Lyon, Univ. 2 Lumière, Thèse, 2006.

This thesis explores the problem of self-empowerment for the French Caribbean Black woman as presented in the novels Moi, Tituba, sorcière...Noire de Salem and Pluie et vent sur Télumée Miracle. The respective authors, Maryse Condé and Simone Schwarz- Bart, use fiction to convey the plight of women in the French Caribbean. They successfully create characters who refuse marginalization imposed by their patriarchal and oppressive societies. Condé’s novel, set in the 17th century first in Barbados, and then in Puritan New England depicts the challenges Tituba overcomes in reaching liberation. Schwarz-Bart presents the story of Télumée, set in Guadeloupe at the beginning of the 20th century. My study focuses specifically on the characters of Tituba and Télumée to show ways that they thwart the dominant social structures and norms that seek to disempower them. It reveals ways that Condé and Schwarz-Bart make use of literature to reverse European perceptions of gender and race. Consequently, the literary fictions they create suggest possible ways of escaping marginalization and refusing racial and gendered subjugation. / Master of Arts

No description available.

Black Sea coast line is a hazardous region especially in winter due to the dominant wave action. Therefore, rubble mound breakwaters used as ship shelters are vital structures especially for the fishermen. Construction of the breakwater requires good quality durable armourstones. Due to the nature of the rubble mound breakwaters, armourstones having various sizes and types are used in the construction of these structures. The deterioration of these armourstones with time in the form of abrasion and disintegration may result in the failure of the breakwater. Therefore, it is important to investigate the durability and quality of the armourstones to be used in these structures. In this thesis, the properties of the armourstones taken from five rock quarries and used in the Hisar&ouml / n&uuml / (Bartin), the Tarlaagzi (Bartin) and the Alapli (Zonguldak) rubble mound breakwaters were studied both in field and laboratory in order to assess their qualities and long term durabilities. Based on the in-situ observations and laboratory tests, the Kavakdere, Kavukkavlagi and the Tarlaagzi limestones are good (durable) rocks. However, the &Ccedil / &ouml / mlek&ccedil / ikuyu andesite is found to be generally marginal rock, and the Kiran sandstone is poor rock. CIRIA/CUR, RDId, RERS and Wet-Dry strength ratio classifications are in good agreement with the in-situ observations and the results of the laboratory tests. However RDIs, Average Pore Diameter and Saturation Coefficient classifications do not fully reflect the reality.

<p>Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus which chronically infects >95% of the global population, and can give rise to a number of malignancies in B cells and epithelial cells. In EBV latently infected epithelial cells, such as nasopharyngeal carcinoma (NPC) and gastric carcinoma (GaCa) cells, viral protein expression is low. In contrast, a cluster of viral microRNAs (miRNAs) called miR-BARTs is highly expressed. MiRNAs are small non-coding RNAs which regulate gene expression by binding to complementary sequences in mRNAs. It is likely that miR-BARTs play a crucial role in EBV-infected epithelial cells, however a comprehensive understanding of miR-BARTs is currently lacking. Here, I present two studies utilizing the phenotypic and the target approaches, respectively, to demonstrate that miR-BARTs can inhibit apoptosis and activate the Wnt signaling pathway. To discover miR-BARTs that can inhibit apoptosis, I individually expressed miR-BARTs in the EBV- GaCa cell line AGS, and identified five miR-BARTs that conferred this phenotype. To identify pro-apoptotic genes targeted by the five anti-apoptotic miRNAs, I validated one previously published target and identified nine novel targets by performing photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in the EBV+ NPC cell line C666. Next, I thoroughly demonstrated that the 10 candidate target genes were substantially suppressed by expression of the relevant miR-BARTs, as measured by 3’UTR-containing firefly luciferase (FLuc) expression, mRNA and protein levels, and knockdown of seven of the 10 candidate genes could suppress apoptosis, mimicking the effects of relevant miR-BARTs. On the other hand, in order to identify miR-BARTs that can activate the Wnt signaling pathway, I analyzed the PAR-CLIP data set of C666 cells and discovered nine anti-Wnt signaling targets of miR-BARTs, including seven novel genes and two pro-apoptotic genes identified above. Using FLuc 3’UTR indicator assays, I proved that the 3’UTRs of all seven newly identified anti-Wnt signaling genes were indeed targeted by the relevant miR-BARTs identified by PAR-CLIP. Utilizing a Wnt signaling FLuc reporter TOPflash which measures the Wnt signaling activation, I confirmed that expression of many miR-BARTs that target Wnt signaling inhibitors can indeed upregulate the Wnt signaling pathway. Together, my results identified and validated a substantial number of novel targets of miR-BARTs involved in apoptosis and the Wnt signaling pathway, indicating that EBV may employ miR-BARTs to heavily target these two pathways to facilitate chronic infection.</p> / Dissertation

