In twentieth-century poets such as W. B. Yeats, T. S. Eliot, Robert Lowell and Allen Ginsberg, the literary apocalyptic--identifiable by its homology with the major elements of the biblical Apocalypse--undergoes progressively complex transmutations. While in the early Yeats the apocalyptic is evocative of earnest Romantic moods, in his later work it is complicated by irony, yoked to the cycles of Yeatsean history, and counteracted by exaggerated postures of defiance. In Eliot, a reductive juxtaposition of the apocalyptic and the contemporary foreshortens the traditional paradigms to a diminutive modern-day scale. In Lowell, the apocalyptic is manifested variously as a bitter inversion of American Puritan eschatology, the telescoping of the personal and the cosmic, and a catastrophe in slow-motion. The climactic point of distortion, however, is reached in Ginsberg's poetry in which apocalyptic horrors form a bizarre combination with humour and bathos. While their treatment of the eschatological is widely divergent, an element common to all four poets is their ambivalence towards the paradigms of an apocalyptic new world.

While the gothic in its various interpretations is well established in contemporary culture, the traditional form, rooted in its late eighteenth century literary conventions, would seem to have little relevance for theatre audiences today. A reappraisal of the convention's foundations, however, offers the playwright opportunities to explore new narratives in which the tradition can be re-inflected in the present. An analysis of the writing of my play Burn, which presents as a contemporary family drama, will demonstrate how the narrative can be structured with deliberate reference to the established tropes of the classic gothic mode. It will be shown that a re-engagement with the tradition in concert with new interpretations of the gothic can reinvigorate the form as a mode of playwriting practice.

Thesis (Ph. D.)--Universität Hamburg, 1993. / Includes bibliographical references (p. 198-212).

Magister Scientiae - MSc / Neurological diseases are socially disabling and often mortal. To efficiently combat these diseases, a deep understanding of involved cellular processes, gene functions and anatomy is required. However, differential regulation of genes across anatomy is not sufficiently well understood. This study utilized large-scale gene expression data to define the regulatory networks of genes expressing in the hippocampus to which multiple disease pathologies may be associated. Specific aims were: ident i fy key regulatory transcription factors (TFs) responsible for observed gene expression patterns, reconstruct transcription regulatory networks, and prioritize likely TFs responsible for anatomically restricted gene expression. Most of the analysis was restricted to the CA3 sub-region of Ammon’s horn within the hippocampus. We identified 155 core genes expressing throughout the CA3 sub-region and predicted corresponding TF binding site (TFBS) distributions. Our analysis shows plausible transcription regulatory networks for twelve clusters of co-expressed genes. We demonstrate the validity of the predictions by re-clustering genes based on TFBS distributions and found that genes tend to be correctly assigned to groups of previously identified co-expressing genes with sensitivity of 67.74% and positive predictive value of 100%. Taken together, this study represents one of the first to merge anatomical architecture, expression profiles and transcription regulatory potential on such a large scale in hippocampal sub-anatomy. / South Africa

BRITO, João Luiz Teixeira de. Poética beat no cinema: “Howl” e On the road. 2015. 228f. – Dissertação (Mestrado) – Universidade Federal do Ceará, Programa de Pós-graduação em Letras, Fortaleza (CE), 2015. / Submitted by Márcia Araújo (marcia_m_bezerra@yahoo.com.br) on 2015-06-08T11:16:58Z No. of bitstreams: 1 2015_dis_jltbrito.pdf: 3466253 bytes, checksum: 20edd3103d946df889c4ffe55c09431e (MD5) / Approved for entry into archive by Márcia Araújo(marcia_m_bezerra@yahoo.com.br) on 2015-06-08T12:59:14Z (GMT) No. of bitstreams: 1 2015_dis_jltbrito.pdf: 3466253 bytes, checksum: 20edd3103d946df889c4ffe55c09431e (MD5) / Made available in DSpace on 2015-06-08T12:59:14Z (GMT). No. of bitstreams: 1 2015_dis_jltbrito.pdf: 3466253 bytes, checksum: 20edd3103d946df889c4ffe55c09431e (MD5) Previous issue date: 2015 / This paper constitutes a comparative study between the pinnacle works of the American beat generation of the twentieth century (“Howl”, by Allen Ginsberg, and On the road, by Jack Kerouac) e their filmic adaptations produced in the first decade of the twentieth first century. Our goal is to bring forth a dialogue established by these four objective elements, based on the analysis of the congress of their individual poetics, and, in light of this, to contribute to a process that appears to be contemporarily inescapable, the relations between cinema and literature. To this end, the following dissertation will consist of the study of regularities of behavior in the adaptation process presented in the corpus before us as a means of deducing and describing possible systemic norms that underlie and regulate the transpositions between the beat literary system and the contemporary cinematographic system. On the other hand, but not separately, as we understand adaptation as rounded semiotic systems, we must consider the contexts in which they are inserted and what relations they actualize within their arrival system, not only that but investigate possible analogies to the departure system, We hope to demonstrate that these different strands of the problem are intertwined and connected if we create a common filed of tension in which the art-works are able to sustain dialogue – this we endeavored to do with the stablishment of an organizing principle, the common theme of madness. Our goal is, ultimately, to try to equate the importance of the product of adaptation and its counterpart in our analysis, transforming the field of Translation Studies into something closer to Compared Studies – of Literature or Cinema, as if our objects of research were ontologically comparable entities. We base our endeavor to achieve this task in the works of Walter Benjamin (2012), Mikhail Bakhtin (2010), Itamar Even-Zohar (1990), Jacques Derrida (1995), Maurice Blanchot (1987), Michel Foucault (1989), Gideon Toury (1995), Patrick Catrysse (1992), amongst others. / Este trabalho constitui um estudo comparativo entre as produções literárias pinaculares da geração beat americana de meados do século XX (“Howl” de Allen Ginsberg e On the Road de Jack Kerouac) e as suas reescrituras fílmicas produzidas na primeira década do século XXI. Procuramos aqui trazer a diálogo as quatro obras e, fundamentando-nos em uma análise do congresso de suas poéticas, contribuir para o estudo de um processo que nos parece contemporaneamente inescapável, a relação entre cinema e literatura. Para tanto, a presente dissertação consistirá do estudo das regularidades de comportamento do processo tradutor apresentadas no corpus que nos é possível analisar de modo a deduzir e descrever as possíveis normas sistêmicas que subjazem e regulam as transposições entre o sistema literário beat e o sistema cinematográfico contemporâneo. Por outro lado, mas não separadamente, na medida em que enxergamos as adaptações como sistemas semióticos acabados, devemos considerar os contextos em que elas se inserem e que relações elas desenvolvem dentro do sistema de chegada, além de investigarmos possíveis analogias com os contextos e sistemas de partida. Esperamos demonstrar que estes lados do problema se interligam se criarmos um campo tenso comum em que as obras possam dialogar, o que buscamos fazer através do estabelecimento de um princípio organizador, o tema comum da loucura. Nossa proposta é, finalmente, tentar igualar a importância do produto da tradução e do elemento de partida em nossa análise, transformando o campo dos estudos da tradução em algo mais próximo dos Estudos Comparados – de Cinema ou Literatura, como se nossos objetos fossem seres ontologicamente equiparáveis. Pautamo-nos, para realizar esta tarefa, nos trabalhos de Walter Benjamin (2012), Mikhail Bakhtin (2010), Itamar Even-Zohar (1990), Jacques Derrida (1995), Maurice Blanchot (1987), Michel Foucault (1989), Gideon Toury (1995), Patrick Catrysse (1992), entre outros.

