Over the past several decades abdominal obesity and physical inactivity have increased at an alarming pace. Since both are related to adverse health risk it is important to determine their independent influence. It is well established that cardiorespiratory fitness (CRF, the ability to perform physical activity) and physical activity (PA) are negatively associated with cardiometabolic risk factors (commonly obtained risk factors for disease, e.g: TG, HDL, etc.). In other words, the higher a person’s levels of PA and fitness, the lower that person’s likelihood of developing cardiometabolic risk factors. Abdominal obesity is positively associated with cardiometabolic risk factors which means the more abdominally obese a person is, the more prone that person is to develop cardiometabolic risk factors. However, it is unknown whether PA influences cardiometabolic risk factors independent of fitness level and/or abdominal obesity. My study objective was to examine whether PA is associated with cardiometabolic risk factors independent of cardiorespiratory fitness and/or abdominal obesity in inactive abdominally obese women. The study enrolled 141 inactive abdominally obese women. PA, cardiorespiratory fitness, and cardiometabolic risk profile were measured in all participants. A novel feature of this study was the use of the accelerometer to objectively measure PA and to divide exercise into different levels of intensity, such as: low PA, moderate to vigorous PA (MVPA), etc. My findings revealed that abdominal obesity was positively associated with cardiometabolic risk independent of PA or CRF. I also observed that CRF was inversely related to cardiometabolic risk independent of PA or abdominal obesity. MVPA explained cardiometabolic risk factors by itself, but with insulin resistance measurements (2-hour glucose, and homeostasis model of assessment) this relationship was abolished when abdominal obesity and CRF were also taken into consideration. The findings of this study provide further support for the recommendation that waist circumference and CRF be included as routine measures screening for cardiometabolic risk factors in inactive obese women. Our findings also support the suggestion that even modest amounts of daily MVPA that are below the recommended threshold of 30 minutes/day convey health benefit. / Thesis (Master, Kinesiology & Health Studies) -- Queen's University, 2013-07-23 13:46:57.088

The metabolic syndrome has become a major public health challenge world-wide and, at least in the industrialized world, the prevalence of the metabolic syndrome is increasing. There is evidence to show that biological and lifestyle risk factors for metabolic syndrome are present in adolescence, which suggests that the antecedents of the disease may lie in early life. The period of adolescence is characterized by a decline in physical activity (PA; lack of PA is a lifestyle risk factor for metabolic syndrome) and an increase in fat mass deposition (a biological risk factor for metabolic syndrome). Therefore, investigating how the development of these two variables relates to adult cardiometabolic risk is important to fuel early intervention. A factor which has the potential to influence these two risk factors, and thus ultimately the metabolic syndrome, is the timing of biological maturity (i.e. whether an individual is early, average or late maturing when compared to peers of the same age). The influence of biological maturity has largely been overlooked in previous research; therefore, the general objective of this thesis was to investigate the associations between biological maturity, adolescent PA and fat mass development, and young adult cardiometabolic risk. Three studies were necessary to realize this objective, and together help to elucidate the role of biological maturity in the adolescent decline in physical activity, fat development, and the development of adult metabolic syndrome. Ultimately, this information will aid in the development and implementation of interventions to decrease prevalence of metabolic syndrome.<p> Study 1: The purpose of study 1 was to investigate whether observed gender differences in objectively measured PA in children (8 to 13 years) are confounded by biological maturity differences. Methods: Four hundred and one children (194 boys and 207 girls) volunteered for this study. An Actigraph accelerometer was used to obtain 7 consecutive days of minute-by-minute PA data on each participant. Minutes of moderate to vigorous PA per day (MVPA), continuous minutes of MVPA per day (CMVPA), and minutes of vigorous PA per day (VPA) were derived from the accelerometer data. Age at peak height velocity (APHV), an indicator of somatic maturity, was predicted and individuals aligned by this biological age (years from APHV). Gender differences in the PA variables were analyzed using a two-way (gender X age) ANOVA. Results: Levels of PA decreased with increasing chronological ages in both genders (p<0.05). When aligned on chronological age, boys had a higher MVPA at 10 through 13 years, a higher CMVPA at 9 through 12 years, and a higher VPA at 9 though 13 years (p<0.05). When aligned on biological age, PA declined with increasing maturity (p<0.05); however gender differences between biological age groups disappeared. Conclusion: The observed age-related decline in adolescent boys and girls PA is antithetical to public health goals and as such is an important area of research. In order to fully understand gender disparities in PA, consideration must be given to the confounding effects of biological maturity.