Made available in DSpace on 2014-06-11T19:31:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-09-27Bitstream added on 2014-06-13T19:20:40Z : No. of bitstreams: 1 moraes_sh_dr_arafo.pdf: 695564 bytes, checksum: 9ac4357d57946680feb71b26574a149e (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / O presente estudo teve como objetivos as análise tomográfica e histológica do preparo do canal radicular com três sistemas rotatórios de NiTi: ProTaper (grupo 1), Mtwo (grupo 2) e K3 (grupo 3). Trinta e seis molares superiores foram radiografados pela técnica de tomografia cone beam (feixe cônico) antes e depois do preparo rotatório do canal mésio-vestibular. Os dentes foram pesados antes e depois do preparo para analisar a capacidade de corte dos instrumentos pela remoção de dentina. Aumento na área do canal, no alargamento do comprimento mésio-distal do canal, centralização e transporte do canal nos terços cervical, médio e apical foram analisadas nas tomografias computadorizadas transferidas para o software Canvas 11. Após o preparo dos canais radiculares as raízes foram descalcificadas, cortadas com 6 μm de espessura e coradas com hematoxilina-eosina, para exame das irregularidades das paredes de dentina do canal radicular e da presença de resíduos no canal. Para avaliar estatisticamente os resultados foi utilizado o método de variância (ANOVA).Os resultados revelaram que houve diferença estatisticamente significante entre os grupos. ProTaper removeu significativamente mais dentina do que Mtwo e K3 (p<0,05). Mtwo removeu mais do que o K3 (p<0,05). Protaper, Mtwo e K3 aumentaram significativamente a área do canal depois do preparo (p<0,05). A diferença foi significativa no terço cervical entre ProTaper e K3 (p<0,05), Mtwo e K3; terço médio entre ProTaper e K3 (p<,0,05), Mtwo e K3 (p<0,05); no terço apical entre ProTaper e K3 (p<0,05), Mtwo e K3.p<0,05). Protaper, Mtwo e K3 aumentaram significativamente o comprimento mésio-distal do canal. A diferença foi significativa entre ProTaper e K3 (p<0,05) , Mtwo e K3 nos terços cervical, médio e apical. Na avaliação da centralização do canal foi encontrada diferença significativa de desvio entre os grupos... / The key goal of the present study was the histological and tomographic analysis of the root canal preparation with three NiTi rotatory systems: ProTaper (group 1), Mtwo (group 2) e K3 (group 3). Thirty six maxillary molar teeth were radiographed with the cone beam technique before and after the mesial-buccal root canal preparation. The teeth were weighted before and after preparation to analyse dentine removal capacity of the cutting instruments. Images from computed tomography were transferred to the software Canvas 11 to allow for analysis of the increase of the root canal area, the widening of the mesial-distal distance, and the root canal centring and transport in the cervical, mesial and apical thirds. After the root canal preparation, the roots were decalcified, cut to 6 μm thickness, from the cervical third to the apical one and dyed with hematoxylin-eosin. The roots were then analysed as to irregularities in the dentine wall of the root canal, and presence of any residue. The variance method (ANOVA) was used to statistically evaluate the results, which presented statistically relevant difference amongst the groups. ProTaper removed dentine more significantly than Mtwo and K3 (p<0,05). Mtwo removed more than K3 (p<0,05). All groups presented significant increase in the area of the root canal after preparation (p<0,05), mainly in the cervical third and the apical third. Cervical third the difference was ProTaper and K3 (p<0,05), Mtwo and K3, and in the apical third the difference was ProTaper and K3 (p<0,05), Mtwo and K3 (p<0,05). Protaper, Mtwo e K3 significantly increased the mesial-distal distance... (Complete abstract click electronic access below)

