H.D., Djuna Barnes et Laura (Riding) Jackson incarnent trois visages du modernisme américain expatrié. C’est autour de leur place paradoxale dans le contexte d’instabilité et de circulation de ce moment littéraire que s’articulent leurs parcours respectifs. Cette thèse cherche à montrer comment l’expérience du déplacement géographique s’incarne dans le texte thématiquement, stylistiquement, grammaticalement, génériquement et dans le genre (gender) pour produire une écriture autobiographique déplacée qui interroge et transgresse les frontières. On analysera comment l’expatriation des trois auteurs et leur marginalité dans la communitas des expatriés produisent une écriture qui remet en question la limite entre personnel et impersonnel. On explorera les représentations du déplacement géographique lui-même comme thématique et esthétique. En adoptant une méthode de cartographie littéraire, nous mettons au jour une écriture nomade et interrogerons le rapport à la nation dans les textes qui travaille le trope du Grand Tour. L’analyse de l’esthétique du déplacement de l’autobiographie sur les éléments organiques du texte met au jour la métaphorisation du déracinement et le processus de déterritorialisation/reterritorialisation de l’expatriation et du genre féminin chez H.D., Barnes et (Riding) Jackson. / H.D., Djuna Barnes and Laura (Riding) Jackson embody three facets of American expatriate modernism. Their trajectories hinge on their paradoxical place in modernism’s context of instability and circulation. This thesis purports to show how their works are imbued with the experience of geographical displacement at various levels (thematic, stylistic, grammatical, generically and in gender). This porosity between life and work results in a displaced autobiographical writing which questions and transgresses frontiers. The first section deals with how these authors’ expatriation and marginality in the expatriate communitas produce texts which probe the limit between the personal and the impersonal. The second part focuses on the representations of the geographical displacement itself—both as theme and aesthetics. By resorting to a literary cartography method, we argue for a nomadic writing and interrogate the writers’ relation to the concept of nation in texts which deploy the Grand Tour trope. The final section analyzes the aesthetic transference of the autobiography on the organic elements of the text. These motifs act as metaphors of the subject’s uprootedness and of the deterritorialization/reterritorialization process at work for expatriate women writers.

In this essay I trace the historical theme in Djuna Barnes’s Nightwood, stressing the importance of the concept of forgetfulness in the text. Read alongside Nietzsche’s On the Use and Abuse of History for Life as well as his later thoughts on genealogy, the novel can be seen to concern itself with that same dilemma of history that he articulates in his philosophy. That is: how not to be overburdened by historical knowledge to the point where it petrifies life and prevents any real and novel action, and how at the same time, to make oneself conscious of ones own historicity, so as not to be governed to much by the past. I argue that Robin inhabits what Nietzsche would call the unhistorical state, whereas the other characters, in contrast, struggle with their relation to the past. Their stories delineate how history is appropriated and the other made self through the use of masks, costumes, memorabilia, nesting, storytelling and bodily inscription.

