Ankle sprains are among the most common injuries sustained by physically active individuals. Although ankle sprains are often considered innocuous in nature, a large percentage of individuals experience repetitive sprains, residual symptoms, and recurrent ankle instability following a single acute sprain; otherwise known as chronic ankle instability (CAI). In addition to repetitive ankle trauma, those with CAI experience reductions in functional capacity over the life span. This indicates that current intervention strategies for CAI are inadequate and require further investigation. The objective of this dissertation was to explore differences in walking and running gait parameters between individuals with and without CAI; as well as, examine the effects of a 2-week Maitland Grade III anterior-to-posterior talocrural joint mobilization intervention on self-reported function, ankle mechanics, postural control, and walking and running gait parameters in a cohort of individuals with CAI. It was hypothesized that individuals with CAI would exhibit different gait kinematics and joint coupling variability patterns compared to healthy individuals and the joint mobilization intervention would improve patient-oriented, clinician-oriented, and laboratory-oriented measures of function in those with CAI. Several observations were made from the results. In the first study, alterations in single joint kinematics and joint coupling variability were found between those with CAI and healthy individuals. In the second study, it was determined that the joint mobilization intervention improved patient-oriented and clinician-oriented measures of function as indicated by improved Foot and Ankle Ability Measure scores, increased weight-bearing dorsiflexion range of motion, and increased reach distances on the Star Excursion Balance Test. However, there were no changes in measures of instrumented ankle arthrometry or laboratory measures of postural control. In the third study, there were no changes in single joint kinematics or joint coupling variability during walking and running associated with the joint mobilization intervention. It can be concluded that joint mobilizations had a significant positive impact on patient-, and clinician-oriented measures of function. Though the laboratory measures did not detect any improvements, joint mobilizations did not produce deleterious effects on function. Therefore, future investigation on the effects of joint mobilization in conjunction with other, more active, rehabilitation strategies is warranted.

Dissertation submitted in partial compliance with the requirements for the Master's Degree in Technology: Chiropractic, Durban Institute of Technology, 2005. / An inversion ankle sprain can be defined as an injury caused by landing forcefully on an inverted, plantarflexed and internally rotated foot. This results in the fibres of the surrounding ligaments to become ruptured without disturbing the continuity of the ligament. Chronic stable ankle sprains was defined as the recurrent giving way of the ankle and there may be residual pain and swelling with no mechanical instability. According to literature, mechanisms involved in the development of chronic ankle sprains are: the lack of appropriate and early immobilization in severe cases, the development of scar tissue, lack of strengthening exercises or the development of hypermobility. Many treatments have been suggested to address these factors and would include: peripheral manipulation of the ankle joint, Muscle Energy Technique, muscle strengthening and stretching, proprioceptive training and deep transverse friction massage. Of the above mentioned treatments, Muscle Energy Technique has not been researched in a clinical setting for the treatment of chronic stable ankle inversion sprains. Therefore the purpose of this study was to investigate the relative effectiveness of Muscle Energy Technique compared to Manipulation in the treatment of chronic stable ankle inversion sprains. / M

Submitted in partial compliance with the requirements for the Master’s Degree in Technology: Chiropractic, Durban University of Technology, Durban, South Africa, 2016. / Purpose: Ankle sprains are amongst the most common injury sustained by athletes and the general public. When an ankle is repeatedly sprained it results in chronic ankle instability syndrome (CAIS). This repeated trauma results in disruption of the afferent nerve supply from the injured joint, which affects the motor neuron pool excitability of the peroneal and soleus muscles resulting in arthogenic muscle inhibition (AMI). Traditional treatment for CAIS focuses on rehabilitation of the affected muscles via strength and proprioceptive training. Recent literature has shown that the addition of ankle joint manipulation resulted in improved clinical outcomes in the treatment of CAIS. The mechanism on how joint manipulation affects AMI is under-investigated especially in extremity joints. Thus this study aimed to determine the immediate effect of ankle joint manipulation on peroneal and soleus muscle activity, by assessing surface electromyography (sEMG) H/M ratio to detect a change in the proportion of the total motor neuron pool being recruited, in participants with CAIS. Methods: The study utilised a quantitative, experimental, pre-test post-test study design. Forty two participants with grade I and II CAIS, aged 18-45 years, were randomly allocated into one of three groups. Group one received a single talocrural joint long axis distraction manipulation, group two received a sham manipulation and group three was the control receiving no intervention. sEMG H/M ratio measurements were taken before and immediately after the intervention using a Biopac wireless emg system. Results: The groups were comparable at baseline for age, gender, body mass index and H/M ratio measurements for the soleus and peroneal muscles (p < 0.050). Intra-group analysis of the soleus muscle H/M ratio showed no statistically significant change over time for the manipulation (p = 0.975) and sham (p = 0.056) groups, with the control group showing a statistically significant (p = 0.019) decrease in the H/M ratio. For the peroneal muscle no statistically significant (p > 0.050) differences were observed in any of the three groups. Inter-group analysis of the soleus muscle H/M ratio measurements showed no statistically significant differences between the three groups (p = 0.470; F = 1.010) over time, with Tukey’s HSD post-hoc test revealing a statistically significant (p = 0.028) difference being observed between the sham and control groups in terms of post soleus muscle H/M ratio measurements. Conclusion: This study failed to show that ankle joint manipulation affects the soleus and peroneal muscles in terms of H/M ratio measurements in participants with CAIS. There may have been a trend of an effect of the sham and manipulation interventions counteracting the muscle fatigue experienced in the control group, however further investigation is required. / M