Desde o seu desenvolvimento na década de 1970 a tomografia computadorizada (TC) passou por grandes mudanças tecnológicas, tornando-se uma importante ferramenta diagnóstica para a medicina. Consequentemente o papel da TC em diagnóstico por imagem expandiu-se rapidamente, principalmente devido a melhorias na qualidade da imagem e tempo de aquisição. A dose de radiação recebida por pacientes devido a tais procedimentos vem ganhando atenção, levando a comunidade científica e os fabricantes a trabalharem juntos em direção a determinação e otimização de doses. Nas últimas décadas muitas metodologias para dosimetria em pacientes têm sido propostas, baseadas especialmente em cálculos utilizando a técnica Monte Carlo ou medições experimentais com objetos simuladores e dosímetros. A possibilidade de medições in vivo também está sendo investigada. Atualmente as principais técnicas para a otimização da dose incluem redução e/ou modulação da corrente anódica. O presente trabalho propõe uma metodologia experimental para estimativa de doses absorvidas pelos pulmões devido a protocolos clínicos de TC, usando um objeto simulador antropomórfico adulto e dosímetros termoluminescentes de Fluoreto de Lítio (LiF). Sete protocolos clínicos diferentes foram selecionados, com base em sua relevância com respeito à otimização de dose e frequência na rotina clínica de dois hospitais de grande porte: Instituto de Radiologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (InRad) e Instituto do Câncer do Estado de São Paulo Octávio Frias de Oliveira (ICESP). Quatro protocolos de otimização de dose foram analisados: Auto mA, Auto + Smart mA, Baixa Dose (BD) e Ultra Baixa Dose (UBD). Os dois primeiros protocolos supracitados buscam redução de dose por meio de modulação da corrente anódica, enquanto os protocolos BD e UBD propõem a redução do valor da corrente anódica, mantendo-a constante. Os protocolos BD e UBD proporcionaram redução de dose de 72,7(8) % e 91(1) %, respectivamente; 16,8(1,3) % e 35,0(1,2) % de redução de dose foram obtidas com os protocolos Auto mA e Auto + Smart mA, respectivamente. As estimativas de dose para os protocolos analisados neste estudo são compatíveis com estudos similares publicados na literatura, demonstrando a eficiência da metodologia para o cálculo de doses absorvidas no pulmão. Sua aplicabilidade pode ser estendida a diferentes órgãos, diferentes protocolos de CT e diferentes tipos de objetos simuladores antropomórficos (pediátricos, por exemplo). Por fim, a comparação entre os valores de doses estimadas para os pulmões e valores de estimativas de doses dependentes do tamanho (Size Specific Dose Estimates SSDE) demonstrou dependência linear entre as duas grandezas. Resultados de estudos similares exibiram comportamentos similares para doses no reto, sugerindo que doses absorvidas pelos uma órgãos podem ser linearmente dependente dos valores de SSDE, com coeficientes lineares específicos para cada órgão. Uma investigação mais aprofundada sobre doses em órgãos é necessária para avaliar essa hipótese. / Since its development in 1970s the computer tomography (CT) technique have gone through major technological advances, becoming an important diagnostic tool in medicine. Consequently the role of CT in diagnostic imaging expanded rapidly, mainly due to improvements in image quality and speed of acquisition. The radiation dose imparted in patients undergoing CT scans has gained attention, leading the radiology community (radiologists, medical physicists and manufacturers) to work together towards dose estimation and optimization. New methodologies for patients dosimetry have been proposed in the past decades, based specially on Monte Carlo calculations or experimental measurements with phantoms and dosimeters. In vivo methodologies are also under investigation. Current dose optimization strategies include mainly tube current reduction and/or tube current modulation. The present work proposes a methodology to experimentally estimate lung absorbed doses due to clinical CT protocols using an adult anthropomorphic phantom and Lithium Fluorite (LiF) thermoluminescent dosimeters (TLD). Seven clinical protocols were selected for phantom irradiation, based on their relevance regarding dose optimization and frequency in two major hospitals routine: the Institute of Radiology from the Medical Faculty from the University of São Paulo (Instituto de Radiologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo InRad) and the Cancer Institute of the State of São Paulo Octávio Frias de Oliveira (Instituto do Câncer do Estado de São Paulo Octávio Frias de Oliveira ICESP). Fours thorax protocols for dose optimization were analyzed: Auto mA, Auto + Smart mA, Low Dose (LD) and Ultra Low Dose (ULD) thorax. The first two aforementioned protocols seek dose reduction by tube current modulation, while the last two propose a decrease on the constant tube current value. Values of 72.9(8) % and 91(1) % of lung dose reduction were achieved with LD and ULD protocols, respectively. Auto mA and Auto + Smart mA provided 16.8(1.3) % and 35.0(1.2) % of lung dose