京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第19885号 / 理博第4212号 / 新制||理||1605(附属図書館) / 32962 / 京都大学大学院理学研究科生物科学専攻 / (主査)教授 森 和俊, 教授 大野 睦人, 教授 杤尾 豪人 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

Type II diabetes mellitus is associated with many detrimental health situations including heart complications. The purpose of this study was to identify a role for PKA-dependent Rap1a signaling in the AGE-RAGE cascade. My hypothesis was Rap1a GTPase increased the downstream effects of AGE-RAGE signaling in diabetes via a PKA-dependent pathway leading to elevated ECM remodeling in the heart. Cardiac fibroblasts were isolated from heterozygous (Het) and diabetic (db/db) mice. To test the hypothesis, gain-ofunction and loss-ofunction treatments were used. PKC-Zeta is known as a major signaling hub that potentially links PKA-dependent and AGE-RAGE signaling cascades so PKC-Zeta inhibition to downregulate PKA-dependent cascade at PKC-Zeta was also used. Results showed a downregulation of signaling markers in the AGE-RAGE cascade when disrupting Rap1a crosstalk at PKC-Zeta. By understanding where the PKA-dependent and AGE-RAGE signaling cascades crosstalk, a new molecular mechanism is understood possibly leading to decreasing remodeling in a diabetic heart.

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Leisure activities for primary school children at a school camp Barbora Čopíková Abstract This diploma thesis is focusing on problematics of games and other activities at a school camp for primary school children. Theoretical part of this diploma thesis describes the age of primary school children and their physical, psychical, social a motor development. Another important part is about the concept of game and their specifics about their division, signs, rules, safety and meaning for primary school children. This part focuses on problematics of competition and leisure time, which mainly relate with the keyword game. There is also included organizing of a school camp a its health, social and educational meaning. Part of thesis is dedicated to meaning of a school camp for teachers and camp counsellors. Another part of this diploma thesis is collection of games and other activities. The research is based on this collection and is focused on finding out how pupils and counsellors think about games at a school camp and how they reflect this collection. The research part contains results of my survey a its interpretation. The results of this survey are described in pie and bar charts. In this part of the thesis is also described the research part, used methods and work conclusions. KEYWORDS: The age of primary...

Historians have long noted Joseph Smith's early interest in Methodism. Demographic studies of early Mormon converts have demonstrated further that many of those attracted to the Mormon message on both sides of the Atlantic came from Methodist backgrounds. These two points, and the many similarities between Methodist and Mormon beliefs and practices, have led many scholars to suggest that Smith's church was influenced by the Methodists who joined the movement. This thesis explores the Methodist backgrounds of those Methodists who converted to the Church of Jesus Christ of Latter-day Saints from 1830, when Joseph Smith formally organized his church(originally called the Church of Christ), to 1838, when the Latter-day Saints moved to Nauvoo, Illinois, and the church experienced a transformation in its theology, worship practices, and organizational structure. I argue that Methodism fundamentally shaped the ways that early Mormonism developed in its first eight years. This was a result of both Methodism's rapid growth and expansive influence in antebellum America and the many early Mormon converts who had previously affiliated with Methodism. This thesis contains four chapters. Chapter 1 examines the historiography on the subject, summarizing the demographic studies previously conducted and the conclusions drawn by other historians. It also provides the theoretical framework that shaped the thesis. Chapter 2 analyzes the conversion narratives of the early converts to Mormonism who came from Methodist backgrounds. I show that these converts generally maintained a positive view of Methodism even after their conversion to Mormonism, and viewed their belief in dreams and visions and the acceptance of charismatic religious experience they were taught while Methodists as instrumental in their eventual acceptance of the Mormon message. Chapter 3 explores an extended analysis of Joseph Smith's various recollections of his "first vision" within the context of Methodist conversion narratives of the era. By analyzing the first vision within the Methodist context, I seek to harmonize key discrepancies in Smith's early and later narratives while still allowing each version to speak for itself. Chapter 4 surveys early Mormon church organization and worship and compares it to that of early American Methodism in an effort to better contextualize early Mormonism within the culture from which it arose and developed. This chapter concludes with a brief summary of the lasting influence of Methodism on Mormon religiosity.

This thesis is an historical archaeological project involving the classification and analysis of the ceramics found at Camp Floyd, a 19th century military site 40 miles southwest of Salt Lake City, Utah. United States military troops were dispatched to the Utah Territory to establish a Pony Express Station and an Overland Stage Trail, to assert federal authority in the Territories, and to end the ongoing conflict between the federal government and the Church of Jesus Christ of Latter Day Saints. The primary research question concerned the ceramic usage patterns at Camp Floyd as compared to other military sites and non-residential sites of the 19th century. The ceramic assemblage recovered from Camp Floyd was classified using Berge's classification system of historical ceramics. A sample from this collection was analyzed in order to assess social and economic differences between officers' and enlisted men.

This essay is one part of my Bachelor’s degree project, the other part being the dance performance OUR VISIONIS FROM HELL. / 34°10'26.6"N 118°39'50.4"W, which was presented in November 2022 at Stockholm University of the Arts. The work was inspired by certain events around the breakup between musician Kanye West and reality star Kim Kardashian. The text aims to further articulate, explain and discuss the topics of the piece, which were heartbreak, violence and pop culture in the arts, as well as referencing the American writers bell hooks and Susan Sontag and their approach to these issues. The essay also goes into the research, conversations and different thinking processes from and within the work. The text is written as a fictional letter to Kanye West and desires to question and criticize his behavior during the fall of 2022.

