Thesis (Ph. D.)--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [351]-383).

Thesis (Ph. D.)--University of Washington, 1997. / Vita. Includes bibliographical references (leaves [240]-248).

Modern writers like Djuna Barnes allow for the post-modern fluidity and explosion of sex and gender without finalizing either in a fixed form. Whereas the classical, archetypal androgyne is made up of two halves, one man and one woman; the deconstructed androgynous figure is not constituted of oppositional terms which would reflect an essential and unimpeachable truth. I reveal the way Djuna Barnes’ Nightwood not only thematizes the fluid androgyne, but also cleverly verbalizes David Wood’s perpetual and un-dischargable “debt” to extra-discursivity while poetically critiquing gender “appropriateness,” societal constraints, and the constitution of identity. Barnes presents a decentralized, ungrounded and non-prescribed world in Nightwood not only through her cross-dressing and androgynous characters, but also in her poetics, her assertion of the open-ended quality of language, and a strong imperative to negotiate our physical existence in a world of fluid gender and sexual boundaries.

This study examines the development of Edward Larrabee Barnes's design concepts for the Dallas Museum of Art, from preliminary concepts and program statements by Director Harry Parker and Dallas Museum trustees, through initial planning and architect selection, to site selection, the Program and Space Study, Barnes's early conceptual plans, and his Dallas Arts District master planning. Influences on Barnes's work and his career development leading to the Dallas commission, his most ambitious museum to date, are examined. Discussion and documentation of design development is based on schematic studies, presentation drawings, models, and trustees' minutes. Design changes during construction and all phases of expansion planning are also discussed. The conclusion summarizes historical influences on the design and Barnes's fulfillment of program concepts.

Among slaughterhouses and suffragists—writers of the American Modernist movement were called to the creative task of reimagining boundaries between human and nonhuman while also extending this conversation onto the site of “New Women.” The threat to “civilized man” by “primal nonhuman animal” becomes tied up with the threat of an independent “wild” woman to a system which traditionally depends upon her domestication. Female animality in modernist texts thus emerges as a symbol of both masculine anxiety and feminine liberation. When women begin to challenge traditional institutions which would see her survive exclusively by contract to a male “keeper,” men become increasingly desperate to establish an apex social, economic, and political position. As such, female animality in these texts is designed to reinforce or resist standard constructs of human/nonhuman and masculine/feminine, yet both assert the feminine-animal-character as a hybrid commodity bred for patriarchal consumption. Despite the heteronormative compulsion to sketch woman as an elusive animal to be hunted (courtship), caged (marriage), and kept (children)—there is also an advantage in recognizing one’s place in such a “jungle,” as scholars have often described progressive-era America. By examining the intersection of animality and feminist theory within modernist literature, it becomes clear that the category of nonhuman animal is one historically manipulated through patriarchal systems to delegate women’s bodies as a site of oppression and subordination. / Includes bibliography. / Thesis (M.A.)--Florida Atlantic University, 2021. / FAU Electronic Theses and Dissertations Collection

This study examines the development of Edward Larrabee Barnes's design concepts for the Dallas Museum of Art, from preliminary concepts and program statements by Director Harry Parker and Dallas Museum trustees, through initial planning and architect selection, to site selection, the Program and Space Study, Barnes's early conceptual plans, and his Dallas Arts District master planning. Influences on Barnes's work and his career development leading to the Dallas commission, his most ambitious museum to date, are examined. Discussion and documentation of design development is based on schematic studies, presentation drawings, models, and trustees' minutes. Design changes during construction and all phases of expansion planning are also discussed. The conclusion summarizes historical influences on the design and Barnes's fulfillment of program concepts.

No description available.

