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FundaÃÃo de Amparo à Pesquisa do Estado do Cearà / CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior / A escassez de medicamentos adequados ao uso pediÃtrico obriga os prescritores a extrapolarem informaÃÃes obtidas atravÃs de testes com indivÃduos adultos para crianÃas, bem como a adaptarem formulaÃÃes desenvolvidas para adultos. Os riscos sÃo elevados podendo comprometer a eficÃcia e a seguranÃa dos tratamentos.Conhecer a problemÃtica da carÃncia de formulaÃÃes farmacÃuticas adequadas ao uso em crianÃas e suas repercussÃes prÃticas em um hospital pediÃtrico do SUS. Estudo descritivo transversal, envolvendo: busca na literatura internacional de medicamentos cuja forma ou formulaÃÃo representam um problema para o uso em crianÃas (MP, medicamentos problema) e identificaÃÃo desses medicamentos no mercado farmacÃutico brasileiro; inquÃrito com mÃdicos de um hospital pediÃtrico (N=48, 98% do total) sobre quais sÃo os MP em sua prÃtica clÃnica e seguimento da prescriÃÃo e preparo de MP sÃlidos na instituiÃÃo. Foi empregada a ClassificaÃÃo AnatÃmica TerapÃutica e QuÃmica de medicamentos e cÃlculo de freqÃÃncias das variÃveis. O projeto foi aprovado pela comissÃo de Ãtica da instituiÃÃo. Foram identificados 131 MPI (medicamentos problema internacionais), 105 destes sÃo comercializados no Brasil, sendo 85 de uso pediÃtrico. Os princÃpios ativos mais freqÃentes foram: salbutamol, furosemida, paracetamol, cisaprida e morfina. Os MP mais citados pelos mÃdicos foram captopril, furosemida, digoxina, espironolactona, hidroclorotiazida e prednisona. A carÃncia de preparaÃÃes orais, parenterais e em baixas doses foram os problemas mais citados. Foi acompanhada a adaptaÃÃo de 24 distintos MP sÃlidos (89 prescriÃÃes). Todas as prescriÃÃes apresentavam inconformidades, bem como todos os procedimentos de preparo. As doses administradas foram 3,47 a 1.125% do preconizado (22,7% inferiores e 39.5% superiores); somente em 37,8% dos casos foi administrada a dose preconizada. A carÃncia de preparaÃÃes apropriadas para uso em crianÃas à um problema em todo o mundo. No Brasil isso à agravado pela falta de condiÃÃes adequadas para a adaptaÃÃo de formulaÃÃes em hospitais, bem como pela inobservÃncia de procedimentos padronizados. / The scarcity of medicines developed to be used in children creates the need of to extrapolate information obtained by tests in adults and of to adapt adult formulations to this age group. The risks are great and can compromise the efficacy and safety of treatments.To know the problem of lack of formulations apropriated to be used in children and its practical repercussions in a SUS pediatric hospital.A cross-sectional, descriptive study, involving: literature search for medicaments whose formulations represents a problem for use in children (Medicine Problem â MP) and the identification of these medicines on the Brazilian market; a survey applied to doctors in a pediatric hospital to know which are the PM in their clinical practice; follow up of prescription and adaptation of solid PM in this institution. The Anatomic Therapeutic Chemical classification of medicines was adopted; the frequencies of variables were calculated; the project was approved by the hospital Ethics Committee.A total of 131 IPM (International Problem Medicine) were identified, 105 of these are marketed in Brazil, including 85 pediatric preparations. The most frequent MP were salbutamol, furosemide, paracetamol, cisaprida and morphine; The doctors (N=48, 98% of total) referred mainly captopril, furosemide, digoxine, espironolactone, hidroclorotiazide e prednisone as PM. Lack of oral, parenteral, or lower doses formulations were the more frequent problems. The preparation of 89 solid PM was followed up; there were inadequacies in all prescriptions and preparing procedures. The final dosis administered were 3,47 to 1.125% of expected (22,7% under and 39 over); only 37,8 of children received the standardized dosis. The lack of appropriate preparations to be used in children is a problem all over the world. In Brazil this problem is aggravated by the lack of adequate conditions in hospitals to adapt formulations and poor compliance with standard procedures.