Prenant pour point de départ le corps pour l’examiner au prisme de la technologie, cette études’intéresse aux représentations du corps dans quatre textes majeurs de Djuna Barnes et de GertrudeStein. Dans The Book of Repulsive Women de Barnes, les corps fragmentés décrits dans les poèmesdialoguent avec les représentations mécanomorphiques du corps féminins chez les Dadaïstes. Lerecueil s’apparente à une série de tableaux vivants exhibant des corps mécanisés vus depuis les ramesdu métro aérien new-yorkais. La discussion envisage ensuite Dr. Faustus Lights the Lights de Stein etles connections entre la métaphore de l’électricité et l’écriture cinématique de Stein. Le lien entre cespratiques est l’automatisme que Stein a étudié chez William James et qui transforme son texte en corpsautomate. Dans cette perspective, Wars I Have Seen de Stein constitue une expérience linguistique àcomparer avec l’écriture conceptuelle de Bob Carlton Brown. Chirurgienne littéraire, Stein opère letexte à l’aide de prothèses verbales. La dernière oeuvre étudiée dans cette thèse est The Antiphon deBarnes, qui est lue à l’aide de la relation conceptuelle entre le corps violenté de Barnes et le corps dutexte autobiographique, et peut être décodée à l’analyse de ses procédés métadramatiques. Dans ledernier chapitre, les deux auteurs sont repensées à l’aulne de leur incarnation personnelle dans leurstextes et des diverses manifestations de la notion du corps et de celle de la technologie. / Having as a starting point the theme of the body and exploring it through the prism oftechnology, this study depicts its representations in four major texts by Djuna Barnes and GertrudeStein. Starting with Barnes’s The Book of Repulsive Women, the fragmented bodies depicted in thepoems come in dialogue with Dadaists’ mechanomorphic representations of female bodies. Thecollection is seen as a series of tableaux vivants displaying mechanized bodies through the alteringpresence of the El. The discussion, then, moves on to Stein’s Dr. Faustus Lights the Lights andconnections are drawn between the metaphor of electricity and Stein’s cinematic writing. The linkingaspect of this association is the practice of “automatism” that Stein explored through William James,which leads to the point that her work is an “automaton” body of text. Following this, Stein’s Wars IHave Seen, is examined as a linguistic experiment compared to Bob Carlton Brown’s conceptualwriting. Stein as a linguistic surgeon operates on the text’s body with the help of word prosthesis. Thelast work in this study is Barnes’s The Antiphon, which is explored via the conceptual correlation ofBarnes’s violated body with her autobiographical textual body, examined through decoding Barnes’smetatheatrical devices. In the final chapter, these two writers are reexamined through their personalembodiment in the texts and through the various manifestations of the themes of body and technology.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Decline cognitive related to neurodegenerative diseases are very commom in patients, probably in function of aging. Since there are few effectives therapeutics approaches to loss memory treatment, but studies about new therapeutics approaches are necessary regarding neuroprotective drugs. Thus, recent works have been showing the efficacy of some neuroprotective compounds like creatine (Cr) in treatment of patients and experimental models with memory defcit. Creatine is a guanidine compound synthesized from glycine, arginine and S-adenosylmethionine in the kidneys, liver and brain that have been presented neuroprotective and neuromodulatory effect in the central nervous systems. Some works suggest that guanidine compounds like Cr could enhance learning by modulation polyamines binding sites at the N-methyl-D-Aspartate (NMDA) receptor and act as energetic buffer intracellular. In these context, the propose of this work was investigate the involvement of Cr transporter (CreaT), cAMP-dependent protein kinase A (PKA) and Ca2+/ calmodulin-dependent protein kinase II (CaMKII) signaling pathway in the spatial learning after intrahippocampal injection of Cr. After training