No description available.

We compare the UV-optical colors of a well-defined set of optically selected pre-merger interacting galaxy pairs with those of normal spirals. The shorter wavelength colors show a larger dispersion for the interacting galaxies than for the spirals. This result can best be explained by higher star formation rates on average in the interacting galaxies, combined with higher extinctions on average. This is consistent with earlier studies which found that the star formation in interacting galaxies tends to be more centrally concentrated than in normal spirals, perhaps due to gas being driven into the center by the interaction. As noted in earlier studies, there is a large variation from galaxy to galaxy in the implied star formation rates of the interacting galaxies, with some galaxies having enhanced rates but others being fairly quiescent.

We have used the Galaxy Evolution Explorer (GALEX) ultraviolet telescope to study stellar populations and star formation morphology in a well-defined sample of 42 nearby optically selected pre-merger interacting galaxy pairs. Galaxy interactions were likely far more common in the early universe than in the present; thus our study provides a nearby well-resolved comparison sample for high-redshift studies. We have combined the GALEX near-ultraviolet (NUV) and far-ultraviolet images with broadband optical maps from the Sloan Digitized Sky Survey to investigate the ages and extinctions of the tidal features and the disks. The distributions of the UV/optical colors of the tidal features and the main disks of the galaxies are similar; however, the tidal features are bluer on average in NUV - g when compared with their own parent disks; thus tails and bridges are often more prominent relative to the disks in UV images compared to optical maps. This effect is likely due to enhanced star formation in the tidal features compared to the disks rather than reduced extinction; however, lower metallicities may also play a role. We have identified a few new candidate tidal dwarf galaxies in this sample. Other interesting morphologies such as accretion tails and "beads on a string" are also seen in these images. We also identify a possible "Taffy" galaxy in our sample, which may have been produced by a head-on collision between two galaxies. In only a few cases are strong tidal features seen in H I maps but not in GALEX.

We describe an ultraviolet spectroscopic survey of interstellar high-velocity cloud (HVC) absorption in the strong λ1206.500 line of Si III using the Space Telescope Imaging Spectrograph aboard the Hubble Space Telescope. Because the Si III line is 4-5 times stronger than O VI λ1031.926, it provides a sensitive probe of ionized gas down to column densities N Si III 5 × 1011 cm-2 at Si III equivalent width 10 m. We detect high-velocity Si III over 91% 4% of the sky (53 of 58 sight lines); 59% of the HVCs show negative local standard of rest velocities. The mean HVC column density per sight line is 〈log N Si III 〉 = 13.19±0.45, while the mean for all 90 velocity components is 12.92±0.46. Lower limits due to Si III line saturation are included in this average, so the actual mean/median values are even higher. The Si III appears to trace an extensive ionized component of Galactic halo gas at temperatures 104.0-4.5 K indicative of a cooling flow. Photoionization models suggest that typical Si III absorbers with 12.5 < log N Si III < 13.5 have total hydrogen column densities N H 1018-1019 cm-2 for gas of hydrogen density n H 0.1 cm-3 and 10% solar metallicity. With typical neutral fractions N H I/N H 0.01, these HVCs may elude even long-duration 21 cm observations at Arecibo, the EVLA, and other radio facilities. However, if Si III is associated with higher density gas, n H ≥ 1 cm-3, the corresponding neutral hydrogen could be visible in deep observations. This reservoir of ionized gas may contain 10 8M and produce a mass infall rate of 1 M yr-1 to the Galactic disk.

Copepods in high elevation lakes and ponds in Colorado are exposed to significant levels of ultraviolet radiation (UV), necessitating development of UV avoidance behavior and photoprotective physiological adaptations. The copepods are brightly pigmented due to accumulation of astaxanthin, a carotenoid which has photoprotective and antioxidant properties. Astaxanthin interacts with a crustacyanin-like protein, shifting its absorbance from 473 nm (hydrophobic free form, appears red) to 632 nm (protein-bound complex, appears blue). In six sites in Colorado, habitat-specific coloration patterns related to carotenoprotein complex have been observed. The objective of this study was to determine whether pigment accumulation or carotenoprotein expression has a greater effect on resistance to UV exposure. For each site, copepod tolerance to UV was assessed by survivorship during UV exposure trials. Average UV exposure was determined for each habitat. Astaxanthin profiles were generated for copepods in each site. Ability to withstand UV exposure during exposure trials was significantly different between color morphs (p < 0.0001). Red copepods were found to tolerate 2-fold greater levels of UVB than blue or mixed copepods. Additionally, red copepods have much higher levels of total astaxanthin than blue or mixed copepods (p < 0.0001) and receive a higher daily UV dose (p < 0.0003). Diaptomid carotenoprotein sequence is not homologous with that of other crustaceans in which crustacyanin has been characterized which prevented quantification of carotenoprotein transcript expression. Overall, diaptomid color morph may be an important indicator of UV conditions in high elevation lentic ecosystems.