Problemas relacionados a medicamentos (PRMs) compreendem erros de medicação (EMs) e reações adversas a medicamentos (RAMs). Este estudo teve por objetivo analisar, classificar, quantificar e intervir nos PRMs ocorridos em pacientes idosos internados. Este estudo prospectivo descritivo de uma série de casos clínicos abrangeu 28 pacientes e 100 prescrições aleatórias a eles destinadas. A identificação dos PRMs se deu por métodos de farmacovigilância ativa e as intervenções farmacêuticas (IFs) foram realizadas diretamente junto à equipe médica. Medicamentos de uso potencialmente inapropriado para idosos foram utilizados por 21,4% dos pacientes; 19% das prescrições possuíam rasuras. Foram encontrados 924 PRMs, sendo 920 EMs e 4 possíveis RAMs, sendo uma delas confirmada. A maioria dos EMs foi classificada como sem prejuízo ao paciente. Foram realizadas 143 IFs em 73 prescrições de 92,9% dos pacientes, sendo a maioria (77,6%) acatada pela equipe médica. Apesar das limitações, demonstrou-se a importância do farmacêutico na investigação, prevenção e solução de PRMs. / Drug related problems (DRPs) include medication errors (MEs) and adverse drug reactions (ADRs). The objective of this study was to analyze, classify, quantify and intervene in DRPs occurred in hospitalized elderly patients. This prospective descriptive study of a case series included 28 patients and 100 random prescriptions to them addressed. The identification of DRPs was carry out by methods of active pharmacovigilance and the pharmaceutical interventions (PIs) were performed directly with the medical staff. Drugs potentially inappropriate for the elderly were used by 21.4% of the patients; 19% of the prescriptions had rasures. There were 924 DRPs, with 920 MEs and 4 possible ADRs 4, one of which confirmed. The majority of MEs was classified as \"without harm to the patient\". Were carried out 143 PIs on 73 prescriptions of 92.9% of the patients, being the majority (77.6%) fully embraced by the medical staff. Despite the limitations, it was possible to demonstrate the pharmacist importance in research, prevention and resolution of DRPs.

A prevalência mundial da obesidade tem aumentado dramaticamente nos últimos anos. Classificada como doença crônica, a obesidade está associada a uma série de doenças, como hipertensão arterial sistêmica, diabetes mellitus tipo 2 ehipercolesterolemia, aumentando a necessidade de uso de medicamentos. Esta situação contribui para a redução da qualidade e expectativa de vida dos indivíduos. A perda de peso significativa por pacientes com obesidade mórbida pode ser obtida através da realização da cirurgia bariátrica que pode exigir ajustes na farmacoterapia em função da redução das comorbidades e das alterações fisiológicas provocadas pela cirurgia. Objetivo: Analisar o impacto da cirurgia bariátrica sobre o perfil de utilização dos medicamentos, enfocando principalmente as classes terapêuticas, o número de medicamentos e doses administradas antes e após a cirurgia. Métodos: Foi realizado um estudo longitudinal do tipo antes e depois. Utilizando uma amostragem por conveniência foram entrevistados consecutivamente 69 pacientes no pré-cirúrgico imediato e seis meses após a realização do procedimento cirúrgico entre 2008 e 2011. Nas entrevistas foram avaliados a presença de comorbidades e o uso de medicamentos com e sem prescrição médica Resultados: Antes da cirurgia 85,5% dos pacientes apresentaram comorbidades associadas à obesidade, sendo as principais: hipertensão, diabetes e hipercolesterolemia. 84,1% dos pacientes estavam em uso de medicamento sob prescrição médica no período pré-cirúrgico e a média de medicamentos utilizados por paciente foi de 4,8. Após a realização da cirurgia, observamos uma diminuição acentuada para as classes dos antidiabéticos (84%), antilipêmicos (77%) e anti-hipertensivos (49,5%), e a média de medicamentos por paciente foi de 4,4. Por outro lado observou-se um aumento importante na utilização de multivitamínicos e medicamentos para desordens do trato gastrointestinal (TGI). A maioria dos medicamentos que continuaram sendo prescritos após a cirurgia teve sua dose reduzida. Conclusão: A cirurgia bariátrica propiciou a redução da dose e da utilização de medicamentos para a maioria das classes terapêuticas. No entanto, pode ser observado um aumento na utilização de medicamentos para tratar distúrbios associados à realização da cirurgia. / The worldwide prevalence of obesity has increased