on Barnes Maze, Cr and/or 3-GPA (inhibitor CreaT), Cr and/or H-89 (PKA inhibitor), Cr and/or STO-609, (inhibitor of CaMKII) bilateral intrahipocappus administration was performed. The results showed that intrahippocampal administration of 3-GPA, H-89 and STO-609 attenuated the facilitatory effect of Cr on spatial learnig performed on barnes Maze. Therefore, we decide investigate the involvement of the PKA (pPKA), CaMKII (pCaMKII) and CREB (pCREB) activation after intrahippocampus creatine administration in rats trained on Barnes Maze. The results showed that Cr enhanced pCREB levels and pCaMKII levels. Thirty minutes after creatine administration was observed pCREB an pCaMKII levels enhancement, on the other hand, pPKA levels enhancement was not observed. These data suggest that spatial learning enhancement elicited by Cr may be mediated by trans-cellular creatine transports, as well, CaMKII/CREB intracellular pathway in rat hippocampus / O declínio cognitivo associado a doenças neurodegenerativas é um sintoma cada vez mais comum encontrado em pacientes, provavelmente devido ao aumento da expectativa de vida da população. Dada a escassez de medidas terapêuticas efetivas para o déficit de memória apresentado por pacientes, evidencia-se a importância da busca de novos compostos e do estudo de seus mecanismos de ação. Nesse contexto, recentes estudos mostraram a eficácia de algumas substâncias com ação neuroprotetora, como a creatina (Cr), na terapia de pacientes com déficit de memória e em modelos experimentais. A Cr é um composto guanidínico sintetizado endogenamente nos rins, fígado, pâncreas e cérebro, que apresenta ação neuroprotetora e neuromoduladora no sistema nervoso central. Estudos mostram que a administração de compostos guanidínicos, como a Cr, podem estar relacionados com a melhora da memória devido à interação com o sítio das poliaminas no receptor N-metil-D-Aspartato (NMDA) e por atuar como tampão energético intracelular. Neste contexto, o objetivo deste estudo foi investigar o envolvimento do transportador de Cr (CreaT), das proteínas quinases dependente de AMPc (PKA) e dependente de Ca2+/calmodulina II (CaMKII) na melhora do aprendizado espacial induzido por Cr no hipocampo de ratos. Após o treino no labirinto de Barnes, os ratos foram injetados no hipocampo, bilateralmente, com Cr e/ou 3-ácido guanidinico propiônico (3-GPA, um inibidor do transportador de creatina); Cr e/ou [N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, Di-HCl Salt] (H-89, um inibidor da PKA); Cr e/ou 1,8-Naphthoylene benzimidazole-3- carboxylic acid (STO-609, um inibidor da CaMKII). A administração de 3-GPA, H-89 e STO-609 diminuiu o efeito facilitatório da Cr na memória espacial de ratos, observado no teste do labirinto de Barnes. De acordo com esses resultados, decidimos investigar o envolvimento da ativação do elemento de ligação responsivo ao AMPc (pCREB), PKA (pPKA) e CaMKII (pCaMKII) após a administração de Cr no hipocampo de animais treinados no labirinto de Barnes. Trinta minutos após a injeção de Cr, foi observado um aumento nos níveis de pCREB e pCaMKII, mas não nos níveis de pPKA no hipocampo de ratos. Estes achados sugerem que a facilitação do aprendizado espacial induzido pela Cr depende do seu transporte para o meio intracelular, assim como, envolve a via de sinalização celular da CaMKII/CREB no hipocampo de ratos.

Barnes's Vagaries Malicieux, and Nin's Delta of Venus, are examples the developing vision of female sex, and both authors use their literary techniques to accomplish their aesthetic vision of amorality. Nin's visions are based on her and her friends' extreme experiences. Her primary concern was expressing her erotic and amorally aesthetic gaze, and the results of her efforts are found in her aesthetic vision of Paris and the amoral lifestyle. Barnes uses metaphor and linguistics to fashion her aesthetic vision. Her technique in "Run, Girls, Run!" both subverts any sense of morality, and offers an interesting and challenging read for its audience. In "Vagaries Malicieux" Barnes's Paris is dark while bright, and creates a sense of nothingness, indicated only by Barnes's aesthetic appreciation.

