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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Molecular mechanisms of insulin resistance in glucagon-producing alpha cells / Molekulare Mechanismen der Insulinresistenz in Glukagon-produzierenden Alphazellen

González Aguirre, Miranda 02 November 2006 (has links)
No description available.
12

Regulation by Glycogen Synthase Kinase-3 Beta of CBP transcriptional coactivator involved in insulin-dependent glucagon gene transcription / Die Regulation des in die Insulin-abhöngige Glukagongentranskription involvierten transkriptionellen Aktivators CBP durch die Glykogen-Synthase-Kinase-3 Beta

Matsiulka, Andrei 16 January 2007 (has links)
No description available.
13

Making Cytological Diagnoses on Digital Images Using the iPath Network

Dalquen, Peter, Savic Prince, Spasenija, Spieler, Peter, Kunze, Dietmar, Neumann, Heinrich, Eppenberger-Castori, Serenella, Adams, Heiner, Glatz, Katharina, Bubendorf, Lukas 20 May 2020 (has links)
Background: The iPath telemedicine platform Basel is mainly used for histological and cytological consultations, but also serves as a valuable learning tool. Aim: To study the level of accuracy in making diagnoses based on still images achieved by experienced cytopathologists, to identify limiting factors, and to provide a cytological image series as a learning set. Method: Images from 167 consecutive cytological specimens of different origin were uploaded on the iPath platform and evaluated by four cytopathologists. Only wet-fixed and well-stained specimens were used. The consultants made specific diagnoses and categorized each as benign, suspicious or malignant. Results: For all consultants, specificity and sensitivity regarding categorized diagnoses were 83–92 and 85–93%, respectively; the overall accuracy was 88–90%. The interobserver agreement was substantial (κ = 0.791). The lowest rate of concordance was achieved in urine and bladder washings and in the identification of benign lesions. Conclusion: Using a digital image set for diagnostic purposes implies that even under optimal conditions the accuracy rate will not exceed to 80–90%, mainly because of lacking supportive immunocytochemical or molecular tests. This limitation does not disqualify digital images for teleconsulting or as a learning aid. The series of images used for the study are open to the public at http://pathorama.wordpress.com/extragenital-cytology-2013/.
14

N-Methyl-D-Aspartat-Antagonisten induzierten apoptotische Zelluntergänge im Gehirn junger Ratten

Miksa, Michael 06 April 2004 (has links)
Der wichtigste exzitatorische Neurotransmitter Glutamat spielt eine grosse Rolle in der Gehirnentwicklung, wie neuronale Migration und Synaptogenese. Ob glutamaterge Stimulation für das Überleben entwickelnder Neuronen notwendig ist, war bislang jedoch unbekannt. Um zu untersuchen, ob eine Hemmung von Glutamatrezeptoren im unreifen Gehirn zu Neurodegeneration führt, wurden Ratten im Alter von 1 bis 31 Tagen für 24 Stunden mit dem N-Methyl-D-Aspartat-(NMDA) Glutamatrezeptorantagonisten Dizocilpin (MK801) behandelt. Die Dichte neuronaler Degeneration wurde mikroskopisch in Kupfer-Silber- und TUNEL- gefärbten Hirnschnittpräparaten ermittelt und Unterschiede mittels ANOVA analysiert (Signifikanzniveau p / The predominant excitatory neurotransmitter glutamate plays a major role in certain aspects of neural development. However, whether developing neurons depend on glutamate for survival remains unknown. To investigate if deprivation of glutamate stimulation in the immature mammalian brain causes neuronal cell death (apoptosis), rat pups aged 0 to 30 days were treated for 24 hours with dizocilpine maleate (MK801), an N-methyl-D-aspartate-(NMDA) glutamate receptor antagonist. Density of neural degeneration was evaluated by a stereological dissector method in cupric-silver and TUNEL-stained brain slices. Groups were compared by ANOVA and significance considered at p
15

Biochemische und zellbiologische Charakterisierung des COP Vesikel vermittelten Proteintransports in Pflanzen

Pimpl, Peter 03 May 2001 (has links)
No description available.
16

Expression und Funktion von Caveolin bei glialen Zellen, insbesondere Oligodendrozyten / Aufgabe und Funktion von oligodendroglialem Caveolin und Caveolin-haltigen Mikrodomänen (CMD) bei der NGF-Signaltransduktion / Expression and function of caveolin in glial cells, especially oligodendrozytes / Role and functions of oligodendroglial caveolin and caveolin-containing microdomains (CMD) in NGF-signalling

Schmitz, Matthias 04 May 2006 (has links)
No description available.
17

Untersuchung der Differenzierungskapazität von Osteoblasten und Osteoblastensubpopulationen in vitro und ihre Beeinflussung durch verschiedene Wuchsfaktoren / In vitro differentiation potential of primary human osteoblasts subpopulations. Expression of adipocytic and osteoblastic markers

Ponce, María Laura 28 June 2005 (has links)
No description available.

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