Background: Assessment of dementia in adults with intellectual disabilities poses specific challenges. Firstly, there is a paucity of validated, standardised and appropriate neuropsychological assessments of memory for adults with intellectual disabilities. Secondly, there are difficulties determining whether performance on neuropsychological assessments are attributable to preexisting intellectual disabilities, ‘normal’ ageing or part of a dementing process. A systematic review was therefore carried out to examine if there are memory changes associated with ‘normal’ ageing in the Down syndrome population. Following this an exploratory empirical research project was undertaken to examine one aspect of construct validity (i.e. convergent validity) of an associative memory test in a sample of adults with intellectual disabilities. This research project is presented as a journal article titled ‘Convergent validity of the Visual Association Test (VAT) in adults with intellectual disabilities’. Methods: 40 participants aged between 18-45 years were recruited from Community Learning Disability Teams. Participants completed the VAT and subtests of the modified Cambridge Cognitive Examination (CAMCOG-DS). IQ was assessed using the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV). Correlational analysis of the test variables were carried out. Participants with a diagnosis of dementia were excluded from the study. Results: All participants performed well on the VAT irrespective of age, gender or IQ. It was well received by participants. No significant correlations were found between the VAT and the subtests of the CAMCOG-DS or with the subtests of the WAIS-IV. Therefore, there was no evidence of convergent validity with this test in this sample of participants. Conclusions: While the VAT was found to be an easy, quick test to use with people with intellectual disabilities and all participants scored above ‘floor’ level, it was not found to have convergent validity with the CAMCOG-DS. Further research is needed to determine if the VAT represents a useful tool for assessment with this population.

In a series of two experiments, the first involving 121 participants and the second 114, I investigated whether level of racial prejudice is related to performance on a cognitive task and helping behavior in participants who had just interacted with the target of their prejudice. The moderating effect of control was tested and, unlike previous research, the responses of African-American participants were studied too. It was proposed that when people interact with the target of their prejudice, they will experience stress and the aftereffects of stress will lead to a decrement in Stroop task performance and a lower likelihood of helping someone in need. Control was believed to moderate this effect such that those given control would suffer less of a performance decrement and would help more often. Data were analyzed using ANCOVA and logistic regression. Racial prejudice was found to affect European-American but not African-American Stroop performance following the interracial interaction. Control moderated this effect and also influenced whether someone helped a person in need.

Tidigare forskning har visat att implicita och explicita attityder formas och förändras oberoende av varandra, samt att allt fler politiker använder sig av sociala medier för att nå ut till sina väljare. Denna studie syftade till att undersöka hur deltagarnas implicita och explicita attityder, gentemot två fiktiva politiker, påverkas av traditionella och sociala medier. I studien användes en experimentell mellangruppsdesign där deltagarna slumpmässigt fördelades till olika betingelser. Dessa bestod av positiva och negativa nyhetsitems från dels traditionella dels sociala medier. I undersökningen, som genomfördes på internet, deltog 126 personer. För att mäta deltagarnas attitydförändringar användes dels ett Implicit Association Test (IAT), dels ett explicit frågeformulär. Traditionella media påverkade explicita attityder signifikant.

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Implicit prejudice, and in particular, the Implicit Association Test (IAT), are paradigmatic examples of psychological concepts and research methods that have recently enjoyed great publicity and accessibility. However, little is known about the possible reflexive consequences of this popularization for the public understanding of prejudice, and by implication, for the formulation of social policy aimed at the reduction of prejudice and racism. Specifically, how does the public interpret and contextualize the claims of the IAT and implicit prejudice? With what social and political preoccupations does this operationalization of implicit prejudice resonate? Furthermore, how do members of the public experience and interpret the IAT as both a scientific instrument and as a bearer of psychological truth? In answer to these questions, this dissertation comprises a report of two empirical studies of public encounters with the IAT and the concepts of implicit prejudice. The first of these focused on popular responses to IAT research in the New York Times. Employing a discourse analytic approach to reader comments, it identified the social and psychological concerns against which the public makes sense of the IAT. In responding to the IAT, readers drew on skeptical and confessional discourses to position themselves reflexively in relation to its claims. I argue that these discourses constitute a space within which strong injunctions to self-scrutiny, impartiality and objectivity are established as moral-psychological ideals. Building on these findings, the second study examined the IAT as a discursive practice through a focus on the lived experience of taking the test. Recruited participants took the IAT, and were subsequently interviewed to elicit moment-by-moment accounts of this process. Hermeneutic-phenomenological analysis of these accounts revealed thematic concerns that both resonated with and augmented those in the analysis of public discourse. In particular, the IAT was experienced as a vivid demonstration of the operationalization of "implicit bias". I argue that the test embodies and communicates this paradigm to test-takers, and therefore functions as a psychological pedagogical tool. The dissertation closes by discussing the implications of these analyses for public understandings of, and responses to, prejudice.

