Web Information Extraction (WIE) is the discipline dealing with the discovery, processing and extraction of specific pieces of information from semi-structured or unstructured web pages. The World Wide Web comprises billions of web pages and there is much need for systems that will locate, extract and integrate the acquired knowledge into organisations practices. There are some commercial, automated web extraction software packages, however their success comes from heavily involving their users in the process of finding the relevant web pages, preparing the system to recognise items of interest on these pages and manually dealing with the evaluation and storage of the extracted results. This research has explored WIE, specifically with regard to the automation of the extraction and validation of online training information. The work also includes research and development in the area of automated Web Information Retrieval (WIR), more specifically in Web Searching (or Crawling) and Web Classification. Different technologies were considered, however after much consideration, Naïve Bayes Networks were chosen as the most suitable for the development of the classification system. The extraction part of the system used Genetic Programming (GP) for the generation of web extraction solutions. Specifically, GP was used to evolve Regular Expressions, which were then used to extract specific training course information from the web such as: course names, prices, dates and locations. The experimental results indicate that all three aspects of this research perform very well, with the Web Crawler outperforming existing crawling systems, the Web Classifier performing with an accuracy of over 95% and a precision of over 98%, and the Web Extractor achieving an accuracy of over 94% for the extraction of course titles and an accuracy of just under 67% for the extraction of other course attributes such as dates, prices and locations. Furthermore, the overall work is of great significance to the sponsoring company, as it simplifies and improves the existing time-consuming, labour-intensive and error-prone manual techniques, as will be discussed in this thesis. The prototype developed in this research works in the background and requires very little, often no, human assistance.

This diploma thesis The issues of juvenile criminal justice focuses on the area of juvenile criminal law which is a specific area of criminal law due to a necessity of a particular attitude towards youth. The legal regulation of the juvenile criminal law is incorporated particularly in ActNo. 218/2003 Coll. on the Responsibility of Juveniles for illegal Acts and on the Justice of Youth. Within the theme, the work seeks to capture especially the deviations that are special for the juvenile criminal law as opposed to the criminal law of adult offenders and to present a comprehensive overview of criminal justice over youth. The most extensive part of the thesis deals with the juvenile proceedings, attention is also paid to the substantive aspects of the juvenile criminal law and a considerable part discusses the proceedings in the affairs of children under fifteen. The introductory chapter defines the basic concepts as applied by the Act on the Justice of Youth, especiallyterminologically definesthose that are subject to special treatment. The following two chapters give an overview of the criminological aspects of juvenile delinquency and also outline the development of the legal regulation of juvenile justice in the Czech lands and present the form of the current legal regulation including its...

This thesis deals with the subject of keeping and using animals in primary schools. The theoretical part of this thesis reviews various scientific studies into the impact of animals on pupils during education and the possible benefits of animal breeding in schools. Furthermore, the conditions for safe breeding and the most frequently kept animals in schools are discussed as well as the risks and difficulties that their breeding and daily maintenance brings. Moreover, it discusses the need to evaluate the welfare of school animals and legislative precautions on the subject in the Czech Republic. The practical part of this thesis details investigations into the number of Prague primary schools where animals were kept in the school year 2017/2018. Through interviewing a representative sample of schools, it was found that 37 % of Prague's primary schools kept an animal. Furthermore, the different species of animals kept in the schools, their location within the schools, the person bearing responsibility for the animals and the usage and the frequency of it within the curriculum were studied. It was found that 52 % of teachers do not use the school animal more often than once a month. Another subject of the research was to find out the reasons for the absence of animals in schools; 92 % of respondents...

Title: Migration of Czech ice hockey players to North America. Objectives: The main objective of this diploma thesis is to evaluate the current development of migration of Czech ice hockey players to North American highest competition - NHL since 1990. The sub-objective of this thesis is to investigate migration factors, then to describe historical developments within migration and to compare with other ice hockey powers. Further analysing the influence of Czech ice hockey players on the performance of teams in North American competitions, as well as introducing leagues themselves. Methods: This thesis used qualitative research which abnormally consists of a questionnaire survey and precedes quantitative research, which includes deskresearch, a method which is also referred to as secondary data analysis, data are mainly drawn from the outputs of mass media and virtual data for this work. Next method of comparison and correlation analysis. Hereinafter the comparation method and correlation analysis are used. Results: This study reveals the importance of focusing on the experiences of the migrants themselves as well as on the factors related to migration. They exist not only in professional field, but also in personal life. All this affects the overall adaptation process. The most motivating factor...

The conditioning preparation of a modern player in top football is an essential part for his excellent sporting performance. The theoretical part of the thesis is focused on conditioning preparation of the player in football, his motor skills and abilities. The thesis focuses in detail on very important skills in this sport, such as speed and speed endurance. The practical part will deal with collecting the speed data of the football player. These data will be processed in both factual and statistical terms. The aim of the research will be the evaluation of the measured data. The results will be compared between the autumn and spring parts of the league, depending on the player's performance. Player data will also be compared with another player on the same position. The conclusion of the thesis is to point out that speed is often a decisive factor in many football situations, and to confirm that while improving the speed abilities, the performance of the player will also increase parallelly.

