be dependent on the solvent type used. All of the DCM extracts had low antioxidant activity and polyphenolic content. None of the extracts produced < 50% cell density at the concentrations tested (1.3 - 20 μg/mℓ). In general, the DCM extracts showed a greater decrease in cell density than the HW extracts. The Ea.hy926 cells were the least affected by the extracts in terms of decreased cell density. The DCM extract of U. urens inhibited α-amylase activity in a mixed manner, which was comparable to the percentage inhibition exerted by the commercial drug, acarbose. Both the HW and DCM extracts of U. urens caused a significant (p < 0.05) increase in glucose uptake into C2C12 myotubes. The HW extract of T. vulgaris had a significant (p < 0.05) inhibitory activity against α-glucosidase (mixed). It also caused the uptake of glucose into C2C12 myotubes, which was significantly (p <0.05) more active than insulin. S. officinalis (DCM extract) also inhibited α-glucosidase activity (p < 0.05) in a mixed manner. Its HW extract displayed potent hypoglycaemic potential by causing glucose uptake into C2C12 myotubes, which was more significant (p < 0.05) than the activity of the positive control, insulin. The DCM extract of A. betulina was active against α-glucosidase (non-competitive), which was comparable to the activity of acarbose. Its HW extract also showed a significant (p < 0.05) glucose uptake activity. Furthermore, the DCM extracts of T. officinalis, A. millefolium, Diabetea and HW extracts of T. foenum-graecum and T. officinalis also caused a significant (p < 0.05) increase in glucose uptake into C2C12 myotubes. This study provides evidence for the antidiabetic potential of T. vulgaris and S. officianlis, in terms of antioxidant capacity and potential to prevent of post-prandial hyperglycaemia and alleviate hyperglycaemia by mimicking the action of insulin. In addition, the organic preparation of U. urens is also a potent α-amylase inhibitor. All herbs tested in this study exerted some form of in vitro antidiabetic activity. The Diabetea mixture, as a traditional preparation, did not have a significant antidiabetic capacity. In vitro observations from this study do not support the use of Diabetea as an antidiabetic preparation and reveal that some of the individual extracts prove more efficacious than the herb mixture. / Dissertation (MSc)--University of Pretoria, 2014. / lk2014 / Pharmacology / MSc / Unrestricted

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Study Hypothesis: People with diabetes when submitted to gingival treatment may have different perceptions and have an impact on their quality of life. Objectives: This study evaluated the effect of gingival treatment on quality of life related to oral health in type-2 diabetic patients (DM2). Methods: 150 patients were included in this study, 100 with gingivitis divided into two groups: diabetes (n=50) and control group (systemically healthy, n=50) in addition to a negative control group (systemically healthy and gingival health, n=50). The groups received professional treatment and oral hygiene instruction. Then the subjects were randomly divided into essential oils (Listerine total care, n=25) or placebo (n=25), six randomized groups total. To assess the impact of the Quality of Life Factor - QoL (OHQoL-UK questionnaire) and its interaction with DM (diabetic or non-diabetic), with treatment (essential oils or placebo) and with time bases (baseline and three months) in clinical factors (plaque and gingival indexes - PI, GI and probing depth - PD), microbiological factors (Porphyromonas gingivalis - Pg, Aggregatibacter actinomycetemcomitans - Aa, Tannerella forsythia - Tf and total bacterial load - TBL), immunological (interleukin 1&#946;-IL-1&#946;) and breath levels (volatile sulfur compound levels - VSC), we used multiple linear regression analysis. Comparative analyzes were performed intra-group (initial vs. final) and inter-group (in each experimental time) using the Bio Estat 5.0 and SPSS 14.0 software. Results: The value obtained in Cronbachs alpha test (0.971), the significance of the Bartletts test (p&#706;0,0001) and the value of 0.935 for KMO test indicated good agreement, correlation variables and adaptation of the size of the instruments sample that OHQoL was shown to be latent when subjected to factor analysis. The Multiple Linear Regression Analysis detected impact between QoL and treatment in GI (p=0.03) between the QoL and TBL (p=0.03) and between QoL and treatment in VSC (p=0.011). Conclusion: Participants with diabetes and gum disease who reported improvement in quality of life tend to have better periodontal health and breath indicators, especially when a daily rinse with essential oils mouthrinse is executed. / Hipótese do estudo: Indivíduos com diabetes quando submetidos ao tratamento gengival podem apresentar diferentes percepções