Following low levels of UV exposure, Escherichia coli cells deficient in nucleotide excision repair recover and synthesize DNA at near wild type levels, an observation that formed the basis of the post replication recombination repair model. In this study, we characterized the DNA synthesis that occurs following UV-irradiation in the absence of nucleotide excision repair and show that although this synthesis resumes at near wild type levels, it is coincident with a high degree of cell death. We confirm that the replication occurring under these conditions involves extensive levels of strand exchange. However, cells undergoing this form of replication accumulate strand exchange intermediates that fail to resolve into discrete molecules, resulting in grossly filamentous, multinucleate cells. Taken together the results demonstrate that the DNA synthesis that occurs in UV-irradiated nucleotide excision repair mutants is aberrant and suggests that post replication repair is not an efficient mechanism to promote survival in the absence of nucleotide excision repair. The role that nucleotide excision repair plays in the recovery of replication following UV-induced DNA damage was further characterized by examining the specific role of UvrD in processing and restoring UV-arrested replication forks. UvrD is a helicase with functions associated with nucleotide excision repair and replication. UvrD catalyzes the removal of the damaged region by nucleotide excision repair proteins and removes the stretch of DNA incised during methyl-directed mismatch repair during replication. Recent biochemical studies have led to the proposal that UvrD may promote fork regression and facilitate resetting of the replication fork following arrest. However, the molecular activity of UvrD at replication forks in vivo has not been directly examined. In this study, we show that UvrD is required for DNA synthesis to recover. However, in the absence of UvrD, the displacement and partial degradation of the nascent DNA at the arrested fork occurs normally. In addition, damage-induced replication intermediates persist and accumulate in uvrD mutants in a manner that is similar to that observed in other nucleotide excision repair mutants. These data indicate that following arrest by DNA damage, UvrD is not required to catalyze fork regression in vivo and suggest that the failure of uvrD mutants to restore DNA synthesis following UV-induced arrest relates to its role in nucleotide excision repair.

京都大学 / 0048 / 新制・課程博士 / 博士(工学) / 甲第21106号 / 工博第4470号 / 新制||工||1695(附属図書館) / 京都大学大学院工学研究科材料工学専攻 / (主査)教授 杉村 博之, 教授 邑瀬 邦明, 教授 山田 啓文 / 学位規則第4条第1項該当 / Doctor of Philosophy (Engineering) / Kyoto University / DGAM

No description available.

This thesis investigates the relationship between success and access to children, slaves, and kin as labor sources during the period of 1833 to 1865 in northeast Mississippi. The theoretical concepts of agricultural intensification and relative intensity were used to measure variability among the households. Artifacts from seven archaeological sites were used to establish mean dates. These sites were tied to their original occupants through historic records. A historic document search revealed the number of slaves and children each family had, and whether they had kin living nearby. Agricultural census records showed the productivity of each farm during the study period. Families were considered successful if they stayed in the study area until death, increased the number of slaves or land owned, or increased their agricultural output. This thesis concluded that the relationship between success and the availability of labor is complex with no one strategy ensuring success.

Turmeric polar extract (TPE) was obtained by dielectric-precipitation of turmeric slurry and found to contain three proteins with two in the 10-11 KDa range being dominant. Antioxidative activity and persistence (AP) of TPE (5%, w/v) respectively showed 87% and 85% greater generation of alkoxy- and peroxyl radicals compared the non-redox-active buffer alone showing significant (p<0.05) pro-oxidative behavior. Conversely, purified curcumin (CU) (0.1% w/v) was dramatically antioxidative with AA and AP values of 2,828 and 1,129%, respectively, compared to the blank. However, a combination of the two at the same concentration dropped these values to 590 and 389%, respectively, reflecting dramatic dampening of the efficacy of CU. Ultraviolet radiation significantly modulated the efficacy of CU where UVB (300 nm) exposure gave the highest enhancement when limited to five min. Data showed that turmeric contains highly pro-oxidant polar proteins that significantly dramatically diminishes the beneficial antioxidative efficacy of its principal phytochemical, CU.