reduction, respectively. The results from all analyzed protocols are compatible with similar studies published in literature, demonstrating the efficiency of the methodology to lung absorbed dose estimation. Its applicability could be extended to different organs, different clinical CT protocols and pediatric phantoms. Moreover, comparison of lung absorbed doses and Size Specific Dose Estimates (SSDE) for the studied protocols exhibited a tendency of linear dependency. Results from similar studies demonstrate a similar behavior between rectal doses and SSDE, suggesting that organ absorbed doses and SSDE values may be linearly dependent, with organ-specific linear coefficients. Further investigation in organ doses is necessary to evaluate this assumption.

Atualmente a implantodontia tem evoluído muito na intenção de substituir perdas dentárias, porém infelizmente nem sempre isto é capaz, uma vez que após a perda dentária, na grande maioria das vezes, o osso remanescente também é reabsorvido, dificultando ou impossibilitando a instalação de implantes osseointegrados. Esse tipo de perda óssea nos maxilares ou as perdas ósseas resultantes de ressecções cirúrgicas, constituem uma preocupação importante na atualidade, uma vez que os cirurgiões dentistas pesquisam um substituto ósseo que devolva a forma e o contorno dos ossos da face e dos maxilares, e/ou que permita a instalação de implantes osseointegrados. Dentre os biomateriais, a utilização do osso bovino liofilizado tem se popularizado e vem ganhando mercado uma vez que reduz a morbidade do paciente evitando a retirada de enxertos autógenos e tem apresentado uma boa previsibilidade de resultados. No presente estudo, foram criados defeitos ósseos na base da mandíbula de coelhos, onde foram enxertados blocos de osso bovino liofilizado com colágeno suíno nos grupos experimentais e deixados vazios nos grupos controle. Os animais foram sacrificados nos tempos 0 (imediatamente após a cirurgia), 3 e 6 meses após o procedimento cirúrgico. As mandíbulas foram coletadas e analisadas através de tomografias computadorizadas de feixe cônico, em que se analisou a capacidade do enxerto de auxiliar no reparo ósseo de defeitos de tamanho crítico criados na mandíbula de coelhos, bem como sua capacidade de manter o contorno e forma do osso. Através da análise tomográfica das áreas enxertadas foi possível concluir que de acordo com a metodologia proposta o enxerto de osso bovino com 10% de colágeno suíno não foi capaz de auxiliar em 100% no reparo ósseo dos defeitos de tamanho crítico criados na mandíbula dos coelhos, mostrando uma camada fina de tecido mole entre o enxerto e o leito Tendo sido eficiente no preenchimento do espaço do defeito e manutenção do contorno ósseo. / Currently implant dentistry has evolved tremendously in the intention of replacing missing teeth, but unfortunately this is not always able, since after tooth loss, in most cases, also the remaining bone is reabsorbed, making it difficult or impossible to install dental implants. This type of bone loss in the jaw or bone loss resulting from surgical resections, are a major concern at present, since the dentists researching bone substitute that restores the shape and contour of the bones of the face and jaws, and/or enabling installation of dental implants. Among the biomaterials, the use of lyophilized bovine bone has become popular and has been gaining ground as it reduces the morbidity of the patient avoiding the removal of autogenous grafts has shown a good and predictable results. In the present study, bone defects were created on the basis of mandible in rabbits, which were grafted blocks lyophilized bovine bone with swines collagen in the experimental groups and control groups left empty. The animals were sacrificed at 0 (immediately after surgery), 3 and 6 months after surgery. The jaws were collected and analyzed using cone beam computed tomography, which analyzed the ability of the graft to aid in bone repair of critical-size defects created in the mandible of rabbits as well as its ability to maintain the contour and shape of the bone. Through the analysis of the tomographic grafted areas was concluded that according to the methodology proposed bovine bone graft with 10% swines collagen was not able to assist in 100% of the bone repair critical size defects created in rabbit jaw, showing a thin layer of soft tissue between the graft and the bed having been efficient space filling of the defect and maintain the bone contour.