<p> Study 2: Understanding the influence of biological age (BA) on the decline in PA would better inform researchers about the effective timing of intervention. The purpose of study 2 was to describe the PA levels and perceived barriers to PA of adolescent girls grouped by school grade and biological maturity status (i.e., early or late maturing) within grades. Methods: 221 girls (aged 8-16 years; grades 4-10) wore an Actical accelerometer for 7 days and then completed a semi-structured, open ended questionnaire on perceived barriers to PA over the 7 day period. Predicted APHV and recalled age at menarche were used to assess maturity among the elementary and high school girls, respectively. Maturity and grade group differences in PA were assessed using MANCOVA and independent sample t-test, and barriers to PA using chi squared statistics. Results: Daily minutes spent in MVPA decreased by 40% between grades 4 to 10. Within grade groupings, no differences in PA were found between early and late maturing girls (p>0.05). Grades 4-6 participants cited more interpersonal (i.e., social) barriers. Grades 9-10 participants cited more institutional barriers to PA, primarily revolving around the institution of school. No differences were found in types of barriers reported between early and late maturing girls. Conclusion: Since PA and types of perceived barriers to PA were dependent on grade, future research should work to identify the most salient (i.e., frequent and limiting) barriers to PA by chronological age in youth.<p> Study 3: Although the metabolic syndrome is thought to be mainly a consequence of obesity, the mechanisms underpinning its development are not that well understood. The purpose of study 3 was to examine total body fat mass (FM), trunk FM and PA developmental trajectories (aligned to BA; years from APHV) of individuals categorized as low and high for cardiometabolic risk at 26 years, while investigating biological and lifestyle risk factors. Methods: The sample were 55 males and 76 females from the Saskatchewan Pediatric Bone Mineral Accrual Study (1991-2007) who were assessed from childhood to young adulthood and had a measure of cardiometabolic risk at young adulthood (26.0 + 2.3 yrs). Height was measured biannually. Total body FM and trunk FM was assessed annually by dual energy-X-ray absorptiometry. PA and dietary intake was evaluated two to three times annually using surveys. Individuals were grouped into maturity status groups (early, average or late) depending on their APHV. Two composite cardiometabolic risk scores were calculated for males and females separately. The first was derived for a sub-sample (N=48) by summing the standardized residuals of inverted high-density lipoprotein cholesterol, homeostasis model assessment for insulin resistance, mean arterial pressure (MAP) and fasting triglyceride levels. A second score was derived for the whole sample by summing the standardized residuals for MAP. Scores for both samples were regressed on to age and adult smoking status. High and low cardiometabolic risk groups were determined based on a sex- specific median split of risk scores. Data were analyzed using random effects models. Models were built in a stepwise procedure with predictor variables added one at a time, using the log likelihood ratio statistic to determine if one model was a significant improvement over the previous one. Results: The final model indicated that once the independent effects of maturity (years from APHV) and height were controlled, the high risk group males and females had significantly (p<0.05) greater total body FM and trunk FM development at all ages. No association was found between young adult cardiometabolic risk and development of PA. Furthermore, in general, timing of biological maturity was not associated with development of PA or FM. Conclusion: Young adults at higher cardiometabolic risk have greater body fat as early as 8 years of age, which lends support to early intervention.<p> General Conclusions: Adolescence has been highlighted as a critical period for the development of adult disease, such as the metabolic syndrome. Results from this thesis support this contention by showing a decrease in PA (by both chronological and biological age) in males and females across adolescence. It further showed that an increase in total and central fatness during adolescence may be critical for the development of the metabolic syndrome in adulthood. Timing of biological maturity, in general, was not shown to have an independent impact on adolescent or young adult PA, adolescent perceived barriers to PA, fat mass development, or young adult cardiometabolic risk. However, further research is required before definitive conclusions can be made about the short and long term impacts of timing of biological maturity on health.

