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The origins and heterogeneity of adipose tissue : investigating the role of the Wilms' tumour 1 (Wt1) geneCleal, Louise Kathleen January 2018 (has links)
Largely as a consequence of the ongoing obesity epidemic, research into adipose tissue biology has increased substantially in recent years. Worldwide, the number of people classed as overweight or obese is growing, and this represents a major public health concern. Adipose tissue is broadly divided into two types; white and brown. Whilst white adipose tissue (WAT) functions to store and mobilise triglycerides, brown adipose tissue burns chemical energy to generate heat. WAT is further divided into visceral “bad” fat and subcutaneous “good” fat depots, and it is an increase in the former that is linked to obesity-associated diseases. As well as adipocytes, several other cell types including haematopoietic and endothelial are found within adipose tissue, and comprise the stromal vascular fraction (SVF). Adipocyte precursor cells (APCs) also reside within the SVF and are essential for the maintenance and expansion of adipose tissue. The protein encoded by the Wilms’ tumour 1 (Wt1) gene is predominantly known to function as a transcription factor, but also has a role in post-transcriptional processing. Deletion of Wt1 in adult mice results in a considerable loss of fat tissue. Moreover, recent work has revealed that a proportion of the APCs from all visceral WAT depots express Wt1, therefore revealing heterogeneity within the APC population. Additionally, visceral WAT depots are encapsulated by a WT1 expressing mesothelial layer, which has its origins in the lateral plate mesoderm (LPM), and can give rise to mature adipocytes. Lineage tracing has demonstrated that a significant proportion of the mature adipocytes in all adult visceral WAT depots (but not subcutaneous) are derived from cells that express Wt1 in late gestation. These findings uncovered key ontogenetic differences between visceral and subcutaneous WAT and led us to ask whether Wt1 functions in visceral adipose tissue biology. Preliminary work has shown that adipocytes derived from Wt1 expressing (Wt1+) precursor cells have fewer, larger lipid droplets than those derived from non-Wt1 expressing (Wt1-) precursors. In this thesis, this heterogeneity is explored further using a Wt1GFP/+ knock-in mouse. When Wt1+ and Wt1- APCs are cultured separately, the Wt1+ population differentiate into adipocytes more readily. Moreover, the Wt1+ APCs are more proliferative than the Wt1-. Preliminary results also suggest that the Wt1+ APCs may secrete a factor(s) that causes the Wt1- APCs to exhibit improved adipogenic differentiation, a result that is supported by data from comparative transcriptomic analysis. Finally, the percentage of APCs decreases when mice are fed a high fat diet. Interestingly, this decrease is more pronounced for the Wt1+ population. Therefore, it appears that as well as exhibiting differing behaviours in vitro, the Wt1+ and Wt1- populations respond differently to physiologically relevant conditions in vivo. Whilst the LPM is a major source of visceral WAT, the origin of subcutaneous WAT is currently unknown. Here, the Prx1-Cre and Prx1-CreERT2 mouse lines are used to investigate this. It is shown that the majority of subcutaneous WAT adipocytes and APCs are labelled by Prx1-Cre, however this is not the case for most of the visceral WAT depots. The exception to this is the pericardial (heart fat) depot, in which approximately 70% of the adipocytes and 40% of the APCs are labelled. Moreover, a proportion of the Prx1-Cre labelled pericardial APCs also express Wt1, therefore suggesting additional heterogeneity. Preliminary results show that this heterogeneity may have functional consequences, at least in vitro. Additionally, lineage tracing studies suggest that the somatic LPM may be one source of subcutaneous WAT and pericardial visceral WAT Finally, it is shown that the conditional deletion of Wt1 in the Prx1-Cre lineage results in abnormal diaphragm development. Congenital diaphragmatic hernia (CDH) is severe birth defect, the etiology of which is not well understood. Here, a new model of CDH has been developed, and the cellular and molecular mechanisms responsible for the defect in this model are investigated.