dramatically in the last years. Classified as a chronic disease, obesity is associated with a number of diseases, such as hypertension, type 2 diabetes mellitus and hypercholesterolemia, increasing the need for drug use. This situation reduces the quality and life expectancy of individuals. The significant weight loss for morbidly obese patients can be obtained by bariatric surgery that may require adjustments in pharmacotherapy due to the reduction of comorbidities and physiological changes caused by surgery. Objective: Analyze the impact of bariatric surgery on the drug use profile, mainly focusing on the therapeutic classes, the number of drugs and doses administered before and after surgery. Methods: We conducted a longitudinal study of type before and after. Using a convenience sampling were interviewed consecutively 69 patients before surgery immediately and six months after the surgical procedure between 2008 and 2011. In the interviews were evaluated the presence of comorbidities and the use of prescription and non-prescription Results: Before surgery 85.5% of patients had comorbidities associated with obesity, the main ones being: hypertension, diabetes and hypercholesterolemia. 84.1% of patients were on prescription drug use in the preoperative period and the average number of drugs used per patient was 4.8. After the surgery, we observed a marked decrease for the classes of antidiabetic (84%), antilipemic (77%) and antihypertensive (49.5%), and the average number of drugs used per patient was 4,4. Moreover we observed a significant increase in the use of multivitamin and medicaments for disorders of the gastrointestinal tract (GIT). Most drugs that continued to be prescribed after surgery was reduced dose. Conclusion: Bariatric surgery led to dose reduction and the use of medications for most therapeutic classes. However, an increase can be observed in the use of drugs to treat disorders associated with surgery.

Investigamos o agonista de Guanilato Ciclase solúvel, BAY 41-2272, como alternativa para compensar falhas nas funções de monócitos. Avaliamos in vitro o efeito do fármaco em células humanas de linhagem e de sangue periférico. O BAY, em células THP-1 e monócitos, aumentou a expressão de CD11b, CD18, CD14, TLR4, TLR2 e CD163 e induziu a produção de TNF-<font face=\"Symbol\">a, IL-1<font face=\"Symbol\">b, IL-6 e IL-12p70. Além disso, o fármaco aumentou a expressão gênica (CYBB, CYBA e NCF2) e protéica (p67PHOX e gp91PHOX) da NADPH oxidase. Ainda, o BAY ativa a via do NF-kB (p65) (dependente de PKG). Mais importante, o fármaco aumentou a atividade microbicida de monócitos de pacientes com DGC e deficiência de MPO a S. aureus e C. albicans. Em animais, o BAY 41-2272 induziu intenso influxo de macrófagos para o peritônio e inflamação. Ainda, potencializou o espraiamento, atividade fagocítica, atividade microbicida, produção espontânea de óxido nítrico e de peróxido de hidrogênio induzida por PMA, em macrófagos peritoneais, aumentando a proteção dos animais desafiados com C. albicans. Em conjunto, nossos resultados confirmam o potencial do BAY 41-2272, ou sua via (GCs/PKG), como alternativa para o desenvolvimento de terapias contra infecções. / We investigated the soluble guanylate cyclase agonist, BAY 41-2272, as an alternative to compensate for failures in of monocytes function. We evaluated the in vitro effect of the drug on human cells lines and peripheral blood cells. The BAY increased expression of CD11b, CD18, CD14, TLR4, TLR2 and CD163 and induce the production of TNF-<font face=\"Symbol\">a, IL-1<font face=\"Symbol\">b, IL-6 and IL-12p70 in THP-1 cells and monocytes. Furthermore, the drug increased NADPH oxidase gene (CYBB, CYBA and NCF2) and protein (gp91phox and p67phox) expression. Also, BAY activates the PKG-dependent NF-kB pathway (p65). More importantly, the drug increased microbicidal activity against S. aureus and C. albicans of monocytes from patients with CGD and MPO deficiency. In animals, BAY 41-2272 induced intense influx of macrophages to the peritoneum and inflammation. BAY potentiated the spreading, phagocytic activity, microbicidal activity, spontaneous production of nitric oxide and PMA-induced hydrogen peroxide release by peritoneal macrophages, increasing host protection against C. albicans. Taken together, our results confirm the potential of BAY 41-2272, or its pathway (sGC / PKG), as an alternative for the development of therapies against infections.