O recente aumento da procura por implantes osseointegráveis consequentemente levou ao aumento dos procedimentos de enxertos ósseos. Com isso, novos materiais têm surgido para estes procedimentos. Um destes materiais é o osso bovino integral (OBIN), cujo diferencial é o seu método de processamento, que visa manter suas características o mais próximas possível ao osso in natura. Por se tratar de um material novo, ainda existem poucos estudos avaliando seu desempenho, sendo a maioria deles estudos pré-clínicos testando sua biocompatibilidade. Portanto, o objetivo deste trabalho foi avaliar o desempenho do OBIN na região maxilofacial através de um modelo experimental em animais. Foram criados defeitos ósseos na base da mandíbula de coelhos, onde foram enxertados blocos de OBIN nos grupos experimentais e deixados vazios nos grupos controle. Os animais foram sacrificados nos tempos 0 (imediatamente após a cirurgia), 3 e 6 meses após o procedimento cirúrgico. As mandíbulas foram analisadas através de tomografias computadorizadas de feixe cônico, onde foi analisada a regeneração óssea qualitativamente e quantitativamente. Na análise qualitativa observou-se que aos três e seis meses, nos animais do grupo controle, não houve regeneração total, restando um defeito côncavo na base da mandíbula, confirmando que o defeito criado possuía tamanho crítico. No grupo experimental, no tempo 0, observou-se grande variação de densidade entre os enxertos e esta variação pareceu influenciar seu desempenho, havendo mais regeneração óssea nos menos densos. No tempo 3, todos os enxertos haviam integrados, com perda de densidade, sugerindo uma reabsorção parcial. Aos seis meses, a reabsorção e regeneração pareciam mais avançadas do que aos três meses. Na análise quantitativa houve diferença estatisticamente significante nos grupos controles entre os tempos 0 e os tempos 3 e 6. Nos grupos experimentais não houve diferença entre os tempos e na comparação entre os grupos controles e experimentais houve diferença estatisticamente significante entre todos os tempos. Os resultados observados sugerem que o OBIN é um material indicado para a realização de procedimentos de enxerto na região maxilofacial, com aparente reabsorção e substituição por osso regenerado, ideal para a reabilitação com implantes ósseo integráveis. / The recent increase in the demand for dental implants consequently led to increased bone grafting procedures. Therefore, new materials have emerged for these procedures. One of these materials is integral bovine bone (IBB) whose differential is its processing, which aims to maintain its characteristics as close as possible to the raw bone. Because it is a new material, there are only a few studies evaluating its performance, with the majority of them constituted of preclinical studies testing its biocompatibility. For this reason, the aim of this study was to evaluate the performance of the IBB at the maxillofacial region through an experimental model in animals. Bone defects were created on the basis of the mandible of rabbits, which were grafted with blocks of IBB in the experimental groups, while control groups were left empty. The animals were sacrificed at time 0 (immediately after surgery), 3 and 6 months after surgery. The jaws were analyzed using cone beam computed tomography, where bone regeneration was analyzed qualitatively and quantitatively. Qualitative analysis showed that at three and six months, in the control group, there was not full regeneration, leaving a concave defect in the base of the mandible, confirming that the defect created had critical size. In the experimental group, at time 0, there was wide variation in density between the grafts and this variation appeared to influence their performance, seeming to be more bone regeneration in less dense ones. At time 3, all grafts were integrated, and a density loss, suggesting a partial resorption of the graft, was also observed. At six months, resorption and regeneration seemed more advanced than at three months. The quantitative analysis did not showed statistically significant difference in controls between time 0 and times 3 e 6. In experimental groups there was no difference between times and comparison between control and experimental groups were statistically significant different between all time. The data suggest that the IBB is a material suitable for the realization of grafting procedures in the maxillofacial region, with apparent resorption and replacement by regenerated bone, ideal for rehabilitation with dental implants.