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Factors influencing tax evasionVenter, Jan Herculaas 06 March 2012 (has links)
Taxation and tax evasion is an observable fact that occurs in all societies. In South Africa, tax evasion is one of the most sinister forms of crime and millions of rands are sidetracked by tax criminals. Studies from various countries indicate that it is not unusual for about half of the possible tax revenues to remain uncollected. Tax evasion is not something that is restricted to poor third world countries, it is a global phenomenon that has been there from the time tax was invented and will in all likelihood be with us until the end of time. Tax evasion is an intricate and overall hidden behaviour, but it has significant social and economic consequences. Taking this into consideration almost anything could influence the taxpayer’s decision to evade tax or not. The decision to comply with tax laws or to evade tax depends on various internal and external factors with regard to the taxpayer and this may differ from person to person. This study discusses the various factors influencing the taxpayer’s decision to comply with tax legislation, and whether these factors differ or correlate in developed and developing countries. Firstly, the factors influencing tax evasion in the United States of America and Switzerland were determined, after which the factors influencing tax evasion in South Africa and Brazil were determined. Secondly, the factors in the developed countries were compared to those in developing countries. Lastly these comparisons were analysed and they determined whether there were any major differences between the factors influencing tax evasion in developed and developing countries. AFRIKAANS : Belasting en belastingontduiking is ‘n waarneembare feit wat in alle samelewings voorkom. Belastingontduiking is een van die mees ernstige vorme van misdaad in Suid-Afrika en miljoene rande word deur belastingontduikers gesteel. Studies vanuit verskillende lande dui daarop dat dit nie ongewoon is dat omtrent die helfte van die moontlike belasting- inkomste nie ingevorder word nie. Belastingontduiking is nie beperk tot arm derdewêreldlande nie, dit is 'n wêreldwye verskynsel, en was daar van die tyd dat belasting uitgevind is en sal in alle waarskynlikheid met ons wees tot aan die einde van tyd. Belastingontduiking is 'n ingewikkelde en grootliks verborge gedrag, maar dit het belangrike sosiale en ekonomiese gevolge. Met dit ingedagte kan byna enigiets die belastingbetaler se besluit beïnvloed om belasting te ontduik of nie. Die besluit om aan belastingwetgewing te voldoen of om belasting te ontduik hang af van verskeie interne en eksterne faktore met betrekking tot die belastingbetaler en verskil waarskynlik van persoon tot persoon. Hierdie studie bespreek die verskillende faktore wat die belastingbetaler se besluit om aan belastingwetgewing te voldoen beïnvloed, en of hierdie faktore verskil of korreleer tussen ontwikkelde en ontwikkelende lande. Eerstens was die doel van die studie om die faktore wat belastingontduiking in die Verenigde State van Amerika en Switserland beïnvloed te bepaal, gevolg deur die bepaling van die faktore wat belastingontduiking in Suid-Afrika en Brasilië beïnvloed. Tweedens is die faktore in ontwikkelde lande met dié in ontwikkelende lande vergelyk. Laastens is hierdie vergelykings ontleed om te bepaal of daar groot verskille is tussen die faktore wat belastingontduiking beïnvloed in ontwikkelde lande in vergelyking met ontwikkelende lande. Copyright 2011, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria. Please cite as follows: Venter, JH 2011, Factors influencing tax evasion, MCom dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-03062012-153138 / > F12/4/149/gm / Dissertation (MCom)--University of Pretoria, 2012. / Taxation / unrestricted
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Understanding the Antecedents of Perceived Authenticity to Predict Cultural Tourists’ Behavioral Intention: The Case of Cambodia’s Angkor WatHong, Ellen 10 September 2021 (has links)
No description available.
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Bilirubin is a Metabolic Hormone that Improves Lipid MetabolismGordon, Darren Mikael January 2020 (has links)
No description available.
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Exploring the link between adipose tissue, obesity and age-related macular degenerationDiaz Marin, Roberto 08 1900 (has links)
L’obésité est en croissance rapide à l’échelle mondiale et représente un facteur de risque important pour plusieurs pathologies, dont la dégénérescence maculaire liée à l’âge (DMLA). Dans l’obésité, le tissu adipeux blanc (WAT) subi un remodelage pathologique caractérisé par le recrutement de macrophages pro-inflammatoires facilitant l’établissement de l’inflammation stérile systémique. Contrairement au WAT, les tissus adipeux brun (BAT) et beige (BgAT) participent à la thermogénèse, un processus qui libère de la chaleur en métabolisant les lipides. En raison de leurs potentiels effets physiologiques bénéfiques, le recrutement d’adipocytes et l’activation de ces types spécifiques de tissu adipeux (AT) ont fait l’objet de multiples recherches et débats. Malgré les avancées considérables dans le domaine, les mécanismes impliqués dans l’activation du BAT et du BgAT ainsi que les mécanismes impliqués dans le développement de l’obésité et leur contribution à des maladies comme la DMLA, restent mal définis.
Dans un premier temps, nous avons développé le protocole RELi pour permettre une extraction et une quantification fiable des protéines du AT murin saturé en lipides. Notre protocole élimine les lipides contaminants en excès, réduit la variabilité du chargement de protéines pour le western blot et l’usage de gènes de ménage standards (Article #1). Ensuite, nous avons étudié l’inflammation au niveau du BAT dans un modèle d’obésité induite par l’alimentation. La délétion de la Neuropiline 1 (NRP1) chez les macrophages résidents du tissu adipeux (ATMs) a provoqué une diminution des densités de la vasculature et de l’innervation. De plus ces souris sont devenues plus sensibles à l’exposition au froid suggérant un rôle des ATMs-Nrp1+ dans la régulation de l’homéostasie du BAT et de la température corporelle (Article #2). Finalement, nous avons exploré l’axe BgAT-DMLA; plus spécifiquement son impact potentiel sur la néovascularization choroïdienne (CNV) en utilisant des approches in vivo et in vitro. Nous avons démontré que la délétion génétique de PRD1-BF1-RIZ1 homologous domain containing 16 (PRDM16), un gène impliqué dans la thermogénèse, conduit à une réduction de la CNV, et que la réintroduction d’AT-PRDM16+ exacerbe la formation de CNV pathologique. Le traitement d’explants de choroïde avec du milieu conditionné par des adipocytes-PRDM16+ augmente la croissance des vaisseaux sanguins. Ensemble, les données suggèrent un rôle sécrétoire potentiel pour le BgAT-PRDM16+ capable d’influencer la formation distale de CNV qui pourrait être pertinente pour la DMLA (Article #3).