The metabolic syndrome has become a major public health challenge world-wide and, at least in the industrialized world, the prevalence of the metabolic syndrome is increasing. There is evidence to show that biological and lifestyle risk factors for metabolic syndrome are present in adolescence, which suggests that the antecedents of the disease may lie in early life. The period of adolescence is characterized by a decline in physical activity (PA; lack of PA is a lifestyle risk factor for metabolic syndrome) and an increase in fat mass deposition (a biological risk factor for metabolic syndrome). Therefore, investigating how the development of these two variables relates to adult cardiometabolic risk is important to fuel early intervention. A factor which has the potential to influence these two risk factors, and thus ultimately the metabolic syndrome, is the timing of biological maturity (i.e. whether an individual is early, average or late maturing when compared to peers of the same age). The influence of biological maturity has largely been overlooked in previous research; therefore, the general objective of this thesis was to investigate the associations between biological maturity, adolescent PA and fat mass development, and young adult cardiometabolic risk. Three studies were necessary to realize this objective, and together help to elucidate the role of biological maturity in the adolescent decline in physical activity, fat development, and the development of adult metabolic syndrome. Ultimately, this information will aid in the development and implementation of interventions to decrease prevalence of metabolic syndrome.<p> Study 1: The purpose of study 1 was to investigate whether observed gender differences in objectively measured PA in children (8 to 13 years) are confounded by biological maturity differences. Methods: Four hundred and one children (194 boys and 207 girls) volunteered for this study. An Actigraph accelerometer was used to obtain 7 consecutive days of minute-by-minute PA data on each participant. Minutes of moderate to vigorous PA per day (MVPA), continuous minutes of MVPA per day (CMVPA), and minutes of vigorous PA per day (VPA) were derived from the accelerometer data. Age at peak height velocity (APHV), an indicator of somatic maturity, was predicted and individuals aligned by this biological age (years from APHV). Gender differences in the PA variables were analyzed using a two-way (gender X age) ANOVA. Results: Levels of PA decreased with increasing chronological ages in both genders (p<0.05). When aligned on chronological age, boys had a higher MVPA at 10 through 13 years, a higher CMVPA at 9 through 12 years, and a higher VPA at 9 though 13 years (p<0.05). When aligned on biological age, PA declined with increasing maturity (p<0.05); however gender differences between biological age groups disappeared. Conclusion: The observed age-related decline in adolescent boys and girls PA is antithetical to public health goals and as such is an important area of research. In order to fully understand gender disparities in PA, consideration must be given to the confounding effects of biological maturity.<p> Study 2: Understanding the influence of biological age (BA) on the decline in PA would better inform researchers about the effective timing of intervention. The purpose of study 2 was to describe the PA levels and perceived barriers to PA of adolescent girls grouped by school grade and biological maturity status (i.e., early or late maturing) within grades. Methods: 221 girls (aged 8-16 years; grades 4-10) wore an Actical accelerometer for 7 days and then completed a semi-structured, open ended questionnaire on perceived barriers to PA over the 7 day period. Predicted APHV and recalled age at menarche were used to assess maturity among the elementary and high school girls, respectively. Maturity and grade group differences in PA were assessed using MANCOVA and independent sample t-test, and barriers to PA using chi squared