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The present study drew from the publicly available Amerispeak survey (n = 6,515) and examined public stigma towards different substances, the relationship between preferences for abstinence-based recovery and stigma toward each substance, and whether perceived dangerousness of substances moderates the relationship between preferences for abstinence-based recovery and public stigma. The results indicate that the general public has greater stigmatizing attitudes towards methamphetamine use disorder than cocaine use disorder, opioid use disorder, and alcohol use disorder. Furthermore, a preference for abstinence-based recovery was associated with greater stigmatizing attitudes toward all SUDs. The perceived dangerousness of a substance did not moderate the relationship between preference for abstinence-based recovery and stigmatizing attitudes towards SUDs but was related to public stigma in several models. Results have implications for creating stigma interventions for the general public, which can be adapted for abstinence-based settings, like healthcare organizations and treatment centers.

BACKGROUND: The prevalence of neonatal abstinence syndrome (NAS) is on the rise in the United States, as the epidemic of opioid misuse continues1. Several infants with in utero exposure to opioids are born with NAS, and exhibit symptoms of withdrawal and dependence upon birth when the maternal source of opioid is discontinued2. Due to the novelty of the syndrome, there are several knowledge gaps in current literature that remain to be explored. LITERATURE REVIEW: The exact mechanism of development of NAS in infants remains unknown, yet the clinical symptomatology and results of a few recent studies suggest that there is an association with NAS severity and dysregulation of autonomic nervous system (ANS) functioning in these infants3. In recent years, pharmacological treatments for these infants have become standardized4. However, non-pharmacological treatments have been adopted from treatment guidelines of other high-risk infant populations and their efficacy warrants further evaluation in infants with NAS. Kangaroo care (KC) is a supportive therapy commonly applied to many high-risk infant populations because of its physiologically stabilizing effects5. The therapy has been demonstrated to be especially beneficial in the treatment of preterm infants, a population that similarly requires additional maturation of their ANS upon birth,6. Neurobehavioral theories suggest ANS functioning in infancy is a strong predictor of long-term social, behavioral, and cognitive development outcomes7,8. PROPOSED PROJECT: This prospective cohort study is designed to provide pilot data to establish if KC can be utilized to mature ANS maturation in infants with NAS. CONCLUSIONS AND SIGNIFICANCE: KC is an inexpensive, readily available, low risk intervention that could improve neurobehavioral outcomes in infants with NAS. The results of this study could reduce clinical symptoms, potentiate long-term behavior outcomes, and better define treatment practices for infants with NAS by facilitating a targeted intervention to improve outcomes.

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Neonatal abstinence syndrome (NAS) is a condition caused by in-utero exposure to opioids, and its occurrence is increasing nationwide. NAS patients are newborns who can experience withdrawal symptoms including tremors, poor feeding, and respiratory distress. Presently, the Finnegan Scoring System, a subjective rating scale, is commonly used to judge the patient's condition and determine appropriate treatment methods. This project sought to develop a sensor system that is capable of objectively assessing symptoms of withdrawal, including tremors and high pitched cry. The system developed is composed of five wireless accelerometers, for attachment to a subject's limbs and chest, and an external microphone. The sensor system is targeted toward quantifying limb movements of the subject and recording audio information that includes samples of the subject's cry. The sensor system was used as part of a research study, and data was collected from recruited participants. A total of 29 out of 30 desired participants were enrolled and studied as part of the data collection process. Gathered data was analyzed using MATLAB, with motion data being searched for tremor activity in NAS participants, and cry samples searched for unique characteristics. Results generated indicate that detection of tremors was successful, and that the average fundamental frequency of cry differs between the NAS and non-NAS participants. Future considerations for this project include expanding to measure more symptoms, and system refinement to minimize the number of sensors. / Master of Science

Graphs (or networks) are now omnipresent, infusing into many aspects of society. This dissertation contributes unified graph-based algorithms and models to help solve large-scale societal problems affecting millions of individuals' daily lives, from cyber-attacks involving malware to tobacco and alcohol addiction. The main thrusts of our research are: (1) Propagation-based Graph Mining Algorithms: We develop graph mining algorithms to propagate information between the nodes to infer important details about the unknown nodes. We present three examples: AESOP (patented) unearths malware lurking in people's computers with 99.61% true positive rate at 0.01% false positive rate; our application of ADAGE on malware detection (patent-pending) enables to detect malware in a streaming setting; and EDOCS (patent-pending) flags comment spammers among 197 thousand users on a social media platform accurately and preemptively. (2) Graph-induced Behavior Characterization: We derive new insights and knowledge that characterize certain behavior from graphs using statistical and algorithmic techniques. We present two examples: a study on identifying attributes of smoking and drinking abstinence and relapse from an addiction cessation social media community; and an exploratory analysis of how company insiders trade. Our work has already made impact to society: deployed by Symantec, AESOP is protecting over 120 million people worldwide from malware; EDOCS has been deployed by Yahoo and it guards multiple online communities from comment spammers.