Implicit prejudice, and in particular, the Implicit Association Test (IAT), are paradigmatic examples of psychological concepts and research methods that have recently enjoyed great publicity and accessibility. However, little is known about the possible reflexive consequences of this popularization for the public understanding of prejudice, and by implication, for the formulation of social policy aimed at the reduction of prejudice and racism. Specifically, how does the public interpret and contextualize the claims of the IAT and implicit prejudice? With what social and political preoccupations does this operationalization of implicit prejudice resonate? Furthermore, how do members of the public experience and interpret the IAT as both a scientific instrument and as a bearer of psychological truth? In answer to these questions, this dissertation comprises a report of two empirical studies of public encounters with the IAT and the concepts of implicit prejudice. The first of these focused on popular responses to IAT research in the New York Times. Employing a discourse analytic approach to reader comments, it identified the social and psychological concerns against which the public makes sense of the IAT. In responding to the IAT, readers drew on skeptical and confessional discourses to position themselves reflexively in relation to its claims. I argue that these discourses constitute a space within which strong injunctions to self-scrutiny, impartiality and objectivity are established as moral-psychological ideals. Building on these findings, the second study examined the IAT as a discursive practice through a focus on the lived experience of taking the test. Recruited participants took the IAT, and were subsequently interviewed to elicit moment-by-moment accounts of this process. Hermeneutic-phenomenological analysis of these accounts revealed thematic concerns that both resonated with and augmented those in the analysis of public discourse. In particular, the IAT was experienced as a vivid demonstration of the operationalization of "implicit bias". I argue that the test embodies and communicates this paradigm to test-takers, and therefore functions as a psychological pedagogical tool. The dissertation closes by discussing the implications of these analyses for public understandings of, and responses to, prejudice.

Statistical association tests of quantitative traits have been widely used in the past decade, to locate loci associated with a disease trait. For instance, Genome Wide Association Studies (GWAS) have led to tremendous success in finding susceptible genes or associated loci. However, most of the past studies were based on unrelated samples focusing on quantitative or qualitative traits. The analysis of polychotomous traits in family samples is very challenging. This dissertation describes three projects related to methods to conduct association tests beyond continuous traits, such as multinomial traits, bivariate traits, and tests involving haplotypes. The first project focuses on developing a statistical approach to test the association between common or low-frequency variants with a multinomial trait in family samples. It is an important issue because there is no computer efficient software available for this type of question. We employ Laplace approximation in conjunction with an efficient grid-search strategy to obtain an approximate maximum log-likelihood function and the Maximum Likelihood Estimate (MLE) of the variance component. We also successfully incorporate the kinship matrix to adjust for the familial correlation, based on a regression framework. Extensive simulation studies are performed to evaluate the type-I error rate and power in scenarios with causal variant with different Minor Allele Frequency (MAF). In the second project, we propose an approach to test the association between a genetic variant and a bivariate trait arising from a combination of a quantitative and a binary trait in family samples, based on Extended Generalized Estimating Equations (EGEE). Multiple phenotype-genotype association tests are often reduced to univariate tests, decreasing efficiency and power. Our approach is shown to be much more powerful and efficient than univariate association tests adjusted for multiple testing. The third project involves the development of a general framework for meta-analysis of haplotype association tests, applicable to both unrelated and family samples. Although meta-analysis has been widely used in single-variant and gene-based tests, there are few existing methods to meta-analyze haplotype association tests. A predominant advantage of our novel approach is that it accommodates cohort-specific haplotypes as well as haplotypes common to all cohorts. The cohort participants may be either related or unrelated. Our approach consists of two stages: in the first stage, each cohort performs a haplotype association test, reports the estimates of effect size, variance, haplotypes, and their frequency. In the second stage, a generalized least square method is applied to combine the results of all the cohorts into one vector of meta-analysis coefficients. Our approach is shown to have the correct type-I error rate in scenarios with different between and within cohort variation. We also present an application to exome-chip data from a large consortium. Through the three projects, we are able to tackle the problem of conducting association tests for non-continuous traits in family samples. All the approaches achieve the correct type-I error rate and are computationally efficient. We hope these approaches will not only facilitate analyses of categorical traits in family samples, but will also provide a basis for future methodological development of statistical approaches for non-continuous traits.

