Final publication is available at http://onlinelibrary.wiley.com/doi/10.1002/term.2060/abstract;jsessionid=F0849D98381EEF9E83401A02B9042F4D.f04t02 / 京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第19602号 / 医博第4109号 / 新制||医||1014(附属図書館) / 32638 / 京都大学大学院医学研究科医学専攻 / (主査)教授 別所 和久, 教授 伊佐 正, 教授 川口 義弥 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13051号 / 論医博第2117号 / 新制||医||1017(附属図書館) / 33141 / (主査)教授 別所 和久, 教授 椛島 健治, 教授 開 祐司 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20807号 / 医博第4307号 / 新制||医||1025(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 椛島 健治, 教授 瀬原 淳子, 教授 上杉 志成 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

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The inflammatory response mounted following Myocardial Infarction (MI) is closely coupled to myocardial wound healing. Recent reports have identified a consortium of T-regulatory cells (Tregs) that contain tissue specific regulatory signatures that modulate the homeostasis of the peripheral tissues they populate during times of challenge, with one of these populations occupying the heart following ischemic injury. Unfortunately, the identification of therapeutic modulators that can harness the expansion or preservation of tissue specific Tregs have yet to be identified. Cortical Bone Derived Stem Cells (CBSCs) can engraft in the MI heart long enough to modulate the inflammatory microenvironment of the infarcted heart, making CBSCs an ideal therapeutic to modulate Treg localization and function. Intramyocardial injection of CBSCs into the MI heart expanded pro-reparative TNFRII+ Treg residence in the MI heart during acute (1 week) and chronic (8 weeks) stages of ischemic injury. This pro-reparative Treg cell signature was also observed systemically in the splenic tissue. The ablation of Tregs in a FoxP3DTR transgenic animals model via diphtheria toxin administration or the administration of FTY720 to block Treg localization to the MI heart solicited infarct size expansion and compromised cardiac function. Paracrine profiling of CBSC secretome identified that CBSCs are enrichened in Osteoprotegrin (OPG), a TNFR decoy receptor. The depletion of OPG from CBSC secretome can compromised TNFRII Treg induction (in vitro) and localization in the ischemic heart following MI. CBSCs directly modulate post-MI cardiac inflammation via the direct modulation of Treg phenotype during acute and chronic stages of ischemic injury. / Cell Biology

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Syftet med denna studie var att klargöra eventuellt samband mellan nutrition och trycksår genom att söka svar på de tre frågorna: Har nutritionen någon betydelse för uppkomst och läkning av trycksår? Vilka näringsämnen behövs för att förhind-ra uppkomsten och främja läkningen av trycksår? Finns de något samband mellan malnutrition och/eller ätsvårigheter och trycksår? Metoden för denna litteraturstu-die innefattade systematisk databassökning och manuell sökning av artiklar från referenslistor. Tio vetenskapliga artiklar med kvantitativ forskning i ämnet har analyserats och sammanställts. Resultatet presenteras i följande fyra tema: Nutri-tionens betydelse, energiintagets betydelse, vitaminers och mineralers betydelse samt bifynd. Analysen indikerar på samband mellan förbättrad nutrition och både minskad incidens och förbättrad läkning av trycksår. / The purpuse of this study is to elucidate the relationship between nutrition and pressure ulcer by seeking the answers to the following three questions: Does nutri-tion have any implication on the appearance and healing of pressure ulcers? What nutrients are needed to prevent appearance and promote healing of pressure ul-cers? Is there a connection between malnutrition and/or eating-difficulties and pressure ulcers? The method for this literature review consisted of a systematic searches in databases and searching through references. Ten scientific quantitative research articles in this subject have been analysed and concluded. The result is presented in four themes: The significance of nutrition, the significance of energy intake, the significance of vitamins and minerals and sub findings. The result of this analysis shows a connection between improved nutritional status and both lower incidence and improved healing of pressure ulcers.