Résumé : La région de l'archipel canadien, située en Arctique, connaît actuellement d'importants changements climatiques, se traduisant notamment par une augmentation des températures, une réduction de l'étendue de la banquise marine et du couvert nival terrestre ou encore une perte de masse significative des calottes glaciaires disséminées sur les îles de l'archipel. Parmi ces calottes glaciaires, la calotte Barnes, située en Terre de Baffin, ne fait pas exception comme le montrent les observations satellitaires qui témoignent d'une importante perte de masse ainsi que d'une régression de ses marges, sur les dernières décennies. Bien que les calottes glaciaires de l'archipel canadien ne représentent que quelques dizaines de centimètres d'élévation potentielle du niveau des mers, leur perte de masse est une composante non négligeable de l'augmentation actuelle du niveau des mers. Les projections climatiques laissent à penser que cette contribution pourrait rester significative dans les décennies à venir. Cependant, afin d'estimer les évolutions futures de ces calottes glaciaires et leur impact sur le climat ou le niveau des mers, il est nécessaire de caractériser les processus physiques tels que les modifications du bilan de masse de surface. Cette connaissance est actuellement très limitée du fait notamment du sous-échantillonnage des régions arctiques en terme de stations météorologiques permanentes. Une autre particularité de certaines calottes de l'archipel canadien, et de la calotte Barnes en particulier, est de présenter un processus d'accumulation de type glace surimposée, ce phénomène étant à prendre en compte dans l'étude des processus de surface. Pour pallier au manque de données, l'approche retenue a été d'utiliser des données de télédétection, qui offrent l'avantage d'une couverture spatiale globale ainsi qu'une bonne répétitivité temporelle. En particulier les données acquises dans le domaine des micro-ondes passives sont d'un grand intérêt pour l'étude de surfaces enneigées. En complément de ces données, la modélisation du manteau neigeux, tant d'un point de vue des processus physiques que de l'émission électromagnétique permet d'avoir accès à une compréhension fine des processus de surface tels que l'accumulation de la neige, la fonte, les transferts d'énergie et de matière à la surface, etc. Ces différents termes sont regroupés sous la notion de bilan de masse de surface. L'ensemble du travail présenté dans ce manuscrit a donc consisté à développer des outils permettant d'améliorer la connaissance des processus de surface des calottes glaciaires du type de celles que l'on rencontre dans l'archipel canadien, l'ensemble du développement méthodologique ayant été réalisé sur la calotte Barnes à l'aide du schéma de surface SURFEX-CROCUS pour la modélisation physique et du modèle DMRT-ML pour la partie électromagnétique. Les résultats ont tout d'abord permis de mettre en évidence une augmentation significative de la durée de fonte de surface sur la calotte Barnes (augmentation de plus de 30% sur la période 1979-2010), mais aussi sur la calotte Penny, elle aussi située en Terre de Baffin et qui présente la même tendance (augmentation de l'ordre de 50% sur la même période). Ensuite, l'application d'une chaîne de modélisation physique contrainte par diverses données de télédétection a permis de modéliser de manière réaliste le bilan de masse de surface de la dernière décennie, qui est de +6,8 cm/an en moyenne sur la zone sommitale de la calotte, qui est une zone d'accumulation. Enfin, des tests de sensibilité climatique sur ce bilan de masse ont permis de mettre en évidence un seuil à partir duquel cette calotte voit disparaître sa zone d'accumulation. Les modélisations effectuées suggèrent que ce seuil a de fortes chances d'être atteint très prochainement, pour une augmentation de température moyenne inférieure à 1°C, ce qui aurait pour conséquence une accélération de la perte de masse de la calotte. // Abstract : Significant climate change is curently monitored in the Arctic, and especially in the region of the canadian arctic archipellago. This climate warming leads to recession of seaice extent and seasonnal snow cover, and also to large mass loss of the archipellago’s ice caps. One of the most southern ice cap, the Barnes Ice Cap, located on the Baffin Island, is no exception to significant mass loss and margins recession as satellite observations exhibited over the last decades. Despite the relative low sea level potential of the small ice caps located in the canadian arctic achipellago in regards to major ice sheets, Antarctica and Greenland, their contribution to the current sea level rise is significant. Climate projections show that this contribution could accelerate significant over the next decades. However, to estimate the future evolution of these ice caps and their impact on climate or sea level rise, a better characterisation of the surface processes such as the evolution of the surface mass balance is needed. This knowledge is currently very limited, mainly due to the sparse