statistics. Results: Daily minutes spent in MVPA decreased by 40% between grades 4 to 10. Within grade groupings, no differences in PA were found between early and late maturing girls (p>0.05). Grades 4-6 participants cited more interpersonal (i.e., social) barriers. Grades 9-10 participants cited more institutional barriers to PA, primarily revolving around the institution of school. No differences were found in types of barriers reported between early and late maturing girls. Conclusion: Since PA and types of perceived barriers to PA were dependent on grade, future research should work to identify the most salient (i.e., frequent and limiting) barriers to PA by chronological age in youth.<p> Study 3: Although the metabolic syndrome is thought to be mainly a consequence of obesity, the mechanisms underpinning its development are not that well understood. The purpose of study 3 was to examine total body fat mass (FM), trunk FM and PA developmental trajectories (aligned to BA; years from APHV) of individuals categorized as low and high for cardiometabolic risk at 26 years, while investigating biological and lifestyle risk factors. Methods: The sample were 55 males and 76 females from the Saskatchewan Pediatric Bone Mineral Accrual Study (1991-2007) who were assessed from childhood to young adulthood and had a measure of cardiometabolic risk at young adulthood (26.0 + 2.3 yrs). Height was measured biannually. Total body FM and trunk FM was assessed annually by dual energy-X-ray absorptiometry. PA and dietary intake was evaluated two to three times annually using surveys. Individuals were grouped into maturity status groups (early, average or late) depending on their APHV. Two composite cardiometabolic risk scores were calculated for males and females separately. The first was derived for a sub-sample (N=48) by summing the standardized residuals of inverted high-density lipoprotein cholesterol, homeostasis model assessment for insulin resistance, mean arterial pressure (MAP) and fasting triglyceride levels. A second score was derived for the whole sample by summing the standardized residuals for MAP. Scores for both samples were regressed on to age and adult smoking status. High and low cardiometabolic risk groups were determined based on a sex- specific median split of risk scores. Data were analyzed using random effects models. Models were built in a stepwise procedure with predictor variables added one at a time, using the log likelihood ratio statistic to determine if one model was a significant improvement over the previous one. Results: The final model indicated that once the independent effects of maturity (years from APHV) and height were controlled, the high risk group males and females had significantly (p<0.05) greater total body FM and trunk FM development at all ages. No association was found between young adult cardiometabolic risk and development of PA. Furthermore, in general, timing of biological maturity was not associated with development of PA or FM. Conclusion: Young adults at higher cardiometabolic risk have greater body fat as early as 8 years of age, which lends support to early intervention.<p> General Conclusions: Adolescence has been highlighted as a critical period for the development of adult disease, such as the metabolic syndrome. Results from this thesis support this contention by showing a decrease in PA (by both chronological and biological age) in males and females across adolescence. It further showed that an increase in total and central fatness during adolescence may be critical for the development of the metabolic syndrome in adulthood. Timing of biological maturity, in general, was not shown to have an independent impact on adolescent or young adult PA, adolescent perceived barriers to PA, fat mass development, or young adult cardiometabolic risk. However, further research is required before definitive conclusions can be made about the short and long term impacts of timing of biological maturity on health.