Non-suicidal self-injury (NSSI) is the intentional destruction of bodily tissue in the absence of suicidal motives. NSSI is strongly associated with self-criticism (Gilbert et al., 2010) and individuals who self-injure often report doing so to punish themselves. Conversely, self-compassion, or the tendency to be caring with oneself, is associated with psychological well-being (Neff et al., 2007). The aim of the present study was to determine whether experimentally inducing self-criticism or self-compassion would lead to changes in implicit identification with NSSI. The Self-Injury Implicit Association Test (SI-IAT; Nock & Banaji, 2007) is an assessment of the strength of the automatic associations that a person holds between themselves and NSSI. Participants were randomly assigned to a self-criticism induction, a self-compassion induction, or a neutral condition and completed the SI-IAT before and after the induction. Results showed that participants in the self-criticism induction experienced an increase in their implicit associations with NSSI while implicit associations in the self-compassion and control conditions generally did not change. Results were not significantly different for those with or without a history of NSSI and highlight the importance of self-criticism in NSSI. Future research should examine increases in self-criticism as a potential precursor of NSSI in longitudinal samples.

Background: Childhood sexual abuse (CSA) has the potential to compromise the socioemotional development of the victim resulting in an increased vulnerability to difficulties regulating emotions and one’s sense of self. Emotion is thought to play a key part in a number of psychological disorders which CSA survivors are at increased risk of developing. A better understanding of the basic emotions experienced in this population and emotion regulation will inform current treatment. Aims: This research aimed to develop a better understanding of the emotions experienced by survivors of CSA and the relationship between “implicit” and explicit emotions and psychopathology. Method: Two empirical studies were conducted. Study 1 employed a cross-sectional consecutive case series design involving 109 survivors of CSA. Participants completed a set of measures relating to basic emotions, emotion regulation and symptoms. Exploratory factor analyses were conducted on the Basic Emotions scale (BES). Regression analyses were used to explore the relationship between emotions experienced, emotion regulation strategies and psychological symptoms. Study 2 examined basic emotions, “implicit disgust self-concept” and psychopathology in a population of CSA survivors (n=26) and a group of individuals currently receiving psychological therapy who reported that they had not experienced childhood trauma (n=25). Participants completed self-report measures pertaining to emotion, emotion regulation, symptoms and cognitive fusion. Participants also completed an implicit association test. Results: Exploratory factor analyses supported the structure of three versions of the BESWeekly, General, and Coping in a sample of survivors of childhood sexual abuse. In all three versions of the scale, disgust explained the largest proportion of variance. The basic emotions of sadness, fear and disgust as well as external dysfunctional coping strategies appear to predict PTSD symptomatology in this sample. The results of Study 2 also support the finding that self-reported disgust is prominent in the emotion profile of CSA survivors. Implicit disgust self-concept was not significantly correlated with other emotions or psychopathology. However, implicit disgust self-concept was found to be significantly associated with cognitive fusion. Discussion: Psychotherapeutic approaches for survivors of childhood sexual abuse should address the emotional experience of this population. In particular, these findings suggest that sadness and disgust should be targeted in therapy.

Family, twin, and adoption studies have indicated that human intelligence quotient (IQ) has significant genetic components. We performed a low-density genome-wide association analysis with a family-based association test to identify genetic variants influencing IQ, as measured by Wechsler Adult Intelligence Scale full-score IQ (FSIQ). We examined 11,120 single-nucleotide polymorphisms (SNPs) from the Affymetrix GeneChips 10K mapping array genotyped in 292 nuclear families from Genetic Analysis Workshop 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). A replication analysis was performed using part of International Multi-Center ADHD Genetics Project (IMAGE) dataset. Twenty-two SNPs were identified as having suggestive associations with IQ (p<10-3) in the COGA sample and eleven of the SNPs were located within known genes. In particular, NTM at 11q25 (rs411280, p=0.000764) and NR3C2 at 4q31.1 (rs3846329, p=0.000675) were two novel genes which have not been associated with IQ in other studies. It has been reported that NTM might play a role in late-onset Alzheimer disease while NR3C2 may be associated with cognitive function and major depression. The associations of these two genes were well-replicated by single-marker and haplotype analyses in the IMAGE sample. In conclusion, our findings provide evidence that chromosome regions of 11q25 and 4q31.1 contain genes affecting IQ. This study will serve as a resource for replication in other populations.