Malaria is more prevalent today and the death toll is on the increase annually. It is one of the leading causes of morbidity and mortality worldwide and most of these deaths are in the poorest regions of the world. About 500 million cases are reported annually with more than 2 million deaths, and most are children. It is the major killer in the tropics and a major public health problem in developing countries and Papua New Guinea (PNG) is no exception. Resistant strains have been reported. This may be enhanced by inappropriate human behaviour in the use of anti-malarial drugs. Human factors include inappropriate prescribing and patient behaviour in using anti-malarial drugs. Despite the establishment of the standard treatment guidelines for malaria in PNG, three out of every four patients have chloroquine-resistant falciparum malaria and malaria remains a major health problem. The aim of this study was to evaluate the influence of an education program on patients carers' understanding and effective use of anti-malarial drugs for the treatment of uncomplicated malaria in children in general health clinics in PNG. The trial design involved a pre-post intervention study with a control group. The study was undertaken in the National Capital District. Papua New Guinea using one Clinic as the intervention site and another as the control site. The two clinics were similar in characteristics as confirmed in the study by demographic data where there were no significant differences observed. The data collection took placed over the period February to April 2002. It included observation of drug provision at study sites and interviews of patient carers on the first day at the clinic and a follow up seven days later. Three questionnaires were developed to evaluate the process and outcomes of malaria drug treatment in the above health facilities. / Prescribing data were collected from prescriptions and patient carers' interviewed prior to the intervention program. Following the provision of drug information to patient carers. similar drug information and compliance questioning was undertaken. Differences in the pre-post elements of the study and in the control group over the study period were evaluated using Chi-Squared, Kruskal-Wallis, Fisher's Exact or Student's t-tests as appropriate. In excess of 100 patients in the pre- and in the post intervention phases were evaluated for their understanding and effective use of the anti-malarial drugs. In addition, 100 clients were in the control group at another clinic. Patients had attended the clinic up to 8 times in the previous year with a median of 2 visits. Amodiaquine, Fansidar, albendazole and paracetamol made up a total of 60% of the drugs prescribed. The use of medicines was strongly supported with 94.4% indicating no problems with the medication. Only 3% of patients received herbal or local remedies for malaria treatment. 1n patients 10 years or less or their carers, it was found, there was a significant improvement in the carers understanding of the medications. There was a statistically significant improvement in patient outcomes from 57.9% to 92.3% reported as cured following the intervention program. The study has also identified low levels of appropriate administration of antibiotic suspensions in children by patient carers. / For example, incorrect responses recorded for amoxycillin suspension were 80.8% (143). Septrim tablets 92% (23), Septrim suspension 86% (123), erythromycin suspension 100% (26), and chloramphenicol suspension 84.4% (38). In this study the face to face (one-to-one) education program was used to influence patient carers understanding and effective use of drugs. The intervention program involved advising, informing, encouraging, and counselling the patient carers verbally on the appropriate and effective use of medicines. The verbal message was reinforced by a suitable label typed in English and Pidgin-English where instructions were clear, simple and unambiguous. The label was then attached to the envelopes or containers containing the drugs. On feedback, the information on the understanding and effective use of drugs was re-emphasized to the carers to reinforce their understanding for future references. Results showed that the intervention program made an impact in improved patient carers understanding and effective use of drugs and children's health outcomes. In conclusion, it is evident that a patient intervention program designed to improve the dosages and frequency of administration of anti-malarial drugs in PNG had no statistically significant outcome. This may be because the current level of understanding was quite high (>70%) and the study experienced a ceiling effect. However, as shown in the results, the patient carers understanding on the appropriate and effective use of drugs was lower during the pre-intervention and control group. / When compared clinic-pre with clinic-post, there was a significant difference (P < 0.05) in the cured group and the improved cure rate increases from 57.9% to 92.3%. When compared control pre with control post groups, there was no significant difference (P > 0.05) in the cured group. Therefore, the study identified an improvement in patient outcomes with respect to malaria. Hence. the simple intervention program in influencing patient carers understanding of the appropriate and effective use of medications led to a marked improvement in patient outcomes.