covering of automatic weather stations or in-situ measurements over the Arctic. Furthermore, several ice caps, among with the Barnes Ice Cap, present a superimposed ice accumulation area which particularities have to be taken into account in the surface processes studies. Given the lack of in-situ data, the approach choosen in this work is to use remote sensing data, that have the advantage to offer a good spatial and temporal coverage. In particular, passive microwave data are very suitable for snowy surfaces studies. To complement these data, physical and electromagnetic snowpack modeling provide a fine characterisation of surface processes such as snow accumulation. The whole work presented in this manuscript thus consisted in developping specific tools to improve the understanding of surface processes of small arctic ice caps. This methodological development was performed and applied on the Barnes Ice Cap using the surface scheme SURFEX-CROCUS and the electromagnetic model DMRT-ML. First results highlight a significant increase in surface melt duration over the past 3 decades on the Barnes Ice Cap (increase of more than 30% over 1979-2010 period). A similar trend is also monitored over the Penny Ice Cap, located in the south part of the Baffin Island (increase of more than 50% over the same period). Then, the surface mass balance over the last decade was modeled by using a physical based modeling chain constrained by remote sensing data. The results give a mean net accumulation of +6,8 cm y−1 on the summit area of the ice cap. Finaly, sensitivity tests, performed to investigate the climatic sensitivity of the surface mass balance, highlight a threshold effect that may lead to a complete disapearence of the accumulation area of the Barnes Ice Cap. With a temperature increase less than 1°C, modeling results suggest it is likely that the threshold will be reached rapidly leading to an increase in mass loss from the ice cap.

Thesis (doctoral)--l'Université de Paris VIII, 1978. / Includes bibliographical references (p. 701-723).

Thesis (B.A.)--Bryn Mawr College. Growth and Structure of Cities Program, 2008. / Includes bibliographical references.

This study uses a narrative analytic approach to explore the similarities and differences between pre-Enlightenment and post-Enlightenment firsthand accounts of madness in order to answer the question; what is the relationship between madness, narrative, understanding, identity and recovery? Drawing on the work of Foucault, the research traces the historical and cultural development of conceptualisations of reason and unreason, the rise of psychiatry and the marginalisation of the voice of madness. I argue that this marginalisation is continued in narrative research where the focus is on the stories of the physically ill, rather than madness. The narrative method provides a means of giving space to these marginalised voices and it is Bakhtin's constructs of dialogicism, polyphony, unfinalizability and the chronotope that provide the tools for the narrative analysis of two female English writers; Margery Kempe and Mary Barnes. The analysis highlights three critical issues in relation to firsthand narratives of madness. First, the blurred boundaries between madness and mysticism and the role of metaphor in understanding distressing experiences. Second, the complex, multi-dimensional nature of subjective timespace that challenges the linear assumptions underlying both narrative and recovery, which, I argue, demands a radical reconceptualisation of both constructs. Third, the liminal social positioning within the analysed accounts is closely related to Bakhtin's notion of unfinalizability, a form of being that enables the search for meaning and the transformation of the self. Insights can be gained from this research that may place stories and understanding central in contemporary healthcare.

This thesis involves both editorial practice and literary analysis. In order to establish an editorial framework for the electronic scholarly edition of Dr. Ralph Barnes Grindrod's pamphlet <em>Slaves of the Needle</em>, I examine current issues in electronic textual editing. In the electronic scholarly edition, approximately twelve of the pamphlet's thirty-five pages are transcribed and encoded using TEI-based code. The second aspect of my master's thesis concerns the depiction of seamstresses in nineteenth-century British literature. <em>Slaves of the Needle</em> provides a non-fiction counterpart to the fictional seamstresses of mid-nineteenth-century literature. Using <em>Slaves of the Needle</em> as a basis for evaluating the accuracy of mid-nineteenth-century characterizations of seamstresses, I show that authors such as Charles Dickens, Elizabeth Gaskell, Ernest Jones, and Charlotte Elizabeth Tonna were familiar with the working conditions of seamstresses. By conducting a close reading of certain representations of the seamstress in both fiction and non-fiction, I develop a theory of why the depiction of some aspects of the seamstress story are more accurate than others.