Cette thèse se situe dans le cadre de l'analyse théorique et numérique de modèles en séparation de phase qui tiennent compte d'effets d'anisotropie. Ceci est pertinent, par exemple, pour l'évolution de cristaux dans leur matrice liquide pour lesquels ces effets d'anisotropie sont très forts. On étudie l'existence, l'unicité et la régularité de la solution des équations de Cahn-Hilliard et d'Allen-Cahn ainsi que son comportement asymptotique en terme d'existence d'un attracteur global de dimension fractale finie. La première partie de la thèse concerne certains modèles de séparation de phase qui, en particulier, décrivent la formation de motifs dendritiques. D'abord, on étudie les équations de Cahn-Hilliard et d'Allen-Cahn qui prennent en compte les effets d'anisotropie forts en dimension un avec des conditions de type Neumann sur le bord et une non linéarité régulière de type polynomial. En particulier, ces modèles contiennent un terme supplémentaire appelé régularisation de Willmore. Ensuite, on étudie ces modèles avec des conditions de type périodique (respectivement, Dirichlet) sur le bord pour l'équation de Cahn-Hilliard (respectivement, d'Allen-Cahn) mais en dimension spatiales plus élevées. Finalement, on étudie la dynamique des équations de Cahn-Hilliard et d'Allen-Cahn visqueux avec des conditions de type Neumann et Dirichlet respectivement sur le bord et une non linéarité régulière et en plus, la présence de simulations numériques qui montrent les effets du terme de viscosité sur l'anisotropie et l'isotropie dans l'équation de Cahn-Hilliard. Dans le dernier chapitre, on étudie le comportement en temps long en termes d'attracteurs de dimension finie, d'une classe d'équations doublement non linéaires de type Allen-Cahn avec des conditions de type Dirichlet sur le bord et une non linéarité singulière. / This thesis is situated in the context of the theoretical and numerical analysis of models in phase separation which take into account the anisotropic effects. This is relevant, for example, for the development of crystals in their liquid matrix for which the effects of anisotropy are very strong. We study the existence, uniqueness and the regularity of the solution of Cahn-Hilliard and Alen-Cahn equations and the asymptotic behavior in terms of the existence of a global attractor with finite fractal dimension. The first part of the thesis concerns some models in phase separation which, in particular, describe the formation of dendritic patterns. We start by study- ing the anisotropic Cahn-Hilliard and Allen-Cahn equations in one space dimension both associated with Neumann boundary conditions and a regular nonlinearity. In particular, these two models contain an additional term called Willmore regularization. Furthermore, we study these two models with Periodic (respectively, Dirichlet) boundary conditions for the Cahn-Hilliard (respectively, Allen-Cahn) equation but in higher space dimensions. Finally, we study the dynamics of the viscous Cahn-Hilliard and Allen-Cahn equations with Neumann and Dirichlet boundary conditions respectively and a regular nonlinearity in the presence of the Willmore regularization term and we also give some numerical simulations which show the effects of the viscosity term on the anisotropic and isotropic Cahn-Hilliard equations. In the last chapter, we study the long time behavior, in terms of finite dimensional attractors, of a class of doubly nonlinear Allen-Cahn equations with Dirichlet boundary conditions and singular potentials.

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