Refugee camps, mostly located in the Global South, host millions of human beings and mirror the overburden and incapacity of humanitarian response. If these places were once supposedly created to aggregate asylum-seekers temporarily, now they have become the norm for prolonged stays where future generations grow.This thesis explores the viability of the UNHCR’s durable solutions for Rohingya Refugees- local integration, resettlement, and repatriation. Moreover, it questions the role of non-state actors when it comes to decision-making in refugee governance. The analysis is conducted through a critical interpretive synthesis. The selected literature was scrutinized and linked to theoretical concepts such as human security, securitization of migration, legal pluralism, and complex interdependence.In summary, the literature analyzed shares a unanimity that, although conditions in the camps are unsustainable for permanent stays, efforts to build better futures for refugees are not being explored enough. This is mainly due to a reluctance of States to accept refugees on behalf of their integrity and security, in the sense that refugees are perceived as threats to their sovereignty. In this sense, potential efforts by non-state actors to provide a sustainable future for refugees fall behind: in a scenario where national security prevails, keeping refugees in the camp seems to be the safest choice.

The purpose of this study was to determine the immediate and long term impact of participation in the 2009 Third Grade Summer Reading Camp, as well as determine the cost-effectiveness of providing this program in comparison to the cost-effectiveness of other reading interventions as identified by Yeh (2010). All students in this study scored an achievement level one on the 2009 FCAT Reading assessment and either attended the summer reading camp or received a good cause exemption for promotion to the next grade level. Data was not available to determine immediate impact of summer school. To determine long term impact of summer school participation, 130 students who attended the program and passed were compared to a random sample of 130 students who received another good cause exemption. Results of an independent t-test indicated students who passed summer school by performing at or above the 50th percentile on the alternative assessment outperformed students who received another good cause exemption on the 2010 FCAT Reading assessment, t(258) = -9.50, p = .000, effect size r = 0.51,and 2011 FCAT Reading assessment, t(258) = -7.43, p = .000, effect size r = 0.42. Ninety percent of students who attended summer school and passed the alternative assessment for promotion made learning gains on the following year’s FCAT Reading assessment; however, the majority of students performed below grade level on the 2010 and 2011 FCAT Reading assessment. Based on school district records for the cost of salaries, benefits, transportation, materials, and supplies, the total cost of summer school was calculated and adjusted for iii inflation to 2006 dollars so a comparison could be made to Yeh’s (2010) costeffectiveness analysis of summer school and other reading interventions that annualized the cost to 2006 dollars. The adjusted cost for the 2009 summer reading program was calculated at $872,681.23. Using this number and dividing by the total number of summer school student, which were 3,012 students, the cost per student annualized to 2006 was $289.74. Data to determine the immediate impact of summer school were not available, therefore, student performance on the 2009 FCAT Reading assessment was compared to their performance on the 2010 FCAT Reading assessment by calculating a paired samples t-test, t(1225) = 40.82, p = .000, d = 1.23, effect size r = 0.52. The effect size d was divided by the cost per student which calculated an effectiveness-cost ratio of 0.004245 compared to that derived by Yeh (2010) of 0.000125. Caution should be taken when interpreting these results as methodology was not in alignment to Yeh (2010) due to the lack of an immediate post-test measure after participation in summer school and an additional year of interventions and education is reflected in the test scores. The cost per student was calculated to be $1,225.26 less than the amount of money reported in Yeh’s (2010) calculations. Based on this information, the diminishing effect of the summer school program on student reading performance in subsequent years, and the majority of students performing below grade level one and two years after summer school participation, it cannot be determined that this program is cost-effective in raising student reading achievement. It is recommended that this study be replicated with adjustments made to address the limitations identified. Further investigation should be made at the state level to iv determine if the current practice of good cause exemptions and summer school offerings perpetuates the achievement gap in reading

The American Civil War is often framed as exclusively masculine, consisting of soldiers, god-like generals, and battle; a sphere where women simply did not enter or coexist. This perception is largely due to the mobilization of approximately six million men, coupled with the Victorian era which did not permit women to engage in the public sphere. Women are given their place however, but it is more narrowly defined as home front assistance. Even as women transitioned from passive receivers to active participants, their efforts rarely defied gender norms. This thesis looks at Confederate female camp followers who appeared to defy societal conventions by entering the male dominated camps and blurred the lines between men and women’s proper spheres. While camp followers could be expanded to include women of the lower class, including black women, laborers, slaves and prostitutes, only middle and upper class white women are analyzed because they were the ones required to maintain respectability. More specifically, I analyze unmarried women, female soldiers, bereaved women and nurses. Barbara Welter articulated and labeled the concept of public versus private spheres, plus the attributes necessary to achieve respectability as the Cult of True Womanhood. The Cult of True Womanhood demanded that women be pious, pure, and submissive within the domestic sphere. It is with this foundation that the camp followers can be analyzed. Their actions appeared to break with the Cult of True Womanhood, but when they explained in memoirs, newspaper accounts, and journals why they entered the camps, they framed their responses in a way that allowed them to appear to conform to the cult.