Les travaux présentés dans cette thèse établissent les bases d’un protocole permettant l’obtention de résultats reproductibles dans l’étude du AT, soulignent l’importance des ATMs- Nrp1+ dans la régulation de l’homéostasie du BAT et explorent pour la première fois l’implication du BgAT-PRDM16+ chez la DMLA neovasculaire. Ce travail établit les bases de la compréhension des mécanismes moléculaires reliant la régulation du AT thermogénique et les pathologies caractérisées par un excès de gras. Ce travail souligne également l’importance d’évaluer l’activation du BgAT chez les patients atteints de la DMLA. / Obesity is rapidly growing worldwide and represents a significant risk factor to several pathologies, including age-related macular degeneration (AMD). In obesity, the white adipose tissue (WAT) undergoes a strong remodeling characterized by the recruitment of pro- inflammatory macrophages, facilitating low-grade chronic inflammation. Unlike WAT, brown (BAT) and beige (BgAT) adipose tissues participate in thermogenesis, a process that releases heat by metabolizing lipids. Due to the likely beneficial physiological effects of BAT and BgAT, the recruitment of adipocytes and activation of these specific types of adipose tissue (AT) has been the subject of much research and debate. Despite considerable advances in the field, the mechanisms involved in BAT- and BgAT-activation as well as mechanisms involved in the development of obesity and their contribution to diseases such as AMD, remain ill-defined.
First, we developed the RELi protocol to allow a reliable extraction and quantification of proteins from murine AT saturated with lipids. Our protocol eliminates excess contaminating lipids, reduces the variability of protein loading in Western blot and stabilizes expression of housekeeping genes (Article #1). Next, we investigated the inflammatory component of BAT in a diet-induced obesity model. The deletion of NRP1 in resident adipose tissue macrophages (ATMs) led to the expansion of the BAT and affected the densities of the vasculature and the innervation. Moreover, these mice became more sensitive to cold exposure, suggesting a role of ATMs-Nrp1+ in the regulation of BAT homeostasis and body temperature (Article #2). Lastly, we explored the axis of BgAT and AMD; more specifically, its potential impact on choroidal neovascularization (CNV) using in vivo and in vitro approaches. We demonstrated that the genetic deletion in BgAT of PRD1-BF1-RIZ1 homologous domain containing 16 (PRDM16), a gene involved in thermogenesis, leads to a reduction of CNV, and that the reintroduction of BgAT-PRDM16+ via AT transplantation exacerbates the formation of pathological CNV. Treatment of choroid explants with PRDM16+-adipocyte-conditioned medium augmented blood vessel growth. Altogether, the data suggest a potential secretory role for BgAT-PRDM16+ to influence distal CNV formation that could be relevant to AMD (Article #3).
The work presented in this thesis establishes the basis of a protocol allowing reproducible results in the study of AT, underlines the importance of ATMs-Nrp1+ in the regulation of BAT homeostasis and explores, for the first time, the involvement of BgAT-PRDM16+ in neovascular AMD. This work sets the basis for the understanding of the molecular mechanisms linking the regulation of thermogenic AT and pathologies characterized by an excess of fat. This work also highlights the importance of assessing the activation of BgAT in patients with AMD.
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The relationship between maternal employment and teenage character traits / Erasmus N.Erasmus, Natasja January 2011 (has links)
The purpose of the study is to determine the relationship between maternal employment and teenage character traits.
Statistics show a significant increase in women entering the labour market and although demographics are changing rapidly, social attitudes and policies may lag behind, and the concept of mothers as principal caretakers and fathers as economic providers remains very much in place. The profound and sometimes contradictory convictions of individual members about working mothers and their children paralleled those of countless others and professional people where matched only by the equally profound lack of facts on which these convictions might be based.
The objective of the study is to measure the perceived character traits of teenage children in terms of self confidence, locus of control, independence, time management and ambition. The questions were measured within two different scenarios: the first, within households where both parents are employed, and the second, within households where only the father is employed. The aim of the study is to determine if there is any correlation between maternal employment and the presence or lack of presence of the specified character traits.
The empirical study was conducted using the quantitative research method with a non–probability sample. The data collection method used for the purpose of this study was in the form of questionnaires, based on the Likert scale. The content validity of the questionnaire was evaluated by a subject matter expert, while the face validity was determined by the Statistical Consultation Services of the North West University. Analysis of completed questionnaires involved descriptive statistics and practical significance.
The target population, high school teachers within the North West and Gauteng Province, consisted of 70 participants.