The goal of this study was to examine age-related changes in spatial memory and its neurobiological substrates as assessed by the Morris water maze (MWM) and the Barnes maze. The MWM is one of the most widely used tests of spatial memory and numerous studies suggest that spatial memory abilities decline with age. To contrast, very few studies exist comparing different ages of mice in the less stressful Barnes maze, and no systematic life span analysis of performance has been published. As the cerebellum is one brain structure that undergoes a quantifiable change in anatomy across the life span (loss of Purkinje neurons), this study evaluated these behavioral tests in terms of sensitivity to both age-related changes in learning as well as age-related changes in the cerebellar cortex. A total of 65 CB6F1 mice were tested at one of five ages (4, 8, 12, 18, or 25 months) on the MWM and Barnes maze. Deficits in spatial memory acquisition were most apparent in both tasks when comparing a subset of good learning mice. Impairment began at 25 months in the MWM and 18 months in the Barnes maze. In all mice, retention was impaired at 25 months on the Barnes maze, but no clear retention deficits were found in the MWM. Unbiased stereology revealed an age-related loss in cerebellar cortical Purkinje neurons from 12-25 months, whereas hippocampus volume remained stable across the life span. Purkinje neuron number, but not hippocampus volume, was correlated with spatial learning in the Barnes maze, with impaired learning associated with lower neuron numbers. For the MWM, Purkinje neuron number was associated with performance in a subset of good learning animals. Overall, mice that learned the Barnes maze well had more Purkinje neurons than poor learners. Both tests were sensitive to heterogeneity in aging at each age tested. Comparisons of good and poor learners across the life span, as well as correlations between the two tasks and brain measures, suggested that the MWM and Barnes maze may be sensitive to different spatial learning abilities and mechanisms of aging. / Psychology

Yes / The ability to either erase or update the memories of a previously learned spatial task is an essential process that is required to modify behaviour in a changing environment. Current evidence suggests that the neural representation of such cognitive flexibility involves the balancing of synaptic potentiation (acquisition of memories) with synaptic depression (modulation and updating previously acquired memories). Here we demonstrate that the p38 MAPK/MAPK-activated protein kinase 2 (MK2) cascade is required to maintain the precise tuning of long-term potentiation and long-term depression at CA1 synapses of the hippocampus which is correlated with efficient reversal learning. Using the MK2 knockout (KO) mouse, we show that mGluR-LTD, but not NMDAR-LTD, is markedly impaired in mice aged between 4 and 5 weeks (juvenile) to 7 months (mature adult). Although the amplitude of LTP was the same as in wildtype mice, priming of LTP by the activation of group I metabotropic receptors was impaired in MK2 KO mice. Consistent with unaltered LTP amplitude and compromised mGluR-LTD, MK2 KO mice had intact spatial learning when performing the Barnes maze task, but showed specific deficits in selecting the most efficient combination of search strategies to perform the task reversal. Findings from this study suggest that the mGluR-p38-MK2 cascade is important for cognitive flexibility by regulating LTD amplitude and the priming of LTP. / Professor Richard Greene at the University of Bradford - startup fund to setup electrophysiological facility and Wellcome Trust 200646/Z/16/Z to S.A.L.C.