Background: It has been reported that the ratio of limb fat to trunk fat (LF/TF) is associated with markers of cardiometabolic risk in elderly men and women. However, it is unknown if LF/TF is associated with cardiometabolic risk beyond that explained by LF and TF independently. Objective: To determine if LF/TF is associated with markers of cardiometabolic risk in elderly men and women after control for LF and TF. A secondary objective was to examine the independent associations of LF and TF with markers of cardiometabolic risk. Methods: Subjects included abdominally obese men (n=58) and women (n=78) between 60 and 80 years of age. Regional adiposity was quantified using magnetic resonance imaging. Insulin resistance, fasting glucose, HDL-cholesterol, plasma triglycerides and adiponectin were determined. Regression analyses and partial correlations were used to assess the independent associations between variables. Results: After control for potential confounders, TF was positively associated with fasting glucose, insulin resistance and plasma triglycerides, and negatively associated with HDL-cholesterol (p<0.05). These associations were strengthened after further control for LF (p<0.05). LF was not associated with any marker of cardiometabolic risk after control for potential confounders (p>0.05). However, after further control for TF, LF was positively associated with HDL-cholesterol and negatively associated with plasma triglycerides (p<0.05). Plasma adiponectin was independently associated with both LF and TF in elderly women (p<0.05) but was not independently associated with either depot in elderly men (p>0.05). LF/TF was not associated with any marker of cardiometabolic risk after control for LF and TF. Conclusions: These results suggest that it is the absolute, rather than relative amounts of LF and TF which have the greatest influence on cardiometabolic risk in elderly men and women. Further, these results suggest that the associations between plasma adiponectin and regional adiposity are significantly influenced by sex in elderly men and women. / Thesis (Master, Kinesiology & Health Studies) -- Queen's University, 2008-12-05 16:08:10.868

Emerging evidence suggests that sedentary behaviour is independently associated with cardiometabolic disease risk in school-aged children and youth. This thesis includes 4 related studies in the pursuit of 2 objectives: 1) To determine the cross-sectional association of sedentary time, interruptions in sedentary time, sedentary bout length, and total movement variability with markers of cardiometabolic disease risk among children and youth, and 2) To examine the impact of 1-day of prolonged sedentary behaviour, with and without interruptions or structured physical activity, on markers of cardiometabolic disease risk, hunger, food intake and spontaneous physical activity levels in children and youth. In Study 1, we found that interruptions in sedentary time and short bouts of sedentary time were beneficially associated with clustered cardiometabolic disease risk in boys and girls aged 8-11 years, independent of total sedentary time, moderate-and-vigorous physical activity (MVPA), and other confounders (all p<0.05), while the opposite was true for screen based sedentary behaviours. In Study 2, we found that movement variability (minute-to-minute changes in movement intensity) was negatively associated with clustered cardiometabolic disease risk and systolic blood pressure independent of MVPA, sedentary time and other covariates in a representative sample of American children and youth aged 12-17 years (all p<0.05). In Studies 3 and 4, we found that prolonged sitting, with or without interruptions and structured MVPA did not result in acute changes in markers of cardiometabolic disease risk, nor subsequent ad libitum food intake or physical activity levels in healthy children aged 10-14 years (all p ≥0.05). Taken together, the studies that make up this thesis suggest that optimal levels of cardiometabolic disease risk are most likely to be seen in children who limit their time engaging in screen-based sedentary behaviours, who frequently interrupt their sedentary time, and who have high levels of variability in their movement behaviours.

Emerging evidence suggests that sedentary behaviour is independently associated with cardiometabolic disease risk in school-aged children and youth. This thesis includes 4 related studies in the pursuit of 2 objectives: 1) To determine the cross-sectional association of sedentary time, interruptions in sedentary time, sedentary bout length, and total movement variability with markers of cardiometabolic disease risk among children and youth, and 2) To examine the impact of 1-day of prolonged sedentary behaviour, with and without interruptions or structured physical activity, on markers of cardiometabolic disease risk, hunger, food intake and spontaneous physical activity levels in children and youth. In Study 1, we found that interruptions in sedentary time and short bouts of sedentary time were beneficially associated with clustered cardiometabolic disease risk in boys and girls aged 8-11 years, independent of total sedentary time, moderate-and-vigorous physical activity (MVPA), and other confounders (all p<0.05), while the opposite was true for screen based sedentary behaviours. In Study 2, we found that movement variability (minute-to-minute changes in movement intensity) was negatively associated with clustered cardiometabolic disease risk and systolic blood pressure independent of MVPA, sedentary time and other covariates in a representative sample of American children and youth aged 12-17 years (all p<0.05). In Studies 3 and 4, we found that prolonged sitting, with or without interruptions and structured MVPA did not result in acute changes in markers of cardiometabolic disease risk, nor subsequent ad libitum food intake or physical activity levels in healthy children aged 10-14 years (all p ≥0.05). Taken together, the studies that make up this thesis suggest that optimal levels of cardiometabolic disease risk are most likely to be seen in children who limit their time engaging in screen-based sedentary behaviours, who frequently interrupt their sedentary time, and who have high levels of variability in their movement behaviours.