Based on the findings emanating from the research, there were no noticeable difference found between teenagers within households where both parents are employed and households where only the father is employed, although the results indicated a tendency for children within households where both parents are employed to be slightly more self confident, lean more towards an internal lotus of control, have higher ambition and are less dependent than those teenagers from households where only the father is employed. These findings, although not noticeable, agree with the literature.
There were limitations that had an impact on the results of this study. The limited population resulted in a small sample. The sample indicated that 41 percent have five years or less experience. Participants indicated that they are not always aware of the household dynamics. Additional limitations include the strict ethical roadblocks when conducting research on children.
It was recommended that a more comprehensive study should follow, which should include the participation of mothers and teenagers alike. This will give the researcher a distinct and clear result of what the influences could be within the household dynamics. / Thesis (M.B.A.)--North-West University, Potchefstroom Campus, 2012.
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The relationship between maternal employment and teenage character traits / Erasmus N.Erasmus, Natasja January 2011 (has links)
The purpose of the study is to determine the relationship between maternal employment and teenage character traits.
Statistics show a significant increase in women entering the labour market and although demographics are changing rapidly, social attitudes and policies may lag behind, and the concept of mothers as principal caretakers and fathers as economic providers remains very much in place. The profound and sometimes contradictory convictions of individual members about working mothers and their children paralleled those of countless others and professional people where matched only by the equally profound lack of facts on which these convictions might be based.
The objective of the study is to measure the perceived character traits of teenage children in terms of self confidence, locus of control, independence, time management and ambition. The questions were measured within two different scenarios: the first, within households where both parents are employed, and the second, within households where only the father is employed. The aim of the study is to determine if there is any correlation between maternal employment and the presence or lack of presence of the specified character traits.
The empirical study was conducted using the quantitative research method with a non–probability sample. The data collection method used for the purpose of this study was in the form of questionnaires, based on the Likert scale. The content validity of the questionnaire was evaluated by a subject matter expert, while the face validity was determined by the Statistical Consultation Services of the North West University. Analysis of completed questionnaires involved descriptive statistics and practical significance.
The target population, high school teachers within the North West and Gauteng Province, consisted of 70 participants.
Based on the findings emanating from the research, there were no noticeable difference found between teenagers within households where both parents are employed and households where only the father is employed, although the results indicated a tendency for children within households where both parents are employed to be slightly more self confident, lean more towards an internal lotus of control, have higher ambition and are less dependent than those teenagers from households where only the father is employed. These findings, although not noticeable, agree with the literature.
There were limitations that had an impact on the results of this study. The limited population resulted in a small sample. The sample indicated that 41 percent have five years or less experience. Participants indicated that they are not always aware of the household dynamics. Additional limitations include the strict ethical roadblocks when conducting research on children.
It was recommended that a more comprehensive study should follow, which should include the participation of mothers and teenagers alike. This will give the researcher a distinct and clear result of what the influences could be within the household dynamics. / Thesis (M.B.A.)--North-West University, Potchefstroom Campus, 2012.
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Die tonale aspekte in die toonreekse van Dallapiccola se seriele komposisies (Afrikaans)Snibbe, Chantal 15 July 2004 (has links)
The technique of twelve-tone serialism was developed by Schoenberg to give structure to atonal compositions. The writer was interested in the fact that Dallapiccola’s twelve-tone compositions, as with Berg’s, were easier received by the general public than the works of other serial composers of the time. The reason being that his twelve-tone rows contain tonal elements. The boundaries of the field of study were determined in chapter 1. Terminology and problems encountered with the study were also discussed. To be able to analyse the tonal aspects of Dallapiccola’s rows, the basic outlines of tonality were clearly defined in chapter 2. It was found that tonal suggestions could be achieved by means of using: * tones that form part of a diatonic scale, * explicit triads, * implicit triads, * scale constructions and * tones that outline the tonic. The different types of twelve-tone rows were discussed and illustrated by means of music examples in chapter 3. A list of published works as well as a short discussion of each composition followed in chapter 4. Mention was made whether a work was tonal, atonal or a twelve-tone composition and Dallapiccola’s use of serial procedures in each composition was discussed. Chapter 5 showed where and how the above criteria were used in his rows. The study thus provides evidence that Dallapiccola had tonal references in mind when planning the rows and that tonal suggestions are common in his works. The twelve-tone rows often employ three, four or five of the criteria of implied tonality in a composition. Of the five criteria, tones that form part of a diatonic scale was used the most. This was discussed with all the rows, except Il prigioniero (row of hope) and Cinque frammenti di Saffo’s first and second tone rows. Dallapiccola used tones to outline the tonic in thirty one twelve-tone rows. Implicit triads were used in all but six works. Scale constructions appeared in nineteen works and Dallapiccola’s love for using a few chromatic notes or three consecutive notes of the implied major scale became apparent. Explicit triads only appeared in thirteen compositions. In the other rows, Dallapiccola created a tonal sense by means of other criteria or had a more chromatic approach. Dallapiccola thus used tonal references in the tone rows of his serial compositions and showed that twelve-tone tonality could be used to create a lyrical idiom. In this way the people that were trained in the tonal school could also appreciate twelve-tone compositions. In the opera Il prigioniero, it is especially evident that the Italian tradition of lyricism and dramatic intensity do exist after verismo composers (Morris 1999:257). / Dissertation (MMus(Performing Art))--University of Pretoria, 2005. / Music / unrestricted
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Situation analysis of perceptions on comprehensiveness of rape prevention interventions by implementing agencies in Addis AbabaDifabachew Setegn Hailegeorgis 02 1900 (has links)
Abstract in English, Xhosa and Afrikaans / The victimization of women and children represents one of the public health problems deserving urgent attention in Ethiopia, making the prevention of rape in all its forms a matter of vital importance.