Background: Much of the research on injection drug use practices has focused on adult populations and relatively little is known about safer and/or unsafe injection practices among youth who use injection drugs (YWID). Unsafe practices may be risk factors for blood borne illnesses, abscesses or other infections, and overdose. Multiple factors may create barriers to the access of clean supplies and the ability to practice safer injection. It is important to understand how YWID engage in safer and/or unsafe injection practices so that use of safer practices may be supported. Purpose: The purpose of this study was to explore the understandings and practices of safer and/or unsafe injection drug use among YIWD, as well as key social factors influencing these understandings and practices. Methods: Ten semi-structured qualitative interviews were conducted with YWID aged 18 to 29 in Halifax, Nova Scotia. Voluntary informed consent was obtained prior to conducting the interviews. All interviews were audio-taped and transcribed, then analyzed using a modified approach to grounded theory for key themes and subthemes. Results: The experiences of the YWID can be categorized into two overarching themes. The first theme relates to the power of the drugs and the control (or, at times, lack of control) YWID have over safer practices. This theme explores how access to clean supplies and understandings of safer use can influence the control YWID have over safer practices. The second theme describes experiences YWID have with “getting clean,” or gaining power over drugs, including experiences with methadone maintenance treatment. Discussion: YWID can and do practice safer use, however multiple factors, such as the perception of cleanliness in injection practices and the availability of clean needles in the community, impact how YWID understand and practice safer injection drug use. Barriers that impede YWID’s ability to practice safer use need to be addressed.

Submitted by Lucienne Costa (lucienneferreira@ufcg.edu.br) on 2018-08-29T14:55:18Z No. of bitstreams: 1 LAIS SANTOS BARBOSA DE SOUZA – DISSERTAÇÃO (PPGED) 2018.pdf: 1794432 bytes, checksum: a58fa81f491e3b7e08a163d3c191dafc (MD5) / Made available in DSpace on 2018-08-29T14:55:18Z (GMT). No. of bitstreams: 1 LAIS SANTOS BARBOSA DE SOUZA – DISSERTAÇÃO (PPGED) 2018.pdf: 1794432 bytes, checksum: a58fa81f491e3b7e08a163d3c191dafc (MD5) Previous issue date: 2018-04-27 / Capes / O objetivo geral deste trabalho é analisar as representações sociais sobre as drogas e sobre os estudantes que usam drogas, construídas por docentes da Rede Estadual de Ensino na cidade de Campina Grande – PB. A pesquisa foi realizada em 08 escolas de Ensino Fundamental e Médio, abarcando diferentes zonas geográficas da cidade. Participaram no total 56 docentes, o que corresponde, em média, a 20% do corpo docente de cada escola. Utilizamos como recurso de produção de dados: a observação do cotidiano escolar, a Associação Livre de Palavras (ALP) e o Questionário com questões objetivas e subjetivas. Para a análise dos dados, utilizamos a Estatística Descritiva; a Análise de Conteúdo Categorial e a Nuvem de Palavras. Verificamos que o processo de objetivação das representações de “drogas na escola” e de “aluno usuário” ocorre por meio de uma mesma metáfora conceitual, sendo compreendidos como um: “problema”. São, portanto, representações sociais associadas. As ancoragens quanto às drogas, no geral, são realizadas através dos modelos médico-psiquiátrico e jurídico-criminal, mas há também uma evolução no sentido de uma compreensão mais social pelos sujeitos. O medo é uma característica muito recorrente nos discursos dos participantes da pesquisa quando se trata dessa temática no cotidiano escolar. Os docentes assinalam os efeitos na vida pessoal dos estudantes e no contexto escolar, as necessidades, os obstáculos para a efetivação de práticas educativas sobre o tema e a responsabilização da família quanto a essa questão. Em relação aos estudantes, a maioria dos participantes da pesquisa lhes caracterizaram a partir de uma perspectiva negativa, quanto ao comportamento, ao desempenho educacional, ao aspecto físico, à dimensão psicológica, às relações interpessoais a às suas famílias. Apenas alguns apontaram para uma perspectiva mais positiva desses estudantes em relação ao seu desempenho escolar. No geral, os participantes apontaram que a falta de formação específica e focada no contexto escolar contribui para a não efetivação de práticas educativas sobre drogas. Esses resultados indicam também a necessidade de um trabalho focado na realidade escolar, mais coletivo, formativo e intersetorial. / The general objective of this work is to analyze the social representations