L'endothélium vasculaire est la première couche de cellules en contact avec le flux sanguin. Au cours de processus pathologiques, les cellules endothéliales subissent des remaniements notoires dus à la présence de nombreux facteurs. Dans ce cas, l'intégrité de l'endothélium, assurée principalement par les jonctions adhérentes endothéliales dont la V(ascular)E(ndothelial)-cadhérine est la protéine clé, est perturbée. La phospho-VE-cadhérine est une caractéristique des cellules endothéliales activées in vitro. Notre laboratoire a montré l'existence d'une forme phosphorylée de VE-cadhérine in vivo au cours de l'angiogenèse physiologique. Des tyrosines importantes ont été identifiées : la tyrosine 685, qui est la cible directe de la tyrosine kinase Src en réponse au VEGF ainsi que les tyrosines 658 et 731. De plus, la VE-cadhérine peut être sensible à la protéolyse. Dans ce travail, la phosphorylation de la VE-cadhérine a été étudiée dans un contexte pathologique d'inflammation et de cancer à l'aide de deux modèles murins de tumeurs hépatiques ou cérébrales. J'ai démontré l'existence in vivo d'une forme phosphorylée de VE-cadhérine sur le site Y658. L'analyse d'une tyrosine kinase particulière, Syk, par si RNA ainsi que par des expériences de phosphorylation in vitro suggèrent fortement l'implication de SYK dans cette phosphorylation. En parallèle, dans le cadre d'une étude sur plusieurs pathologies, nous avons mis en évidence la présence d'une forme circulante de VE-cadhérine. La VE-cadhérine, tant par sa phosphorylation que par sa présence dans les fluides biologiques, pourrait être une signature de l'endothélium activé (phosphorylation) et/ou agressé (protéolyse).

Alors qu’à la fin du Ve siècle s’effaçait le pouvoir impérial de Rome sur l’ensemble de ses territoires occidentaux, le pouvoir en Gaule se retrouva entre les mains de deux groupes de dirigeants : il y avait, d’une part, les évêques, issus pour la plupart de la classe aristocratique gallo-romaine, qui s’étaient donné comme mission de maintenir la romanité et la foi catholique vivantes dans les cités dont ils étaient les véritables chefs, et, d’autre part, les rois d’origine germanique qui occupaient différents royaumes, taillés à même les territoires cédés par Rome quelques décennies auparavant. Supporté par l’épiscopat, le règne de Clovis, roi d’origine franque et fondateur de la première dynastie catholique en Gaule, s’imposa à ce moment critique de l’histoire gallo-romaine. Malheureusement, les sources écrites qui décrivent l’avènement et la postérité du règne sont rares. Ce travail s’attachera à présenter les lettres qui établirent les fondements du royaume franc ainsi que la première œuvre qui, plusieurs années après la mort de Clovis, fit état de sa carrière afin de constater dans quelle mesure et dans quelles circonstances les évêques qui les écrivirent purent influencer la foi et la politique du roi franc.

The purpose of this thesis is to describe and explain the influence of the Practical and Applied Arts on randomly selected comprehensive high school students. The research examined the history of the Practical and Applied Arts, the reasons for students taking the courses, the state of Practical and Applied Arts in Saskatchewan,the future of Practical and Applied Arts, the need for more research, and the effect the courses had on graduates career and education choices (over the ten-year period immediately following high school graduation). <p>Data were collected by an online questionnaire and analyzed using descriptive statistics. The data were analyzed by the researcher. A seven member interpretation panel purposely chosen to represent four different profiles was used to interpret and provide meaning to the data.

La fonction de barrière de l'endothélium vasculaire est affectée par des modifications de la cadhérine des cellules endothéliales (VE-cadhérine) telles que la phosphorylation sur tyrosine dans son domaine cytoplasmique et le clivage de son domaine extracellulaire (sVE). Ce travail s'est articulé en deux parties : 1- Etude de ces modifications dans le contexte de la polyarthrite rhumatoïde (PR), et les mécanismes sous-tendus. Ce travail a permis de montrer que la VE-cadhérine est une cible du TNFα, une cytokine essentielle dans la PR, qui induit de la libération de sVE de façon dépendante de l'activité kinase de Src, suggérant l'implication d'un mécanisme de phosphorylation sur tyrosine dans ce processus. De plus, la VE-cadhérine est aussi la cible des protéases de la matrice extracellulaire telles que MMP-2. L'application de ces données fondamentales à la clinique a permis de montrer que sVE était retrouvée dans le sang de patients PR (n=63) et que son taux était corrélé à l'activité de la maladie. Ainsi, le dosage de sVE est d'intérêt dans la prise en charge des patients. 2-Etude de la phosphorylation de la VE-cadhérine dans un contexte d'angiogenèse hormono-régulée au cours du cycle ovarien chez la souris. Les résultats ont montré que le site Y685 de la VE-cadhérine est phosphorylé dans l'ovaire et l'utérus de souris de façon régulée pendant le cycle, ce qui permet de proposer ce modèle physiologique pour étudier la phosphorylation de la VE-cadhérine in vivo. L'analyse de souris knock-in Y685F de la VE-cadhérine (VE-Y685F) a montré que l'absence du site confère une perméabilité accrue dans l'ovaire et l'utérus mais aussi dans les petits capillaires de la peau. De plus, dans deux modèles d'induction d'arthrite, les souris VE-Y685F ont présenté un taux de sVE plus élevé que les contrôles. Au total, sVE et la phosphorylation de la VE-cadhérine ont un vaste champ d'application dans le traitement de la PR ainsi que pour le développement de nouvelles thérapies pouvant s'étendre à d'autres pathologies vasculaires.

The purpose of this thesis is to describe and explain the influence of the Practical and Applied Arts on randomly selected comprehensive high school students. The research examined the history of the Practical and Applied Arts, the reasons for students taking the courses, the state of Practical and Applied Arts in Saskatchewan,the future of Practical and Applied Arts, the need for more research, and the effect the courses had on graduates career and education choices (over the ten-year period immediately following high school graduation). <p>Data were collected by an online questionnaire and analyzed using descriptive statistics. The data were analyzed by the researcher. A seven member interpretation panel purposely chosen to represent four different profiles was used to interpret and provide meaning to the data.