The purpose of the study was mainly to describe the extent of rape prevention interventions in Addis Ababa and examine efforts to assist rape survivors based on the perceptions of professionals working for organizations operating in this context. The study had a further purpose of identifying difficulties faced by government institutions and making suitable recommendations for the improvement of rape prevention interventions and programs in the future.
A qualitative descriptive research approach was adopted mainly involving in-depth interviews for primary data collection. The study involved 14 research participants purposively selected from five government institutions.
The study findings indicated Gandhi Memorial Hospital to be the only institution in Ethiopia implementing an integrated rape prevention intervention. Efforts were directed largely at secondary prevention, with little attention being paid to primary prevention. Recommendations included tackling the multiple factors influencing rape at different levels of the social-ecological model simultaneously through the implementation, strengthening, and intensification of well-designed, comprehensive rape prevention interventions and programs. / Ukuxhatshazwa kwabafazi nabantwana e-Ethiopia kufana nenye yeengxaki zempilo kwaye kudinga ukuthathelwa ingqalelo ngokungxamisekileyo. Oku kwenza ukuba ukuthintela ukudlwengulwa ngazo zonke iindlela kube ngumbandela obaluleke kakhulu.
Injongo yesi sifundo ibikukucacisa iindlela zokuthintela ukudlwengulwa eAddis Ababa, nokuvavanya imizamo yokunceda abo bakhe badlwengulwa, ngokokubona kwabo basebenzela amaqumrhu aququzelela lo msebenzi. Enye injongo yesi sifundo ibikukuchonga ubunzima obufunyanwa ngamaziko aseburhulumenteni ajongene neli candelo ukuze kunikwe iingcebiso zokuphucula amacebo neenkqubo zokuthintela ukudlwengulwa.
Kuqhutywe uhlobo lophando lomgangatho nolucacisayo, apho kuqokelelwe iinkcukacha zolwazi ngokwenza udliwano ndlebe olunzulu. Kusetyenzwe nabathathi nxaxheba abali-14 abakhethwe ngobuchule kumaziko aseburhulumenteni ama-5.
Okufunyaniswe sesi sifundo kubonakalise ukuba isibhedlele esiyiGandhi Memorial siso sodwa esinenkqubo elungelelaniswe kakuhle yokuthintela ukudlwengulwa. Imigudu yokhukhusela ijoliswe ekuncedeni kwiziqhamo zodlwengulo nasekufundiseni ngodlwengulo (secondary prevention) hayi kudlwengulo ngqo (primary prevention). Amacebiso esifundo aquka ukulwa neemeko eziphembelela udlwengulo olwenzeka kumazinga ahlukeneyo oluntu, ngaxeshanye nokuqinisa ukusetyenziswa kweenkqubo eziqulunqwe kakuhle zokuthintela udlwengulo. / Die viktimisering van vroue en kinders is een van talle kwessies in die openbare gesondheid van Ethiopië wat dringend aandag vereis, aangesien die voorkoming van verkragting in enige vorm van die allergrootste belang is.
Die doel van hierdie studie was om die omvang te bepaal van intervensies om verkragting in Addis Abeba te voorkom, en om die hulp wat aan verkragtingslagoffers verleen word, te ondersoek op grond van die belewenisse van beroepslui wat in hierdie verband vir organisasies werk. Hierdie studie het dit verder ten doel gehad om die probleme aan te toon waarmee staatsinstellings in hierdie opsig te kampe het, en om beter intervensies en programme vir die voorkoming van verkragting aan te beveel.
ʼn Kwalitatiewe en deskriptiewe navorsingsbenadering is gevolg. Dit het omvattende onderhoude behels waartydens primêre data versamel is. Altesame 14 deelnemers by vyf staatsinstellings is vir hierdie doel gekies.