Whilst high levels of cardiorespiratory fitness and physical activity may protect against cardiometabolic risk factor clustering, evidence suggests these outcomes are below optimal in English youths. Adolescence is a key stage in health behaviours development, and thus represents an opportunity for interventions aiming to improve the cardiometabolic health, fitness and activity levels of this population. Recently, there has been growing interest in the efficacy of low-volume high-intensity interval training (HIT) as a time efficient way of improving health and fitness outcomes in adults. Contrastingly, the effects of low-volume HIT in adolescents remains relatively unknown. The first aim of this programme therefore was to develop a novel school-based low-volume HIT intervention. The second was to determine the effectiveness of this model for improving the cardiometabolic health, cardiorespiratory fitness and physical activity levels of adolescents. Study one examined adolescents’ views towards high-intensity exercise, and the proposed low-volume HIT intervention. This data was used to design the novel low-volume HIT model. In Study 2, participants’ heart rate and perceived exertion responses to three prototype prescriptions of low-volume HIT, based on boxing, dance and football were examined. Here, it was indicated that these activities were capable of eliciting a high-intensity training response (~90% of maximum heart rate). Study 3 incorporated the main intervention, which examined the effect of a 10-week multi-activity low-volume HIT intervention (named Project FFAB [Fun Fast Activity Blasts]) on various health and fitness outcomes in adolescents. Here, beneficial effects were detected in the intervention participants compared to the controls for triglycerides, waist circumference, lipid accumulation product and daily moderate-to-vigorous physical activity. Study 4 assessed the fidelity of the intervention, and found that this had been largely upheld. Collectively therefore, it appears that Project FFAB represents a viable strategy for improving aspects of cardiometabolic health and physical activity levels in adolescents.

Obesity, elevated blood pressure and dyslipidemia are highly prevalent in Hispanic children. Compared to their non-Hispanic White peers, Hispanic children experience higher prevalence of obesity and hypertension. The Hispanic population in Tennessee has been growing, with about a tenth of newborn babies being Hispanic. This study aimed to: 1. Examine the influence of sociodemographic factors on Hispanic children’s cardiometabolic risk; 2. Assess the relationship between food group intake and cardiometabolic risk in Hispanic children; and 3. Evaluate the efficacy of non-traditional biomarkers for detecting cardiometabolic risk in Hispanic children. Data for the study came from a larger cross-sectional pilot study of metabolic syndrome in Hispanic children attending a community health center in Johnson City, TN. Descriptive and multiple logistic regression analyses were used. The prevalence of overweight and elevated blood pressure were 40.7% and 31.0% respectively. Children of obese mothers were more likely than children of mothers with normal body mass index to engage in less than three days of at least 60 minutes of vigorous physical activity (PA) per week (OR: 6.47: 95% CI: 1.61-26.0). Children whose mothers did not engage in moderate PA were more likely to have elevated blood pressure (OR: 2.50, 95%CI: 1.02-4.53); and to engage in less than three days of at least 60 minutes of vigorous PA per week (OR: 2.92, 95% CI: 1.18-7.24), than children whose mothers engaged in moderate PA. Children generally exceeded fruit and legume intake recommendations, but did not meet vegetable, wholegrain, dairy and fiber recommendations. Higher legume (OR: 0.052, 95% CI: 0.04-0.64), dairy (OR: 0.61, 95% CI: 0.37-0.99) and fiber intake (OR: 0.88, 95% CI: 0.81-0.96) were protective against elevated blood pressure, but only fruit intake was protective against overweight (OR: 0.93, 95% CI: 0.87-0.99). Leptin, C-peptide and TNF-α showed significant positive correlations with cardiometabolic risk factors. The optimal cut-offs for detecting three or more cardiometabolic risk factors were: leptin, 5.95 ng/ml, C-peptide, 0.73 ng/; and TNF-alpha, 4.28 pg/ml. Helping mothers to achieve and maintain a healthy BMI and promoting children’s consumption of more vegetables, fruits, dairy and fiber could help reduce cardiometabolic risk in Hispanic children.