A região da articulação temporomandibular (ATM) possui uma limitação na obtenção de imagens pela radiografia convencional. A tomografia computadorizada é o exame mais indicado pela alta especificidade e sensibilidade, para o diagnóstico, planejamento cirúrgico e tratamento das lesões ósseas. O objetivo deste trabalho consiste na avaliação de lesões ósseas simuladas na cabeça da mandíbula pela tomografia computadorizada. Foram utilizadas 15 mandíbulas secas, onde foram criadas lesões esféricas, com o auxílio de brocas esféricas cirúrgicas de uso odontológico com tamanhos variados (nº 1, 3, 6) na cabeça da mandíbula. As lesões foram avaliadas por meio da TC multislice (64 canais), por 2 examinadores independentemente, em 02 ocasiões distintas, utilizando 2 protocolos: axial, coronal, sagital e imagens parassagitais para visualização dos pólos (anterior, lateral, posterior, medial, superior). Posteriormente, as imagens foram comparadas com as lesões presentes na mandíbula seca (Padrão Ouro) avaliando o grau de especificidade e sensibilidade da TC. Estatística de Kappa, teste de validade e teste do Qui-Quadrado foram utilizados como métodos estatísticos. Como resultados observaram a vantagem da associação dos cortes axial, coronal e sagital com cortes parassagitais para detecção de lesões na região de cabeça de mandíbula. Para determinada localização de lesões nos pólos, os tipos de protocolos não apresentaram diferenças significativas em relação as porcentagens de concordância. Os protocolos para visualização da região de cabeça da mandíbula foram estabelecidos no intuito de melhorar a visualização da presença de alterações de cada pólo da cabeça da mandíbula. No que se refere aos pólos avaliados pelos cortes parassagitais houve melhor visualização no pólo anterior e posterior no sentido látero medial. Nos pólos superior, medial e lateral foram mais bem visualizados no sentido ântero-posterior. / There are limitations for image acquisition using conventional radiography of the temporomandibular joint (ATM) region. Computerized tomography (CT) scan is a better option due to its higher specificity and sensitivity for diagnosis, surgical planning and treatment of bone injuries. The purpose of this study is to evaluate simulated bone injuries of the head of the jaw by CT scan. Spherical lesions were created in the head of 15 dry jaws with dentist drills (sizes 1, 3, and 6). Lesions were evaluated using the CT multislice (64 bits) by 2 examiners independently, in 2 different occasions, using 2 protocols: axial, coronal, and sagittal and parasagittal images for head of the mandible visualization (anterior, lateral, posterior, medial, and superior). Images were compared with the dry jaw (gold standard) regarding the presence of injuries, evaluating the degree of specificity and sensitivity of the CT. Kappa statistics, validity tests, and chi-square tests were used as statistical methods. As a result, we observed the advantage of the association of axial, coronal and sagittal slices with parasagittal slices for detection of lesions in the region of mandibles head. For some lesions localized in polar regions, protocols did not show statistically significant differences regarding the proportion of agreement. Protocols for visualization were created to improve the visualization of lesions in each polar region of the jaws head. Regarding parassagittal slices, there was better lateromedial visualization of the anterior and posterior poles and better anteroposterior visualization of superior, medial, and lateral poles.