Volgens die bevindings is die Gandhi Gedenkhospitaal die enigste instelling in Ethiopië wat ʼn geïntegreerde program vir die voorkoming van verkragting ingestel het. Sekondêre voorkoming geniet voorrang, terwyl primêre voorkoming min aandag geniet. Daar word aanbeveel dat tegelykertyd werk gemaak word van die veelvuldige faktore wat verkragting op verskillende vlakke van die sosiaal-ekologiese model beïnvloed. Dit moet gedoen word deur deeglik ontwerpte, omvattende intervensies en programme om verkragting te voorkom in werking te stel, uit te bou en te verskerp. / Sociology / M.A. (Sociology)
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A theoretical framework for constructive interpersonal leadership relations in knowledge-based organisationsLouw, M. (Marianne) 10 1900 (has links)
Text in English with abstracts in English, Afrikaans and Venda / In this qualitative study, the research objective was to present a theoretical framework for the phenomenon of interpersonal leadership relations (denoting both the dyadic relationship between two leader/followers and the leadership communication taking place in the dyad) in knowledge-based organisational contexts.
It is posited that the interpersonal leader-follower dyad (LFD) may be viewed from a systems theory perspective as a system consisting of two system parts (individuals). These individuals are labelled ‘leader/followers’ to emphasise their mutual interdependence, and to indicate that these roles may be interchangeable, based on the knowledge needs in a particular situation (in line with the tenets of shared leadership). The dyadic system is influenced by its environment, the organisational context. However, the primary focus of this study is on interpersonal leadership communication as symbolic interaction between the leader/followers in the LFD. These three systemic levels are represented as major themes in the model resulting from this study: Theme 1 – an organisational environment that supports constructive interpersonal leadership relations (ILR); Theme 2 – symbolic interaction in the LFD; and Theme 3 – personal attributes that enhance ILR.
The data were collected from two convenience samples. In-depth, semi-structured interviews were conducted with participants in Sample 1, while questionnaires were used to collect data from Sample 2. In both cases, thematic analysis was used to analyse and interpret the data.
The major contribution of the study is the resulting theoretical framework of ILR, which comprises a theoretically based definition of ILR; a generic model of ILR; and current guidelines for fostering constructive ILR in knowledge-based contexts, with reference to the three systemic levels.
The following definition was phrased based on the study: Constructive interpersonal leadership relations (ILR) in a knowledge-based organisational context is a dyadic process of symbolic communication between two expert leader/followers who mutually influence each other and share meaning to strengthen their relationship and to collaboratively transfer and apply knowledge to achieve organisational goals.
In terms of the environment, it was found that organisational leaders should actively model and promote the following: a collaborative leadership concept, workplace spirituality, cultural inclusivity, and adaptation to advancing communication technologies.
Regarding symbolic interaction in the LFD, the following communication practices were found to be central to constructive ILR: active listening, supporting followers as unique individuals, respectful communication, considering followers’ input, facilitating constructive redefinition of the other leader/follower’s self, role-taking (taking the perspective of the other leader/follower’s role), awareness of attribution, conflict management through non-threatening, respectful and preferably face-to-face discussion, facilitating a sense of meaning or purpose at work for the other leader/follower, and fostering constructive relationship properties such as trust. It was found that ILR may produce system outputs into the organisation that contribute to the organisational culture and climate, job performance, employee morale and engagement, and staff retention.
Personal attributes were organised into personal values and competencies that support ILR. The most important personal values were identified as honesty, love or supportiveness, respect, relationships or engagement, trust, and professional excellence. Essential competencies were identified as listening skills, emotional communication competencies (particularly self-awareness, self-reflection and attending to others’ emotions), engagement skills, conflict management skills, and multicultural competency (including generational skills). / In hierdie kwalitatiewe studie word ’n teoretiese raamwerk voorgelê vir die verskynsel ‘interpersoonlike leierskapsverhoudings‘ (verwysende na beide die diadiese verhouding tussen twee leier/volgelinge en die leierskapskommunikasie wat in die diade plaasvind) in kennisgebaseerde organisatoriese kontekste.
Die uitgangspunt is dat die interpersoonlike leier-volgeling-diade (LVD) vanuit ‘n sisteemteoretiese perspektief beskou kan word as ‘n sisteem wat uit twee sisteemdele (individue) bestaan. Hierdie individue word ‘leier/volgelinge‘ genoem om hulle wedersydse interafhanklikheid te beklemtoon; en om aan te toon dat hierdie rolle uitruilbaar mag wees, afhangende van die kennisbehoeftes in ’n gegewe situasie (met verwysing na die teorie van gedeelde leierskap). As ’n sisteem word die LVD ook deur die omringende omgewing of organisatoriese konteks beïnvloed. Die primêre fokus van hierdie studie is egter op interpersoonlike leierskapskommunikasie as simboliese interaksie tussen die leier/volgelinge in die LVD. Hierdie drie sistemiese vlakke word in hierdie studie deur die hooftemas in die studie verteenwoordig en ook as sulks in die voortvloeiende model uitgebeeld: Tema 1 – ’n organisatoriese omgewing wat konstruktiewe interpersoonlike leierskapsverhoudings (ILV) ondersteun; Tema 2 – simboliese interaksie in die LVD; en Tema 3 – persoonlike eienskappe wat ILV bevorder.
Die teoretiese raamwerk van ILV bestaan uit die volgende: ’n teoreties gefundeerde definisie van ILV; ’n generiese model van ILV; en ’n raamwerk van huidige riglyne vir die kweek van konstruktiewe ILV in kennisgebaseerde kontekste, met verwysing na die drie sistemiese vlakke van omgewing, diade en individuele leier/volgelinge.