A dissertation submitted in partial compliance with the requirements for the Master's Degree in Technology: Chiropractic, Durban University of Technology, 2007. / Ankle sprains account for 85% of all injuries to the ankle (Garrick, 1997). Inversion sprains result from a twisting of a weight-bearing foot into a plantarflexed and inverted position leading to lateral ankle ligament injury. Louwerens and Snijders (1999) state that there are multiple factors involved in ankle sprains or lateral ankle instability. These include injury to the lateral ankle ligaments, proprioceptive dysfunction and decrease of central motor control. Other factors that still need further research include the role of the fibularis muscles, the influence of foot geometry and the role of subtalar instability in ankle sprains (Louwerens and Snijders, 1999). This study focused on the fibularis muscles. Fibularis longus and brevis muscles are found in the lateral compartment of the leg and function to evert/pronate the foot and plantarflex the ankle. Fibularis tertius is found in the anterior compartment and its function is to evert and dorsiflex the foot. Myofascial trigger points in these three muscles refer pain primarily over the lateral malleolus of the ankle, above, behind and below it (Travell and Simons, 1993 2: 371). This is the exact area where ankle sprain patients experience pain. Travel and Simons (1993 2:110) state that a once off traumatic occurrence can activate myofascial trigger points. When considering the mechanism of injury of a lateral ankle sprain, the importance of the fibularis muscles becomes obvious. When the ankle inverts during a lateral ankle sprain, these muscles are forcefully stretched whilst trying to contract to bring about their normal action. Therefore these muscles are often injured from traction when the foot inverts (Karageanes, 2004). It stands to reason that as a result of this mechanism of injury myofascial trigger points may develop in the fibularis muscles. It was hypothesised that fibularis muscle trigger points would prove to be more prevalent in the injured leg when compared to the uninjured leg. To further investigate this hypothesis, an analytical, cross sectional study (phase 1) was done on 44 participants between the ages of 15 and 50. Consecutive convenience sampling was used and participants were screened according to phase 1’s inclusion and exclusion criteria. According to Travel et al. (1999 1: 19) myofascial trigger points (whether active or latent) can cause significant motor dysfunction. Trevino, et al. (1994) stated that fibularis muscle weakness is thought to be a source of symptoms after an inversion sprain. Treatment for ankle sprains involves minimising swelling and bruising and encouraging adequate ankle protection in the acute phase. The patient is advised to rest for up to 72 hours to allow the ligaments to heal (Ivins, 2006). After the acute phase has passed, rehabilitation is focused on. This includes improving the ankle range of motion and proprioception. Attention is also given to strengthen the muscles, ligaments and tendons around the ankle joint. In the recommended treatment protocol however, no mention is made of evaluating the musculature around the ankle joint for myofascial trigger points and or treating these points. McGrew and Schenck (2003) noted that if the musculature and neural structures surrounding the ankle joint were affected during an ankle sprain injury, and were left unresolved, they would lead to chronic instability. It was hypothesised that lateral ankle pain due to inversion ankle sprain injuries may be due to referred pain from the fibularis muscle trigger points. Patients treated with dry needling of the fibularis muscle trigger points would therefore show a greater improvement in terms of subjective and objective clinical findings when compared to a placebo treatment (detuned ultrasound) applied to the fibularis muscle trigger points. / M

The purpose of this study was to determine if prophylactic ankle tape and/or ankle braces improve dynamic stability in TTS measure. All subjects were healthy and had no prior history of ankle injuries. Data collection consisted of each subject performing a single leg jump-landing with ankle tape, ankle brace, combination of the two, and control (no tape or brace) conditions. Dynamic stability was assessed with time to stabilization force plate measure. Significant plane by ankle tape interaction (p=0.045) was found. No significant plane by ankle tape by ankle brace interaction (p=0.637), no significant ankle tape by ankle brace interaction (p=0.483), or plane by ankle brace interaction (p=0.697) were found. A notable finding was that subjects took longer to stabilize in the anterior/posterior direction than medial/lateral direction. In conclusion ankle tape, ankle brace, and the combination of ankle tape and ankle brace did not statistically improve dynamic stability in healthy ankles.