The predominately rural state of Mississippi responded to high teenage pregnancy rates by enacting a 2011 law requiring school districts to choose between an abstinence-only and an abstinence-plus program for their high schools. However, there is limited extant research on Mississippi's sex education policies, creating a research gap that inhibits developing successful programs to reduce teenage pregnancy rates. There is specifically a need to compare the two types of allowed programs with a focus on rural areas. This study compared programs by examining students' abstinent sexual attitudes, social norms, self-efficacy, sexual abstinence behaviors, and perceived effectiveness of sexual education and decision making to address whether those variables differed by program and if programs and genders interacted. The study was informed by the health belief model, social cognitive theory, and the theory of reasoned action. The study collected data from 366 students who had taken one of the two programs completed 4 surveys: a demographic survey, the Sexual Risk Behavioral Belief and Self-Efficacy scale, the Sexual Abstinence scale, and the Effectiveness of Sexual Education scale. Students who completed the abstinence-plus program had higher levels of abstinent sexual attitudes, abstinent social norms, abstinent self-efficacy, and sexual decision-making self-efficacy when compared to students who completed the abstinence-only program, with a small effect size for abstinent social norms. Sexual abstinence behavior scores did not differ by program and programs and genders did not interact. Future studies should include a pretest and posttest evaluation. Analyzing these programs facilitates social change by informing the design of effective programs that focus on at-risk youth sexual behaviors.

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No description available.

L’addiction ou dépendance aux substances psychoactives est une affection chronique, fréquente et grave, émaillée de rechutes et de périodes d’abstinence. Les études épidémiologiques montrent que l’abstinence aux opiacés est fortement associée à une prévalence accrue de la dépression. Nous résumons ici les principaux aspects cliniques de la dépendance aux opiacés et de la dépression, en détaillant leurs mécanismes physiopathologiques. Puis, nous présentons notre modèle d’abstinence aux opiacés chez la souris. Suite à un traitement morphinique chronique et au cours de l’abstinence apparaissent progressivement des comportements apparentés à la dépression. Ce traitement morphinique modifie profondément le fonctionnement du système sérotoninergique, notamment dans le noyau du raphé dorsal. De plus, les déficits comportementaux observés peuvent être prévenus par un traitement chronique par la fluoxétine, un antidépresseur ciblant ce système. Nous avons généralisé ce modèle à l’héroïne, un autre opiacé illicite. Nous avons révélé par des approches génétiques de délétion constitutive et conditionnelle les rôles distincts des 3 récepteurs opioïdes (mu, delta et kappa) lors de l’abstinence à l’héroïne. Enfin, nous avons initié une étude de caractérisation, à l’échelle de l’ensemble du génome, des adaptations transcriptomiques (ARN messagers et micro-ARN) dans le noyau du raphé dorsal au cours de l’abstinence à l’héroïne et du traitement antidépresseur. Ce travail devrait permettre d’améliorer notre compréhension des mécanismes neurobiologiques à l’œuvre dans la comorbidité entre dépendance aux opiacés et dépression et pourrait suggérer de nouvelles pistes thérapeutiques. / Addiction is a chronic, frequent and serious brain disease, with relapse alternating with abstinence periods. Epidemiological studies show that abstinence, notably from opiates, is strongly associated with depression.Here we present the main clinical aspects of opiate addiction and depression, and most recent advances in molecular pathophysiology of both disorders. Then, we present our mouse model of opiate abstinence. Following chronic morphine exposure, depressive-like behaviours progressively emerge. Morphine treatment profoundly disrupts serotonergic signalling, notably in the dorsal raphe nucleus. In addition, behavioural deficits can be prevented by chronic treatment with fluoxetine, an antidepressant targeting serotonergic neurons. We then generalized our mouse model to heroin, another major illicit opiate. Using constitutive and conditional knockout strategies, we documented distinct roles for all 3 opioid receptors (mu, delta and kappa) in heroin abstinence. Finally, we initiated a large-scale analysis of transcriptomic regulations (mRNA and micro-RNA) occurring in our model as a function of heroin abstinence and fluoxetine treatment.These studies should reveal an unforeseen contribution of the dorsal raphe nucleus to addiction. They should uncover new molecular mechanisms underlying depressive-like behaviors in mice during opiate abstinence and thus put forward new therapeutic targets in humans.