Die volgende definisie is op grond van die navorsingsresultate geformuleer: Konstruktiewe interpersoonlike leierskapsverhoudings (ILV) in ’n kennisgebaseerde organisatoriese konteks is ’n diadiese proses van simboliese kommunikasie tussen twee kundige leier/volgelinge wat mekaar wedersyds beïnvloed en betekenis deel om hulle verhouding te versterk en kennis samewerkend oor te dra en aan te wend om organisatoriese doelwitte te bereik.
In terme van die organisatoriese omgewing is bevind dat organisatoriese leiers, veral senior leiers, die volgende aktief moet modelleer en bevorder in die organisasie: ’n samewerkende leierskapskonsep, spiritualiteit in die werkplek, kulturele insluiting, en aanpassing by vooruitgang in kommunikasietegnologie.
Met verwysing na simboliese interaksie in die LVD is die volgende praktyke bevind as sentraal tot konstruktiewe ILV: aktiewe luistergedrag, die ondersteuning van volgelinge as unieke individue, respekvolle kommunikasie, die inagneming van volgelinge se insette, die fasilitering van die konstruktiewe herdefiniëring van die ander leier/volgeling se self, rol-inneming (die inneem van die rolperspektief van die ander leier/volgeling), bewustheid van attribusie, die bestuur van konflik deur nie-bedreigende, respekvolle en – waar moontlik – aangesig-tot-aangesig bespreking, die fasilitering van ’n sin van doel of betekenis by die werk vir die ander leier/volgeling, en die kweek van konstruktiewe verhoudingseienskappe (vertroue, uitruilbare leier/volgeling-rolle en wedersydse invloed is geïdentifiseer as belangrik). Dit is ook bevind dat ILV sisteemuitsette in die organisasie mag genereer wat bydra tot die organisatoriese kultuur en klimaat, werkprestasie, werknemers se moreel en betrokkenheid, en personeelbehoud.
Persoonlike eienskappe is verdeel in waardes en vaardighede wat ILV ondersteun. Die belangrikste waardes is geïdentifiseer as eerlikheid, liefde, respek, verhoudings, vertroue, en professionele uitnemendheid. Die volgende vaardighede is geïdentifiseer as noodsaaklik: luistervaardighede, emosionele kommunikasievaardighede (met spesifieke verwysing na selfbewussyn, selfrefleksie en aandag aan ander se emosies), betrekkingsvaardighede, konflikbestuursvaardighede, en multi-kulturele vaardighede (wat generasievaardighede insluit).
Die date is ingesamel uit twee gerieflikheidsteekproewe. Indiepte-, semi-gestruktureerde onderhoude is gevoer met Steekproef 1 (kundiges op gebiede verwant aan ILV in kennisgebaseerde kontekste), terwyl vraelyste gebruik is om data te verkry by Steekproef 2 (leier/volgelinge in kennisgebaseerde kontekste). Tematiese ontleding is in beide gevalle gebruik om die data te ontleed en te interpreteer. / Kha iyi ngudo ya u tandula ‘qualitative’, ndivho ya ṱhoḓisio yo vha u ṋetshedza mutheo wa thiyori kha sia ḽa vhushaka ha vhurangaphanḓa vhukati ha vhathu (zwine zwa amba vhushaka ha tshumisano vhukati ha vharangaphanḓa/vhatevheli vhavhili na vhudavhidzani kha vhurangaphanḓa vhune ha khou bvelela nga kha tshumisano yeneyo) kha nyimele ya tshiimiswa yo ḓitikaho nga nḓivho.
Zwo sumbedziswa uri tshumisano ya murangaphanḓa-mutevheli vhukati ha vhathu (leader-follower dyad (LFD)) i nga lavheleswa u bva kha sia ḽa sisiṱeme ya thyori sa sisiṱeme ine ya vha na zwipiḓa zwivhili (vhathu). Vhathu avha vha vhidzwa ‘vharangaphanḓa/vhatevheli’ hu u itela u khwaṱhisedza u ḓitika havho nga muṅwe, na u sumbedza uri mishumo iyi i nga imelelana, zwo ḓitika nga ṱhoḓea dza nyimele yeneyo. (zwi tshi tevhedza vhatevheli vha vhurangaphanḓa uvho). Sisiṱeme ya tshumisano i ṱuṱuwedzwa nga nyimele yayo, nyimele ya tshiimiswa. Fhedziha zwa ndeme kha ngudo iyi ndi nga vhudavhidzani ha vhurangaphanḓa vhukati ha vhathu sa tshiga tsha tshumisano vhukati ha vharangaphanḓa/vhatevheli kha LFD. Maga aya mararu a sisisṱeme a imelelwa nga ṱhoho khulwane kha nḓila yo livhisaho kha ngudo iyi: Ṱhoho 1 – mupo/nyimele ya tshiimiswa i ṱuṱuwedzaho vhushaka ha vhurangaphanḓa vhu vhuedzaho vhukati ha vhathu (interpersonal leadership relations (ILR)); Ṱhoho 2 – Tshiga tsha tshumisano kha LFD; na Ṱhoho 3 – Vhuvha ha muthu vhune ha konisa ILR.