Electrical trees are micrometre-size tubular channels of degradation in high voltage polymeric insulation, a precursor to failure of electrical power plant. Hence, electrical trees critically affect the reliability of power systems and the performance of new insulation designs. Imaging laboratory-grown electrical trees has been an important tool for studying how trees develop. Commonly, electrical trees prepared in transparent or translucent polymers are imaged using traditional optical methods. Consequently, most of the analysis has been based on two-dimensional (2D) images of trees, thus, valuable information may be lost. However, electrical trees are complex interconnected structures that require a tree-dimensional (3D) approach for more complete analysis. This thesis investigates a method for imaging and analysis of electrical trees to characterise their 3D structure and provide a platform for further modelling. Laboratory created electrical trees were imaged using X-ray Computed Tomography (XCT) and Serial Block-Face Scanning Electron Microscopy (SBFSEM), 3D imaging techniques that provide sub-micrometre spatial resolution. Virtual replicas of the trees, which are the 3D geometrical models representing the real electrical trees, were generated and new indices to characterise the 3D structure of electrical trees were developed. These parameters were indicative of differences in tree growth and thus, they can be used to investigate patterns and classify the structure of electrical trees. The progression of the tree was analysed using cross-sections of the tree that are orthogonal to the growth: the number of tree channels and area covered by them were measured. The fractal dimension of the tree was calculated from the 3D model and from the 2D projections, the latter being lower for all the tree-type structures studied. Parameters from the skeleton of the tree such as number of nodes, segment length, tortuosity and branch angle were measured. Most of the mean segment lengths ranged 6-13 µm, which is in accordance to the 10µm proposed by various tree-growth models. The capabilities of XCT and SBFSEM imaging techniques were evaluated in their application to electrical trees. Bush and branch trees, including early-growth electrical trees (of length 20-40 µm), were analysed and compared using the comprehensive tool of visualisation and characterisation developed. A two-stage tree-growth experiment was conducted to analyse the progression and development of tree branches using XCT: tree channels after the second stage of growth were wider than after the first, while the fractal dimension remained the same. The capabilities of XCT and SBFSEM were tested for imaging electrical trees in optically-opaque materials such as micro and nano-filled epoxy compounds. The general structure of trees in epoxy filled up to 20 wt% micro-silica was observed using both techniques. The use of a virtual replica as the 3D geometrical model for the simulation of the electric field distribution using Finite Element Analysis (FEA) was preliminary explored. A combination of the imaging techniques is proposed for a more complete structural analysis of trees. It is believed that a great impact towards understanding electrical treeing will be achieved using the 3D technical platform developed in this thesis.