Mok, Kam Ming. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2010. / Includes bibliographical references (leaves 36-44). / Abstracts in English and Chinese. / Abstract --- p.ii / Chinese abstract --- p.iii / Acknowledgement --- p.iv / Table of contents --- p.V / List of figures --- p.vii / List of tables --- p.viii / Chapter Chapter 1: --- Introduction --- p.1 / Chapter Chapter 2: --- Review of literature --- p.3 / Chapter 2.1 --- Why prevent ankle ligamentous sprain? --- p.3 / Chapter 2.2 --- A sequence of injury prevention --- p.4 / Chapter 2.3 --- Biomechanical approaches in defining injury mechanism --- p.5 / Chapter 2.4 --- Injury mechanism of ankle ligamentous sprain in sports --- p.6 / Chapter 2.5 --- Model-Based Image-Matching motion analysis --- p.7 / Chapter Chapter 3: --- Development of an ankle joint Model-Based Image-Matching motion analysis technique --- p.9 / Chapter 3.1 --- Introduction --- p.9 / Chapter 3.2 --- Materials and method --- p.10 / Chapter 3.2.1 --- Cadaver test --- p.10 / Chapter 3.2.2 --- Model-Based Image-Matching motion analysis --- p.12 / Chapter 3.2.3 --- Statistical analysis --- p.14 / Chapter 3.3 --- Results --- p.15 / Chapter 3.3.1 --- Validity --- p.15 / Chapter 3.3.2 --- Intra-rater reliability --- p.16 / Chapter 3.3.3 --- Inter-rater reliability --- p.17 / Chapter 3.4 --- Discussion --- p.17 / Chapter 3.5 --- Conclusion --- p.21 / Chapter Chapter 4: --- Biomechanical motion analysis on ankle ligamentous sprain injury cases --- p.22 / Chapter 4.1 --- Introduction --- p.22 / Chapter 4.2 --- Materials and method --- p.24 / Chapter 4.2.1 --- Case screening --- p.24 / Chapter 4.2.2 --- Model-Based Image-Matching motion analysis --- p.24 / Chapter 4.3 --- Results --- p.28 / Chapter 4.3.1 --- High Jump Injury --- p.28 / Chapter 4.3.2 --- Field hockey Injury --- p.28 / Chapter 4.3.3 --- Tennis Injury --- p.29 / Chapter 4.4 --- Discussion --- p.30 / Chapter 4.5 --- Conclusion --- p.34 / Chapter Chapter 5: --- Summary and future development --- p.35 / References --- p.36 / List of publications --- p.42 / List of presentations at international and local conference --- p.43 / List of Awards --- p.44

Chan, Yue Yan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2008. / Includes bibliographical references (leaves 36-40). / Abstracts in English and Chinese. / Abstract --- p.i / Chinese abstract --- p.ii / Acknowledgement --- p.iii / Table of Contents --- p.iv / List of figures --- p.vi / List of tables --- p.vii / Chapter Chapter 1: --- Introduction --- p.1 / Chapter Chapter 2: --- Review of literature --- p.4 / Chapter 2.1 --- Chapter introduction --- p.4 / Chapter 2.2 --- Anatomy and kinematics of the ankle --- p.4 / Chapter 2.3 --- Epidemiology of ankle sprain --- p.6 / Chapter 2.4 --- Grading system for classification of ankle sprain --- p.7 / Chapter 2.5 --- Previous measures of protecting ankle from sprain injury --- p.7 / Chapter 2.6 --- Usage of motion sensors in human motion detection --- p.9 / Chapter Chapter 3: --- A mechanical supination sprain simulator for studying ankle supination sprain kinematics --- p.11 / Chapter 3.1 --- Chapter Introduction --- p.11 / Chapter 3.2 --- Methods --- p.12 / Chapter 3.3 --- Results --- p.17 / Chapter 3.4 --- Discussion --- p.17 / Chapter Chapter 4: --- Identification of simulated ankle supination sprain from other normal motions by gyrometers and accelerometers --- p.19 / Chapter 4.1 --- Chapter introduction --- p.19 / Chapter 4.2 --- Methods --- p.20 / Chapter 4.2.1 --- Data collection --- p.20 / Chapter 4.2.2 --- Support Vector Machine for classification of human motion --- p.22 / Chapter 4.2.3 --- Training the Support Vector Machine --- p.23 / Chapter 4.2.4 --- Support Vector Machine verification --- p.24 / Chapter 4.2.5 --- Choose the optimal position of motion sensor --- p.25 / Chapter 4.3 --- Results --- p.25 / Chapter 4.4 --- Discussion --- p.29 / Chapter Chapter 5: --- Summary and future development --- p.34 / References --- p.36 / List of publications --- p.41 / List of presentations at international and local conferences --- p.41 / Appendix I: --- p.42 / Related publication: / "Chan, Y. Y., Fong, D. T. P., Yung, P. S. H., Fung, K. Y., & Chan, K. M (1998). A mechanical supination sprain simulator for studying ankle supination sprain kinematics. Journal of Biomechanics. 41(11), 2571-2574." / Appendix II: --- p.46 / Ethical approval of the investigation of ankle torque and motion signal pattern in foot segment during simulate sprain and other motion