Data yo kuvhanganywa u bva kha sambula dzine dza vha dza tsinisa. Mbudziso dzo ṱanḓavhuwaho, dzi sa langiho kufhindulele kha vhavhudziswa dzo itwa hu na vhadzheneli kha Sambula ya u thoma (1), ngeno khwesheya dzo shumiswa u kuvhanganya data kha Sambula 2. Kha nyimele dzoṱhe ho shumiswa ṱhaṱhuvho i re na vhushaka na ṱhoho u itela u ṱhaṱhuvha na u ṱalutshedza data.
Zwine ngudo iyi ya vhuedza khazwo ndi mvelelo ya mutheo wa thyori wa ILR, ine ya vha na ṱhalutshedzo yo ḓitikaho nga thyori ya ILR, nḓila ya u angaredza ya ILR; na tsumbanḓila dza zwino u itela mbuelo ya ILR kha nyimele yo ḓitikaho nga nḓivho, zwo lavhelesa kha maga a sisiṱeme.
Ṱhalutshedzo i tevhelaho yo vhekanywa zwi ḓitika nga ngudo: Vhushaka ha vhurangaphanḓa Vhuvhedzaho vhukati ha vhathu (ILR) kha nyimele ya tshiimiswa yo ḓitikaho nga nḓivho ndi maitele a tshumisano ya tshiga tsha vhudavhidzani vhukati ha vharangaphanḓa/vhatevheli vha re na nḓivho vhane vha ṱuṱuwedzana na u kovhekana zwine zwa amba u itela u khwaṱhisa vhushaka havho khathihi na u fhirisa na u shumisa nḓivho u itela u zwikelela zwipikwa zwa tshiimiswa.
Zwi tshi ya nga nyimele, zwo wanala uri vharangaphanḓa vha tshiimiswa vha tea u vhumba na u ṱuṱuwedza zwi tevhelaho: muhumbulo wa tshumisano kha vhurangaphanḓa, zwa tshimuya mushumoni, u katela zwa mvelele, na u ṱanganedza u shumiswa ha thekhinoḽodzhi ya vhudavhidzani.
Maelana na tshumisano nga tshiga kha LFD, maitele a vhudavhidzani a tevhelaho a wanala a one a ndeme kha ILR ire na mbuelo: u thetshelesa nga vhuronwane, u tikedza vhatevheli hu na kupfesesele kwa uri vhathu vho fhambana, vhudavhidzani ha ṱhonifho, u dzhiela nṱha mihumbulo ya vhatevheli, u ṱuṱuwedza u ṱhalutshedza nga nḓila yo fhambanaho i vhuedzaho ya vhaṅwe vharangaphanḓa/vhatevheli vha shumaho u ya nga vhone vhaṋe, u dzhia dzhenelela (u vhona nga nḓila ine vhaṅwe vharangaphanḓa/vhatevheli vha vona ngayo), u tangnedza nḓivho, ndaulo ya phambano nga kha nyambedzano i sa shushedziho, ya ṱhonifho, nga maanḓa nga nyambedzano vhathu vho livhana zwifhaṱuwo, u ṱuṱuwedza nḓivho ya ṱhalutshedzo kana ndivho ya mushumo kha vhaṅwe vharangaphanḓa/vhatevheli, u ṱuṱuwedza zwithu zwi fhaṱaho vhushaka vhu vhuedzaho u fana na u fulufhedzana. Zwo tumbulwa uri ILR i bveledza sisiṱeme ya mvelelo u vha tshiimiswa tshine tsha dzhenelela kha mvelele na vhuḓipfi, kushumele kwa mushumo, u ṱuṱuwedzea na u dzhenelela ha vhashumi, nauri vhashumi vha sa ṱuwe.
U ṱanganedzea ha muthu zwo vheekanywa zwi tshi ya nga mikhwa ya muthu ene muṋe na vhukoni zwine zwa tikedza ILR. Mikhwa ya muthu ya ndemesa yo topolwa sa u fulufhedzea, lufuno, ṱhonifho kana u dzhenelela, fulufhelo, na vhukoni kha zwa phurofeshinaḽa. Vhukoni ha ndeme ho sumbedzwa sa vhukoni ha u thetshelesa, vhukoni ha vhudavhidzani ha muhumbulo (nga maanḓa u ḓiḓivha, u ḓilingulula/sedzulusa na u dzhiela nzhele vhuḓipfi ha vhaṅwe vhathu), vhukoni ha u dzhenelela, vhukoni ha ndaulo ya phambano, na vhukoni ha u dzhenelela kha mvelele nnzhi (zwi tshi katela vhukoni ha zwa murafho). / Communication Science / D. Litt. et Phil. (Communication)
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