about drugs and students who use drugs, built by teachers of the State Education Network in the city of Campina Grande - PB. The research was carried out in 08 schools of Elementary and Middle School, covering different geographical areas of the city. A total of 56 teachers participated, which corresponds, on average, to 20% of the faculty of each school. We use as a data production resource: the observation of everyday school, the Free Association of Words (ALP) and the Questionnaire with objective and subjective questions. For the analysis of the data, we use Descriptive Statistics; Categorical Content Analysis and the Word Cloud. We verified that the process of objectifying the representations of "drugs in school" and "user student" occurs through a same conceptual metaphor, being understood as a "problem". They are, therefore, associated social representations. Drug anchorages, in general, are carried out through the medical-psychiatric and legal-criminal models, but there is also an evolution towards a more social understanding by the subjects. Fear is a very recurrent characteristic in the discourses of the research participants when it comes to this theme in the daily school life. Teachers point out the effects on the personal life of students and on the school context, the needs, obstacles to the implementation of educational practices on the subject and the responsibility of the family on this issue. Regarding the students, most of the participants of the research characterized them from a negative perspective regarding behavior, educational performance, physical aspect, psychological dimension, and interpersonal relations to their families. Only a few have pointed to a more positive view of these students in relation to their school performance. In general, the participants pointed out that the lack of specific training focused on the school context contributes to the non-implementation of educational practices on drugs. These results also indicate the need for work focused on school reality, more collective, formative and intersectoral.

A prevalência mundial da obesidade tem aumentado dramaticamente nos últimos anos. Classificada como doença crônica, a obesidade está associada a uma série de doenças, como hipertensão arterial sistêmica, diabetes mellitus tipo 2 ehipercolesterolemia, aumentando a necessidade de uso de medicamentos. Esta situação contribui para a redução da qualidade e expectativa de vida dos indivíduos. A perda de peso significativa por pacientes com obesidade mórbida pode ser obtida através da realização da cirurgia bariátrica que pode exigir ajustes na farmacoterapia em função da redução das comorbidades e das alterações fisiológicas provocadas pela cirurgia. Objetivo: Analisar o impacto da cirurgia bariátrica sobre o perfil de utilização dos medicamentos, enfocando principalmente as classes terapêuticas, o número de medicamentos e doses administradas antes e após a cirurgia. Métodos: Foi realizado um estudo longitudinal do tipo antes e depois. Utilizando uma amostragem por conveniência foram entrevistados consecutivamente 69 pacientes no pré-cirúrgico imediato e seis meses após a realização do procedimento cirúrgico entre 2008 e 2011. Nas entrevistas foram avaliados a presença de comorbidades e o uso de medicamentos com e sem prescrição médica Resultados: Antes da cirurgia 85,5% dos pacientes apresentaram comorbidades associadas à obesidade, sendo as principais: hipertensão, diabetes e hipercolesterolemia. 84,1% dos pacientes estavam em uso de medicamento sob prescrição médica no período pré-cirúrgico e a média de medicamentos utilizados por paciente foi de 4,8. Após a realização da cirurgia, observamos uma diminuição acentuada para as classes dos antidiabéticos (84%), antilipêmicos (77%) e anti-hipertensivos (49,5%), e a média de medicamentos por paciente foi de 4,4. Por outro lado observou-se um aumento importante na utilização de multivitamínicos e medicamentos para desordens do trato gastrointestinal (TGI). A maioria dos medicamentos que continuaram sendo prescritos após a cirurgia teve sua dose reduzida. Conclusão: A cirurgia bariátrica propiciou a redução da dose e da utilização de medicamentos para a maioria das classes terapêuticas. No entanto, pode ser observado um aumento na utilização de medicamentos para tratar distúrbios associados à realização da cirurgia. / The worldwide prevalence of obesity has increased dramatically in the last years. Classified as a chronic disease, obesity is associated with a number of diseases, such as hypertension, type 2 diabetes mellitus and hypercholesterolemia, increasing the need for drug use. This situation reduces the quality and life expectancy of individuals. The significant weight loss for