p. 1-101 / Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-05-02T19:07:04Z No. of bitstreams: 1 7777777777777aaa.pdf: 645591 bytes, checksum: d42bcd7410890d638848d6e5f366302c (MD5) / Approved for entry into archive by Maria Creuza Silva(mariakreuza@yahoo.com.br) on 2013-05-04T17:42:39Z (GMT) No. of bitstreams: 1 7777777777777aaa.pdf: 645591 bytes, checksum: d42bcd7410890d638848d6e5f366302c (MD5) / Made available in DSpace on 2013-05-04T17:42:39Z (GMT). No. of bitstreams: 1 7777777777777aaa.pdf: 645591 bytes, checksum: d42bcd7410890d638848d6e5f366302c (MD5) Previous issue date: 2009 / Objetivo: identificar fatores associados ao baixo risco cardiometabólico (RCM) em mulheres obesas (MOb) atendidas em ambulatórios especializados do SUS, Salvador – BR. Métodos: estudo caso-controle, pareado pela idade com 306 MOb, IMC ≥30kg/m², sendo 66 (21,6%) casos – todos não hipertensos, normolipídicos e não diabéticos e 240 (78,4%) controles. Dados secundários foram obtidos dos prontuários médicos e primários através de inquérito domiciliar e de exames laboratoriais. Foram realizadas análises: descritiva, bivariada e regressão logística condicional. Resultados: associações positivas, estatisticamente significantes, foram detectadas entre baixo RCM e consumo de ≥3 porções de frutas/dia (ORaj = 20,1; IC95%: 5,6 – 71,9); PCR do 1º. quartil (ORaj = 4,1; IC95%: 2,0 – 8,3) e da adiponectina plasmática (AdipoQ) a partir do 3º. quartil (ORaj = 2,3; IC95%:1,1 – 4,8). Conclusão: este estudo sugere que dieta rica em fibras solúveis (≥3 porções de frutas/dia), valores da PCR ≤3,70mg/L e da AdipoQ >10,00µg/mL podem dificultar, retardar ou impedir o aparecimento de outros fatores de risco ou doenças metabólicas em MOb. / Salvador

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / The oxidative biomarkers play an important role in the genesis of cardiometabolic risk related processes. This study aimed to investigate in clinically healthy young non-obese subjects, the total antioxidant capacity of plasma and its possible associations with anthropometric, body composition, clinical, biochemical and dietary related to cardiometabolic risk. This study evaluated individuals between the ages of 18 and 25 y, of two college of the state of Sergipe. Anthropometric parameters and body composition were measured using standardized techniques and previously described in the literature. Mechanical sphygmomanometer mercury column was used for the measurement of systolic and diastolic pressure. After fasting for 12 hours, by venipuncture, blood samples were collected to make biochemical parameters analysis and plasma antioxidant capacity. The samples (serum and plasma) were conditioned at -80°C until assay. Serum glucose, total cholesterol, high density lipoprotein, triglycerides and total antioxidant capacity plasma was evaluated by colorimetric or turbidimetric assays. The daily dietary intake was assessed by food frequency questionnaire semi-quantitative. Comparisons between groups categorized by the 25th percentile of total antioxidant capacity plasma were performed using the Mann-Whitney- U test for numerical variables. The Spearman correlation were used to track the between total antioxidant capacity plasma and other variables. The results were presented as mean ± SD or absolute frequency and relative. The confidence interval was 95% and the level of statistical significance of 5%. The study included 139 subjects with a mean age of 21,4 ± 1,9 years, with 77% belonging to the female sex. There was no statistical difference between the groups established by percentile value 25th (2,635 mM) of the distribution of CAT using established groups. Regarding the components of cardiometabolic risk almost 