京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第22837号 / 人健博第79号 / 新制||人健||6(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 岡 昌吾, 教授 藤井 康友, 教授 萩原 正敏 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DGAM

The morphology of asphalt mixtures plays a vital role in their properties and behaviour. The work in this thesis is aimed at developing a fundamental understanding of the effect of the asphalt morphology on the strength properties and deformation mechanisms for development of morphology-based analysis framework for long-term response prediction. Experimental and computational methods are used to establish the relationship between the mixture morphology and response. Micromechanical modeling is employed to understand the complex interplay between the asphalt mixture constituents resulting in strain localization and stress concentrations which are precursors to damage initiation and accumulation. Based on data from actual asphalt field cores, morphology-based material models which considers the influence of the morphology on the long-term material properties with respect to damage resistance, healing and ageing are developed. The morphology-based material models are implemented in a hot-mix asphalt (HMA) fracture mechanics framework for pavement performance prediction. The framework is able to predict top-down cracking initiation to a reasonable extent considering the variability of the input parameters. A thermodynamic based model for damage and fracture is proposed. The results from the study show that the morphology is an important factor which should be taken into consideration for determining the short- and long-term response of asphalt mixtures. Further understanding of the influence of the morphology will lead to the development of fundamental analytical techniques in design to establish the material properties and response to loads. This will reduce the empiricism associated with pavement design, reduce need for extensive calibration and validation, increase the prediction capability of pavement design tools, and advance pavement design to a new level science and engineering. / Asfaltblandningars morfologi har en avgörande betydelse för deras egenskaper och beteenden. Arbetet i denna avhandling syftar till att utveckla en grundläggande förståelse för effekten av asfaltsmorfologin för deras hållfasthetsegenskaper och deformationsmekanismer och utveckling av ramverksanalysmorfologi baserat på långsiktig förutsägelse. Experimentella beräkningsmetoder används för att fastställa sambandet mellan blandningens morfologi och respons. Mikromekanisk modellering används för att förstå det komplexa samspelet mellan asfaltmassans beståndsdelar som resulterar i spänningslokalisering och spänningskoncentrationer som är föregångare till initiering av skador och ackumulation. Morfologibaserade materialmodeller beaktar påverkan av morfologin på de långsiktiga materialegenskaperna med avseende på skademotstånd, helande samt åldrande, och är utvecklade från data hos verkliga asfaltsfältskärnor. Morfologinbaserade materialmodeller är implementerade i en varmblandad asfalt-( HMA )-brottmekanik-ramverk för förutsägelse av beläggningsprestanda. Ramverket kan i rimlig utsträckning förutspå variationen i ingångsparametrarna ’top-down’ sprickbildningsinitiering. En termodynamiskbaserat ramverk föreslås för skador och brott. Resultaten från studien visar att morfologin är en viktig faktor som bör beaktas för att bestämma respons av asfaltblandningar på kort och lång sikt. Ytterligare förståelse av inverkan av morfologin kommer att leda till utvecklingen av grundläggande analytiska tekniker i design för fastställning av materialegenskaper och belastningars respons. Detta kommer att minska empirism som förknippas med beläggningskonstruktionen, minska behovet av omfattande kalibrering och validering, öka förutsägelseförmågan av designverktyg för beläggningen, samt avancera beläggningsdesign till en ny vetenskaplig nivå och ingenjörskonst. / <p>QC 20150420</p>

Tato práce se zaměřuje na pokročilou zobrazovací technologii, rentgenovou počítačovou tomografii (CT). Tato nedestruktivní technika je využívána pro výzkum různých biomateiálů ve tkáňovém inženýrství a materiálové vědě obecně (skafoldy, polymery, keramické materiály, kompozity aj.). Vizualizace a kvantifikace ve 3D jsou výhodné v rámci multidisciplinárního přístupu, který je často v těchto odvětvích uplatňován. Záměr této práce lze rozdělit do dvou oblastí. Prvním tématem je optimalizace měřicí procedury různých měkkých materiálů pomocí CT s laboratorními rentgenovými zdroji. To zahrnuje převážně zobrazování ve fázovém kontrastu, konkrétně metodu volného šíření záření (VŠZ). Tato práce teoreticky popisuje VŠZ a demonstruje tento jev na řadě experimentů. Následné nezbytné zpracování dat získaných VŠZ je implementováno a vyhodnoceno na základě míry zlepšení obrazových dat. Druhé téma ukazuje konkrétní aplikace CT v materiálovém inženýrství. Několik studií s různými CT zařízeními ukazuje příklady možných aplikací a obrazového zpracování. Příklady korelace CT dat s jinými doplňkovými technikami ukazují, jak může být CT aplikována v multioborovém přístupu ke komplexnímu řešení vědeckých problémů.