Total ankle arthroplasties (TAAs) are mechanical devices used to replace the articular surfaces of the ankle joint in order to relieve pain for patients with osteoarthritis. Since most osteoarthritis is post-traumatic, and due to the highly variable individual foot geometry, TAAs are rarely inserted into normal geometry. This leads to serious problems with stresses and contact pressures in TAA components. This study uses finite element (FE) modeling to determine how hindfoot alignment, or how far in varus or valgus the most distal part of the calcaneus is perpendicularly from the axis of the tibia, affects the stresses and contact pressures in the articulating surfaces of two different TAA models. To investigate the effects of foot alignment on hardware stresses after TAA, FE models were generated. Models of the mobile bearing, three component Scandinavian Total Ankle Replacement (STAR) and the fixed bearing, two component Zimmer Trabecular Metal Total Ankle (Zimmer) were generated from laser scans of the hardware and virtually implanted into 3D models of the tibia and talus. Ligaments were modeled as linear springs to impart physiologically realistic flexibility in the model. The stance phase of a walking gait cycle was applied and stresses and contact pressures at the articulation between model components were recorded for various degrees of hindfoot alignment [1]. Data analyzed shows that both models have areas of high concentrations of stress and contact pressure. The Zimmer TAA seems to favor a valgus alignment due to the lower stresses and contact pressures in valgus alignments compared to varus. Though the STAR does not generally favor one alignment over the other, it does have significantly lower stresses and contact pressures than the Zimmer. These differences may be due to the geometric congruency of the STAR versus the anatomical articulation of the Zimmer.

[Truncated abstract] First metatarsophalangeal joint (MTPJ1) motion is an important factor in normal weight transference during walking. Disruptions to normal range can influence joints both proximal and distal to the MTPJ1, potentially leading to pain and dysfunction. Whilst the MTPJ1 has been investigated significantly, the numerous methodologies described to quantify range of motion can be questioned and makes comparisons difficult. Range of MTPJ1 motion is commonly assessed in a clinical setting to determine pathology as well as to make decisions on appropriate intervention. The anatomical and biomechanical influence of tendo Achilles load and MTPJ1 motion has been well described; however few studies measuring MTPJ1 range control for Achilles load or describe ankle joint positioning. Further to this the effects of reducing tendo Achilles stiffness on MTPJ1 extensions has yet to be investigated. The purpose of this study was to describe a technique to quantify passive MTPJ1 extension and to determine the influence of ankle joint position on joint range. Secondly the effect of calf muscle stretching on MTPJ1 range was also investigated. The information gathered will assist both research and clinical protocols for quantifying MTPJ1 range, and provide a greater understanding of the anatomic and biomechanical relationship between tendo Achilles load and MTPJ1 extension. In order to fulfil the purposes of the study it was necessary to establish a reliable methodology to quantify non weight bearing MTPJ1 extension. Reliability testing was undertaken in three parts. '...' The results demonstrated a statistically significant increase in joint range immediately following a one minute stretch for variables ankle joint range of motion as well as MTPJ1 extension for ankle joint plantar flexed at 10 Newton's and ankle joint neutral and plantar flexed at 30 Newtons. No significant differences were noted in ankle or MTPJ1 range of motion in either the control group on immediate re-testing, or in both groups after a one week stretch program. The findings of this study support those documented in the literature pertaining to the ankle joint position, tendo Achilles load and plantar fascial stiffness to MTPJ1 range of motion. Increased stiffness at the MTPJ1 was noted dependant on ankle joint position from ankle joint plantar flexion through to ankle joint dorsiflexion. This appears most likely due to increases in tendo Achilles load and subsequent forces transmitted to the plantar aponeurosis. The present study also demonstrated a trend towards increased joint extensibility and limb dominance. The study also supports previous literature into gender differences and joint extensibility, with a positive trend towards increased MTPJ1 range evident in the female subjects tested. The study also demonstrated the immediate effect of calf muscle stretching on ankle and MTPJ1 range of motion. It remains however unclear as to the exact mechanisms involved in producing increased joint range be it reflex inhibition or actual changes to the viscoelastic properties of the soft tissues. Despite this, no changes were evident following a one week stretching program, which supports previous literature describing a short lag time before soft tissues revert to baseline length properties following a single stretch session.