morbidly obese patients can be obtained by bariatric surgery that may require adjustments in pharmacotherapy due to the reduction of comorbidities and physiological changes caused by surgery. Objective: Analyze the impact of bariatric surgery on the drug use profile, mainly focusing on the therapeutic classes, the number of drugs and doses administered before and after surgery. Methods: We conducted a longitudinal study of type before and after. Using a convenience sampling were interviewed consecutively 69 patients before surgery immediately and six months after the surgical procedure between 2008 and 2011. In the interviews were evaluated the presence of comorbidities and the use of prescription and non-prescription Results: Before surgery 85.5% of patients had comorbidities associated with obesity, the main ones being: hypertension, diabetes and hypercholesterolemia. 84.1% of patients were on prescription drug use in the preoperative period and the average number of drugs used per patient was 4.8. After the surgery, we observed a marked decrease for the classes of antidiabetic (84%), antilipemic (77%) and antihypertensive (49.5%), and the average number of drugs used per patient was 4,4. Moreover we observed a significant increase in the use of multivitamin and medicaments for disorders of the gastrointestinal tract (GIT). Most drugs that continued to be prescribed after surgery was reduced dose. Conclusion: Bariatric surgery led to dose reduction and the use of medications for most therapeutic classes. However, an increase can be observed in the use of drugs to treat disorders associated with surgery.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / A ideia de que drogas e esportes caminhem em sentidos opostos parece ser senso comum na sociedade brasileira: o esporte se associa à saúde, à cidadania e à liberdade; a droga à degradação, à violência e ao vício. A relação entre o esporte e a droga se resume, nesse sentido, em uma postura maniqueísta que parece advir da observação em separado destes dois fenômenos e não da própria relação entre os mesmos. Apesar da existência de uma extensa bibliografia referente às temáticas da droga e do esporte, foi observada, conforme o levantamento da literatura pertinente, uma carência de pesquisas que abordem o uso do esporte como meio de prevenção e diminuição do consumo de drogas. O objetivo deste estudo foi analisar os fundamentos do discurso em prol do esporte enquanto instrumento capaz de combater e prevenir o uso de drogas. Para tanto, foram analisados os seguintes documentos: Política Nacional do Esporte; Política Nacional Sobre Drogas; Carta Brasileira de Prevenção Integrada da Área da Saúde na Perspectiva da Educação Física. A metodologia utilizada foi a da Análise do Discurso preconizada por Orlandi (2001). A interpretação dos dados se realizou segundo os fundamentos do campo interdisciplinar do Imaginário Social. Os resultados da pesquisa mostraram que a relação entre o esporte e a droga materializa um conflito de forças entre as atitudes prometeica e dionisíaca. De modo que o esporte, representando um instrumento de afirmação dos valores prometeicos, se opõe à droga, associada à dissociação destes valores por meio da manifestação dionisíaca. / The idea that drugs and sports go in opposite directions seems to be common sense in Brazilian society: the sport is associated with health, citizenship and freedom, the degradation of drugs, violence and addiction. The relationship between sports and drugs is summarized in this sense, in a Manichean attitude that seems to result from the observation of these two separate phenomena and not the actual relationship between them. Despite the extensive literature relating to issues of drugs and sports, was seen as lifting the relevant literature, a lack of research that address the use of sport as a means of prevention and reduction of drug consumption. The objective of this research was to analyze the fundamentals of speech for the sport as a means of combating and preventing the use of drugs. Thus, we analyzed the following documents: the National Sports Policy, National Policy on Drugs; Brazilian Charter on the Prevention Integrated Area Health Education Physics in Perspective. The methodology used was the analysis of discourse advocated by Orlandi (2001). The interpretation of the data held on the grounds of the interdisciplinary field of social imaginary. The survey results showed that the relationship between sport and drug substance of a conflict between the forces and attitudes dionysiac promised. So that the sport, an instrument of affirmation of the values promised, as opposed to drugs, associated with the dissociation of these values through the dionysiac expression.