For several millennia man has in some way farmed his waters by holding fish captive in ponds. Not until the second half of the nineteenth century, however, as a result of a general concern in the industrialised nations that fishery stocks were declining, were serious attempts made to breed fish artificially. The most concerted of these attempts in Britain effectively began in 1873 when Sir James Maitland (1848-1897), a Scottish landowner, commenced experiments which evolved into the construction of the world's largest salmonoid piscicultural establishment. This operation, the Howietoun Fishery, sold its produce nationally on the open market, a new departure in pisciculture. It also advanced the piscicultural process scientifically in selectively breeding fish superior to nature's own. Maitland's work was not, in itself, particularly successful commercially. This was not, however, the result of commercial failure on his behalf but rather a reflection of his desire to develop pisciculture for the public good in an attempt to restock impoverished fisheries and to disseminate knowledge in the hope that others would be encouraged to imitate his example on a more commercial basis. Maitland's piscicultural work was highly important to the development of what has today become a significant global industry, though his contribution has not hitherto been recognised. The thesis intends to set out Maitland's piscicultural advances and their significance. It offers a detailed analysis of Maitland's entrepreneurship and casts its net wider to draw in some discussion of his work away from Howietoun, particularly on his membership of the Fishery Board for Scotland where it examines the debate over state support for nineteenth century British science. The thesis concludes with an analysis of the development of Howietoun in the seventy years after its founder's death. In addition to Maitland's own writings, the thesis uses evidence from Howietoun's general records, Maitland's family papers, Fishery Board for Scotland material, and a very wide variety of published sources.

No description available.

abstract: Spatial regression is one of the central topics in spatial statistics. Based on the goals, interpretation or prediction, spatial regression models can be classified into two categories, linear mixed regression models and nonlinear regression models. This dissertation explored these models and their real world applications. New methods and models were proposed to overcome the challenges in practice. There are three major parts in the dissertation. In the first part, nonlinear regression models were embedded into a multistage workflow to predict the spatial abundance of reef fish species in the Gulf of Mexico. There were two challenges, zero-inflated data and out of sample prediction. The methods and models in the workflow could effectively handle the zero-inflated sampling data without strong assumptions. Three strategies were proposed to solve the out of sample prediction problem. The results and discussions showed that the nonlinear prediction had the advantages of high accuracy, low bias and well-performed in multi-resolution. In the second part, a two-stage spatial regression model was proposed for analyzing soil carbon stock (SOC) data. In the first stage, there was a spatial linear mixed model that captured the linear and stationary effects. In the second stage, a generalized additive model was used to explain the nonlinear and nonstationary effects. The results illustrated that the two-stage model had good interpretability in understanding the effect of covariates, meanwhile, it kept high prediction accuracy which is competitive to the popular machine learning models, like, random forest, xgboost and support vector machine. A new nonlinear regression model, Gaussian process BART (Bayesian additive regression tree), was proposed in the third part. Combining advantages in both BART and Gaussian process, the model could capture the nonlinear effects of both observed and latent covariates. To develop the model, first, the traditional BART was generalized to accommodate correlated errors. Then, the failure of likelihood based Markov chain Monte Carlo (MCMC) in parameter estimating was discussed. Based on the idea of analysis of variation, back comparing and tuning range, were proposed to tackle this failure. Finally, effectiveness of the new model was examined by experiments on both simulation and real data. / Dissertation/Thesis / Doctoral Dissertation Statistics 2020

While there are many proposals for fixing congestion between San Francisco and Oakland in California by adding a new bridge or tube, these solutions will take decades to implement even though a solution is needed now. This thesis assesses sixteen different strategies for reducing congestion in the short-term in the four categories of improving transit, promoting carpooling, implementing intelligent transportation systems practices, and incentivizing alternatives to using the Bay Bridge. Top priorities include HOV improvements on the West Grand Avenue and Powell Street onramps, altering WestCAT Lynx and BART transit services, partnering with rideshare apps to increase transit station accessibility (last mile problem), partnering with vanpool/minibus apps, promoting carpooling and implementing a citizen report system for carpool violators, shifting corporate cultures away from requiring employees to drive and drive alone, and lastly, altering land-use planning practices. To reach this conclusion, an inventory of current proposals and relevant research was compiled. Ridership and capacity data for the various modes of transportation across the bay were assessed for shortfalls and opportunities. Through this research and its resultant conclusions, focus can be placed on the best strategies to pursue in the near-term, while the Bay Area waits on a second bridge or tube in the long-term.

Many groups have been pushing for a shift from automotive oriented transportation and land use, to transit-oriented transportation and land use. These groups have many valid reasons. However, just as it is fair to point out issues about auto travel, so too is it fair to see how transit performs at meeting certain goals. This paper examines the important characteristic of accessibility afforded to travelers. This is quantified through the calculation of accessibility indexes for stations, for the specific case of two existing rail systems and four proposed rail extensions in the San Francisco Bay Area. As a whole, the four extensions investigated increase regionwide rail accessibility by 18.5 percent, not an insignificant increase. However, the new stations are on average less accessible than their existing counterparts. Two of the four extensions perform well on accessibility measures, either their stations have high accessibility, or jobs around them contribute to high accessibility for nearby stations. The other two extensions however perform poorly on accessibility measures. In a time of limited resources, the accessibility results clearly indicate how the four extensions should be prioritized. The more successful extensions have good access to activity centers. Extensions having good connectivity with other lines can also enhance accessibility if providing significant travel time savings.