Ankle sprains are one of the most common musculoskeletal injuries. Physiotherapy treatment and advice to rest, use ice, use compression, and elevate the ankle (RICE advice) is believed to speed up the functional recovery and enhance healing associated with acute ankle sprains. However, there is limited evidence to support the efficacy of RICE treatment. This study investigated whether physiotherapy (including RICE advice) was as effective as RICE advice alone in improving the time to recovery in a clinical situation.The evidence for RICE advice was reviewed along with the different treatment modalities currently used by physiotherapists in New Zealand for acute ankle sprain. This review highlighted the low number and poor quality of studies investigating RICE and early intervention physiotherapy management for ankle sprains. RICE principals appear to be relatively inexpensive and somewhat effective for pain relief and may reduce further tissue damage in the acute stage of Grade I and II ankle sprains. Evidence extrapolated from studies investigating the use of post surgical ice appears to support the use of ice in the acute stage of an ankle sprain to minimise bleeding and oedema. The intermittent application of ice is more effective for pain relief in the acute phase than sustained icing. Physiotherapy interventions such as TENS for pain relief and bracing for the support of Grade II - III ankle sprains have been shown to be beneficial for pain relief in the acute phase. A need for further high quality, randomised controlled trials (RCT's) was identified.Subsequently a RCT was conducted with 28 participants to investigate the difference between (a) early intervention physiotherapy management combined with RICE advice, and (b) self management RICE advice without physiotherapy.Twenty eight individuals (males n = 22, females n = 6), between the ages of 16 and 40 with acute ankle sprains, who met the inclusion criteria, were approached by physiotherapists working on this project and invited to participate. Dependant variables were pain, function, swelling, compliance and medication use up to Day 11 post injury. Swelling, pain and function were measured over three assessments on Days 1, 3 and 11, using volumetric analysis, a visual analogue scale (VAS) and a functional question derived from a validated functional questionnaire respectively. Medication use and compliance were elicited from information gathered in a participant home diary. Both groups were similar on Day 1 in respect to their initial pain, swelling, the number of participants who were referred for X-rays, and the time taken to present to the physiotherapist. However the RICE group had significantly higher function scores (p = 0.042). The RICE group also had a significantly higher use of medication on Day 1 (p = 0.035) and Day 11 (p = 0.048). For both groups there was a statistically significant decrease in swelling (p = 0.003), pain scores (p = 0.000), and an increase in function scores (p = 0.000) in relation to time over the eleven days of assessment. The physiotherapy group had significantly improved function scores (p = 0.042) from Day 1 to Day 11 compared to the RICE group. There were no significant differences between groups for swelling, pain scores, and their first day of documented non-compliance. The within day range of error in the volumetric measurements was within 189.9 ml and 1.2 ml. Three trials were conducted per person within a Day session. The first volumetric analysis was significantly less than the subsequent two measurements (p = 0.040).It was concluded that, in the early stage of an ankle injury both physiotherapy and RICE, and RICE advice alone, resulted in significant improvements in swelling, pain and function. Early intervention physiotherapy was significantly better at improving the functional ability of participants by Day 11. Early intervention physiotherapy may also identify complications associated with ankle sprains.Despite its limitations this research could potentially lead to changes in the standard treatment protocols for soft tissue ankle injuries. Implementation of self management RICE by patients in the acute stage would initially reduce the cost of physiotherapy treatments, and may lead to equal improvements in pain and swelling outcomes. However, it appears that physiotherapy may lead to better functional outcomes which would reduce the costs associated with time off work, and rehabilitation. It is important to note that these findings are based on a small sample size and on Grade I or II ankle ligament sprains, and that treatment for more severe ankle injuries may be better with physiotherapy, or surgery, rather than self management RICE by patients. Findings contribute to the growing body of 'best practice' evidence for health practitioners. Keywords: Acute soft tissue injuries, ankle, sprain, early intervention, physiotherapy, RICE, volumetric measurement.