Résumé : Le contexte récent d’accélération de la fonte des glaciers et calottes glaciaires (GCG) de l’archipel arctique canadien, jumelé aux difficultés de suivi des GCG de cette région, rendent essentiels le développement et l’utilisation de nouvelles approches innovatrices de suivi. Le potentiel de la stéréo radargrammétrie (SRG) RADARSAT-2 est ici caractérisé pour l’extraction d’élévations et le calcul de changements d’élévation et de bilans de masse (historiques et récents) sur les calottes glaciaires Barnes et Penny (Nunavut, Canada). Par la méthode semi-automatisée de recherche de corrélation à partir de couples stéréoscopiques RADARSAT-2 de 2013 (mode wide ultra-fin; résolution spatiale de 3 m; taille d’image de 50 km x 50 km), une précision verticale de ~7 m (LE68) est mesurée sur la terre ferme, et cette valeur de précision est possiblement légèrement supérieure sur la calotte Barnes, étant donné la variabilité de profondeur de pénétration. Par captage 3D, une précision altimétrique de ~3-4 m (LE68) est mesurée par différents photo-interprètes à partir de couples RADARSAT de 2012 en zone d’ablation de la calotte Penny. Sur la calotte Barnes, les changements d’élévation mesurés par rapport aux premiers modèles numériques de terrain disponibles permettent de mesurer un bilan de masse spécifique historique (1960-2013) de -0,49 ± 0,20 m w.e./année, pour un bilan de masse total de -2,9 Gt/année. Entre 2005 et 2013, le bilan de masse spécifique de cette calotte augmente significativement à -1,20 ± 0,86 m w.e./année, pour un bilan de masse total de -7 Gt/année. En zone d’ablation de la calotte Penny, un changement d’élévation annuel moyen de -0,59 m/année est mesuré entre 1958 et 2012. Parallèlement, plusieurs aspects méthodologiques et techniques sont discutés et analysés. Des profondeurs de pénétration nulles (bande C) sont mesurées à partir des images acquises sur la calotte Barnes à la toute fin de la saison d’ablation (fin septembre/début octobre), alors que cette profondeur augmente à ~2,5-3 m pour des images acquises à la fin octobre/début novembre (période de gel). Nos résultats suggèrent aussi que le modèle de fonction rationnelle, lorsqu’utilisé avec des images RADARSAT-2 en mode wide ultra-fin, permet d’obtenir des précisions plus constantes que le modèle hybride de Toutin. De par son indépendance des conditions météorologiques, son utilisation possible sans point de contrôle et sa simplicité de traitement, la SRG RADARSAT-2 s’avère donc être une excellente alternative aux technologies actuelles pour le suivi de GCG situés dans des régions affectées par des contraintes opérationnelles importantes. / Abstract : Given the recent melt acceleration of the Canadian arctic archipelago’s ice caps and the monitoring difficulties of this remote region, the development of new innovative monitoring tools has become essential. Here, the potential of the RADARSAT-2 stereo radargrammetry (SRG) is characterized for elevations extraction, as well as for elevation changes/mass balances calculations (historical and recent) on Barnes and Penny ice caps (Nunavut, Canada). Using the semi-automatic approach of correlation search from RADARSAT-2 stereoscopic couples of 2013 (wide ultra-fine mode; spatial resolution of 3 m; coverage of 50 km x 50 km), a vertical precision of ~7 m (LE68) is measured on ice-free terrain and this precision is possibly slighty worse on the ice cap because of the penetration depth’s variability. On the other hand, the 3D vision extraction approach reveals an altimetric precision of ~3-4 m (LE68) on the ablation area of the Penny Ice Cap. On the Barnes Ice Cap, elevation changes calculated relative to the oldest digital elevation models available allows to calculate an historical specific mass balance (1960-2013) of -0,49 ± 0,20 m w.e./year, resulting in a total annual mass balance of -2,9 Gt/year. Between 2005 and 2013, the specific mass balance of this ice cap increases to -1,20 ± 0,86 m w.e./year, which equals to a total annual mass balance f -7 Gt/year. On Penny Ice Cap’s ablation area, an average elevation change of -0,59 m/year is measured between 1958 and 2012. As also suggested in the literature, the recent melt acceleration is highly linked to warmer summer temperatures. Methodological and technical aspects are also presented and analyzed. No penetration depth (C band) is perceived on elevations derived from late ablation season images (late September/beginning of October), while a penetration of ~2,5-3 m is measured from images acquired in late October/beginning of November (freeze period). Our results also suggest the superiority and better consistency of the rational function model for geometrical correction of wide ultra-fine mode RADARSAT-2 images, compared to the hybrid Toutin’s model. Because of its all-weather functionality, its possible use without any ground control point and the simplicity and facility of its treatment, the RADARSAT-2 SRG represents a really good technology for glacier monitoring in regions affected by serious operational constraints.