Cone penetration in sands is a complex process: it contains several challenges that geomechanicians face, such as large displacements, large strains, strain localization, and microscale phenomena such as particle crushing and sand fabric evolution. In order to gain a deeper understanding of the penetration process and the mechanisms controlling penetration resistance, capturing these displacement and strain fields and microscale phenomena is necessary. Furthermore, as more sophisticated theoretical models become available for the simulation of the cone penetration problem, the experimental validation of those methods becomes vital.<br><div><br></div><div>This dissertation presents a multiscale study of the cone penetration process in silica sands. The penetration problem is investigated using a combinational approach consisting of calibration chamber experiments, digital image correlation (DIC) analysis, and X-ray computed Tomography (XCT) scans. Three silica sands with different particle characteristics are used in the experimental program. These three sands have similar particle size distributions; however, they differ in particle morphologies and particle strengths. These differences allow a study of the effect of microscale sand properties on the macroscale response of the sands to the cone penetration process. The three silica sands used in this research are fully characterized using laboratory experiments to obtain particle size distributions, particle morphologies, particle crushing strengths, minimum and maximum packing densities, and critical-state friction angles. Subsequently, both dense and medium-dense samples of the three sands are compressed in a uniaxial loading device placed inside an X-ray microscope (XRM) and scanned at multiple stress levels during uniaxial compression. Results from uniaxial compression experiments indicate that: (1) the compressibility of the sands is closely tied to particle morphology and strength, and (2) the anisotropy in the orientations of interparticle contact normals generally increases with axial stress; however, this increase is limited by the occurrence of particle crushing in the sample.<br></div><div><br></div><div>Subsequently, cone penetration experiments are performed under different confinement levels on dense samples of the three sands in aspecial half-cylindrical calibration chamber equipped with DIC capabilities. For each penetration experiment, incremental displacement fields around the cone penetrometer are obtained using DIC analysis, and these incremental displacement fields are further analyzed to compute the incremental strain fields. A novel methodology is developed to obtain the shear-band patterns that develop around the penetrometer automatically. Furthermore, differences in the shear-band patterns in deep and shallow penetration environments are also investigated. Results show that strain fields tend to localize intensely near the penetrometer tip, and the shear bands tend to develop along the inclined face and near the shoulder of the penetrometer. Significant differences in the shear band patterns in deep and shallow penetration environments are also observed.<br></div><div><br></div><div>After each cone penetration experiment, a specially developed agar-impregnation technique is used to collect minimally disturbedsand samples from around the penetrometertip. These agar-impregnated sand samples are scanned in the XRM to obtain 3D tomography data, which are further analyzed to quantify particle crushing around the penetrometer tip. The results show that: (1) for a given sample density, the amount of crushing around the cone penetrometer depends on the confinement and the sand particle characteristics, (2) the level of crushing is not uniform around the penetrometer tip, with more severe crushing observed near the shoulder of the penetrometer, and (3) the regions with more severe particle crushing around the penetrometer approximately overlap with regions of high shear strain and volumetric contraction. A framework is also proposed to obtain the ratio of penetration resistance in more crushable sands to penetration resistance in less crushable sands. Furthermore, a novel resin-impregnation technique is also developed to collect undisturbedsand samples from around the penetrometer tip. The resin-impregnated sand sample collected after one of the penetration experiments is scanned in the XRM to obtain the 3D tomography data, which is then analyzed to obtain the distribution of interparticle contact normal orientations at multiple locations around the penetrometer tip. These analyses indicate that the interparticle contact normals tend to orient themselves with the incremental principal strains around the penetrometer: below the penetrometer tip, the interparticle contact normals orient vertically upwards, while closer to the shoulder of the penetrometer, the interparticle contact normals become more radially inclined.<br></div><div><br></div><div>Data presented in this dissertation on penetration resistance, incremental displacement fields, incremental strain fields, particle crushing, and interparticle contact normal orientations around the cone penetrometer are aimed to be useful to researchers working on the multiscale modeling of penetration processes in granular materials and aid in the further development of our understanding of penetration processes in sands.<br></div>