Global ETD Search

541	Cyclic Nucleotide Phosphodiesterases (PDEs) in Smooth Muscle : Expression, Function and Mechanism Zhai, Kui 20 November 2012 (has links) (PDF) The aim of the present thesis was to characterize the role of the different families of phosphodiesterases (PDEs), the enzymes degrading 3'-5'-cyclic adenosine monophosphate (cAMP), in controlling the cAMP signalling in two distinct smooth muscle cells (SMCs), the rat aorta SMC (RASMCs) and the rat bladder SMC (RBSMCs).In cultured RASMCs, we firstly characterized the pattern of cAMP-PDE expression and activity. We then showed, by using a FRET-based cAMP sensor to explore cAMP signals in living cells, that PDE4 inhibition unmasks an effect of PDE1 and PDE3 on cytosolic cAMP hydrolyzis, whereas PDE3 and PDE4 act synergistically at the submembrane compartment. The mechanisms of this subcellular compartmentation need to be characterized. In neonatal RBSMCs, we showed that both PDE3 and PDE4 are involved in regulating the phasic contractions albeit through distinct mechanisms. PDE4 inhibition inhibits the carbachol-enhanced contractions through a protein kinase A-dependent pathway involving an increase in Ca2+ sparks frequency which activates BK channels to ultimately decrease Ca2+ transients, whereas PDE3 inhibition acts through a protein kinase G-dependent pathway through a still unknown mechanism.In conclusion, our work shows that in the SMC, the different cAMP-PDE families exhibit a specificity in their function and/or mechanism of action, thus participating to a subcellular signaling compartmentation. Phosphodiesterases Cyclic nucleotides CAMP Smooth muscle Vascular Baldder Contractile tone
542	Conformational Changes in Ligand Binding Processes Voß, Béla 30 January 2015 (has links) No description available. 571.4 Ligand Binding Protein Molecular Dynamics Simulations Physics Biophysics Conformational Changes Computer Simulations MloK1 CRM1 cAMP MD Biologie (PPN619462639)
543	Die Britse owerheid en die burgerlike bevolking van Heidelberg, Transvaal, gedurende die Anglo-Boereoorlog Pretorius, Willem Jacobus. January 2007 (has links) Thesis (D.Phil.(Geskiedenis))--Universiteit van Pretoria, 2007. / Abstract in English and Afrikaans. Includes bibliographical references (leaves 368-378).
544	Musik im Konzentrationslager Sachsenhausen / Brauer, Juliane, January 1900 (has links) Originally published as author's dissertation-- Freie Universität Berlin, 2007. / Includes bibliographical references (p. [393]-418).
545	Das KZ Ravensbrück : Geschichte eines Lagerkomplexes / Strebel, Bernhard. Tillion, Germaine. January 2003 (has links) Univ., Diss. u.d.T.: Strebel, Bernhard: Der Lagerkomplex des KZ Ravensbrück: Studien über Terror, Zwangsarbeit und Vernichtung--Hannover, 2001. / Literaturverz. S. [575] - 598.
546	Entgrenzung und KZ-System das Unternehmen "Wüste" und das Konzentrationslager in Bisingen 1944/45 / Glauning, Christine, January 1900 (has links) Thesis (doctoral)--Universität Göttingen, 2004. / Includes bibliographical references (p. 411-451) and indexes.
547	The development of team members in family crisis intervention at Camp Branch Baptist Church, Sedalia, Missouri Ayers, Charles Robert. January 2004 (has links) Ministry research project (D. Min.)--Midwestern Baptist Theological Seminary, 2004. / Submitted in partial fulfillment of the requirements for the Doctor of Ministry Degree. Includes bibliographical references (leaves 254-257).
548	Confronting the intractable an evaluation of the Seeds of Peace experience / Schleien, Sara Melissa. January 2007 (has links) (PDF) These (Ph.D.)--University of Waterloo, 2007. / Title from PDF title page. Available through UMI ProQuest Digital Dissertations. Includes bibliographical references (leaves 118-131). Also issued in print.
549	The development of team members in family crisis intervention at Camp Branch Baptist Church, Sedalia, Missouri Ayers, Charles Robert. January 2004 (has links) (PDF) Ministry research project (D. Min.)--Midwestern Baptist Theological Seminary, 2004. / Submitted in partial fulfillment of the requirements for the Doctor of Ministry Degree. Includes bibliographical references (leaves 254-257).
550	The development of team members in family crisis intervention at Camp Branch Baptist Church, Sedalia, Missouri Ayers, Charles Robert. January 2004 (has links) Thesis (D. Min.)--Midwestern Baptist Theological Seminary, 2004. / Abstract. Includes bibliographical references (leaves 254-257).

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