25% of the sample had more than one component, 7.9% over two and 0.7% more than three, the most prevalent being reduced HDL cholesterol (15%). The value of CAT did not differ between the groups for the components of cardiometabolic risk. With regard to nutrient intake, individuals showed higher CAT less of trans fat consumption values, vitamin D, iodine and zinc. Inadequacies in energy intake, saturated fat, fiber, and vitamin D were substantial though not significant. There was no statistical difference to the daily dietary intake of any food groups according to the categorization of CAT. The CAT plasma was positively correlated with the PCSI variables (r =0,15, p =0,04) and glucose (r = 0,15, p = 0,03) and negatively with SBP (-0,18, p = 0,01). In the case of young people, non-obese and clinically healthy, unlike what occurs in people with diseases already installed the CAT was unable to predict the components of cardiometabolic risk, possibly because of the introduction of active compensatory mechanism in physiological conditions. / Os biomarcadores oxidativos desempenham importante papel na gênese de processos relacionados ao risco cardiometabólico. O presente estudo teve como objetivo investigar, em indivíduos jovens, não obesos e clinicamente saudáveis, a capacidade antioxidante total do plasma e suas associações com os parâmetros antropométricos, de composição corporal, clínicos, bioquímicos e dietéticos, relacionados ao risco cardiometabólico. Foram avaliados indivíduos com idade entre 18 e 25 anos, de duas instituições de ensino de nível superior do estado de Sergipe. Os parâmetros antropométricos e de composição corporal foram aferidos mediante técnicas, previamente padronizadas e descritas na literatura. Esfigmomanômetro mecânico de coluna de mercúrio foi utilizado para a aferição da pressão arterial sistólica e diastólica. Após jejum de 12 horas, mediante punção venosa, foram coletadas amostras de sangue, separadas em soro e plasma e acondicionadas a -80°C As concentrações séricas de glicose, colesterol total, lipoproteína de alta densidade, triacilgliceróis e capacidade antioxidante total do plasma foram analisadas por ensaios colorimétricos ou turbidimétricos. A ingestão dietética diária foi estimada mediante aplicação de questionário de frequência alimentar semi-quantitativo. As comparações entre grupos, categorizados pelo percentil 25 da capacidade antioxidante total do plasma, foram realizadas utilizando o teste de U-Mann-Whitney. Foi utilizado o teste de Spearman para rastrear as correlações existentes entre a capacidade antioxidante total do plasma e as demais variáveis estudadas. O intervalo de confiança foi de 95% e o nível de significância estatística de 5%. Participaram do estudo 139 indivíduos com idade média de 21,4 ± 1,9 anos, sendo 77% pertencente ao sexo feminino. Não houve diferença estatística entre os grupos estabelecidos pelo valor do percentil 25 (2,635 mM) da distribuição da CAT. Quanto aos componentes do risco cardiometabólico quase 25% da amostra apresentou mais de um componente, 7,9% mais de dois e 0,7% mais de três, sendo o mais prevalente o HDL-colesterol reduzido (15%). O valor de CAT não diferiu entre os grupos para os componentes do risco cardiometabólico. A CAT do plasma se correlacionou positivamente com as variáveis PCSI (r=0,15, p=0,04) e glicemia de jejum (r=0,15, p=0,03) e negativamente com a PAS (-0,18, p=0,01). Tratando-se de indivíduos jovens, não obesos e clinicamente saudáveis, diferente do que ocorre em populações com doenças já instaladas, a CAT não foi capaz de predizer os componentes do risco cardiometabólico, possivelmente, em razão da instauração do mecanismo compensatório atuante em condições fisiológicas.