e gerar impacto sobre sua qualidade de vida. Objetivos: Este estudo avaliou o efeito do tratamento gengival sobre a qualidade de vida relacionada à saúde bucal de indivíduos diabéticos (DM). Metodologia: Foram incluídos no presente estudo 150 indivíduos, sendo cem com gengivite divididos em dois grupos: diabetes (n=50) e Controle (sistemicamente saudável, n=50) em adição a um grupo controle negativo (sistemicamente saudável e com saúde gengival, n=50). Os grupos receberam profilaxia profissional e instrução de higiene bucal. Em seguida os indivíduos foram aleatoriamente distribuídos em óleos essenciais OE (Listerine cuidado total, n=25) ou placebo (n=25), totalizando seis grupos aleatorizados. Para avaliar o impacto do Fator de Qualidade de Vida - FQV (questionário OHQoL-UK), bem como sua interação com DM (diabético ou não diabético), com tratamento (óleos essenciais ou placebo) e com o tempo (baseline e três meses), nos fatores clínicos (índices de placa e gengival IP, IG e profundidade de sondagem PS), microbiológicos (Porphyromonas gingivalis - Pg, Aggregatibacter actinomycetemcomitans - Aa, Tannerella forsythia - Tf e carga bacteriana total - CBT), imunológicos (interleucina 1&#946; IL-1&#946;) e halitométricos (níveis de compostos sulforados voláteis CSV), foram utilizados modelos de Regressão Linear Múltipla. Análises comparativas foram realizadas intra-grupo (inicial vs. final) e inter-grupos (em cada tempo experimental) com auxílio do software Bio Estat 5.0 e SPSS 14.0. Resultados: O valor obtido em Alpha de Cronbach (0,971), a significância do teste de Bartlett (p&#706;0,0001) e o valor de 0,935 para o teste KMO indicaram boa consistência, correlação de variáveis e adequação do tamanho da amostra do instrumento OHQoL que foi demonstrado estar latente quando submetido a uma análise fatorial. O Modelo de Regressão Linear Múltipla detectou impacto entre o FQV e o tratamento em IG (p=0,03), entre o FQV e CBT (p=0,03) e entre FQV e tratamento com OE em CSV (p=0,011). Conclusão: Participantes com diabetes e gengivite que relataram melhora na qualidade de vida tendem a apresentar melhores indicadores de saúde periodontal e hálito, principalmente quando fizeram uso diário de solução à base de óleos essenciais.

Diabetes Mellitus typ 2 är ett vanligt och allvarligt folkhälsoproblem på global nivå. Sjukdomen uppkommer ofta till följd av ohälsosamma levnadsval som fysisk inaktivitet och osund kosthållning. Egenvård i syfte att stärka individers självkontroll och förändring av ohälsosamma levnadsvanor är därför en central del av diabetesvården. E-hälsa är ett tidsaktuellt hjälpmedel som kan användas för att identifiera hälsorelaterade behov och därmed stärka egenvården. Syftet med litteraturöversikten var att sammanställa aktuell forskning om hur individer med Diabetes Mellitus typ 2 upplever användandet av e-hälsa som stöd för egenvård i det vardagliga livet. Metoden är en systematisk litteraturöversikt baserad på 11 artiklar varav nio med kvalitativ design och två med mixad design. I resultatet framkom det att e-hälsa kan stödja individers egenvård på flera sätt; för att uppnå medvetenhet och acceptans i sjukdomen, för motivation till livsstilsförändring, för att involvera personer i omgivningen och för att kommunicera med hälso- och sjukvård. Deltagarna i studierna beskrev positiva upplevelser av e-hälsa. E-hälsa är ett bra stöd för egenvård vid Diabetes Mellitus typ 2 och ett komplement till den redan befintliga diabetesvården. Förslag till framtida arbete är vidare utbildning inom e-hälsa till såväl vårdpersonal som individer. / Type 2 Diabetes Mellitus is a worldwide common and serious public health problem. The disease often arises as a result of unhealthy lifestyle choices such as physical inactivity and unhealthy diet. Self-care is therefore a central part of diabetes care in order to strengthen individuals self-control and to change unhealthy lifestyles. E-health is a modern tool that can help identify health related needs and thereby support selfcare. The aim of the literature review was to compile current research on how individuals with Type 2 Diabetes Mellitus experience the use of e-health as support to self-care in everyday life. The chosen method is a literature review based on 11 articles, of which nine has a qualitative design and two has a mixed design. The results showed that e-health can support everyone’s self-care in several ways; to achieve disease related awareness and acceptance, motivation in lifestyle change, involving people in the environment and to communicate with health care providers. The participants described positive experiences of e-health. E-health is a relevant support for self-care management in Type 2 Diabetes Mellitus and a complement to the existing diabetes care. A proposal for future work is further education in e-health for both health care providers and individuals.